FG-MR Jobs

Ph D thesis in MRI velocimetry

2012-01-27T10:28:00.000+01:00

Dear colleagues

the laboratoire Navier (Universite Paris Est, France) is offering a Ph D position
in the field of MRI velocimetry for rheo-NMR, available from September 2012.
We would be happy to consider the application of any of your motivated students.
Details and contacts:

https://docs.google.com/open?id=0B6DBIxdQKdLQZDJjNGJjZjAtYjhhMC00YWQzLWIwOTUtMDQwNWZmOTZiMDU4

With best regards

Stephane Rodts

Tenured researcher position

2012-01-27T10:27:00.000+01:00

Dear colleagues

we would like to bring to your attention a tenured researcher position that is
available at Universite Paris Est, France, in the field of NMR and MRI for material
sciences. We are looking for someone who can contribute to our activities in the field
of MR applications to civil engineering and environmental sciences, with a wide flexibility
as to the nature of the main interests of the individual concerned. Details and contacts:

https://docs.google.com/open?id=0B6DBIxdQKdLQNDRiYWY5OTgtYjc0ZC00ZDU3LWE0YjAtOTAxZDYyYjRjOGY3

With best regards

S. Rodts

Postoctoral position in Structural Biology

2012-01-27T10:26:00.001+01:00

UNIVERSITY OF OXFORD
DEPARTMENT OF BIOCHEMISTRY

Postdoctoral Research Associate in Structural Biology

We are seeking to appoint a highly motivated Postdoctoral Research
Associate in the laboratory of Dr. Ioannis Vakonakis for studies of
proteins involved in centriole assembly. The successful candidate will
join a multidisciplinary collaboration between Oxford and the groups of
Prof. Pierre Gönczy (EPFL) and Dr. Michel Steinmetz (Paul Scherrer
Institute) in Switzerland. Recently, our joint efforts elucidated the
origins of centriolar 9-fold symmetry (Kitagawa, Vakonakis et
al.,Cell144, 364-375, 2011), a critical step in the centrosomal
duplication process that ensures genome stability in animals. We now
seek to build upon this breakthrough by studying the structure/function
relationship of centriolar components such as SAS-6, SAS-5, SAS-4,
ZYG-1, SPD-2 and others. The successful candidate will contribute to the
analysis of these targets using structural (crystallography, solution
NMR and/or small angle scattering) and biophysical methods.

Applicants should possess/be expected to obtain a PhD in natural
sciences and should have experience in aspects of the structural biology
pipeline, for example protein production and purification, NMR
spectroscopy or X-ray crystallography. Past experience with
complementary biophysical techniques (ITC, AUC, CD etc) and biomolecular
interactions is desirable. Previous familiarity with centriolar or
relevant biological systems would be an advantage but is not essential.

This full-time post is funded by the Biotechnology and Biological
Sciences Research Council (BBSRC)for up to three years in the first
instance and is based in the New Biochemistry building, South Parks
Road, Oxford. More information about our group can be found by clicking
on the link below:

http://www2.bioch.ox.ac.uk/~rrnmr

This position is graded on the University’s grade 7 scale, for which the
salary range is £29,099 - £35,788 per annum. The actual starting salary
offered will be based on qualifications and relevant skills acquired and
will also be determined by the funding available.

For further general information, phone (01865) 613204, quoting reference
number BR/493.

Applications for this vacancy are to be made online.

To apply for this role and for further details, including the job
description and selection criteria,

please click on the link below:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=101979

The closing date for applications is Monday, 20thFebruary 2012. It is
envisioned that interviews for shortlisted candidates will take place
within approximately 10-14 days.

The University of Oxford is committed to equality and values diversity

Position at NMRTEC

2012-01-27T10:25:00.001+01:00

NMRTEC is opening a position for a doctoral thesis in the field of analytical chemistry dedicated to complex system and combinatorial chemistry.

As a part of the ITN READ European network, it is intended to conduct an extensive study on the development of analytical methods for the analysis of complex mixtures. This will include the study of large chemical libraries, auto-assembling systems, complex protein ligand interactions, and the study of polymers and disordered biological systems. Methods developed will include mostly NMR (1D, 2D, and multinuclear), diffusion measurement by NMR (DOSY) but also other techniques such as SAXS and mass spectrometry.
This is a joined PhD project between NMRTEC and the biomolecular NMR academic laboratory (IGBMC, Dr. Marc André Delsuc).

A successful candidate should have strong interest specifically in NMR but also in analytical and spectroscopic techniques. A good knowledge in biological and pharmaceutical sciences is an advantage.
According to EU rules for ITN projects the applicant:
- has less than 4 years of experience since gaining a university degree and has not been awarded a doctoral degree;
- shall not be a national of the State in which the hosting partner's research team is located (France);
- must have resided in the France for no more than 12 months during the past 3 years.

The application should consist of the following parts:
• a brief letter explaining/motivating your interest in the position;
• a detailed Curriculum Vitæ, including a list of publications (if appropriate);
• a complete list of courses taken and grades obtained (including transcripts of academic records);
• contact details of two referees;
• any other relevant information.

links : http://www.systemschemistry.com/read/index.htm
http://www.igbmc.fr/research/3/team/35/
http://www.nmrtec.com

Contact : Marc-André Delsuc : madelsuc@unistra.fr

Research Fellowship NMR

2012-01-27T10:24:00.000+01:00

Research Fellow in Nuclear Magnetic Resonance Technology
University of Nottingham, UK
School of Physics & Astronomy

Applications are invited for the above post based in the Sir Peter
Mansfield Magnetic Resonance Centre which is part of the School of
Physics and Astronomy. The successful candidate will lead an ambitious
hardware development project that focuses on the the design and
implementation of a novel spectrometer for dynamic nuclear polarisation (DNP) enhanced NMR spectroscopy. The project involves extensive industrial collaboration and is funded by the Novel Technology Initiative in Cross-disciplinary Sciences of the EPSRC. The project covers the whole field of DNP research, including the testing of novel radicals, theoretical spin dynamics calculations and the design and construction of novel hardware.

Candidates should have a PhD in physics, physical chemistry or a related
discipline and preferably have experience in one or several of the
following fields: Microwave technology, Cryotechnology, Magnetic
Resonance hardware technology, Laser Optics. Additional expertise in NMR
theory or practical experience with dynamic nuclear polarisation would
be beneficial but not essential. Candidates should have good
communication skills and enjoy working with a variety of different
people across discipline boundaries.

This post will be offered on a fixed-term contract for a period of three
years. Salary will be £27,319 - £31,671 per annum, depending on skills and experience.

Informal enquiries should be addressed to Dr Walter Köckenberger, email:
walter.kockenberger@nottingham.ac.uk

For more details and/or to apply on-line please access:
http://www.nottingham.ac.uk/Jobs/CurrentVacancies/ref/SCI992X2. If you
are unable to apply on-line please contact the Human Resources
Department, tel: (44 (0)115 846 6172. Please quote ref. SCI/992X2.

PhD student position at Wageningen

2012-01-27T10:23:00.000+01:00

Diffusional Nanoprobes for Multi-length Scale material Characterisation (DINAMISCH)

In the DINAMISCH project we aim at overcoming the current bottlenecks in non-invasive multi-length scale characterisation during structure formation and degradation in semi-solid matter by diffusional probing using advanced magnetic resonance methods. DINAMISCH is an academic-industrial collaboration between Wageningen University and two industrial partners, SyMO-Chem and Unilever. DINAMISCH is part of the research programme of COAST, the Dutch public-private partnership on Analytical Science and Technology.

We are now searching for a Ph.D. Student (4 years) who will develop and apply novel magnetic resonance methods for probing materials at different length scales (nano/meso/micro). The focus will be on PFG and MRI methodologies for assessment of structure formation/degradation under dynamic conditions. This will also require the joint deployment of novel rheo- and DNP approaches. The student will work closely with a postdoc working on design and manufacturing of diffusional nanoprobes and with industrial researchers at Unilever and SyMO-Chem. The PhD student will be based at the Laboratory of Biophysics, Wageningen University.

For more information contact Dr. Henk Van As (Henk.VanAs@wur.nl) or Prof. Dr. John van Duynhoven (John.vanDuynhoven@wur.nl).

NMR position Glasgow

2012-01-27T10:22:00.001+01:00

Characterisation of an endotoxin-sensing molecular switch

This project, in collaboration with Marine Biotech Limited, will examine the molecular recognition events that underlie the recognition of bacteria by Factor C, the initiator of the Horseshoe Crab’s innate defence system, using structural biology and biophysical techniques. The successful applicant will be a highly qualified and motivated graduate with a life sciences or chemistry degree and relevant experience. They will be trained in molecular biology, recombinant protein expression and purification, structural biology and biophysical techniques - in particular biomolecular NMR spectroscopy.

http://www.findaphd.com/search/ProjectDetails.aspx?PJID=36797
http://www.gla.ac.uk/colleges/mvls/graduateschool/informationforprospectivestudents/phdandmresscholarships/phdopportunities/

Dr. Brian O. Smith --------------------------- Brian Smith at glasgow ac uk
Institute of Molecular, Cell and Systems Biology & School of Life Sciences,
College of Medical, Veterinary & Life Sciences,
Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
Tel: 0141 330 5167/6459/3089 Fax: 0141 330 4600
----------------------------------------------------------------------
The University of Glasgow, charity number SC004401

Post Doc low field NMR

2012-01-18T16:20:00.000+01:00

Post-Doc Position at CEA-Saclay (Paris) in low-field NMR

A one-year post-doctoral position is available to join the group of Dr. Dimitris Sakellariou at the Laboratory of Structure and Dynamics by Magnetic Resonance at the French Alternative Energies and Atomic Energy Commission of Saclay in Paris. Our focus is primarily directed at developing low-field (0.5 to 2.5 Tesla) NMR spectroscopic applications. The project is funded by the CEA for one year.

The net salary will be approximately 2000 - 2500 Euros/month (depending on the experience of the candidate).

Prospective candidates should have demonstrated experience in Magnetic Resonance Spectroscopy, relaxometry, in solid-state NMR, instrumentation or connected areas experimental physics and engineering.

Applicants should send 3 references in a cover letter as well as a full CV including the list of their publications and conference presentations to dsakellariou@cea.fr. Deadline for the application: January 30, 2012.

PhD projects

2012-01-18T16:19:00.001+01:00

4 year PhD studentships in Translational Medicine are available at the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at Guy’s & St Thomas’ NHS Foundation Trust (GSTFT) and King’s College London (KCL). Excerpts from the call are copied below while the full call can be found here:

http://biomedicalresearchcentre.org/Resources/Professionals/Training/Fellowshipinfo/BRCPhDstudentshipsCallforApplications2012FINALAC(2).pdf

The BRC’s new 4 Year PhD Studentship programme represents an innovative approach to supporting the most promising graduates to undertake in depth postgraduate training in translational research leading to the award of a PhD. To facilitate training in Translational Medicine, students will have dual supervision by one clinician/clinical scientist and one basic scientist. The programme is designed to allow students to broaden their knowledge of translational research by undertaking three laboratory rotations and core training modules during Year 1. Applicants will select their choice of potential PhD projects from the BRC Studentship project list posted on the BRC website. This training period will help prepare students in the relevant research methodologies and/or develop the necessary understanding of the project area relevant to the final PhD project, to be undertaken during Years 2-4.

PhD Students will become full time students of King’s College London, and members of the BRC Faculty of Translational Medicine. Students will have access to core facilities, write up areas, bioinformatics and training support via the BRC resource centre.

Under this PhD Studentship programme call, the BRC are seeking to appoint up to 10 PhD Students to undertake translational biomedical research in a scientific area covered by the Centre. Funding under this scheme provides:

1) a stipend of £20,191 per annum for 4 years, which should also be used to cover MRes and PhD registration/tuition fees at the UK student rate.

2) a £2,000 contribution towards laboratory rotation expenses in year 1.

3) a £5,000 per annum consumables budget for years 2-4.

http://biomedicalresearchcentre.org/Professionals/EducationAndTraining/STEMFellowship/2012PhDProjectList.aspx

Available projects include a number focussed on the translatable application of magnetic resonance including a cluster of Magnetic Resonance Imaging based projects while our own group offers a project in the area of NMR metabolomics.

http://biomedicalresearchcentre.org/Resources/Professionals/Training/Fellowshipinfo/PhDProjectProformas/cantumourcellmovementplasticitybeidentifiedinmultiplecancersusingNMR-metabolomics.pdf

Applicants should have or expect to obtain a first-class or upper second-class degree or equivalent and have a track record in academic excellence. Previous research experience is desirable. Additional eligibility criteria for entry into the KCL graduate programme is detailed on the online postgraduate prospectus which can be accessed via the following link http://www.kcl.ac.uk/gsp08

Applications to the BRC should be made by electronic submission to include the following:

1) A two page CV

2) A covering letter setting out clearly which THREE BRC projects the applicant is most interested in applying for (the list of available projects is available at www.biomedicalresearchcentre.org ). These should be ranked in priority order 1-3, with projects ranking 1 being the candidate’s 1st choice.

Applications should be emailed to brc@gstt.nhs.uk by the deadline below.

The deadline for receipt of applications under this scheme is 5pm on Monday 30 January 2012. A structured visit to the BRC at Guy’s Hospital and interviews for shortlisted candidates has been provisionally scheduled for 13-14 February 2012 in the BRC on the guy’s Hospital Campus of KCL. All applicants should make a note of these interview dates, since it is likely that candidates shortlisted for interview will be notified only the week before. Successful applicants are expected to take up their studentships in October 2012.

NMR Spectroscopist

2012-01-12T07:50:00.001+01:00

The Department of Chemistry and Biochemistry at the University of Delaware
seeks an NMR Spectroscopist for its departmental NMR Facility. The rapidly
growing NMR facility is located in a newly built 4,650 ft2 NMR Magnet Hall, and
consists of 6 spectrometers operating at frequencies from 400 to 850 MHz.
These instruments serve more than 30 research groups at the University of
Delaware and beyond, and are used for modern NMR experiments on a wide variety
of systems, including biomacromolecules, inorganic materials, polymers, and
small molecules, both in solution and the solid state. The successful
candidate will report to the NMR Facility Director, and will be responsible for
operating and maintaining the instrumentation, for implementing new NMR
experiments, for training and supervising student and postdoc users, and for
assisting in the preparation of proposals for new equipment. The candidate
will be expected to maintain a broad knowledge of state-of-the-art NMR
technology and equipment.

Candidates must have a Ph.D. in chemistry or a related area with four years'
experience in solid-state and solution NMR spectroscopy and its applications to
biological systems and small molecules. Candidates must have demonstrated
expertise in solid-state and solution NMR spectroscopy, including development
and implementation of new NMR experiments, and in particular multidimensional
experiments for structural analysis of biological systems. Candidates must
have knowledge of NMR hardware and software for data collection and processing
in modern solution and solid-state NMR spectrometers, as well as extensive
experience with computers. Candidates must have excellent communication and
organizational skills, the ability to positively interact with a diverse group
of NMR users, and a strong motivation to learn new NMR techniques. More
information is available at the departmental web site
(http://sites.udel.edu/nmr). Applications and three letters of recommendation
should be electronically submitted to Ms. Susan Cheadle (scheadle@udel.edu).
In addition, applicants should go to http://www.udel.edu/udjobs/ and attach a
letter of application and curriculum vitae (including telephone number and
e-mail address) as one document. Review of applications will begin on Jan. 30,
2012, and will continue until the position is filled. All application
materials shall be shared with departmental faculty.

Employment offers will be conditioned upon successful completion of a criminal
background check. A conviction will not necessarily exclude you from
employment.

The University of Delaware is an Equal Opportunity Employer which encourages
applications from Minority Group Members and Women. The University's Notice of
Non-Discrimination can be found at
http://www.udel.edu/aboutus/legalnotices.html

Post-Doctoral Position

2012-01-12T07:48:00.001+01:00

Post-Doctoral Position in NMR Spectroscopy of Lithium Ion Battery Materials

An opening for a Postdoctoral Fellow is available in the Department of Chemistry and Chemical Biology at McMaster University. The successful candidate will work in the research group of Dr. Goward and the focus of this industry-funded position will be research on development and application of in situ NMR measurements of electrochemical lithium ion cells, with an aim to understand processes in vehicle batteries. This position is intended for a physical chemist interested in moving into a new research area, or for an NMR spectroscopist, interested in using their NMR expertise in this applied field. (knowledge of electrochemistry and material chemistry is also an asset). This research project will involve close collaboration with material scientists, chemists, and mathematicians, as well as research scientists with our Industrial Partners.

The fellowship is open to candidates of any nationality and selection will be based upon the candidate's research potential. The start date of the position is May 1, 2012. The duration of the position will be initially one year with extension for the second year contingent on satisfactory performance. The annual salary will be $45,000 CAD. We will begin reviewing applications on March 1, 2012. Applications received after this date will be accepted until the position is filled, and to ensure full consideration, applicants are advised to submit all supporting materials by the deadline.

Applicants should provide at least three letters of recommendation. They may be sent directly to:

Dr. Gillian Goward
Department of Chemistry and Chemical Biology
McMaster University
Hamilton, Ontario, CANADA L8S 4M1
Phone: +1 (905) 525 9140 ext. 24176
Fax: +1 (905) 522-2509
Email: goward@mcmaster.ca
URL: www.chemistry.mcmaster.ca/goward

McMaster is committed to Employment Equity and encourages applications from all qualified candidates, including aboriginal peoples, persons with disabilities, members of visible minorities and women.

Postdoctoral position in solid state NMR

2012-01-11T15:53:00.001+01:00

In the Research Group Macromolecular Interactions at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany. We are looking for an open-minded, enthusiastic candidate motivated to employ solid-state NMR spectroscopy to study the molecular mechanisms of host-pathogen interactions involved in innate immunity. The project focuses on the recognition of bacterial amyloid-like fibrils by specific host proteins and aims to identify molecular patterns of these fibrils recognized by the innate immune system. The successful candidate will join an interactive, dedicated team using NMR spectroscopy in combination with a wide range of state-of-the-art biophysical and proteinbiochemical techniques to study the structure and function of amyloids and other ordered aggregates in bacterial and viral infections. The project will be carried out in close collaboration with Dr. Barth van Rossum at the FMP in Berlin, and there will be the opportunity to tightly interact with both groups.

The HZI is a member of the Helmholtz Association of German Research Centres and dedicated to undertake biomedical research in the field of infection biology to expand our knowledge of the fundamental mechanisms behind medically relevant infectious diseases. It is part of a lively scientific community connected to the Technical University of Braunschweig, the University of Hannover and the Hannover Medical School. The Institute offers excellent working conditions for structural biologists, with state of the art technical equipment including facilities for the expression of proteins in mammalian, insect cell and bacterial systems, and excellent support for the development of personal soft-skills.

Prerequisites:

Strong experience in biomolecular NMR spectroscopy, ability to work as part of an international team and excellent communication skills in English (written and spoken) are a prerequisite. Experience in protein expression and purification will be considered an advantage. Candidates should hold a PhD in biophysics, biochemistry, chemistry, biology or related fields.

Starting date: as soon as possible

Duration: Initial contract for 2 years, with option for extension

Salary: TVöD E13 + Bonus to E14

Please send your application including CV, publication list, statement of research interests and the contact data of at least two referees referring to code 68/2011 to:

Helmholtz Centre for Infection Research, Dept. of Human Resources, Inhoffenstraße 7,
38124 Braunschweig, or by E-Mail: JobsHZI@helmholtz-hzi.de

For further information, please contact Prof. Christiane Ritter
Telephone: +49-531-6181-7065, e-mail: christiane.ritter@helmholtz-hzi.de.

Postdoctoral positions Spain

2012-01-11T15:50:00.001+01:00

PhD student and two Postdoctoral positions in Structural determination of protein complexes at the IRB Barcelona (SPAIN)

The protein NMR group of Dr. Maria J. Macias has openings for two positions, a PhD and a Postdoct, to conduct solution NMR and/or X-Ray studies of proteins and complexes. Applicants should have a degree in Chemistry, Biochemistry or related. For the Postdoctoral position experience in structural biology is required.
The offered positions correspond to the project named "Structural and functional studies on Smad transcription factors" (PI: Maria J. Macias)

A second Postdoctoral position is available for the project Synthesis of modified peptides and structural characterization of their interactions with pharmacologically relevant proteins. Synthesis of inhibitors (PIs: Maria J. Macias and Antoni Riera). For this position, experience in peptide chemistry and/or chemical ligation is of advantage, and no experience in molecular biology is required.
Applicants should send to maria.macias@irbbarcelona.org or to antoni.riera@irbbarcelona.org their C. vitae, including a list of their publications, a cover letter explaining the candidate’s interest in the position and the names and contact details (including e-mails) of three individuals we may contact for reference letters.

Furthermore, applicants should be ready to apply for fellowships. Applications for the “la Caixa”/IRB Barcelona International PhD Programme Fellowships are now being accepted. The IRB Barcelona International Postdoctoral Programme co-funded by the FP7 Marie Curie-COFUND Programme is expected to be launched on 13 January 2012.

------------------------------------------------
Pau Martín Malpartida
Protein NMR Lab.
PCB-IRB
Barcelona Science Park
Josep Samitier 1-5 08028 Barcelona, Spain
Tel : +34 93 4037190
http://www.maciasnmr.net
eMail: pau.martin@irbbarcelona.org

Postdoc

2012-01-11T15:48:00.000+01:00

An opening exists at the University of Georgia for a postdoctoral associate to work on structural characterization of proteins using advanced NMR techniques. Primary responsibilities reside with our role in the Northeast Structural Genomics Consortium (NESG). These responsibilities involve structure improvement and validation of structures using RDC and RCSA data, as well as the production of a number of biologically relevant protein structures. Our lab also has strong programs in the glycobiology and vesicle trafficking areas, and we anticipate opportunities to be involved with these activities as well. We have excellent NMR instrumentation with a 600 MHz machine dedicated to the NESG project and higher field instruments with cryogenic probes at 800 and 900 MHz.

It is especially important that candidates have experience with advanced NMR methodology (either solution or solids) and are interested in the development of novel approaches to solving challenging problems in the structural biology area. Please send a letter describing your interests, along with a CV and the names of three individuals that may be contacted for reference letters, to James H. Prestegard (jpresteg@ccrc.uga.edu) by January 25, 2012. The University of Georgia is an AA/EEO employer.

James H. Prestegard
Complex Carbohydrate Research Center
University of Georgia
315 Riverbend Rd
Athens, GA 30602-4712
706-542-6281
jpresteg@ccrc.uga.edu

2 years Post-doctoral position

2012-01-11T15:47:00.001+01:00

2 years Post-doctoral position:

NMR study of paramagnetic AxMO2 (A = Li, Na) layered oxides to help understanding the structure-properties relationship

ICMCB - CNRS
87, Avenue du Docteur Schweitzer , 33608 PESSAC cedex (France)

Starts in between May and October 2012.

For more information, please contact :
Dany CARLIER
carlier@icmcb-bordeaux.cnrs.fr
Tel : 00 33 (0)5 40 00 35 69

--
Dany CARLIER-LARREGARAY
ICMCB-CNRS
Maître de conférences - Université Bordeaux1
33 +5 40 00 35 69

PhD and PostDoc positions SSNMR

2012-01-11T15:46:00.001+01:00

PhD and PostDoc positions in solid-state NMR

Development and applications of high-resolution solid-state NMR methods to study molecular systems of pharmaceutical, energy and environmental interest

Job summary:

Two research grants (1 PhD and 1 PostDoc) are available for highly motivated candidates with an outstanding academic record in the Science or Engineering disciplines, at the Group for Synthesis, Structure and Technological Application of Materials – SYSTAM – at the University of Oviedo (Spain) and the Center for Research in Ceramics and Composite Materials – CICECO – at the University of Aveiro (Portugal) within the framework of project MAT2010-15094. This project aims at employing state-of-the art solid-state NMR (SSNMR) methodology and computational methods to understand the underlying intermolecular interactions, which play a crucial role in the molecular arrangement of pharmaceutical systems and elucidate the chemical structure of inorganic-organic hybrid materials of environmental and catalytic interest. The successful candidates will have access to fully equipped SSNMR spectrometers ranging from 400 to 800 MHz located at both universities and at the installations of the Portuguese NMR network. The candidates will also have access to several diffraction equipments including sophisticated high-resolution single-crystal/powder X-ray and electron diffraction equipments.

See below the job description and application details for each position (Note: the PostDoc position description is just after the PhD position details written below)

L. Mafra

--------------------------------
Luís Mafra, PhD
CICECO research laboratory
Chemistry Department
University of Aveiro
3810-193 Aveiro
Portugal
---------------------------------
e-mail: lmafra@ua.pt
Office: +351 234 247135 (ext. 24754)
Fax: +351 234 370 084

####### PhD position ##############################################

Job description:

Duration: The PhD grant will have an initial duration of 12 months, with a predicted starting date of 01 March 2012, and a possible extension up to a period of 60 months. The further extension will be possible depending upon the success on application to different Spanish (as FPI, FPU, Severo Ochoa or PPI-Uniovi) or European programs.

Application deadline: 31 January, 2012

Activity Outline: The objectives of the project will be to perform experimental and computational studies of tridimensional structure of compounds with pharmaceutical interest based on solid-state NMR spectroscopy combined with X-ray diffraction methods and computer simulations. The systems to be studied may include two research lines:
i) Pharmaceutical systems: polymorphism and the study of intermolecular forces implied in the transformation between pharmaceutical hydrates and anhydrates; study of polymeric scaffolds hosting drugs to investigate the structure and intermolecular drug-drug and drug-host interactions involved in the mechanism of swelling, drug impregnation, and drug release.
ii) Systems of environmental, energy and catalytic interest: Study of hybrid materials to capture CO2 and to convert catalytically the CO2 to various commodity chemicals. The hybrid materials to be studied include ionic liquids and Metal Organic Frameworks (MOFs).

Academic Requirements: Prospective applicants should possess a degree in Science or Engineering disciplines (Physics, Chemistry, Physical Chemistry, Computational Chemistry or related fields). Previous experience in computational methods or NMR spectroscopy is an advantage but not mandatory. The candidate should have a final course classification equal or above 16/20. The candidates should, preferably, have less than two years after graduation.

Evaluation Criteria and Process: The evaluation criteria are: i) Final classification of Undergraduate (value: 8/20) and Masters (value: 5/20) degrees; ii) Previous experience in related areas (value: 2/20); iii) Scientific publication record (value 2/20); Interview (value 3/20). All eligible candidates will first be classified in terms of absolute merit. Those approved will then be ordered consecutively in terms of relative merit. The candidate rated highest in the relative merit list will be invited to occupy the position. The selected person will be informed by email.

Documents Required: i) Application letter mentioning the contacts of two or three reference contacts; ii) Curriculum Vitae, dated and signed; iii) Photocopy (or scanned copy) of identity card or passport; iv) Academic degree certificate(s). Applications should be sent by email to Dr. Luís Mafra (lmafra@ua.pt) and Prof. Santiago García-Granda (sgg@uniovi.es) within the time frame of the call.

#######PostDoc position ##############################################

Job description:

Duration: The PostDoc grant will have an initial duration of 10 months, with a predicted starting date of 01 March 2012, and a possible extension period of 12 additional months till the end of 2013. Further contracts are possible depending upon the success on application to different Spanish programs (as Juan de la Cierva, Ramón y Cajal, Clarín) or European programs.

Application deadline: 31 January, 2012

Activity Outline: The objectives of the project will be to perform experimental and computational studies of tridimensional structure of compounds with pharmaceutical interest based on solid-state NMR spectroscopy combined with X-ray diffraction methods and computer simulations. The systems to be studied may include two research lines:
i) Pharmaceutical systems: polymorphism and the study of intermolecular forces implied in the transformation between pharmaceutical hydrates and anhydrates; study of polymeric scaffolds hosting drugs to investigate the structure and intermolecular drug-drug and drug-host interactions involved in the mechanism of swelling, drug impregnation, and drug release.
ii) Systems of environmental, energy and catalytic interest: Study of hybrid materials to capture CO2 and to convert catalytically the CO2 to various commodity chemicals. The hybrid materials to be studied include ionic liquids and Metal Organic Frameworks (MOFs).

Academic Requirements: Prospective applicants should possess a PhD in Science or Engineering disciplines (Physics, Chemistry, Physical Chemistry, Computational Chemistry or related fields). Previous experience in computational methods and/or solid-state NMR spectroscopy is an advantage. The candidate should have a top research profile with international experience. The candidates should be preferably under 35 and less than four years after the obtaining their PhD.

Evaluation Criteria and Process: The evaluation criteria are: i) Final classification of Undergraduate (value: 2/20) and Masters (value: 3/20) degrees; ii) Previous international experience in related areas (value: 5/20); iii) Scientific publication record (value 7/20); Interview in English (value 3/20). All eligible candidates will first be classified in terms of absolute merit. Those approved will then be ordered consecutively in terms of relative merit. The candidate rated highest in the relative merit list will be invited to occupy the position. The selected person will be informed by email.

Documents Required: i) Application letter mentioning the contacts of two or three international reference contacts; ii) Curriculum Vitae, dated and signed; iii) Photocopy (or scanned copy) of identity card or passport; iv) Academic degree certificate(s). Applications should be sent by email to Dr. Luís Mafra (lmafra@ua.pt) and Prof. Santiago García-Granda (sgg@uniovi.es) within the time frame of the call.

Senior Tenure-Track

2012-01-11T15:45:00.001+01:00

Senior Tenure-Track or Tenure-Eligible Investigator Position in Structural Biology & Biophysics

The Structural Biophysics Laboratory (SBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) is seeking an outstanding tenure-track or tenure-eligible principal investigator to carry out original, independent, and innovative research in an area of Structural Biology or Biophysics integrated with molecular biology. This intramural position is similar to that of an associate (or higher) professor in academia.

Areas of emphasis include structural biology of biomacromolecular systems and/or characterization of dynamic assembly/function of macromolecular complexes that impact the biological processes relevant to cancer and/or AIDS. The incumbent will establish/continue a highly competitive and collaborative program, with an emphasis or utilization of NMR spectroscopy, including solid-state NMR. Applicants must have a Ph.D. or equivalent degree and have demonstrated expertise and a record of achievement.

To apply, please submit a cover letter, curriculum vitae, description of research plans (~ 5 pages), and have 3 letters of recommendation set to: Ms. Deanna Doughtery, Administrative Officer, NCI-Frederick, PO Box B, Bldg. 578, Frederick, Maryland, 21702-1201, Tel. 301-846-5199, FAX 301-846-6053, E-mail: SBLsearch@mail.nih.gov. PDF files are encouraged.

--------------------------------------
Please share this announcement with your colleagues.
Best wishes,
Andy Byrd

===============================================
R. Andrew Byrd 301-846-1407
Chief, Structural Biophysics Laboratory FAX 301-846-6231
Macromolecular NMR byrdra@mail.nih.gov
http://ccr.cancer.gov/staff/staff.asp?profileid=5544

Center for Cancer Research
National Cancer Institute-Frederick
P.O. Box B, Bldg. 538
Frederick, MD 21702-1201
===============================================

PhD studentship

2012-01-11T15:44:00.001+01:00

A 4 year PhD studentship contract is available in my group starting september 2012 to work on the structural and functional aspects of the recognition of chromatin structure by the ING4 tumor suppressor.

We seek a motivated student with a strong interest in structural biology, and with a Master degree (to be completed before september 2012).

The PhD researcher will be involved in sample preparation and structural analysis by NMR and other techniques. The laboratory hosts two Bruker spectrometers (800 and 600 MHz) with a full complement of probes for biomolecular studies). Electron microscopy and crystallography platforms are also available at CIC bioGUNE. Functional assays will be carried out in collaboration with an external group.

CIC bioGUNE (http://www.cicbiogune.es) is a research institute in biosciences created and supported by the Basque Government in 2005 to foster bioresearch and biotech industry in the Basque Country. It is located near Bilbao, an area with a high standard of living, a mild climate and a vibrant cultural environment.

Information about the current activity and publications of the lab can be found in the following link

http://www.cicbiogune.es/secciones/investigacion/ficha_laboratorio.php?idioma=en&unidad=5&subgrupo=28

Interested applicants should send their CVs to fblanco@cicbiogune.es before the 31st of january 2012.

Best regards

---
Francisco J. Blanco
Ikerbasque Research Professor
Structural Biology Unit, CIC bioGUNE
Parque Tecnológico de Bizkaia, Edificio 800
48160 Derio, Spain
Phone: 34 946572521
Fax: 34 946572502
fblanco@cicbiogune.es
www.cicbiogune.es

Post-Doc in Montpellier

2012-01-11T15:43:00.002+01:00

The NMR group at the Centre de Biochimie Structurale (CBS) in Montpellier (France) is looking for a highly motivated researcher to join the team as a post-doc to work for two years on a project funded by the Chaires d’Excellence program of the French Research Funding Agency (ANR). The project, leaded by Pau Bernadó, aims the structural and dynamic characterization of a family of intrinsically disordered proteins linked to neurodegenerative diseases, and to reveal the molecular basis of the aggregation process causing these pathologies. This objective will be achieved by the integration of NMR, SAXS and single-molecule FRET data into novel computational approaches.

The successful candidate should have a PhD in chemistry, biology or physics and experience in solution state biomolecular NMR spectroscopy. Previous experience with protein expression and purification will be considered favourably. Knowledge in other biophysical techniques and computational methods will be favourably evaluated.

The laboratory hosts high-field state-of-the-art NMR spectrometers for biomolecular applications: A 700 MHz and a 500 MHz both equipped with cryoprobes and a 600 MHz. In addition to NMR, the CBS has an outstanding infrastructure covering all techniques for structural biology and biophysics including X-ray crystallography, cryo-electron microscopy, advanced fluorescent and super-resolution microscopes, single-molecule manipulation, molecular and cell biology, and high-performance computation.

Montpellier is a major biology area with a focus on basic research, biomedicine, plant biology and environmental science. Its science drive, the beauty of the region and its high quality of life, and the short commute to other major regional research areas (Barcelona, Paris, Toulouse, Marseille) make it an ideal destination for scientists from all over the world.

Applications and informal queries about the project and the lab should be addressed to Pau Bernadó (pau.bernado@cbs.cnrs.fr). Interested candidates should send their CV and the names of persons willing to write a recommendation letter in a cover letter describing their research interests and motivation.

Pau Bernadó, PhD
Group Leader

Centre de Biochimie Structurale
29, rue Navacelles
34090 Montpellier
France

Tel. +33(0)467417912
e-mail: pau.bernado@cbs.cnrs.fr

Postdoc

2012-01-11T15:42:00.002+01:00

Post-Doc Position at CEA-Saclay (Paris) in NMR / MRI instrumentation

A one-year post-doctoral position is available to join the group of Dr. Dimitris Sakellariou at the Laboratory of Structure and Dynamics by Magnetic Resonance at the French Alternative Energies and Atomic Energy Commission of Saclay in Paris. Our focus is primarily directed at developing a novel instrumentation for in vivo Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) of complex matter and small animals. The project is funded by the European Research Council for the next two years.

The duration is 12 months (with the possibility to renew it for another 12 months) and the net salary will be approximately 2100 - 2600 Euros/month (depending on the experience of the candidate).

Prospective candidates should have demonstrated experience in Magnetic Resonance magnet and coil (shims, gradients and rf) engineering, in clinical or pre-clinical MRS studies, solid-state NMR, instrumentation or connected areas experimental physics and engineering.

Applicants should send 3 references in a cover letter as well as a full CV including the list of their publications and conference presentations to dsakellariou@cea.fr.

NMR tenure track position at Brown University

2012-01-11T15:42:00.001+01:00

Structural Biology Faculty Position - Assistant Professor

The Department of Molecular Pharmacology, Physiology & Biotechnology at Brown
University announces the opening of a faculty position at the rank of Assistant
Professor, effective July 1, 2012. Qualifications include a Ph.D. and/or M.D.
degree with relevant postdoctoral research training and a record of excellence
in research. The successful applicant will be an experimentalist in the area
of NMR spectroscopy who will be expected to pursue an independent,
externally-funded research program. The applicant should demonstrate a
commitment to graduate and undergraduate education, and will have the
opportunity to participate in predoctoral training programs within the Division
of Biology and Medicine and the campus at large. Research space will be
provided in a new, state-of-the-art facility with access to modern core
facilities, NMR spectrometers, X-ray equipment, crystallization robotics, and
biophysical analysis instrumentation, such as ITC, DSC, CD and mass
spectrometry (LTQ Orbitrap) among others. Recent upgrades to the Brown
University structural biology infrastructure include the planned addition of an
850 MHz NMR spectrometer and new X-ray crystallography and small angle X-ray
scattering (SAXS) equipment.

Candidates should submit a curriculum vitae with complete bibliography, a 3-5
page description of research plans, and a one-page teaching statement.
Applicants should arrange for at least three reference letters to be sent under
separate cover. Review of materials will commence on January 15, 2012, and will
continue until the position is filled. Materials should be submitted
electronically in PDF format to Structural_Biology@brown.edu or by mail to:
Betsy Jacobson, Department of Molecular Pharmacology, Physiology &
Biotechnology, Brown University, Box G-E3, Providence, RI 02912.

Brown University is an Equal Opportunity/Affirmative Action employer and
welcomes applications from women and minorities.

Postdoc

2012-01-11T15:40:00.000+01:00

In connection with a collaboration agreement with Janssen Pharmaceutica,
Beerse, Belgium, the University of Liege has a postdoctoral vacancy available.

We are looking for a highly motivated individual with a sound understanding of
ssNMR theory and extensive experience in implementing, setting up, running,
processing and evaluating ssNMR experiments, preferably in the context of
pharmaceutical applications. The successful candidate will be responsible for
setting-up a ssNMR research environment suitable for pharmaceutical
applications of ssNMR - as a tool for trouble shooting as well as a tool for
the development and characterization of solid form formulations (tablets,
powders, suspensions, including nano-particle based forms). Ability to work
independently and very good communicative skills are a must. He/she will be
involved in collaborative projects with Janssen Pharmaceutica.
The NMR group in Liege is equipped with two Bruker 400 MHz ssNMR spectrometers.
Potential applicants are encouraged to contact Christian Damblon for more
information about this position (or life in the historic city of Liege).
Applications must be received before end of February 2012.

Prof. Christian Damblon
Institut de Chimie
allée de la Chimie, 3 (Bât. B6)
Sart Tilman - 4000 Liège
Tel. +32 4 366 3788
c.damblon@ulg.ac.be

Postdoc

2012-01-11T15:39:00.001+01:00

A two-year post-doc position is available in the field of Solid State NMR

At: Nano-SiSTeMI Interdisciplinary Centre, University of Piemonte Orientale

Where: Alessandria, Italy; Milan, Italy

Task: The aim of the project, in collaboration with Bruker (Italy) is to develop,

implement and use innovative solid state NMR (SS-NMR) techniques for the study of

a broad range of solids including catalysts, materials for photovoltaic devices,

optoelectronic and sensing, polymer composites, hybrid materials, cements, etc... The

responsibility also includes in providing (a) assistance and training in SS-NMR, (b)

designing and development of pulse programs, (c) experimental and interpretational

service to support collaborative and multidisciplinary research on national and

international levels and (d) day-to-day maintenance and upgrading of the facility.

The position plays two distinct roles. One is part of the NMR centered program of the

Prof. Marchese group. The other is as part of the characterization facilities available

to collaborating research groups, both within the department and external, that service an extremely wide-ranging program of materials-centered research.

Salary: 24-26 k€/year depending on the candidate experience

Contacts:
Prof. Leonardo Marchese, +39 0131 360262 (mob. + 39 3482879225) leonardo.marchese@mfn.unipmn.it
Dr. Angelo Ripamonti, +39 02 70 63 63 70, angelo.ripamonti@bruker.it

solid state NMR Platform Manager

2012-01-11T15:38:00.002+01:00

***A Position as solid state NMR Platform Manager is being offered at

CIC Energigune, Parque Tecnologico de Alava, 01510, Spain

CIC Energigune is a new energy research centre based in the Basque Country of Spain. Its mission is to play a leading role on the international stage in the field of energy storage technologies and contribute to the industrial competitiveness of Basque Country. CIC has a world-class research facility, cutting-edge equipments, an experienced management team, and a scientific committee composed of prominent scientists, entrepreneurs, and industrial experts. (www.cicenergigune.com).
The Basque Country is renowned for the beauty of its natural surroundings. It offers high standards of living and quality of life, in terms of health, housing, leisure, sports, etc, making it an attractive area to live in.

CIC Energigune is now inviting applications for the position of Nuclear Magnetic Resonance (NMR) Platform Manager to custom-build the area´s NMR platform in the field of energy storage technologies.

***What we offer

We are offering a permanent position that will give you a unique opportunity to apply your capabilities and develop new projects related to this technical platform.

In addition to the appeal of the entire project, the CIC Energigune offers a competitive basic salary augmented by benefits that compare favourably with the best European private and public institutions.

***What we need

We are looking for a motivated and experienced professional capable of taking this unique opportunity with the following requirements:

* An MS degree preferably in Physics or Chemistry. PhD is not compulsory but will be valuable.

* Ideally several years of experience doing research with solid state NMR and also if possible some liquid NMR. More specifically, the candidate should have :

- An experience in multidimensional quadrupole and spin 1/2 solid state NMR is required

- An ability to match/tailor suitable NMR experiments to the scientific inquiries in materials research for energy applications

- The understanding of the pulse sequences and have the ability to modify and/or write them, and

- The skills to use simulation programs of solid state NMR parameters such as SIMPSON or SPINEVOLUTION are also valued

* An open-mind and creativity, willing to work in new experiments such as in-situ NMR of batteries or other energy harvesting, conversion or storage devices

* Inter-personal and communication skills to work effectively within a multi-disciplinary team or to provide supports for other facility users

Applicants should be fluent in English. Knowledge of Spanish and/or Basque will be considered useful but not compulsory.

All applicants are invited to submit a detailed curriculum vitae and two reference letters. Applications should be loaded at http://www.cicenergigune.com/en/trabajar/enviar-curriculo/.

Applications will be reviewed upon receipt and the search will continue until the position is filled.

CIC energiGUNE is committed to affirmative action, equal opportunity and the diversity of its workforce.

Postdoc

2012-01-11T15:35:00.001+01:00

A postdoc position on protein-ligand interactions and fragment-based drug design by NMR is available at the Helmholtz Zentrum München

http://www.helmholtz-muenchen.de/fileadmin/0-templates/www-helmholtz-muenchen-de/php/jobs.php?id=1243&L=1

Job Details

The candidate will be responsible for characterizing protein-ligand interactions and implementing fragment-based approaches by NMR spectroscopy for the identification and optimization of small molecule inhibitors targeting disease-linked pathways. The scientist will be working in the group of Michael Sattler at the Institute of Structural Biology (http://www.helmholtz-muenchen.de/stb) in close collaboration with structural biologists using NMR-spectroscopy and X-ray crystallography for studying protein-ligand interactions. Interactions are expected with the Protein Expression and Purification Facility and the Assay Development and Screening Facility. The scientist should establish NMR-monitored fragment-based screening and support on-going projects in the identification and optimization of small molecule hits and leads using structural biology (NMR and X-ray crystallography). Tasks include:

- Implementing a fragment library and NMR-monitored screening
- Application of NMR based methods for protein-ligand interactions (ligand and target based)
- Hit validation and structural analysis of protein-ligand complexes by NMR and/or X-ray crystallography
- Implementation and development of new methods and techniques
- Interaction and project-driven collaborations with biologists and chemists, e.g. for establishing structure-activity relationships

The candidate is expected to interact and collaborate with researchers at HMGU.

Qualifications

- Doctoral degree in Chemistry, Biochemistry, Life Sciences, Physics, or related
- Demonstrated strong experience with structural biology and/or structure-based techniques for studying protein-ligand complexes
- Experience with training and supervision of students is desired
- We expect high motivation, creativity and a strong commitment to team work.
- Strong communication and organizational skills are expected
- Previous experience with chemical compound libraries is desirable

Our Offer

- Research scientist in the Institute of Structural Biology at the Helmholtz Zentrum München
- Supporting innovative research on important biological pathways linked to human disease.
- Working in a vibrating and scientifically stimulating environment with excellent facilities for NMR (http://www.bnmrz.org), structural biology, protein biochemistry, cell biology, imaging, animal models, and more.
- Opportunities and support in management skills

For further information please contact Michael Sattler (sattler@helmholtz-muenchen.de)

The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.

Applications should be addressed to Waltraud Wolfson (waltraud.wolfson@helmholtz-muenchen.de)

Helmholtz Zentrum München
German Research Center for Environmental Health (GmbH)
Ingolstädter Landstr. 1
85764 Neuherberg
Germany

junior research associate

2012-01-11T15:34:00.000+01:00

We are seeking for potential candidates to apply for a position as a
CNRS junior research associate in conjunction with our group.

The focus of the research will be on developing advanced NMR methods
for the analysis of mixtures of small molecules, with particular
attention to perspective applications to natural products. Our ongoing
activity aims at resolving the complex NMR spectra of multicomponent
mixtures by relying on pseudochromatographic experiments (Angew. Chem.
2006, 45 , 5950-5953), multiple-quantum analysis (Anal. Chem. 2010,
82, 3266-3269 ) and adapted signal processing.

The candidate will be located at the Institut de Chimie des Substances
Naturelles (Gif-sur-Yvette), in the Paris area, which hosts several
high-field spectrometers, including a 950 MHz.

The ideal candidate should have a disposition towards teamwork, an
inquisitive mind and a solid background on the development and application
of modern NMR methodology, with a Ph. D. degree and at least one year
of post-doctoral work in the area.

As the CNRS national competition is highly selective, a strong
publication record is necessary.

For additional information, please contact Stefano Caldarelli

PhD SSNMR

2011-11-21T18:59:00.000+01:00

We are looking for a young, open-minded, enthusiastic, committed and diligent individual with a background in chemistry, physics or material-sciences (German Diploma/MSc equivalent).
The successful candidate will work on the multi nuclear solid state NMR characterization of immobilized catalysts, metal-clusters, metal-nanoparticles and their interactions with substrates. The immobilized catalysts are made in-house by covalently binding metal-containing catalysts to the surface of nano-structured silica materials with different morphologies (porous or nanoparticles) via organic linkers or obtained by a cooperating group at the CNRS-Toulouse.

The structure of the immobilized catalysts on the support material, its interactions with substrates and the influence of macroscopic parameters such as temperature on its properties are investigated. The catalytic activity of the catalysts is tested by model reactions, in particular hydrogenations.
Previous hands-on experience with solid state NMR or heterogeneous catalysis will be helpful, but is not necessary.

We offer a state-of-the-art research infrastructure including solid-state NMR (600, 500 400 and 300 MHz) spectrometers and a wet-chemistry lab including GC, HPLC, UV/Vis and other techniques. An additional 400MHz DNP-NMR solid state NMR spectrometer will be installed at the end of 2012.

The NMR lab is headed by an academic staff scientist, who provides user support. The group is part of the research group FOR-1583, the research network SFB 598, the LOEWE-research group SOFT-CONTROL and various national and international cooperation projects. The group is located at the Campus Lichtwiese of the Technical University Darmstadt.
Enquiries and applications shall be addressed to Gerd Buntkowsky (gerd.buntkowsky at chemie.tu-darmstadt.de).

Prof. Dr. Gerd Buntkowsky
Dekan
Physikalische Chemie der kondensierten Materie
Technische Universität Darmstadt
Eduard-Zintl-Institut für Anorganische und Physikalische Chemie
Petersenstr. 20, D-64287 Darmstadt
phone : +49 6151/16-2607 fax: +49 6151/16-4347

email : gerd.buntkowsky@chemie.tu-darmstadt.de
Research : http://www.researcherid.com/rid/B-3206-2010
WWW : http://www1.tu-darmstadt.de/fb/ch/akbuntkowsky

Postdoctoral position at St. Jude

2011-11-21T18:58:00.001+01:00

Dear colleagues,

a postdoctoral position is available immediately in my lab at St. Jude Children's Research Hospital in Memphis, TN, for a candidate motivated to pursue structure/function relationships of highly dynamic protein complexes in the ubiquitin pathway. The project focuses on the recognition of highly flexible proto-oncogenes by their cognate ubiquitin ligases and how dynamic interconversion of multiple bound states relates to function in health and disease. The successful candidate will use NMR spectroscopy, other biophysical and biochemical techniques to dissect the binding mechanism and establish structure/function relationships.

Requirements
This position is an ideal opportunity for either (1) an experienced NMR spectroscopist who would like to complement his or her expertise with other, diverse tools for understanding protein complex function and mechanism, or (2) for an enzymologist/biophysicist interested in structural biology of dynamic protein complexes. The fellow would benefit from both the outstanding environment in the lab and the highly collaborative St. Jude community.

Candidates should have recently earned/expect to earn a Ph.D. in a related field, and should have experience in protein biochemistry, enzymology, biophysics, or NMR spectroscopy.

Supplemental Application Requirements
Mail Postdoc Application: No
Letter of Interest Required: No
Curriculum Vitae Required: Yes
Description of Research Interest Required: Yes
3 Letters of Recommendation Required: Yes
Outline of Past Accomplishments Required: No
Outline of Career Aspirations Required: No

Contact
For the add please see https://hospital.stjude.org/apps/apo/positionList.jsf

Please send a CV and a brief description of research and career goals and arrange to have three letters of recommendation sent to

Tanja Mittag, PhD
Assistant Member
Structural Biology
St. Jude Children's Research Hospital
262 Danny Thomas Place, MS 311
Danny Thomas Research Center, Room D1034F Memphis, TN 38105
office: (901) 595-6261
lab: (901) 595-6182
Email: tanja.mittag@stjude.org
http://www.stjude.org/mittag

Ph.D. Position

2011-08-08T19:39:00.001+02:00

Ph.D. Position
Myelin Water Imaging
Institute of Neuroscience and Medicine (INM-4)
Research Centre Juelich, Juelich, Germany

This position is primarily aimed at the development and application of myelin water mapping in the human brain in vivo using different relaxometric modalities.
The Research Centre Juelich (http://www.fz-juelich.de/) is one of Europe's largest interdisciplinary research centres with 4,600 employes, 7 research institutes with 46 divisions. The Institute of Medicine and Neuroscience INM-4 (Medical Imaging Physics http://www.fz-juelich.de/inm/inm4/EN/Home/home_node.html) offers a highly interdisciplinary environment with physicists, engineers and neuroscientists working on a better understanding of the brain with the help of advanced brain imaging methods and state of the art technology. Among others, a unique 9.4T combined MR-PET scanner offers unprecedented research opportunities.
We are interested in an individual with a solid physics background documented by outstanding academic performance and advanced computer programming skills. The work will involve developing protocols suited for myelin water fraction and absolute water content imaging in vivo at different field strengths; comparing the water pools revealed by the different relaxometric modalities; implementation of new imaging methods; advanced data processing techniques; comparison with other MR modalities, e.g. diffusion. The available instrumentation includes several human scanners, such as a 3T Siemens Trio and a combined 3T MR-PET Siemens scanner, 4T Bruker/Siemens system, 9.4T MR-PET Siemens system as well as a 9.4T home-built animal scanner based on Siemens and Varian consoles. There are also extensive facilities for all aspects of MRI hardware development and data analysis.

Interested persons should email a Curriculum Vitae including name, address and email address of at least one reference to:

Dr. Ana-Maria Oros-Peusquens
Institute of Neuroscience and Medicine (INM-4)
Research Centre Juelich
Leo-Brandt-Str, 52428 Juelich
tel.: +49-2461 61 2107
fax: +49-2461 61 2820
a.m.oros-peusquens@fz-juelich.de

POSTDOC POSITION AVAILABLE

2011-08-08T19:36:00.001+02:00

3 YEAR POSTDOC POSITION AVAILABLE WITHIN NMRSTR
http://www.nmrstr.ugent.be

The NMR and Structure Analysis unit of the Department of Organic Chemistry of Gent University (Belgium) is involved in research activities in the (bio)chemical and material sciences using NMR spectroscopy as the main investigative tool. With four fully equipped Bruker NMR spectrometers, it is the main academic NMR facility active in the chemical and material sciences in Belgium. The equipment inclides an AVANCE–II 700 MHz instrument, housed within the unit and part of the Interuniversitary NMR Facility jointly operated between Ghent University, the Vrije Universiteit Brussel (VUB) and Antwerp University (UA), as well as an Avance-III 500 MHz (in installation), an AVANCE-II 500 MHz and an AVANCE 300 MHz. Equipment includes three- and four-channel setups, hrMAS at 700 MHz and a high gradient amplitude diffusion probe (1600 T/m) at 500 MHz.

A three year, University funded postdoctoral position is available starting preferably before January 1st 2012 (negotiable), to further develop and implement techniques and methodologies for the solution NMR based investigation in the following projects:

· The characterization of the impact of chemically modified nucleosides on the structure and dynamics of DNA duplexes intended to mimic protein active sites. This involves the use of both unlabelled and selectively labeled DNA systems.

· In situ characterization of colloidal dispersions ranging from quantum dots and rods to pigment and latex particles – this also involves methodological developments in diffusion respectively STD NMR spectroscopy.

The duties of the successful applicant include:

Scientific research within the context of one of the above research projects.
Scientific involvement (including co-authorship) in short term research projects with external partners.
Scientific support and co-manager of the Interuniversity 700 MHz high field NMR facility and the new 500 MHz facility within the department.
Mentoring of Master and PhD students.
Contribute to the educational activities of the department.

We offer:

The opportunity to fully participate in our current research projects, within the best equipped NMR facility in the country.
The opportunity to develop a proper research interest, i.e. based on the applicants own interest.
A competitive salary amounting to 1800-2100 €/month (commensurate with age and experience).

To be eligible, applicants should:
Demonstrate knowledge and practical expertise in solution NMR spectroscopy, as demonstrated by publications in international journals and/or oral communications at national or international meetings.
Demonstrate technical knowledge in the operation of NMR equipment (hardware and software) including implementation of pulse sequences.
Demonstrate interest for MSc student mentoring
Have acquired a PhD degree by the time of appointment (foreseen 1/1/2012).

The Universiteit Gent is an equal opportunity employer. Ghent is a pleseant city with medieval centre and good quality of living
For further information contact Prof. José C. Martins via e-mail: Jose.Martins@UGent.be
Ghent University: http://www.ugent.be/nl
City of Ghent: http://www.visitgent.be/

PhD students and postdocs positions

2011-08-08T19:35:00.002+02:00

PhD students and postdocs positions on new applications of NMR in environmental sciences

Short description of projects:
Project1: Use high-resolution NMR to measure intramolecular variation of the heavy hydrogen isotope deuterium in historical plant samples, to link past climate with physiological changes, and to define plant-climate interactions relevant for future plant productivity.
Project2: Apply quantitative 13C NMR to primary metabolites and to tree rings, to establish links between intramolecular 13C variation and partitioning of metabolites in plants.
Project3: NMR Characterization of Soil Phosphorus and Carbon Forms during Long Term Succession
We look for highly creative students seeking a career in interdisciplinary research at the interface between chemistry, biology and earth sciences. Applicants should have a university education in chemistry, biochemistry, or equivalent. Experience in NMR, stable isotopes or plant physiology is of advantage.
For project details and applications (including cover letter describing your motivation for this position, CV including a list of university courses with grades, a copy of your graduate work, and names and addresses of two persons willing to act as references), please contact Prof. Jürgen Schleucher, jurgen.schleucher@chem.umu.se

Research Scientist, Solid State NMR Spectroscopy

2011-08-04T11:52:00.001+02:00

A full time position is available for an experienced research scientist with skills in solid state NMR spectroscopy. This is a leading role in the University-wide NMR Facility, which has recently implemented ARC funding for a major initiative in solid-state NMR spectroscopy.
The appointee will consolidate advanced solid state NMR spectroscopic techniques to enable research in the areas of molecular & life sciences, medicine, materials engineering and polymers within UNSW and with partner organisations, as well as train research staff and students in this area of specialization.
This is a fixed term, full time position for a period of three years. Salary Level A (Completed PhD): A$74,129 - A$79,288 per year (plus 17% employer superannuation and leave loading). Applications close: 22/08/2011

See the full description and how to apply at http://www.hr.unsw.edu.au/services/recruitment/jobs/22071104.html #8145.

Location: NMR Facility, University of NSW, Sydney, Australia; see www.nmr.unsw.edu.au

Contact the manager, Dr. James Hook for further information; email: j.hook@unsw.edu.au

Research Fellow (Postdoc) in Solid State NMR

2011-08-04T11:51:00.001+02:00

A full-time position is available at the Institute of Solid State Physics of the Technical University Darmstadt, Germany (Group of Prof. M. Vogel).

The successful applicant is an experienced scientist in the field of solid state NMR. He or she has a consolidated knowledge of 1D and 2D NMR studies on dynamics and structure of disordered solids, profound skills in the operation, maintenance, and development of NMR equipment, and experience in simulation of NMR data.

The responsibilities associated with this position include:

- Management and maintenance of the NMR facility featuring, among others, spectrometers for MAS, NMR diffusometry (SFG and PFG), and NMR relaxometry

- Own research activities in the field of molecular dynamics in disordered materials, including complex fluids in nanoporous materials, weakly hydrated proteins, and lithium ion conductors

- Training of PhD, master, and bachelor students

The position is for 2 years with a possible extension to up to 5 years

Additional information about our research activities can be found on our websites:
http://www.fkp.tu-darmstadt.de/groups/ag_vogel/

Applications should be submitted until 01 September 2011 to:

Prof. Dr. Michael Vogel
Institut für Festkörperphysik
Technische Universität Darmstadt
Hochschulstr. 6
64289 Darmstadt, Germany
michael.vogel@physik.tu-darmstadt.de

PhD position Leiden University

2011-08-04T11:50:00.001+02:00

The Solid State NMR group at the Leiden Institute of Chemistry, Leiden
University has a PhD studentship (38 hrs a week) available in the Modular
Design of a Bio-Inspired Tandem Cell for Direct Solar-to-Fuel Conversion.

Apply before august 21, 2011.

Project description
The successful candidate will participate in the SOLARFUELTANDEM
collaborative research project (CPR) of the European Science Foundation
Eurocores programme EUROSOLARFUELS. The principle objective of this
collaborative project, shared between its 10 European contributors, is the
modular design of a bio-inspired nanostructured organic-inorganic
heterojunction tandem cell for solar to fuel conversion. The vision is to
work from a combination of natural and artificial modules for catalysis and
charge separation and explore a range of different combinations for
functional tandem device concepts. This allows the consortium to work in
parallel on modular systems integration and optimization of components.
Self-assembled Zn chlorin nanocylinders forming excitations with internal
charge transfer character will be aligned in an alumina solid membrane to
form a supramolecular sensitizer for ultrafast charge separation and charge
injection into a low-bandgap Si semiconductor. In this heterojunction
system, two regions of the solar spectrum can be used in tandem to overcome
the thermodynamic barrier for water oxidation and hydrogen production with
visible light in a single device. Two complementary synthetic strategies
will ensure access to a wide library of Zn chlorins. Post-functionalization
of Chl a and BChl c will ensure rapid preparation of compounds for
self-assembly and photophysical studies, also with 13C labels. Total
synthesis will give full control over the pattern of substituents for
fine-tuning of all required physicochemical properties. We will use most
sturdy natural PS2 and Pt modified PS1 systems from C. merolae with a very
high photosynthesis rate as working photocatalysts for optimization of
catalyst interfacing to semiconductors. In a parallel supramolecular
approach we will prepare homogenous Ru/Ir/Co water oxidation and Fe/Ni/Co
hydrogen formation catalysts for immobilization and interfacing to natural
and artificial electron transfer units. Optical spectroscopy, NMR, EPR,
electrochemistry, X-ray crystallography and modeling will be used in the
partnership to assess the kinetics of the multi-electron catalysis and dual
band gap electron transfer mechanisms to guide the design. The final aim of
the CPR is to give proof of principle of a functional tandem device. The PhD
student will primarily contribute to the CPR with structure-determination
and structure-function studies of chlorosome-type supramolecular dye
sensitizers. This contribution to the project will be considered a success
if he or she can guide the design of the chlorosome cylindrical rods into an
operational functional supramolecular dye sensitizer for application in an
artificial reaction center concept.

See also:
EUROSOLARFUELS: http://www.esf.org/index.php?id=6397
Ganapathy S et al. (2009) Zinc chlorins for artificial light-harvesting
self-assemble into antiparallel stacks forming a microcrystalline
solid-state material. Proceedings of the National Academy of Sciences
106:1147211477.
Ganapathy S et al. (2009) Alternating syn-anti bacteriochlorophylls form
concentric helical nanotubes in chlorosomes. Proceedings of the National
Academy of Sciences 106:85258530.

Appointment:
You will be employed for a period of maximally 4 years, which is expected to
lead to the completion of a Ph.D. thesis. Appointment will be through the
Organization for Fundamental Research of Matter (FOM).
An appointment with FOM includes a pension build-up and facilitates other
benefits such as an annual holiday premium.
All our PhD students are embedded in the Leiden University Graduate School
of Science (www.graduateschools.leidenuniv.nl) and in the Research School
The Leiden Institute of Chemistry (LIC). Our graduate school offers several
PhD training courses at three levels: professional courses, skills training
and personal effectiveness. In addition, advanced courses to deepen
scientific knowledge are offered by the research school. This guarantees a
challenging environment to develop on-the-job the skills and academic
networks.

Further information:
You will be supervised by Prof. Dr. H.J.M. de Groot
(groot_h@chem.leidenuniv.nl). For more information please contact this email
address.

Applications:
Qualified applicants are invited to submit their application before August
21, 2011. They should include a letter of interest, a full curriculum vitae,
and names and email addresses of two references and sent to
groot_h@chem.leidenuniv.nl with subject FOM-Solarfueltandem.

Postdoctoral position at the IRB Barcelona

2011-08-04T11:49:00.002+02:00

The Laboratory of Molecular Biophysics at the IRB Barcelona (www.irbbarcelona.org) offers postdoc positions (starting date 01/01/2012) for development and application of novel computational tools to quantitatively exploit the information contained in high resolution NMR and single molecule techniques. The project aims to characterize the structural heterogeneity and dynamics of multi-domain proteins with intrinsically disordered regions involved in cancer and neurodegenerative diseases.

The laboratory belongs to the Joint BSC-IRB Research Programme in Computational Biology, which provides direct access to the Barcelona Supercomputing Center (Marenostrum). The laboratory has a strong multi-disciplinary and international character.

Previous experimental and/or computational experience in NMR (liquid or solid state), single molecule techniques or molecular simulation (advanced sampling methods) is required.

Interested candidates should send their CV and 2 letters of recommendation to Dr. Xavier Salvatella (xavier.salvatella@irbbarcelona.org). Positions open until filled. Salary negotiable upon experience.

Post Doctoral Position - PET/MRI Applications in Tumor Biology

2011-08-04T11:48:00.001+02:00

Post Doctoral Position
PET/MRI Applications in Tumor Biology
Biological Imaging Center
California Institute of Technology

Post Doctoral Position. This position is aimed at development and application of multimodal PET/MRI in small animal models of cancer. The Biological Imaging Center (http://bioimaging.caltech.edu/) and Caltech Brain Imaging Center (http://magnet.caltech.edu/) are highly interdisciplinary endeavors with biologists, chemists, physicists, and engineers working on a number of animal models of disease and developmental processes. We are interested in an individual who is firmly grounded in imaging theory and practice with an interest in applications in tumor biology. This work will involve various PET and MR methodologies in rodent model systems; including DTI and DCE MRI, as well as simultaneous µPET imaging with both small molecule and antibody tracers. Small animal MRI facilities at Caltech include a 11.7T/89mm scanner and a 7T/30cm scanner with µPET insert. There are also extensive facilities for all aspects of MRI hardware development and data analysis.

Interested persons should email or mail a biosketch including names, addresses, & email addresses of three references to:

Russell E. Jacobs, PhD
m/c 139-74 Caltech
1200 E. California Blvd
Pasadena, CA 91125-7400
rjacobs@caltech.edu

Postdoctoral position in NMR and biomaterials science.

2011-08-04T11:46:00.002+02:00

A postdoctoral position is available for research in the area of interactions and dynamics of the nuclear pore complex (NPC), the sole mediator and gatekeeper for trafficking between the nucleus and cytoplasm. Our studies use advanced biophysical and structural methodologies, in particular various NMR techniques applied in vitro and in vivo, to characterize the dynamic atomic-scale behavior of the components of this macromolecular gating system. This work will also seek to further refine our nanoscale artificial mimic that faithfully reproduces key features of trafficking through the NPC, including transport-factor mediated cargo import (1). Such NPC-inspired molecular sorters could have many practical analytical and preparative applications.

Interested candidates should have a strong background in one or more of the following areas: multidimensional NMR (liquids or solids), protein expressions methods, materials science, and computer simulations of molecular structure, and have completed their Ph.D.

This project is a collaboration between the NPC research focused groups of Prof. Michael Rout and of Prof. Brian Chait at Rockefeller University, and the NMR-focused lab of Prof. David Cowburn at Albert Einstein College of Medicine. NMR facilities include twelve spectrometers located at the two Universities and at the New York Structural Biology Center ranging from 500-900 MHz, and including solid state systems, with an additional DNP-solids system expected in 1q 2013. There are extensive facilities in the labs and in central resources for protein production, mass spec, and high performance computing.

The position is available immediately, and interested candidates should forward the biographical sketches including the names of three references to Beth Anne Hatton; hattonb@mail.rockefeller.edu; Administrative Assistant.

The Rockefeller University and Albert Einstein College of Medicine are an Affirmative Action/Equal Opportunity/VEVRAA employers and solicits applications from women and under-represented minorities.

(1) Jovanovic-Talisman, T., Tetenbaum-Novatt, J., McKenney, A.S., Zilman, A., Peters, R., Rout, M.P., and Chait, B.T. (2009). Artificial nanopores that mimic the transport selectivity of the nuclear pore complex. Nature 457, 1023-1027.

facility manager

2011-07-20T19:41:00.001+02:00

A facility manager position is available in the Chemistry department of the Heinrich-Heine Universität Düsseldorf starting from September 1, 2011.

The responsibilities associated with this position will be:
Management of the NMR facility and organization of the NMR service.
Support of research and administrative tasks.
Teaching and training of Bachelor-, Master- and PhD students.

The successful applicant has a profound knowledge of 1D, 2D and 3D homo- and heteronuclear NMR spectroscopy, practical experience in the operation and maintainance of Bruker spectrometers, skills in managing a service-oriented NMR facility, and is able to find practical solutions to spectroscopic problems, including the investigation of kinetics and dynamics and simulation of higher order spectra.

The position is initially limited to two years with the possibility of turning into a permanent position.

Scientific qualification (Habilitation) is not possible.

Further information (in German):

http://www.uni-duesseldorf.de/home/fileadmin/redaktion/ZUV/Dezernat_3/Stellenausschreibungen/Doku_wiss_Besch/30T11-3.1.pdf

For application please contact:

Prof. Dr.
Christoph Janiak
Institut für Anorganische Chemie und
Strukturchemie
Universität Düsseldorf
Universitätsstr. 1
D-40225
Düsseldorf
janiak@uni-duesseldorf.de

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52425 Juelich
Sitz der Gesellschaft: Juelich
Eingetragen im Handelsregister des Amtsgerichts Dueren Nr. HR B 3498
Vorsitzender des Aufsichtsrats: MinDirig Dr. Karl Eugen Huthmacher
Geschaeftsfuehrung: Prof. Dr. Achim Bachem (Vorsitzender),
Dr. Ulrich Krafft (stellv. Vorsitzender), Prof. Dr.-Ing. Harald Bolt,
Prof. Dr. Sebastian M. Schmidt
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PhD position

2011-07-20T15:22:00.000+02:00

A PhD position is available at the Freie Universität Berlin, Department of Biochemistry to analyse HLA-DM catalyzed peptide loading of MHC class II proteins by NMR spectroscopy and other biophysical methods.

Nascent MHC II proteins are preloaded with self-peptides. In the endolysosomal compartment the exchange of the self-peptide for higher affine antigenic peptide is catalyzed by the MHC-like molecule HLA-DM. This leads to immunogenic MHC II-peptide complexes that are presented on the cell surface for T-cell recognition.

Within an interdisciplinary team including immunologists, crystallographers and molecular modellers we gained critical insights into MHC peptide loading by biochemical and spectroscopical analysis of the reaction over the past years (Günther et al., PNAS 2010; Schlundt et al., Angewandte Chemie 2009), however the precise mode of action of the HLA-DM catalyzed peptide exchange is still missing. Your task will be to target the mechanism of HLA-DM catalysis. This involves the expression and purification of MHC class II proteins (a heterodimer of ~46kD) based on working protocols integrating different labeling schemes for NMR analysis. The high molecular weight and seemingly short half-live of the MHC II - HLA-DM complex is likely to involve the design and purification of modified constructs as well as more sophisticated NMR methods including H/D exchange and relaxation dispersion experiments.

We are looking for candidates with a strong interest in structural biology and ideally with experience in protein purification and a basic knowledge of protein NMR spectroscopy.

Funding is available for a minimum of three years.

For application please contact:

Prof. Dr. Christian Freund
Freie Universität Berlin
Thielallee 63
14195 Berlin
freund@fmp-berlin.de or chfreund@zedat.fu-berlin.de

Postdoc

2011-07-20T15:16:00.000+02:00

Structural studies of Vpx, the accessory protein of the HIV-2

We are looking for a candidate to apply for a 2 years postdoctoral position in
the Laboratory of Biological NMR and Crystallography at the University Paris
Descartes. The project will aim to determine the structure of the Vpx protein
(112 amino acids) and of its complexes with inhibitors identified after
screening of small compound libraries, using high-field multidimensional NMR
and Molecular Modeling. HIV-2 is the second leading cause of AIDS in humans and
we are interested with the Vpx protein that increases the efficiency of
infection by lentivectors of various origins, allows the transport of viral DNA
to the nucleus and promotes the accumulation of retroviral DNA in some cells of
the immune system. Vpx thus allows viral dissemination but its role in the
replication of HIV-2 and its molecular mechanism are still not understood.

The objectives of this project are to understand at the structural and
mechanistic level, how Vpx inhibits cell defenses against viral infection. We
aim to identify partners of Vpx in cells and to elucidate its exact role in
viral dissemination and its role in the replication of HIV-2. Finally, we want
to understand how cellular factors can modulate the early stages of lentiviral
infection. The obtaining the Vpx protein structure, identification of partners
and the study of their complexes will make our contribution to the
understanding of the mechanisms involved in the various activities of this
protein. The study of the protein Vpx will be greatly simplified by the
experience we have gained from structural and functional studies performed on
the Vpr protein.

The protein Vpx has been obtained by chemical synthesis and will be produced by
overexpression in Coli and 15N labeled. The project will be based on functional
and structural experiments that associate liquid-state Nuclear Magnetic
Resonance and Molecular Modeling. The candidate should have a good experience
in the protein overexpression et their purification in bacterial systems and a
good expertise in multidimensional heteronuclear NMR and molecular modeling.
The starting date is January 2012 for a two years funding. Application, CV and
reference letters should be submitted to:

Dr Serge Bouaziz
serge.bouaziz@parisdescartes.fr
http://lcrbw.pharmacie.univ-paris5.fr/

Postdoc Position

2011-07-20T14:22:00.000+02:00

A 12 months postdoctoral position is opened in the framework of a collaboration between the CNRS/Rhodia joint Research Lab ‘Laboratoire Polymères et Matériaux Avancés’ (LPMA, UMR 5268), Lyon, France, and the CNRS/University Paris-Est Créteil joint Research Lab ‘Institut de Chimie et des Matériaux Paris-Est’ (ICMPE, UMR 7182), Thiais, France. The postdoctoral researcher will develop his/her research activities at ICMPE, Thiais, in the department ‘Systèmes Polymères Complexes’ and will be co-supervised by Cédric Lorthioir (ICMPE) and Paul Sotta (LPMA). Rhodia is a global specialty chemicals manufacturer with 5 multidisciplinary Research & Development Centers worldwide. Lyon is the main Rhodia R&D Center for Europe. CNRS is one of the main governmental research organization in France, involved in all scientific fields.

Partially polar polymers are very sensitive to water. For example a dry semi-crystalline polymer like polyamide (PA) can absorb up to 12 wt% water in saturated humid atmosphere (Relative Humidity = RH 100). The water content drastically affects the glass transition temperature, which may be shifted from 80°C in the dry state down to -10°C in the humid state, and therefore the mechanical and other properties.

The purpose of this work is to combine advanced Solid-State NMR approaches to investigate the molecular dynamics in polyamides. Selective Solid-State NMR experiments, performed as a function of temperature, will allow identifying the specific types of motions corresponding to the various relaxation processes observed in these materials, in the amorphous phase. The mobility and mobility gradients in the amorphous phase located in the vicinity of the crystallites will be characterized by selective excitation of the crystalline signal combined with 1H spin diffusion. Model polyamide materials with a variable, controlled crystallinity will be considered. The dynamics will be studied both in the dry state and in the presence of various amounts of water. These experiments will clarify the mechanisms by which water plasticizes polyamide.

The position is to start any time in 2011. It is opened to an experimental physicist/physico-chemist, with a PhD thesis in the field of polymer physics or chemical physics. An experience in Solid-State NMR, if not mandatory, will be highly appreciated. Gross salary is about 2000 Euros/month. To apply, please send an application letter together with a detailed CV and contact details of two academic referees to either of the following contact persons:

1) Paul Sotta
Laboratoire Polymères et Matériaux Avancés
CRTL
85, rue des Frères Perret
69192 Saint-Fons Cedex, France

Tel: +33 (0)4 72 89 64 66
E-mail: paul.sotta-exterieur@eu.rhodia.com

2) Cédric Lorthioir
Institut de Chimie et des Matériaux Paris-Est
Equipe ‘Systèmes Polymères Complexes‘
2-8, rue Henri Dunant
94320 Thiais, France

Tel: +33 (0)1 49 78 13 08
E-mail: lorthioir@icmpe.cnrs.fr

Postdoctoral Position in biomolecular SSNMR spectroscopy in Grenoble (France)

2011-07-20T14:19:00.001+02:00

The biomolecular NMR group at the Structural Biology Institute (IBS) in
Grenoble is looking for a highly motivated young researcher to join its team as
a post-doctoral researcher on a project funded by the French Research Funding
Agency ANR (project leader Paul Schanda). The project aims at the molecular
level understanding of the function and dynamics of large proteins, as well as
the development of novel solid-state NMR methods for studying dynamics. A
two-year contract is offered.

We are currently studying two biomolecular systems, (i) a large oligomeric
enzymatic assembly of several hundred kDa, and (ii) a membrane protein involved
in the transport of metabolites through membranes. Substrate entry and release,
binding of substrates and cofactors as well as the intrinsic dynamics in these
systems are central to function. We currently develop and apply innovative
solid-state NMR methods to probe protein dynamics in order to relate intrinsic
flexibility to function. We want to reinforce our team with an enthusiastic
postdoctoral researcher with a strong interest in NMR spectroscopy (and the
development thereof) and fundamental aspects of protein function.
The successful candidate will be working on a large enzymatic assembly, using
solid-state NMR methods, complemented by solution-state NMR, as well as on
development of solid-state NMR techniques to address protein dynamics.

Ideally, the successful candidate should have a PhD in chemistry, biochemistry,
biology or physics and experience in solid- or solution-state biomolecular NMR
spectroscopy. Experience in protein expression and purification is useful.

The laboratory hosts a 600MHz solid-state NMR spectrometer equipped with 3.2mm
and 1.6mm MAS probes as well as 600MHz and 800MHz spectrometers equipped with
cryogenic probes for solution-state NMR. It has access to the nearby 1 GHz NMR
spectrometer of the European high field NMR centre in Lyon. Applicants will
also have access to a fully equipped wetlab for preparation of isotopically
labeled NMR samples.

Grenoble is a pleasant city situated in the heart of the French alps, and has
one of Europe’s most vibrant structural biology communities centered around
the European Synchroton Radiation Facility (ESRF), the Laue Langevin Institute
(ILL), the Structural Biology Institute (IBS) and the EMBL Grenoble.

Applications and informal queries about the research projects and the lab
should be addressed by e-mail to Paul Schanda, paul.schanda@ibs.fr
Please include in your application a recent CV, names and e-mail addresses of
potential references and a cover letter describing your research interest and
the motivation why you are interested in working with us.

Paul Schanda, Ph.D.
Biomolecular NMR group
Structural Biology Institute Grenoble
41, rue Jules Horowitz
F-38027 Grenoble
France

Senior Research Fellow in Solid-State NMR

2011-07-20T10:26:00.001+02:00

Senior Research Fellow in Solid-State NMR
Department of Physics

£36,862 - £44,016 pa

Fixed Term Contract for 3 Years

You will work together with the Principal Investigators (PIs), the group's existing experimental officer and technical and secretarial support, to provide an optimum environment for carrying out advanced solid-state NMR research in the Warwick Magnetic Resonance Centre, including pushing forward research projects, both together with the PIs and independently.

As well as fulfilling the duties and responsibilities outlined in the further details, you should develop your own research strands, including taking responsibility for driving such projects forward, designing the research, writing papers and procuring external research funding: this can be independently or together with the PIs.

Informal enquiries: John Hanna; e-mail: J.V.Hanna@warwick.ac.uk and Steven Brown; email; S.P.Brown@warwick.ac.uk

Please quote job vacancy reference number 71278-071.

The closing date/time for applications is midnight (British time) at the end of Friday 05 August 2011.

http://www.jobs.ac.uk/job/ACY927/senior-research-fellow-in-solid-state-nmr/

You must apply using the procedure described below:

http://www2.warwick.ac.uk/services/humanresources/jobsintro/apply/procedure

Steven Brown
Department of Physics
University of Warwick
Coventry CV4 7AL

Tel: 00 44 24 76574359
Fax: 00 44 24 76150897

email: S.P.Brown@warwick.ac.uk
webpage address: http://go.warwick.ac.uk/nmr/members/academic/steven/
Warwick group webpage: http://go.warwick.ac.uk/nmr/
The UK 850 MHz solid-state NMR facility: http://go.warwick.ac.uk/850mhz/

Magnetic Resonance at Warwick: Watch the video: http://go.warwick.ac.uk/nmr/millburn

getting to Millburn House: http://go.warwick.ac.uk/nmr/getting_here

Research/Computer Associate

2011-07-05T09:29:00.000+02:00

Research/Computer Associate
Department of Biochemistry
Vacancy Reference No: PH08371 Salary: £27,428-£35,788

Limit of tenure applies*

Applications are invited for a postdoctoral research associate, funded by the Collaborative Computing Project for NMR (CCPN), to develop an interface for small molecule screening as an additional module to our CcpNmr Analysis Software. This module would include a graphical user interface to control the workflow for fragment-based screening using NMR and software components for the efficient analysis and screening of NMR spectra for the identification and characterisation of small molecule ligands.

The successful candidate should have a PhD in an appropriate field, be familiar with either NMR spectroscopy or small molecule screening, and have a good working knowledge of Python programming as well as demonstrated experience in the development of software applications. The applicant must be able to work as part of the existing team, and needs to have the initiative and drive to make sure that their part of the project is completed successfully. The project would be carried out in collaboration with our industrial partners and a willingness to travel and to work with our collaborating partners is also important.

Applications should consist of a completed CHRIS/6 form (which can be downloaded from http://www.admin.cam.ac.uk/offices/hr/forms/chris6/) with a CV and the names and addresses of three referees. This should be returned, quoting the reference number, via e-mail to jobs@bioc.cam.ac.uk OR by post to the Personnel Secretary, Department of Biochemistry, Building O, Downing Site, Cambridge CB2 1QW UK.

* Limit of tenure: 1 year.

Closing date: 15 July 2011.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD position, Ecole Normale Superieure, Paris

2011-07-04T12:02:00.001+02:00

A three-year PhD fellowship is available in the NMR group at Ecole Normale Superieure in Paris.

The graduate student will participate to a project focused on the exploration of the dynamics of intrinsically disordered proteins with new nuclear spin relaxation methods. A full description is available here:
http://www1.chimie.ens.fr/Resonance/files/Ferrage_PhD_proposal.pdf

Interested applicants should send their CV to Fabien Ferrage (Fabien.Ferrage@ens.fr)
--
Fabien Ferrage
Associate Scientist @CNRS
NMR laboratory
Department of Chemistry
Ecole normale superieure
24, rue Lhomond
75231 Paris Cedex 05
France
tel: (33) 1 44 32 32 65
fax: (33) 1 44 32 24 02
http://www1.chimie.ens.fr/Resonance/fabien_ferrage.html

Postdoc Saclay

2011-07-04T12:01:00.001+02:00

12-month post-doctoral position announcement at Saclay, near Paris, at CEA.

Towards a better understanding of gases encapsulation in cage-molecules by NMR and computational chemistry approaches

Dissolved gases are of great importance in various fields of biology (e.g. oxygen, carbon dioxide), medicine (e.g. hyperpolarized 129Xe for MRI applications) and environmental sciences (e.g. green house gas emission like methane or carbon dioxide). Since 2009, the laboratory is involved in a project that aims at a better understanding of hydrophobic interactions of dissolved gases in water through their encapsulation in synthetic cage-molecules. Only a few empirical rules governing the reversible gas receptor interactions are admitted and very little theoretical works have been reported in the literature. In this context, a 12-month postdoctoral position is available at CEA/IRAMIS in Saclay (France, near Paris) under the supervision of Gaspard HUBER, Patrick BERTHAULT and Jean-Pierre DOGNON.

The post-doctoral fellow will be involved in two joined aspects. First, he/she will have to devise and perform NMR experiments designed to acquire reliable kinetic and thermodynamic data, as well as instructive NMR parameters, for various dissolved gases (e.g. small alkanes and noble gases) and cage-molecules (varying size, shape, electronegativity, steric hindrance within two cage-molecule families : cryptophanes and cucurbiturils). Second, he/she will be involved in a computational chemistry approach, mandatory for the interpretation of NMR results. Both aspects should result in the formulation of new laws on gases complexation and on the proposal of new cage molecules, synthesized by our colleagues chemists involved in the project.

The candidate should have good skills in liquid NMR spectroscopy and chemical physics. An experience in computational chemistry would be greatly appreciated. Knowledge in statistics, useful for the determination of experimental errors, would also be valuable.

The position can start from December 2011. The monthly salary is ca. 2200 € (before tax). Interested candidates should send a CV and two recommendation letters to gaspard.huber@cea.fr.

Post-doc at the interface between NMR and EM at CEA Saclay

2011-07-04T12:00:00.000+02:00

A new postdoctoral position is becoming available at CEA Saclay (45 min by train from the center of Paris) in high-field multidimensional NMR applied to large biological assemblies, to be coupled with an exciting ANR granted project on the mechanisms of DNA gating in bacteriophages. The work is focussed on the molecular bases of the head-to-tail connector assembly and function in bacteriophage SPP1. It is based on functional and structural experiments, and in particular the coupling of liquid-state and solid-state Nuclear Magnetic Resonance, X-ray crystallography, Electron Microscopy and Molecular Modelling. Experience in advanced liquid-state and/or solid-state NMR is essential. Expertise in protein purification and molecular modeling will be useful. Starting date is from September 2011. A one year funding that can be extended to three years on a related project is available. Please submit application and CV to: sophie.zinn@cea.fr.

Dr Sophie Zinn-Justin
Laboratoire de Biologie Structurale et Radiobiologie
iBiTec-S, CEA Saclay
91190 Gif-sur-Yvette

http://www-dsv.cea.fr/dsv/instituts/institut-de-biologie-et-de-technologies-de-saclay-ibitec-s/unites/service-de-bioenergetique-biologie-structurale-et-mecanismes-sb2sm-ura-2096-cnrs/laboratoire-de-biologie-structurale-et-radiobiologie-lbsr/equipe-analyse-de-complexes-proteiques-par-rmn-et-cristallographie-b.-gilquin/projets-de-recherche/structure-de-l-enveloppe-nucleaire-interne-et-role-dans-la-signalisation-cellulaire-assemblage-de-grands-complexes-viraux-sophie-zinn-justin

NMR SPECIALIST

2011-07-04T11:56:00.001+02:00

NMR SPECIALIST- CALL FOR INTEREST

University of Trento, Italy

Faculty of Engineering

Department of Materials Engineering and Industrial Technologies

NMR Laboratory “Klaus Müller”

The Materials Chemistry group of the Department of Materials Engineering and
Industrial Technologies at the University of Trento, Italy, has a position open
for a NMR specialist.
Accordingly, we launch a call for interest for a permanent position in
Materials Chemistry with an emphasis in areas related to materials
characterization by Solid State NMR.
A leadership role in the Solid State NMR Laboratory “Klaus Müller” of the
Department (equipped with two 400 MHz and one 300 MHz Solid State NMR
spectrometers) and the development of strong externally funded research
programs in the field of advanced materials are expected.

The position can be either at the level of associate or full professor,
depending on the candidate’s CV.
Potentially interested Candidates should send a complete resume, including the
names of at least 2 reference persons, to:

prof. Sandra Dirè
Department of Materials Engineering and Industrial Technologies (DIMTI)
Via Mesiano 77
38123 Trento, Italy
e-mail: sandra.dire@ing.unitn.it

http://www.unitn.it/dimti

Postdoc Italy

2011-07-04T11:54:00.001+02:00

The Materials Chemistry Group of the
Department of Materials Engineering and Industrial Technologies,

is looking for an enthusiastic young researcher with a strong background in
Solid State NMR to join our team as a post-doctoral fellow.

The NMR laboratory “Klaus Mueller” is equipped with two 400 MHz and one 300
MHz Solid State NMR spectrometers and our group is mainly involved in sol-gel
synthesis and characterization of inorganic and hybrid O/I materials.

The candidate is expected to be an independent individual that is able to work
well within a team of interdisciplinary researchers

This is a full time 24 month, non-tenure track academic position.

Potentially interested Candidates should send a brief one-page description of
research interest and plans, a CV and contact information for at least 2
reference persons, to:

prof. Sandra Dirè
Department of Materials Engineering and Industrial Technologies (DIMTI)
Via Mesiano 77
38123 Trento, Italy
e-mail: sandra.dire@ing.unitn.it

http://www.unitn.it/dimti

Postdoctoral Position in Radiology

2011-07-04T11:53:00.000+02:00

Postdoctoral Position in Radiology at the Johns Hopkins School of Medicine

Location: Baltimore, MD

There is a postdoctoral fellowship position available within the Russell H. Morgan Department of Radiology, Johns Hopkins School of Medicine and the F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute for candidates interested in the synthesis of peptides as MRI contrast agents. The candidate is expected to be an independent individual that is able to work well within a team of interdisciplinary researchers.

Requirements:

The successful candidate should have a Ph.D. in Chemistry, Materials Science, Biology, Biomedical Engineering or closely related fields. Candidates with expertise in peptide synthesis and/or high resolution NMR are preferred. Applicants should submit a brief one-page description of research interest and plans, a CV and contact information for three references to Dr. Michael McMahon (mcmahon@mri.jhu.edu).

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Michael T. McMahon, Ph.D. Phone: (410)502-8188
Assistant Professor
F.M. Kirby Research Center for Functional Brain Imaging
Kennedy Krieger Institute
707 N. Broadway
Baltimore, MD 21205

The Russell H. Morgan Department of Radiology and Radiological Sciences
Johns Hopkins School of Medicine
CRB II Room 4M 63
1550 Orleans St.
Baltimore, MD 21231
http://www.linkedin.com/in/michaeltmcmahon

Postdoctoral teaching fellowship in NMR methodology for the study of inorganic materials

2011-07-04T11:52:00.000+02:00

A postdoctoral teaching fellowship in NMR methodology is available in the ENSCL (Lille, France). It will start in September 2011. This position may be turned into a permanent position of assistant professor in Lille after a training period.

You will join the team of Glasses and NMR methodology in Lille NMR center. You will contribute to the development of original NMR methods for the study of glasses and catalysts. In particular you will be expected to develop techniques for the observation of low-gamma nuclei. You will have access to all the NMR facilities (five superconducting magnets, ranging from 900 MHz to 100 MHz for proton Larmor frequency). Lille is a pleasant city situated in the heart of Europe (30 min from Brussels, 1 h from Paris, 1h from London by train). The university of Lille combines research groups with strong expertise in NMR and EPR spectroscopy as well as catalysis and material science.

You will teach (i) solid-state NMR to graduate students in chemistry as well as (ii) physics (magnetism, electricity) to first-year undergraduate students in chemistry.

You will have a PhD, or equivalent, in Physics or Chemistry. A working knowledge of French is required.

The closing date for application is Monday 11 July 2011.

Applications and informal queries about the lab and research projects should be directed by email to Lionel Montagne ( lionel.montagne@univ-lille1.fr ).

________________________________________________________________
Olivier Lafon

University of Lille North of France
F-59652, Villeneuve d'Ascq, Cedex, France

Tel : 33 3 20 43 41 43 Fax : 33 3 20 43 68 14
email : olivier.lafon@ensc-lille.fr

webpage adress : http://uccs.univ-lille1.fr/spip.php?article199
Lille group webpage : http://uccs.univ-lille1.fr/spip.php?article142

Assistant Professor

2011-07-04T11:51:00.001+02:00

Fixed Term Contract for 5 years

You will join the team of academic and research officers based in the Warwick Centre for Magnetic Resonance (MR). The centre is housed in a purpose built laboratory in Millburn House and combines Nuclear Magnetic Resonance (NMR) and Electron Paramagnetic Resonance (EPR) facilities with expertise being drawn from both the Departments of Physics and Chemistry.

Candidates with expertise in all areas of Magnetic Resonance Spectroscopy are welcomed, especially those with a track record involving the development and/or exploitation of one or more Magnetic Resonance research technique. You will be expected to establish an internationally-leading research activity in a Magnetic Resonance discipline. You will have access to all of the research facilities housed within the Millburn House Centre for Magnetic Resonance.

You will teach and contribute to research leadership, supervision and administration in the Integrated Magnetic Resonance Centre for Doctoral Training, and promote synergy of this activity with the Department of Physics and partner universities.

You will have a PhD, or equivalent, in Physics or a related subject, and will be an active researcher, with a strong record of publications in refereed international journals.

The closing date/time for applications is midnight (British time) at the end of Monday 04 July 2011.

Interview date: 15 July 2011.

http://www.jobs.ac.uk/job/ACU215/assistant-professor/

Please quote job vacancy reference number 71212-061.

Steven Brown
Department of Physics
University of Warwick
Coventry CV4 7AL

Tel: 00 44 24 76574359
Fax: 00 44 24 76150897

email: S.P.Brown@warwick.ac.uk
webpage address: http://go.warwick.ac.uk/nmr/members/academic/steven/
Warwick group webpage: http://go.warwick.ac.uk/nmr/
The UK 850 MHz solid-state NMR facility: http://go.warwick.ac.uk/850mhz/

Magnetic Resonance at Warwick: Watch the video: http://go.warwick.ac.uk/nmr/millburn

getting to Millburn House: http://go.warwick.ac.uk/nmr/getting_here

MRI Scientist for TIIL

2011-07-04T11:50:00.001+02:00

MRI Scientist for TIIL

Translational Imaging Industrial Laboratory (TIIL; part of Singapore Bioimaging Consortium), is a new initiative from Singapore’s A*Star (Agency for Science Technology and Research), providing global biopharma companies with a high quality and state-of-the-art array of preclinical imaging resources directed at enhancing the efficiency and pace of the drug development process.

The Laboratory is currently seeking to recruit an experienced MRI physicists to join our team. The in vivo imaging laboratory assists in drug discovery programmes and focuses on the validation and development of imaging and spectroscopic methods for a number of disease areas, including cardiovascular diseases, oncology, and metabolic disorders.

Particulars:
As part of TIIL, this role will support the development and implementation of MRI methods in order to understand mechanism(s) of drug action, drug efficacy, and safety, and long-term outcomes. These methods may then be incorporated as part of the drug discovery program, ranging from target identification to therapeutic application.

We are looking for a highly motivated individual, who can work independently in a fast-paced environment. This person will collaborate in multidisciplinary teams across disease areas and will keep meticulous records. Responsibilities for this position include performing in vivo MR experiments, analyzing and integrating related data, summarizing results for reporting and publication, and daily operations of the laboratory.

Qualifications and Expertise:

The desired candidate will:

• have an MSc or PhD or equivalent in Medical Physics, Biomedical Engineering, Biomedical Sciences or related fields, with at least 3 years of industrial experience

• have an advanced knowledge of the area of MRI physics and applications

• have a working knowledge of C/C++

• have experience with MR imaging and spectroscopy

• have experience and expertise in pulse sequence programming and applications development

• have digital image/spectroscopy processing or graphical/visual programming skills (Matlab, Analyze, IDL)

• have experience in performing small animal MRI experiments - Animal skills, such as handling, restraining, anaesthesia and injections (IP, IM, IV) in rodents and rabbits
• have familiarity with FDA and QSR regulations

• have the ability to communicate and collaborate with members of a multidisciplinary team

• have the ability to follow directions and perform tasks with continuous attention to detail and safety

• have good communication skills to be effective in a global organization

• must be able to provide at least three references to support qualifications

Research Fellowship in NMR Technology/DNP NMR

2011-07-04T11:49:00.001+02:00

*Research Fellowship in NMR Technology/DNP NMR *

Applications are invited for a post based in the Sir Peter Mansfield Magnetic Resonance Centre which is part of the School of Physics and Astronomy at the University of Nottingham. The successful candidate will lead an ambitious hardware development project that focuses on the the design and implementation of a novel spectrometer for Dynamic Nuclear Polarisation enhanced NMR spectroscopy. The project involves extensive industrial collaboration and is funded by the Novel Technology Initiative in Cross-disciplinary Sciences of the EPSRC.

Candidates should have a PhD in physics or a related discipline and preferably have experience in one or several of the following fields: Microwave technology, Cryotechnology, Magnetic Resonance hardware technology, Laser Optics. The successful candidate will join a interdisciplinary group of physicists, chemists and engineers.

Salary will be £27,319 - £31,671 per annum, depending on skills and experience. This post will be offered on a fixed-term contract for a period of three year.

Informal enquiries should be addressed to Dr Walter Köckenberger, Email: walter.kockenberger@nottingham.ac.uk.

For more details and/or to apply on-line please access: _http://www.nottingham.ac.uk/jobs/currentvacancies/ref/SCI992. _If you are unable to apply on-line please contact the Human Resources Department, tel: ++44 115 951 3262. *Please quote ref. SCI/*SCI992*. Closing date: 8^th July 2011.*

--
Walter Köckenberger
Sir Peter Mansfield Magnetic Resonance Centre
School of Physics & Astronomy
University of Nottingham
Nottingham NG7 2RD
United Kingdom

p: (44) 115 9515161
f: (44) 115 9515166

NMR Specialist Genomic Biology

2011-07-04T11:48:00.001+02:00

The Institute for Genomic Biology has a position open for a NMR Specialist.

http://www.igb.illinois.edu/sites/default/files/upload/NMR%20Specialist%20Ad%205-2011.pdf

Position Announcement

NMR Specialist

Institute for Genomic Biology
University of Illinois Urbana Champaign

The Core Facilities in the Institute for Genomic Biology has purchased a
600 MHz NMR and a Protasis capillary flow probe for natural product
isolation. The new NMR Specialist will primarily be responsible for
developing training materials and maintenance schedules, training NMR
users, and maintaining the NMR. Secondary responsibilities will include
working with users of the optical microscopy instruments.

Currently the core facility at the institute for Genomic Biology houses
$2.5 million of optical microscopy, cleanroom and bioanalytical
equipment and is staffed by three full time academic professionals and
an administrative assistant.

Key Responsibilities
Provide quality training to NMR users.
Develop NMR training materials.
Maintain the NMR including scheduled Cryogen fills.
Work with NMR users to maximize efficient use of the NMR
Aid with training microscopy users as time permits.

Minimum Qualifications Masters Degree in Chemistry or related field. NMR
experience.

Desired Qualifications
Experience with proton NMR.
Experience with NMR hardware and software.

This is a full time 12 month, non-tenure track Academic Professional
position with full university benefits. The successful candidate would
start in the early fall. Salary will be commensurate with training and
experience. Please create your candidate profile at
http://jobs.illinois.edu and upload your letter of interest (including
email address), resume and contact information for three professional
letters of reference by June 22, 2011. Position available as soon as
possible after the close date. Applicants may be interviewed before the
closing date; however, no hiring decision will be made until after that
date. All requested information must be submitted for your application
to be considered. For further information regarding the application
procedures, you may contact Kim Johnson, kljohns@igb.illinois.edu.
Illinois is an Affirmative Action/Equal Opportunity Employer and
welcomes individuals with diverse backgrounds, experiences, and ideas
who embrace and value diversity and inclusivity.
(www.inclusiveillinois.illinois.edu)

Post-doc position in spin physics at ETH Zurich

2011-07-04T11:46:00.000+02:00

The Spin Physics and Imaging group (Degen Lab at ETH Zurich) is looking for an enthusiastic spin physicist with a strong background in magnetic resonance to join our team as a post-doctoral associate. Our lab is working on combining single nitrogen vacancy spins in diamond (NV centers) with scanning probe microscopy, for application in nanoscale magnetic sensing, imaging, and single spin readout.

Experience that will be valued includes:
- Quantum simulations of spin systems
- Design and application of complex EPR and NMR pulse sequences
- Hands-on experience with microwave and radio-frequency circuitry (we use frequencies up to 20 GHz)
- Experimental or theoretical experience with manipulation and readout of single spin systems, such as optics experiments on quantum dots.

For inquiries and applications please contact Christian Degen at degenc@ethz.ch, or visit our website at http://www.spin.ethz.ch/. Please include in your application a recent CV and a short motivation why you are interested in working with us.

The post-doctoral position is funded through the Swiss national competence center in Quantum science and technology (http://www.nccr-qsit.ethz.ch/), a platform that offers great opportunities for networking with a number of excellent groups in the field of quantum science.

-------------------------------------
Prof. Christian Degen
Department of Physics, HPF F6
ETH Zurich
Schafmattstrasse 16
8093 Zurich
Switzerland

Phone: +41 44 633 2336
Email: degenc@ethz.ch
Web: http://www.spin.ethz.ch
-------------------------------------

PhD position, Australia

2011-06-01T12:58:00.000+02:00

The MacDiarmid Institute for Advanced Materials and Nanotechnology at
the Victoria University of Wellington (Wellington / New Zealand) is
offering a PhD position, available from July 2011.

The research will be in the field of soft matter (complex fluids
investigated by means of Rheo‐NMR under high shear rates, application
of multidimensional NMR methods) with the focus on spatio‐temporal
fluctuations in banded‐flow, wall slip effects and start up flow of
micellar, polymeric and colloidal particles based on fast 3D NMR
velocimetry. The research to be undertaken concerns addressing
fundamental questions related to soft matter as well as the
development of the necessary NMR methodology (including hardware).

The successful applicant will be given the opportunity to work with
Dr. Petrik Galvosas and Professor Paul Callaghan in a well recognised
NMR group (http://www.macdiarmid.ac.nz/nmr/) with strong national and
international collaborations.

The PhD position is fully funded (including fees) and will enable the
successful applicants to stay in a well established academic
(http://www.victoria.ac.nz/scps/index.aspx) as well as urban
environment (http://www.wellingtonnz.com/). The scholarship provides a
non‐taxed living allowance of NZ$25,000 per annum, which is a very
comfortable living salary in Wellington, plus the PhD tuition fee for
three years.

Please refer to the Soft Matter and RheoNMR link at
http://www.victoria.ac.nz/scps/study/scholarships.aspx for further
details.

------------------------------------------------------------------------
Dr. Petrik Galvosas
School of Chemical and Physical Sciences
Victoria University of Wellington
PO Box 600
Wellington 6140, New Zealand
Tel: +64-4-463 6062 (office)
+64-4-463 5911 (lab)
Fax: +64-4-463 5237
mailto:Petrik.Galvosas@vuw.ac.nz

PhD or postdoctoral fellowships, Tuebingen,

2011-06-01T12:52:00.001+02:00

Max Planck Institute for Developmental Biology
Tuebingen, Germany.

PhD or postdoctoral positions funded by tax free fellowships are available in the research group of Remco Sprangers and in the research group of Silke Wiesner. We are looking for candidates that have a strong interest structural biology and biochemistry. More details about the projects that combine NMR spectroscopy, X-ray crystallography and biochemical approaches can be found below. Both laboratories are very well equipped, including new 600 and 800 MHz NMR spectrometers, crystallization robots and state-of-the-art instrumentation for protein expression and purification. In addition, we have regular access to the synchrotron facility at the SLS.

Applicants for the PhD positions should have a strong background in biochemistry, chemistry and/or biophysics. Applicants for the postdoctoral positions should have a PhD in NMR spectroscopy or X-ray crystallography. Please contact remco.sprangers@tuebingen.mpg.de or silke.wiesner@tuebingen.mpg.de by June 15, 2011 and include a pdf file with a brief CV, names of two referees and a summary of research interests and previous research projects.

The research group of Remco Sprangers (http://www.eb.tuebingen.mpg.de/research-groups/remco-sprangers) studies how protein motions determine enzymatic function. We are especially interested in the machinery that degrades mRNA. Structural changes in the degradation complex allow for a tight regulation of the mRNA decay process that is crucial for cellular homeostasis. To understand how this is achieved on an atomic level, we use novel techniques in high resolution NMR spectroscopy (methyl TROSY) in combination with X-ray crystallography and biochemical experiments.

The research group of Silke Wiesner (http://www.eb.tuebingen.mpg.de/research-groups/silke-wiesner) is interested in the structure, function, and regulation of the ubiquitination machinery. Ubiquitination marks proteins for degradation and thereby controls cellular signaling and behavior. We seek to provide a molecular basis for protein ubiquitination and to understand how diseases like cancer arise from dysfunctional ubiquitination enzymes. We gain structural information from NMR and/or X-ray crystallography and combine this information with investigations targeted at functional aspects using both in vitro and in vivo studies.

Leiterin / Leiter der NMR-Abteilung Regensburg

2011-06-01T09:38:00.002+02:00

An der Universität Regensburg ist in der Abteilung Zentrale Analytik der Fakultät für Chemie und Pharmazie zum nächstmöglichen Zeitpunkt die Stelle einer
Akademischen Rätin/ eines Akademischen Rates
als Leiterin / Leiter der NMR-Abteilung
im Beamtenverhältnis auf Probe / Lebenszeit zu besetzen.
Die Stelle ist nach Besoldungsgruppe A13 /A 14 bewertet.Zu den Aufgaben gehört die wissenschaftliche, organisatorische und technische Leitung und Weiterentwicklung der NMR-Abteilung, die Beratung in NMR-spektroskopischen Fragen und die Mitwirkung in Ausbildung und Lehre. Erwünscht ist auch die Durchführung von Forschungsprojekten.Voraussetzung ist ein abgeschlossenes Universitätsstudium (bevorzugt Chemie) und eine Promotion auf einem aktuellen Gebiet der NMR-Spektroskopie. Erfahrung mit Strukturrechnungen möglichst inklusive residualer dipolarer Kopplungen ist erwünscht.Neben den allgemeinen beamtenrechtlichen Voraussetzungen ist für die Übernahme in ein Beamtenverhältnis eine mindestens zweijährige wissenschaftliche oder praktische hauptberufliche Tätigkeit nach dem Erwerb der Promotion auf diesem Gebiet erforderlich. Die Universität strebt eine Erhöhung des Frauenanteils an und fordert daher qualifizierte Frauen ausdrücklich zur Bewerbung auf.Schwerbehinderte werden bei im Wesentlichen gleicher Eignung bevorzugt berücksichtigt.
Wir freuen uns auf Ihre ausführliche Bewerbung, die Sie bitte bis zum 20.06.2011 an folgende Adresse senden:
Universität Regensburg
Institut für Organische Chemie
Zentrale Analytik / NMR-Abteilung
Prof. Dr. Ruth M. Gschwind
Universitätsstr. 31
93053 Regensburg

PhD position France

2011-04-08T09:58:00.000+02:00

A PhD position is available at Rennes, France (collaboration between INRA-APBV (Yield under abiotic stress) and Cemagref (IRM-Food)). The project concerns in particular the update of the cellular and metabolic events which contribute to the reallocation of nitrogenous and carbon from senescing leaf tissues in order to define the mains determinants and to improve their efficiency. The ambition based on the two laboratories collaboration is to associate a fine analysis at the cellular level of the structural organization of leaf tissues by an original approach of NMR relaxometry with the concomitant description of the metabolic orientation of products stemming from organels and macromolecules degradation by metabolomic approaches. We will be also testing the validity of the NMR analysis as an efficient integrative tool to characterize senescing tissues and as an effective means of diagnostic and medium throughput phenotyping tool of stress conditions.

The project is highly interdisciplinary and will combine NMR for identification of water in different cell parts with cell biology techniques (non aqueous sub-cellular fractionnation, sub-cellular metabolic profiling, TEM, leaf senescence characterisation (molecular pysiological and biochemical markers).

Applications close - 15 Juin 2011.

Interested applicants should contact Dr Maja Musse (maja.musse@cemagref.fr) or Dr Laurent Leport (laurent.leport@univ-rennes1.fr) directly by submitting their CV.

Maja Musse, PhD
NMR/MRI group
Food process engineering research unit Cemagref
17, avenue de Cucillé
CS 64427
35044 Rennes cédex
tél : 02 23 48 21 79
fax : 02 23 48 21 15
mailto:maja.musse@cemagref.fr

PhD Scholarship in Sydney

2011-04-07T16:39:00.002+02:00

Nanoscale Organisation and Dynamics Group
College of Health and Science, University of Western Sydney, Australia
Nanoscale Postgraduate Research Award

Nanoscale PhD Scholarship in Advanced Clinical MRI

The Nanoscale Organisation and Dynamics Group at the University of Western Sydney is seeking two doctoral students to commence a project involved in the development of Advanced MRI Techniques for Clinical Imaging in 2011.

About the Project
The successful applicants will undertake a project in the field of developing next generation diffusion MRI techniques for clinical imaging and are expected to have a research background and some experience in more than one of the following areas:

· Magnetic resonance theory and application
· Operation of Bruker NMR spectrometers
· Mathematical modelling
· Computer visualisation
· Imaging visualisation software such as Amiraâ
· Computational software such as Mapleâ Matlabâor Mathematicaâ

Academic Criteria
Applicants should hold an excellent Bachelor Hons degree in a relevant field, or equivalent qualifications and/or experience.

What does the scholarship provide?

· Tax free stipend of $30,000 per annum and a funded place in the doctoral degree. International candidates may be charged fees
· Funding is also available for project costs and conference travel

Need more information?

· Contact Professor William Price to discuss the project: w.price@uws.edu.au; +61 2 4620 3336
· Contact the Research Training, Policy and Programs Officer to discuss enrolment and scholarships:

Ms Sandra Lawrence: sg.lawrence@uws.edu.au
· Find out more about the research being undertaken in the Nanoscale Organisation and Dynamics Group at
http://www.uws.edu.au/nanoscale/nanoscale_organisation_and_dynamics

How to apply
Submit an application form, research proposal and CV by the closing date. The application form can be downloaded from the web:

www.uws.edu.au/research/scholarships
APPLICATIONS CLOSE 20 APRIL 2011
_______________________________________________________________

Professor William S. Price
Nanoscale Organisation and Dynamics Group
College of Health and Science
Campbelltown Campus - Building 21.G.45
University of Western Sydney
Penrith South DC NSW 1797
AUSTRALIA
E-mail: w.price@uws.edu.au
Phone: [61 2] 4620 3336
FAX: [61 2] 4620 3025
Mobile: 0404 830 398

http://www.uws.edu.au/nano
http://www.uws.edu.au/nmr
http://www.anif.org.au/

PhD (6) - Postdoc (5)

2011-04-07T16:37:00.001+02:00

Large investment in UltraSense NMR for Analyses, screening and diagnostics.

UltraSense NMR is a large research and development programme, granted by EFRO(EU) and GO, in cooperation between science and business. The project will be run by a consortium between Radboud University Nijmegen: Institute of Molecules and Materials, UMC St. Radboud, University of Twente and 3 knowledge companies: Future Chemistry, Spinnovation Analytical and NovioGendix. Goal of the project is to develop hyperpolarisation equipment and strategies based on both physical (DNP) and chemical (pH2) principles. With the ultrasensitive microfluidic and continuous flow technology and equipment, we will be developing new diagnostic services and a molecular diagnostic test for prostate cancer. For this research programme we are looking for multidisciplined researchers, familiar with the field of physics, chemistry, biophysics, metabolic profiling, molecular diagnostics, who will be working closely together to generate a multidisciplinary research and development team responsible for generating the technology as well as the described prototype products. For the abovementioned developments we are looking for enthusiastic PhD students and postdoctoral researchers who like to be part of a multidisciplinary team in an internationally oriented environment:

1. PhD 1 with a background in synthetic (bio)organic chemistry, continuous flow chemistry, tagging of biomolecules, and with a strong affinity and knowledge of NMR.

2. PhD 2 with NMR/MR experience, preferably experience with working with PHIP. and a strong affinity and knowledge of synthetic organic chemistry.

3. PhD 3 with a master degree in (bio-)chemistry, biophysical chemistry or comparable fields. Experience with NMR and development of new metabolic assays in body fluids, cells and tissue will be appreciated.

4. PhD 4 with a background in Microfluidics and chip technology, lab on a chip, this position will be located at University of Twente

5. PhD 5 with a background in Biomarker tracing and analysis with preferably experience in molecular diagnostics, cancer research, this position will be located at UMC St. Radboud

6. PhD 6 with experience in magnetic resonance. Knowledge of DNP and/or metabolic profiling is a benefit.

7. Postdoc 1 (2 yrs) with a background in organic synthetic chemistry and a strong affinity and knowledge of flow chemistry and NMR techniques.

8. Postdoc 2 (2 yrs) with a strong background in magnetic resonance with an emphasis on methodological development.

9. Technical Researcher/Postdoc (4 yrs) with outstanding technical skills focusing on the development of a novel DNP spectrometer and hyphenated probe in a microfluidic context.

10. Postdoc 4 (2 yrs) with a background in NMR/MR, or pH2 based technology, preferably expertise in methodological development, instrumentation and pH2 hardware development.

11. Postdoc 5 (2 yrs) with NMR/MR experience in the field of biomolecules or biomarker research/ analysis and preferably experience with working with hyperpolarisation or PHIP.

When interested in these vacancies, please send an e-mail to: m.dewith@science.ru.nl

Please accompany your e-mail with a cv and refer to the vacancy you’re interested in!
--

--
Marian de With
Radboud University
Institute for Molecules and Materials
Physical Chemistry
Tel. +31 24 3652678
Fax +31 24 3652112
Web: www.ru.nl/physchem

Visiting address:
Heyendaalseweg 135
6525 AJ Nijmegen
Postal address:
Postbus 9010
6500 GL Nijmegen

PhD MRI

2011-04-07T16:35:00.001+02:00

A PhD position is available at Cemagref, Rennes (IRM-Food). This collaborative project amongst the groups IRM-Food and PV-BIA, INRA (Marc Lahaye) aimed at characterisation of microstructure distribution of apple fruit by quantitative MRI.

All the necessary details regarding this position are detailed below. Applications close 15 Juin 2011.

Interested applicants should send the required application document at: maja.musse@cemagref.fr.

Purpose:
The quantitative MRI and NMR relaxometry offer the possibility to access macroscopic (tissue distribution), mesoscopic (local porosity) and microscopic (subcellular water distribution) changes and associated with chemical and mechanical characterisation of tissues, would make it possible to understand the influence of tissue structure to mechanical properties of the fruit. The main questions that the thesis will try to answer are:

- Among the hystological (cell dimensions), biophysical (turgor pressure, membrane permeability) and chemical characteristics, what are those who determine the relaxation times and diffusion coefficient?

- What is the influence of the porosity and its distribution within the tissues on the mechanical properties of the fruit?

- Do the distributions of the relaxation times and diffusion coefficient measured by MRI and their time variation depend on the plant variety?

- Is it possible to consider the relaxation times, diffusion coefficient and the porosity measured by MRI for the phenotyping?

Relaxation times and apparent diffusion coeficient measured by MRI and NMR will be correlated with macrovision and microscopic images of apple parenchyma and with its chimical and mechanical properties. Fruits with known and very different chaarcteristcs (cell dimensions, firmness, elasticity of apple flesh) will be used.

Scills required by the candidate:
The candidate should have bases on MRI/NMR physics, some knowelage of biology and be able to work in an interdisciplinary environment. A Master's degree or equivalent is required.

Maja Musse, PhD
NMR/MRI group
Food process engineering research unit Cemagref
17, avenue de Cucillé
CS 64427
35044 Rennes cédex
tél : 02 23 48 21 79
fax : 02 23 48 21 15
mailto:maja.musse@cemagref.fr

Doktoranden-Stelle (m/w)

2011-03-23T13:24:00.001+01:00

Doktoranden-Stelle (m/w)

Am Max-Planck-Institut für Festkörperforschung (Stuttgart) ist eine Doktoranden-Stelle (m/w) für Projekte im Bereich der Charakterisierung neuartiger Elektrolyte zu besetzen. Voraussetzungen sind ein abgeschlossenes Studium der Chemie oder Physik, experimentelles Geschick und die Fähigkeit, sich in eine interdisziplinär arbeitende Gruppe einzufügen. Erfahrungen im Bereichen der NMR-Spektroskopie wären vorteilhaft.
Die geplanten Arbeiten sind zum einen grundlagenorientiert, zum anderen eingebunden in Projekte zur Entwicklung neuer Materialien für Brennstoffzellen und Batterien (insbesondere Membranen), die zusammen mit anderen Instituten, Universitäten und Unternehmen durchgeführt werden.
Siehe auch:
www.fkf.mpg.de/maier/people/kreuer.html

Ihre Bewerbung mit den üblichen Unterlagen schicken Sie bitte an:

Max-Planck-Institut für Festkörperforschung
K. D. Kreuer
Heisenbergstr. 1
70569 Stuttgart
oder:
kreuer@fkf.mpg.de

Postdoc Diffusion NMR

2011-03-23T13:22:00.000+01:00

A position for a Project Scientist is available in the Knowledge Centre for Materials Chemistry (KCMC, http://www.materialschemistry.org) at the University of Manchester. The role is focused on the development and delivery of a capability to use diffusion NMR to investigate the dynamic behaviour of colloids and nanomaterials in aqueous dispersions. This work would be done in collaboration with external sponsors including industry, charities and research councils.

Candidates should hold a PhD in chemistry or materials science, and a strong research track record in NMR spectroscopy and specifically in diffusion NMR, the related data analysis, and the use of these techniques to investigate the association and behaviour of molecular assemblies in liquid media. Experience in colloid and surface science is also required. Experience of working with industry is desirable

The successful candidate will be working as part of a large research team and will be expected to communicate results at project meetings, in written reports and to industrial sponsors. Short-term projects will be based on a number of clearly defined goals that must be delivered in a timely manner. We therefore seek highly motivated candidates with excellent communication and interpersonal skills, with the ability to interact with persons at all levels within the academic and business communities, and who would enjoy working in a challenging environment and interacting with industry. The position will be particularly suited to candidates who are interested in both fundamental AND applied aspects of science.

The closing date is 18th April 2011; further details may be found at http://www.manchester.ac.uk/aboutus/jobs/vacancies/research/vacancy/?ref=113848. For informal enquiries please contact Professor N Tirelli (nicola.tirelli@manchester.ac.uk).

PhD student or Postdoctoral fellow

2011-03-23T12:37:00.000+01:00

Seeking a PhD student or Postdoctoral fellow with NMR experience and interest in Microbial Glycobiology

A PhD or postdoctoral position is available immediately at the University of Alberta. The successful candidate will be jointly supervised by Dr. Roderick Wasylishen (Department of Chemistry and Canada Research Chair in Physical Chemistry, http://ramsey.chem.ualberta.ca/) and Dr. Christine Szymanski (Department of Biological Sciences and Alberta Ingenuity Centre for Carbohydrate Science, http://www.biology.ualberta.ca/faculty/christine_szymanski/).

The student will be involved in a multidisciplinary project examining bacterial capsular polysaccharides and developing new techniques to examine bacterial-host interactions using high-resolution magic-angle spinning NMR. The NMR Facilities in the Department of Chemistry are well equipped for the collaborative research project. Specifically we have access to a Varian 600 with a nanoprobe for magic-angle spinning experiments. Details of the other NMR spectrometers in the Department can be found at: http://nmr.chem.ualberta.ca/ and http://ramsey.chem.ualberta.ca/

Applicants should have a strong background in NMR and biological chemistry. Knowledge of solid-state NMR, molecular modeling and NMR programming would be an asset.

Interested applicants should send a single PDF document containing a CV, one-page statement of research interests and contact information of three references to: cszymans@ualberta.ca

predoctoral fellowship

2011-03-14T16:52:00.001+01:00

Dear colleagues,

A predoctoral fellowship is available for 6 months (extended up to 12 months) to perform theoretical and experimental studies of small molecules of pharmaceutical interest based on solid-state NMR spectroscopy. The successful applicant will also have the possibility to pursue with a doctoral programme.
All the necessary details regarding this position are detailed below (contact details and deadlines at the bottom of the message at the end).

Interested applicants should send the required application document (check below) to Dr. José Gomes (jrgomes@ua.pt) or directly to me.

regards,
luis

postdoctoral position King's College

2011-03-14T16:51:00.001+01:00

A postdoctoral position supported by the King's College London British Heart Foundation Centre of Excellence is available at King's College London in the field of ROS biology. The project is a collaborative effort amongst the groups of Prof Ajay Shah MD (Cardiovascular Division, King's College London), Dr Conte and Dr Steiner (Randall Division of Cell and Molecular Biophysics, King's College London) aimed at elucidating the molecular mechanism of controlled ROS production in higher organisms.

The project is highly interdisciplinary and will combine structural biology (X-ray and NMR) with biophysical (ITC), biochemical and cell biology work. The post requires experience in molecular biology/protein biochemistry. Proven prior experience in protein expression using the baculovirus system is also considered very important. Additional experience with biophysical methods complementary to structural biology and/or oxygen biochemistry is welcomed.

The post is available immediately and funding is initially for 18 months. Salary will be commensurate to prior experience and qualifications. Interested applicants should contact Dr Maria R Conte (sasi.conte@kcl.ac.uk) directly by submitting their CV together with the names of three referees. Informal inquiries are welcome.

Deadline for this application is 21st March 2011.

---------------------------------------------------------------------
Maria R Conte
Reader in Structural Biology
Randall Division of Cell and Molecular Biophysics
King’s College London
New Hunt’s House
Guy’s Campus
London SE1 1UL, United Kingdom

Tel +44 (0)20 7848 6194
Fax +44 (0)20 7848 6435
Email sasi.conte@kcl.ac.uk
sasi.conte@hotmail.com

Position of NMR manager in Lille, France

2011-03-14T16:49:00.000+01:00

The laboratory of Structural and Functional Glycobiology (UGSF - CNRS UMR 8576) at the University of Lille, France, is looking for a research engineer to manage the liquid state part of the NMR Platform at the University. Composed of several Bruker spectrometers, including a 900MHz Avance III instrument with cryogenic probehead and a SampleJet, a 800MHz Avance III spectrometer for solid state and HRMAS NMR, the platform has the specificity within the national network of high-field NMR (www.tgir-rmn.org) of combining expertise in liquid and solid state NMR.

The applications of high resolution biomolecular NMR at the UGSF cover most types of biomolecules, with a particular accent on oligosaccharides and proteins, and their interactions. Research at the UGSF aims to develop novel methods (pulse sequences, reduction of sample size, use of sample changer, HRMAS) and novel instrumentation to improve the quality of the measurements, and extract maximal information for the biological systems of interest.

The ideal candidate will be in charge of the maintenance of the different spectrometers, relations with the constructor, planning of the experiments, and set-up of the experiments for novel and experienced users. He/she will play an important role in choosing and implementing existing and novel NMR experiences, and will be particularly involved with the set-up of automatic screening protocols of molecular interactions.

A PhD in high resolution biomolecular NMR and a first professional experience in a NMR laboratory are important criteria for the selection. Further information about the position can be obtained from Guy Lippens, the principal investigator of the 900MHz project (Guy.Lippens@univ-lille1.fr, tel (00 33) 3 20 33 72 41). For administrative information, candidates should contact Mme Martine Ratajczak (martine.ratajczak@univ-lille1.fr 03 20 33 72 40) before March 28th 2011.

Postdoctoral Fellow

2011-03-14T16:48:00.002+01:00

Applications are invited for a Postdoctoral Fellow / Research Associate position at the Center for Biomedical Imaging of the EPFL in Lausanne, Switzerland, in the area of Hyperpolarized Magnetic Resonance Imaging and Spectroscopy.

Hyperpolarized Magnetic Resonance (MR) is a revolutionary and promising technique with a proven potential in biomedicine. Based on Dynamic Nuclear Polarization (DNP), a low-temperature technique used to increase the nuclear spin order, hyperpolarization leads to an improvement in signal-to-noise ratio on the order of 10’000 times. It allows for the detection of tiny amounts of biological substances in vivo and to follow the metabolic pathways of chosen molecules.

Unique hyperpolarizers have been developed within the Swiss DNP Initiative regrouping several departments of the EPFL and the Paul Scherrer Institute. The Center for Biomedical Imaging (CIBM) provides access to two high-field animal MRI systems, one working at 9.4T and the other at 14.1T. One 5T hyperpolarizer is coupled to the 9.4T scanner and another is about to be installed and coupled to the 14.1T scanner.

The selected candidate will be involved in the development of new technologies and protocols to perform in vivo cardiac and brain DNP-enhanced experiments. Emphasis will be put on the use of novel hyperpolarized substrates for metabolic and molecular imaging. Applications in the field of cardiology and oncology will be tested on rodents.

We are seeking for a candidate with a PhD in Physics, Chemistry, Biomedical engineering or related field. The candidate is expected to have a strong background in MR physics from his or her Ph.D. Experience with Varian sequence programming is desirable but is not required. The selected candidate will be part of a team composed of several PhD students and experienced researchers involved in the physical, chemical, biological and biomedical aspects of hyperpolarized MR.

The position is open immediately and for up to 4 years. For consideration, please submit your application including a cover letter, a full CV, and the names and email addresses of three references to arnaud.comment@epfl.ch.
----------------------

Arnaud Comment
Laboratory for functional and metabolic imaging (LIFMET)

mailing address:

LIFMET-IPSB-SB
EPFL, Station 6
CH-1015 Lausanne
Switzerland

Phone +41 21 693 7982
Fax +41 21 693 7960

http://sdnpi.epfl.ch

post-doctoral research position

2011-03-14T16:48:00.001+01:00

A full time post-doctoral research position is available for a period of one year at the Università del Piemonte Orientale “Amedeo Avogadro”, Alessandria (Italy), on "NMR relaxometric characterization of Gd-based systems for the development of dual imaging probes".

Our lab is part of the European COST Action D38, ”Metal-based Systems for Molecular Imaging Application” and our research activities are aimed at developing efficient Imaging Probes based on Gd(III) complexes. Within the frame of a Regional Project on Innovative Platform for Medical Imaging and in collaboration with academic and industrial partners (University of Turin, Bracco Imaging, Advanced Accelerator Applications, Fluody), we are committed at the synthesis and characterization of innovative dual PET-MRI, SPECT-MRI and MRI-optical probes for the synergistic exploitation of the peculiar properties of the two diagnostic techniques. After complete physico-chemical characterization, these Imaging probes will be tested in vitro and in vivo with Magnetic Resonance Imaging on tumors and other cardiovascular or neurological pathologies.

Candidates are expected to have a PhD degree in Chemistry with a background in coordination chemistry and proven experience in NMR spectroscopy.

NMR facilities include high resolution JEOL ECP-400 and a Bruker Avance III 500 NMR, all equipped with a direct Z-gradient multinuclear probe; Solid-state Bruker Avance III 500 spectrometer with a wide bore 11.7 T magnet; JEOL FA-200 X-band EPR spectrometer; low resolution Stelar NMR spectrometer operating at 20-80 MHz and a Fast Field Cycling Stelar SmartTracer spectrometer operating over a 0.01-10 MHz frequencies range equipped with a variable temperature unit control.

Start date: June-July 2011
Interested candidates should send their biographical sketch and a cover letter summarising research experience and interests to:
Mauro Botta (mauro.botta@mfn.unipmn.it).

____________________________________________

Prof. Mauro Botta
Dipartimento di Scienze dell 'Ambiente e della Vita
Università del Piemonte Orientale "A. Avogadro"
Viale Teresa Michel 11, 15121 Alessandria (Italy)
Tel: 0131-360253
Fax: 0131-360250
e-mail: mauro.botta@mfn.unipmn.it

PhD student project/position

2011-03-07T10:47:00.001+01:00

PhD student project/position

A PhD student project/position is available in the area of NMR applied to asymmetric homogeneous catalysis. The project will be jointly supervised in the NMR Department (Dr. Christophe Farès) and in the Department of Homogeneous Catalysis (Prof. Benjamin List) of the MPI for Coal Research in Mülheim an der Ruhr (http://www.kofo.mpg.de/).

The specific goals are to address fundamental questions related to the mechanism of the high stereoselectivity in novel organocatalysts developed at this institute and to discover and develop new strategies towards the characterization of catalytic intermediate and transition states based on advanced NMR methods.

The PhD student will work in collaboration with synthetic chemists in order to optimize compounds which will stabilize intermediate states. She/He will also have full access to a modern NMR laboratory, equipped with seven spectrometers, including a 600-MHz instrument with a cryogenically cooled-probehead.

The position is for a period of three years. We are looking for a talented and motivated individual with a good background in NMR, that wish to invest time and energy to satisfy their curiosity in understanding the fundamental mechanisms behind organocatalysis. A genuine interest in interdisciplinary science will be essential. Education in a relevant discipline such as organic chemistry will be an advantage.

Applications must contain

1. a complete CV with details on education, previous research activities and a list of publications (if any)
2. contact details of at least two personal references

The complete application should be sent to:
Dr Christophe Farès, Department of NMR, 45470 Mülheim an der Ruhr, Germany or fares@mpi-mulheim.mpg.de.
The application must be received no later than March 31, 2011.
For further information regarding this position, please contact Dr Christophe Farès, Department of NMR, 45470 Mülheim an der Ruhr, Germany (Tel: +49 208 306 2130)

Genentech Postdoctoral Fellow

2011-03-07T10:46:00.000+01:00

Genentech Postdoctoral Fellow: Structural Biology/NMR Spectroscopy

We have an opportunity for a highly talented Postdoctoral Fellow to join the Protein NMR Group in the Structural Biology Department at Genentech. Our research encompasses the structural analysis of proteins of therapeutic interest, with an emphasis on determining their conformations and ligand-binding properties.

Genentech is now applying our expertise in protein expression, assay development, antibody engineering and drug design to pursue some of the most challenging therapeutic targets in the human proteome, including G protein-coupled receptors and ion channels. The successful candidate will focus their postdoctoral research on the NMR structural analysis of human membrane proteins involved in ion transport and the mechanisms of their functional regulation. The interaction of these proteins with potent and selective antibody fragments, peptides and/or small molecule inhibitors will also be examined. Significant progress on the high-level expression and purification of the proposed membrane structural targets has already been achieved. Moreover, you would be working with a highly collaborative group of scientists whose expertise includes protein NMR spectroscopy, soluble and membrane protein crystallography, ion channel electrophysiology and assay development.

The protein NMR facility includes dedicated 800, 600, and 500 MHz spectrometers, Linux workstations, a fully equipped protein expression and purification lab with expertise in membrane protein production, and access to the Central California 900 MHz spectrometer.
Requirements:

Recent PhD graduate in Biochemistry, Structural Biology or a related discipline, with a strong publication record providing evidence of productive, independent contributions in science. The applicant must have demonstrated expertise in protein expression and purification, and protein NMR spectroscopy . Prior experience working with membrane proteins will be a strong asset, but is not essential. The successful candidate must be motivated, capable of working independently, and enjoy working in a collaborative setting.

Interested candidates should apply at www.gene.com, but feel free to send their CV and cover letter directly to Dr. Melissa Starovasnik (star@gene.com) and Dr. Christopher Koth (kothc@gene.com). Please visit http://www.gene.com/gene/research/postdoctoral for additional information.

solid-state NMR engineer position

2011-03-07T10:45:00.002+01:00

A one-year solid-state NMR engineer position available

A one-year engineer position is available in the Magnetic Resonance Laboratory (LRM), INAC/SCIB at CEA Grenoble for the technical maintenance of three BRUKER solid-state NMR spectrometers: two AVANCE 400, one of them coupled to a gyrotron, and one DSX 200. The NMR facility is localized at two different sites and will get very soon a complete system to perform solid-state high-resolution NMR coupled to Dynamic Nuclear Polarization (DNP).

Applications fields in high-resolution solid-state NMR at CEA-Grenoble are very broad, ranging from synthetic polymers to biological material, as well as new materials for nanotechnologies. Research at LRM includes methodological developments (pulse sequence design, DNP, NMR/DFT coupling, …) and original instrumentation in order to improve the low intrinsic sensitivity of NMR.

The successful candidate will be in charge of the maintenance and troubleshooting of the spectrometers, contact with suppliers, spectrometer time schedule, supervising external users, and users training. The candidate will be strongly involved in the setup of DNP/NMR experiments, including optimization of sample-preparation protocols for DNP.

The candidate profile includes a PhD thesis in high-resolution solid-state NMR. Previous professional experience in a NMR facility will be particularly considered. Communication and integration skills are highly appreciated.

Further information concerning this position can be obtained from the LRM scientists Sabine Hediger (sabine.hediger@cea.fr, tel +33 4 38 78 68 12) and Gaël De Paepe, DNP project leader (gael.depaepe@cea.fr, tel +33 4 38 78 58 30).

Motivated candidates should send their CV, two letters of reference, and one letter of motivation before 21st of March 2011 to:

Michel Bardet
INAC/SCIB/LRM
17 rue des Martyrs
38054 Grenoble
Cedex 9 - France
tel. 33 4 38 78 57 72 (office)
33 4 38 78 38 33 (secretary)

email : michel.bardet@cea.fr

Two Group Leader Positions – Bio NMR

2011-03-07T10:44:00.001+01:00

Rector of Masaryk University opens positions

Two Group Leader Positions – Bio NMR, CEITEC - Central European Institute of Technology, Brno, Czech Republic

We are seeking outstanding applicants for two positions of group leaders who are willing to accept the challenge of starting independent world-class research groups in the field of bio-NMR for Structural Biology Research Program of CEITEC. Structural Biology Research Program will run core facilities for X-ray crystallography, high-end cryo electron microscopy and tomography, studies of biomolecular interactions, and high-field NMR spectroscopy.

You will be part of CEITEC - Central European Institute of Technology in Brno, Czech Republic (www.ceitec.eu), an academic research institution established jointly by Masaryk University, Brno University of Technology, Mendel University in Brno, University of Veterinary and Pharmaceutical
Sciences Brno, Institute of Physics of Materials, Veterinary Research Institute. The institute will host 600 scientists in state-of-the-art equipped laboratories. Genomics and Proteomics of Plant Systems, Molecular Medicine, Molecular Veterinary Medicine, and Brain and Mind Research represent other Life Science Research Programs of CEITEC. CEITEC will also host high throughput –omics core facilities. The material sciences programmes are part of CEITEC as well.

The High-field NMR Core Facility will be equipped with six high-resolution NMR systems ranging from 500 to 950 MHz. Central Supporting Laboratory for preparation of biomacromolecules for NMR, X-ray, and CRYO-EM and Laboratory of Protein Expression in Eukaryotic Cells will be available on site. Group resources include funds for post-doc positions, personnel and running costs.

The successful candidate must hold a PhD degree in a relevant field and should show:

- proven track record of high quality scientific productivity as judged by publications in high-impact peer-reviewed journals, providing evidence of excellence in bio NMR research and its applications
- success in obtaining extramural research funding
- experience in supervising other scientists

An interest in close collaboration with local experimental groups is essential. We will offer internationally competitive conditions and benefits in line with your experience. The positions are available from 2011 on for an initial period of five years. The beginning of the employment relationship and the onset of group operations is negotiable.

Your application should include:
- CV
- detailed description of your training and research career
- list of publications (separate listings of original research papers, reviews, book chapters)
- list of obtained research grants (name, topic, funding source, amount)
- summary of your teaching experience
- reprints of selected publications (10 at maximum)
- outline of your research plan in a form of a brief and concise executive summary (1-2 pages, A4 or Letter format)

Electronic applications must be received by 15 April, 2011, to ensure consideration. Please submit your application to the coordinator of the Structural Biology Research Program Prof. Vladimír Sklenář at:

sb.nmr(at)ceitec.muni.cz

Postdoctoral Fellowship

2011-03-07T10:41:00.001+01:00

Postdoctoral Fellowship in NMR Methods to Study Molecules of Environmental and Biological Interest
(Project Ref. PTDC/QUI-QUI/100998/2008)

Job Description:
A 1-year postdoctoral position is available starting from May 2011, (extendable for additional 7 months) to study the “solid structure” of ionic liquids (ILs) with relevance to the pharmaceutical industry. For this purpose solid-state NMR will be used to study selected ionic solids (ISs). The research will be centered in the use of NMR techniques in tandem with molecular modelling to study the physical chemistry of molecular interactions in ILs and ISs.

This project will be performed at the NMR centers at the Universities of Aveiro (solids NMR) and Nova de Lisboa (liquids NMR).

Multinuclear liquid-state NMR experiments (including diffusion NMR experiments) will be employed to study ILs. This project will have a strong emphasis in the study of ISs, with low melting points, using advanced high-resolution multinuclear solid-state NMR methods. These studies will be complemented with first principles calculation of NMR parameters and molecular dynamics simulations. In a later stage the solvation of different molecules of pharmaceutical interest in biocompatible ILs will be addressed.

The successful candidate will have the opportunity to work in a challenging environment with access to state-of-the-art NMR equipment. The successful candidate will have the opportunity to work in a competitive and multidisciplinary environment and participate in a project of relevance to the pharmaceutical industry and with impact in environmental issues. Aveiro is a very pleasant city near the seacoast, located between Porto and Lisbon with everything within walking distance.

Equipment: The candidate will have access to all equipments within the Portuguese NMR network (http://ptnmr.dq.ua.pt) ranging from 400 MHz to 800 MHz solid-state and solution NMR spectrometers with a variety of probes and other accessories for solids and liquids and will have access also to a shared computer cluster (http:// http://wikis.ua.pt/flamingo/). Both institutes are well equipped with 6 BRUKER AVANCE III NMR (400 to 600 MHz) spectrometers equipped with more than 20 probes. Details may be found in the aforementioned link.

Duration: 12 months extendable to 19 months, preferably from May 2011.

Candidate Profile:
- The candidate should hold a PhD in Chemistry, Physics, Physical Chemistry, Materials Sciences or related disciplines.
- Previous experience in solid-state NMR spectroscopy (instrumentation and theory) is required.
- Good informatics skills and experience with molecular modelling calculations is highly appreciated.
- Candidates with previous experience in NMR studies, considering this project research topic, are also of our interest.

Selection criteria:
1- Evaluation of the CV:
- Past experience in NMR spectroscopy, with preference for those candidates with experience in solids NMR is required.
- Analysis of relevant publications of interest for this project.
2- Interview if necessary, where proof of knowledge is tested.
3- Analysis of the reference contacts given by the candidates

Salary: 1495 EUR/month (Free of taxes)

Documents for the application:
Applicants should send: Cover letter, Detailed Curriculum Vitae and at least two reference contacts, preferably, by email to Dr. Luís Mafra (lmafra@ua.pt)

Alternatively, the documents should be sent to:

Dr. Luís Mafra
Departamento de Química
CICECO
Universidade de Aveiro,
3810-193 Aveiro
Portugal
Tel. (+351) 234 370620
(Reception of the documents by email is preferable)

Deadlines:
Applications will be accepted from March 1 to March 31, 2011.

The candidates will be informed by email about the result of the selection process.

Professorship Rennes

2011-03-07T10:38:00.000+01:00

A permanent professor position is available at the University of Rennes 1 (Pharmaceutical and biological sciences faculty and LTSI) in september 2011.

Teaching
The Professor will be in charge of the education department of Mathematics and Physics pharmaceuticals. She/He will teach Mathematics, Statistics, Physics and Informatics in different levels of the curriculum of Pharmacy and Nutraceutical Engineering. She/He will be responsible for the development of innovative teaching at the interface between different disciplines.

Research
The research project focuses on methodological and technological developments in the domain of quantification in Magnetic Resonance Imaging and Spectroscopy (MRI, MRS), including an important translational component.
This professor position is attached to the Laboratory of Signal Processing and Image (LTSI, UMR INSERM 642), in the emerging team METRIQ currently made up of 1 full professor, 5 associate professor, 1 researcher, 4 PhD students and 1 technician. The Professor, by his/her experience, will be more particularly brought to reinforce and instigate research topics recently initiated by the team including methodological (physical, information processing) and technological aspects (electronic sensors, computer engineering) of MRI / MRS. One goal is to bring the innovations within the clinical team on the field. To do this, the local environment is particularly favorable: the team is the “support”, with a dedicated research engineer, of the small animal imaging component of the PRISM* platform, while having access to MRI of Rennes University Hospital (a 1.5 T and a 3 T clinical systems, and a 3 T with 50% time dedicated for research).She/He will be brought to work closely with, biologists, pharmacists and physicians.

* The PRISM platform gathers several imaging facilites on three sites :
- Beauregard (Cemagref) : 1 whole body MRI (0.2 T and 1.5 T)
- Villejean (UR1 IFR 140) : small animal MRI 4.7 T, 2 vertical 500MHz NMR spectrometers
- Saint-Gilles (INRA) : CT-scan, US, γ-scintigraphy and PET scan

Contacts :
Hervé Saint-Jalmes : herve.saint-jalmes@univ-rennes1.fr
Marie Le Floch : marie.le-floch@univ-rennes1.fr
Lotfi Senhadji : lotfi.senhadji@univ-rennes1.fr

Professor position at Paris 13 University

2011-03-07T10:37:00.001+01:00

Professor position (sections 31/64) at Paris 13 University – Bobigny campus
NMR: Metabolomics or Structural Biology

The CSPBAT (Chemistry, Structure, and Properties of Biomaterials and Therapeutic Agents) laboratory, UMR CNRS 7244, was created in January of 2009 to regroup several research teams affiliated to the Paris 13 University that previously belonged to other laboratories in the Paris area (Ile de France). The SBMB team is a multi-disciplinary group that uses various spectroscopic methods to study biomolecules and biological samples (liquids, cells, and tissues).

Research profile: This Professorship position is open to candidates with a research program centered on one of the themes developed by the SBMB team of the CSPBAT laboratory:

Metabolomics based on NMR spectroscopy: The approach has been developed in our laboratory over the past ten years through collaborations with the nearby hospital research groups. The major themes involve exploration of kidney function, liver function, and cancer. The metabolomic studies will be conducted in the SMBH medical Faculty and will fall within the scope of the scientific interests of the medical staffs of Jean Verdier and Avicennes Hospitals.

NMR Structural studies on model systems in vitro: Another group in the SBMB team develops research in the field of DNA-protein interactions, particularly involving DNA aptamers. The goal is to improve the affinity or specificity of the aptamers for their targets (proteins, antibiotics, RNA or DNA structural motifs) to develop therapeutic or diagnostic tools.

New research projects in collaboration with the other teams in the laboratory would be considered, in particular projects concerned with the development of bio-captors or polymer-based biomaterials with biological activity.

Teaching profile:
General teaching in the field of Chemistry and/or Biology (undergraduate level). NMR and its applications in the field of public health (Masters level).

The laboratory is located at UFR SMBH in Bobigny.

People to contact:
Veronique Migonney (Director of the CSPBAT Laboratory) : Veronique.migonney@univ-paris13.fr
Telephone number: +(33) 1 4940 33 52/33 46 (secretary)

Edith Hantz: (Head of the SBMB team)
edith.hantz@univ-paris13.fr
Telephone number: +(33) 1 4838 76 85

Professorship

2011-03-07T10:33:00.000+01:00

We are looking to recruit a ‚young’ talent (age 35-40) for a professorship in chemistry / physical chemistry at the University of Strasbourg, one of the best French research institutions in sciences. The candidate should be an expert in solution NMR spectroscopy and in the physical chemistry of molecular systems in solution. She/He should develop independent research on complex molecular systems. Ideally static or dynamic mixtures should be investigated using NMR spectroscopy under consideration of the thermodynamics and kinetics of such systems.

Nous souhaitons recruter un "jeune" talent (35-40 ans) sur un poste de Professeur cette année. Le(a) candidat(e) dois posséder à la fois de solides connaissances en spectroscopie RMN en solution et en physico-chimies des molécules et systèmes moléculaires en solution. En particulier, il(elle) doit développer des recherches indépendantes sur des systèmes moléculaires complexes et des mélanges statiques ou dynamiques alliant la RMN liquide et les processus d'équilibres à la fois sous l'angle thermodynamiques et cinétiques.

Contact (if possible before end of February 2011):
Prof. M. W. Hosseini
UMR-CNRS 7140 (Tectonique Moléculaire)
Université de Strasbourg
Institut Le Bel
4, rue Blaise Pascal CS 90032
67081 STRASBOURG CEDEX France
Tel. (33) 0368851323
Fax (33) 0368851325
E-Mail: hosseini@unistra.fr

Postdoctoral Research Fellowships at the University of Warwick

2011-02-08T20:04:00.001+01:00

The solid-state NMR group at the University of Warwick would like to advertise the following University of Warwick scheme to fund post-doctoral research fellowships.

Candidates with strong CVs and publication records meeting the eligibility requirements (have passed PhD viva and be within 3 years of PhD graduation) are requested to contact

Steven Brown (S.P.Brown@warwick.ac.uk)
or John Hanna (J.V.Hanna@warwick.ac.uk)

by 15th February.

http://www2.warwick.ac.uk/fac/cross_fac/ias/prf/

Institute of Advanced Study
University of Warwick
Postdoctoral Research Fellowships (5 posts)
(£27,428 pa)

Fixed Term Contract for 2 years, beginning October 2011

The Institute of Advanced Study (IAS) at the University of Warwick invites applications from outstanding researchers who are at the beginning of a promising academic career. Applications are welcome from across all Faculties and disciplines, and, in keeping with the ethos of Warwick’s IAS, interdisciplinary research applications are strongly encouraged.

You will be based in the IAS but will have a strong presence in a home academic department. Therefore, all applications MUST be supported by a Warwick academic nominator and your proposed research project should closely complement your nominated academic department’s current research interests. Nominators will be required to make a strong case for the applicant’s strategic contribution to the research within their department.

You will have been awarded your PhD, or equivalent, in any discipline and be within 3 years of your PhD graduation. Therefore you must have passed your viva and submitted the final copy of your thesis to be eligible. You should also not have more than 3 years postdoctoral research/teaching experience or hold, nor have held, a permanent academic post.

Please note that although the Fellowships will be located in the IAS, you must be nominated by an academic in a Warwick department. The nomination form can be downloaded www.go.warwick.ac.uk/ias/prf .

Closing date: 8 March 2011

Steven Brown
Department of Physics
University of Warwick
Coventry CV4 7AL

Tel: 00 44 24 76574359
Fax: 00 44 24 76150897

email: S.P.Brown@warwick.ac.uk
webpage address: http://go.warwick.ac.uk/nmr/members/academic/steven/
Warwick group webpage: http://go.warwick.ac.uk/nmr/
The UK 850 MHz solid-state NMR facility: http://go.warwick.ac.uk/850mhz/

Magnetic Resonance at Warwick: Watch the video: http://go.warwick.ac.uk/nmr/millburn

getting to Millburn House: http://go.warwick.ac.uk/nmr/getting_here

Full Time Position

2011-02-08T20:03:00.000+01:00

The Rock and Fluid Science Department of Shell Innovation, Research & Technology seeks a PhD graduate in Physics or equivalent sciences for a full-time position to further advance Magnetic Resonance Relaxometry and Magnetic Resonance Imaging technologies at its research facility in Houston, TX USA. The position will suit an experimental researcher with a background in MRI and NMR physics or engineering, who is interested in working in a more applied environment.

Further information related to this position, as well as a link to submit applications, can be found at:

http://impact-gs.jobstreet.com/templates/shell_my/jobdesc_global.aspx?eid=NKnk6pi3lDhEDJ%2b5ntow7TQhp7M%3d&uid=469%7c23089%7c%7c&did=0&its=0&src=8&ref=&cc=&agn=

The deadline for submitting applications is 28 February 2011.

Matthias Appel
Project Leader, Rock and Fluid Science Department
Shell Innovation, Research and Technology
Houston, TX, USA

Postdoc Oxford

2011-02-08T20:02:00.000+01:00

UNIVERSITY OF OXFORD
Department of Chemistry
Physical and Theoretical Chemistry Laboratory
Postdoctoral Research Assistant - NMR of photoactive proteins
Grade 07S : Salary £28,983 - £35,646 p.a.
Post Ref. DN11001/PJH

Applications are invited for a postdoctoral research assistant to work with Professor Peter Hore on a research project funded by DARPA (http://www.darpa.mil/). The post is available initially for up to 18 months, with a possible total duration of up to three years.

This position is part of a large project entitled Quantum Effects in Magnetoreception funded by the Defense Advanced Research Projects Agency as part of the programme Quantum Effects in Biological Environments (QuBE). The broad aims of the project are: (a) to design and perform a set of experiments that will determine definitively whether manifestly quantum effects are exploited in the avian magnetic compass sensor; (b) to develop the existing quantum mechanical model of magnetic effects on radical pair reactions; (c) to design and construct a proof-of-principle magnetic sensor around the reactions of radical pairs in model compounds. A central part of the project will involve optical and magnetic resonance experiments on the photo-active proteins photolyase and cryptochrome to establish their suitability as chemical sensors of weak magnetic fields.

The applicant should ideally have experience of protein NMR spectroscopy. The successful candidate will have the opportunity to work with colleagues from a range of disciplines on projects at the chemical/physical/life sciences interface.

The Hore group is located in the Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford, OX1 3QZ (www.chem.ox.ac.uk). To find out more about the group’s research, please visit http://research.chem.ox.ac.uk/peter-hore.aspx.

Applicants should either already have a PhD in a relevant subject area, or have submitted their thesis prior to taking up the post.

For further particulars of the post, including how to apply, please visit our website http://www.chem.ox.ac.uk/jobs.asp. These should be downloaded before an application is made. Informal enquiries should be addressed to peter.hore@chem.ox.ac.uk who would be pleased to supply further information about the project. Please quote reference DN11001/PJH in all correspondence.

The closing date for applications is 28 February 2011.
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P J Hore
Department of Chemistry, University of Oxford
Physical and Theoretical Chemistry Laboratory
South Parks Road, Oxford OX1 3QZ, UK

Tel: +44 (0)1865 275415 Fax: +44 (0)1865 275410

Email: peter.hore@chem.ox.ac.uk
Website: http://hore.chem.ox.ac.uk/
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Post-Doctoral Research Associate

2011-01-26T16:58:00.001+01:00

Post-Doctoral Research Associate: Druggability of Multi-Subunit Protein Interfaces
Department of Chemistry
Vacancy Reference No: MA07682 Salary: £27,319-£35,646

Limit of tenure applies*

A postdoctoral position is available in the research group of Dr Alessio Ciulli to study the druggability of protein-protein interfaces within a family of multi-subunit E3 Ubiquitin Ligases involved in protein degradation. Our goal is to understand the molecular basis underlying small molecule recognition of native interfaces of multi-protein complexes and to exploit the information gained for the fragment-based design of novel chemical probes of biological function. The project will use a combination of structural, biophysical, computational and biochemical techniques to study protein-ligand and protein-protein interactions. For more information, please check our group website (http://www-ciulli.ch.cam.ac.uk/).

The successful candidate will have the opportunity to join the Cambridge Molecular Therapeutics Programme (see http://www.cmtp.cam.ac.uk/cmtp.html), an interdisciplinary initiative based in Cambridge to explore new strategies for drug discovery against cancer and infectious diseases. We are equipped with state-of-the-art facilities to conduct cutting-edge research in all aspects of modern chemical biology, structural biology and biophysics.

Applicants should have (or be about to receive) a PhD in chemistry, biochemistry, structural biology, or a related area. Proven experience in NMR spectroscopy, X-ray crystallography or related techniques in chemical/structural biology and structure-based drug design is essential. Some experience in synthetic organic chemistry or cell biology is desirable but not necessary. The ability to work in a creative, interdisciplinary and dynamic research environment at the interface of chemistry and biology is paramount, and good written and oral communication skills are essential.

The post is available from March 2011. Applications should include a CV, publications list, a cover letter summarising research experience and interests, contact details for three professional referees, and a completed form CHRIS/6 Parts I and III (downloadable from http://www.admin.cam.ac.uk/offices/hr/forms/chris6/), and should be sent to Dr Alessio Ciulli, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW (email: ac313@cam.ac.uk).

* The funds for this post are available until December 31st 2012 in the first instance.

Closing date: 28 February 2011.

The University values diversity and is committed to equality of opportunity.

The University of Cambridge only advertises their own and college vacancies on this website; we do not advertise any external vacancies.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

2011-01-26T16:57:00.001+01:00

Dear Colleagues,

I anticipate one or more openings for postdoctoral associates to work on structural and functional characterization of either proteins involved in vesicle trafficking or proteins involved in glycan interactions. These are challenging projects involving both protein-protein and protein-membrane associations. The work is well illustrated by our recent publication in Nature Structural and Molecular Biology (17(7):876-81, 2010). It is especially important that candidates have experience with advanced NMR methodology (either solution or solids) and are interested in the development of novel approaches to solving challenging problems in the structural biology area.

Our lab has access to excellent NMR instrumentation, including 800 and 900 MHz instruments with cryogenic probes. We also have strong biochemical collaborations that facilitate preparation and characterization of samples. Athens is a University town in the Southeastern part of the United States with excellent cultural amenities and a moderate cost of living. The position could begin as early as March 1, 2011, and we anticipate stable funding for several years.

Please forward this description to individuals who may be interested in the position and ask them to send a letter describing their interests, along with a CV and the names of three individuals we might contact for reference letters. The University of Georgia is an AA/EEO employer.

Sincerely, J.H. Prestegard

James H. Prestegard
Complex Carbohydrate Research Center
University of Georgia
315 Riverbend Rd
Athens, GA 30602-4712 USA
706-542-6281
jpresteg@ccrc.uga.edu

Postdoc

2011-01-26T16:56:00.001+01:00

Umeå University - with its 33,500 students and over 4,200 employees - is an organisation in constant change and development. Umeå University conducts groundbreaking research within several areas - several in which we are among the best in the world - within others regarded as the leaders in Sweden. We are one of Sweden’s largest providers of education and offer a broad and attractive range of courses and programmes. Our campus constitutes an inspiring environment for everyone that studies and works here. We wish to co-operate with companies and organisations throughout the Umeå region and all over the world.

2 postdoctoral positions (2 years)
in Protein Biophysics with focus on NMR applications and Copper transport

The research activities at the Department of Chemistry have a focus on Biological Chemistry, Biogeochemistry, and Technical Chemistry. Within the area of Biological Chemistry, one of the major directions is the study of protein folding, structure, and dynamics. Within the research group of Wittung-Stafshede, folding of metalloproteins and oligomeric proteins has been studied for many years by using strategic protein systems in combination with a range of biophysical/spectroscopic methods. The current major focus is on (a) understanding mechanisms of proteins involved in copper transport in the cytoplasm as well as on (b) effects of macromolecular crowding on protein biophysics. One postdoctoral fellow will study key proteins involved in copper transport (position 1), the other postdoctoral fellow will use NMR as a major tool to study proteins, for example in cell-like environments (position 2). Both projects are open to flexibility, new ideas and collaborations.

The candidates should have a Ph.D. in chemistry/biophysics/biology, or equivalent, which is not more than three years old. The person must have hands on experience with copper transport proteins (position 1) and training in solution NMR (position 2). For both positions, skills in protein expression and purification as well as basic protein thermodynamic/kinetic data analysis are necessary. Good communication skills in written and spoken English are required.

The application should include (1) a Curriculum Vitae, (2) copies of degree certificates and publications, (3) names and contact information to at least three reference persons and (4) a cover letter with a motivation.

The application can be submitted either electronically (MS Word or PDF format) or in hard-copy (two copies) form.

For further information about the positions, please contact Prof. Pernilla Wittung-Stafshede, phone: +46-(0)90 786 53 47, e-mail: pernilla.wittung@chem.umu.se.

Note: If you apply for both positions, two separate applications must be submitted.

Union information is available from SACO, +46-(0)90-786 53 65, SEKO, +46-(0)90-786 52 96 and ST, +46-(0)90-786 54 31.

Your complete application, marked with reference number 315-37-11 (position 1) or 315-38-11 (position 2), should be sent to jobb@umu.se (with reference number on the subject line) or in paper form to the Registrar, Umeå University, SE-901 87 Umeå, Sweden to arrive April 11, 2011 at the latest.

We look forward to receiving your application!

http://www8.umu.se/umu/aktuellt/arkiv/lediga_tjanster/315-37-11_315-38-11_sv_eng.html

contact:
Pernilla Wittung-Stafshede
Professor, Chemistry Department
Umeå University
901 87 Umeå, Sweden
pernilla.wittung@chem.umu.se
phone: 090-786 5347

PhD Positions

2011-01-26T16:55:00.001+01:00

4 PhD Positions in "Hyperpolarised 13C MR Imaging Methods"

Description:
The Technische Universität München (TUM) is seeking applications from highly motivated candidates for PhD (Dr. rer. nat.) positions in hyperpolarised magnetic resonance (MR) imaging. Hyperpolarised 13C metabolic imaging is a novel technique to investigate cellular processes and physiological parameters minimally invasive. You will be involved in developing and investigating MR methods for hyperpolarised imaging of novel biological contrast mechanisms. The four different positions focus on the following aspects of hyperpolarisation: alternative 13C-labelled agents, advanced MR methods for an efficient signal acquisition and reconstruction. Overall goal is to advance the diagnostic information of MR for applications including oncology and cardiology. Depending on the specific task this will require good physical, biological and chemical understanding. Candidates having previous experience in magnetic resonance will be preferred.
You will be collaborating with a team of experienced scientists from the MR group at GE, the Medical Engineering (Prof Haase), Chemistry (Prof Glaser) and Nuclear Medicine (Prof Schwaiger) departments at TUM, get unique access to latest hardware, as well as an extensive internal and external network of collaborating sites. The TUM and GE Global Research provide excellent infrastructure for conducting cutting-edge research.

Qualifications:
The applicant should have a Masters degree and a strong background in physics, electrical engineering, biochemistry, biology, chemistry or related subjects. Fluency in English is required.

Our offer:
The Ph.D. students will be employed by the TUM (3/4 TVöD E13; equivalent to other TUM PhD positions) and additionally members of the TUM graduate school which offers additional education in sciences and transferable skills courses and seminars.

Application Details:
Applications should include curriculum vita, certificates and transcript of BA/MA/Diplom or equivalent degree, summary of the previous work, letter of motivation and names of 2 references. Please send your application within one pdf-document to axel.haase@tum.de

Contact:
Prof. Axel Haase
TU München
IMETUM
Boltzmannstr. 11
85748 Garching
axel.haase@tum.de
http://www.imetum.tum.edu/

Facility Manager/Research Scientist

2011-01-26T16:54:00.000+01:00

The Singapore Bioimaging Consortium (SBIC) is one of the research institutes
under the Agency for Science, Technology and Research (A*STAR). SBIC aims to
advance imaging technology for understanding disease processes, early
diagnosis, and better prognosis in pre-clinical models, and their translation
into the clinic. There are several active research teams developing NMR and MRI
methods and analyses in collaboration with other groups using positron emission
tomography (PET), and optical techniques, with shared facilities in SBIC. There
are extensive collaborations with academic institutions and industry.

Facilities and Equipment:
The SBIC is located in the Helios building on the Biopolis campus. The NMR/MRI
facility currently hosts a state-of-the-art Varian 9.4 T and a Bruker 7 T
ClinScan MRI, a Bruker 400 MHz NMR spectrometer, a HyperSense dynamic
polarization system, a BioScan NanoSPECT/CT, and a Siemens microPET/CT.

A Facility Manager/Research Scientist position, for Nuclear Magnetic Resonance
(NMR) spectroscopy and Magnetic Resonance Imaging (MRI), is available at the
Singapore Bioimaging Consortium (SBIC). The successful applicant will be
responsible for managing, specifying new equipment, training users, and
maintaining the NMR/MRI facility to ensure scientific outcomes of the highest
standard.

Highly motivated candidates with prior experience in maintaining MRI/S systems
and with NMR spectroscopy will be preferred. Candidates with trouble-shooting
skills including that with RF coils, and performing quality control testing
will be preferred. Job responsibilities will include cryogen filling of the
magnets, software upgrades, instruction of users, and trouble shooting.
Experience with mapping B1/B0 homogeneity, calibrating RF pulses, and
fabrication skills for minor equipment such as animal holders for MRI-PET will
be an advantage.

The preferred background will include, but not be limited to biophysics,
biochemistry, chemistry, and physics. Experience with electronics, computer
systems administration (Linux/Unix and Windows), and programming languages are
desirable. The possibility will exist to run your own experiments and/or to
collaborate with others. Good organization and communication skills are
required to work with the multi-disciplinary teams.

For further information about SBIC staff, projects, and instrumentation, visit
our website: http://www.sbic.a-star.edu.sg/.
Or contact Philip Kuchel (on philip_kuchel@sbic.a-star.edu.sg) ...he has
recently taken over from Prof Sir George Radda as ED of the SBIC
Interested candidates should submit his/her resume to the following email
address: recruit@sbic.a-star.edu.sg.

Postdoc NMR / X-Ray Proteins

2011-01-17T16:50:00.001+01:00

TWO Postdoctoral Positions in Structural determination of protein complexes using solution NMR and X-Ray Crystallography at the IRB Barcelona (SPAIN)

The protein NMR group of Dr. Maria J. Macias has openings for two postdoctoral positions to conduct solution NMR and X-Ray studies of proteins in complex with protein fragments and/or with RNA. No experience with protein expression and purification is required. Applicants should send by email to maria.macias@irbbarcelona.org the C. vitae including the list of their publications, a covering letter explaining the candidate interest in the positions and email addresses of two referees. Applications close on 15 February 2011.

Funding for the positions is provided for 1 year in the first instance, but applicants should be ready to apply for competitive fellowships. The IRB Barcelona International Postdoctoral Programme (Info at http://postdoc.irbbarcelona.org) is currently open with the application deadline next 15th of February. The offered positions correspond to the projects named "Structural and functional studies on the cpeb family of RNA-binding family of proteins" and "Structural studies on human transcription factors".

Postdoc Membrane Proteins

2011-01-12T11:53:00.001+01:00

Structural studies of membrane proteins by NMR
A post-doctoral position is available to work on the structural studies of a variety of
membrane proteins (cytochrome P450, cytochrome b5, cytochrome-P450-reductase,
and a combination of these proteins to probe protein-protein interactions)
and amyloid proteins using NMR spectroscopy. We are presently utilizing a combination
of high-resolution solution NMR and solid-state (static and MAS) NMR techniques to
solve high-resolution structures and characterize the dynamics of membrane proteins
embedded in suitable model membranes including micelles, isotropic bicelles, bicelles,
and lipid bilayers. Excellent solution and solid-state NMR facilities (spectrometers ranging
from 400 MHz to 900 MHz), protein expression capabilities, and computational facilities
are available.

Interested applicants should have experience in any of the following areas:
structural biology of proteins by solution NMR, solid-state NMR methods development,
solution NMR methods development to study protein dynamics.

For more details about our research projects and recent publications, please visit our website:
www.umich.edu/~ramslab.

If you are interested in working on these exciting projects in collaboration with highly
enthusiastic and dynamic group of researchers, please send your CV by email to:
ramamoor@umich.edu.

Ayyalusamy Ramamoorthy
Professor of Biophysics and Chemistry
University of Michigan
Ann Arbor
MI 48109-1055
www.umich.edu/~ramslab

Postdoc France

2011-01-12T11:51:00.001+01:00

The biomolecular NMR research group of Dr. Eric Guittet (http://www.icsn.cnrs-gif.fr/guittet) at the Institut de Chimie des Substances Naturelles in Gif-sur-Yvette, suburb of Paris (France), is looking to recruit Master students, PhD students and postdocs from all nationalities.

Our laboratory uses modern NMR techniques to decipher the molecular mechanisms underlying biological functions for a variety of systems involving proteins such as enzymes, unfolded proteins and macromolecular complexes. We are also interested in structure-based drug design and in developing new methodology for protein NMR resonance assignment and dynamic studies of slow motions in proteins.

We are seeking candidates for the following projects:

- Investigation of the catalytic role of interdomain motion in a 60kDa enzyme. (PI Ewen Lescop)
- Analysis of the interactions of WH2/Tbeta domains with actin, investigation of their functions in the regulation of actin polymerization. (PI Carine van Heijenoort)
- Investigation of membrane proteins. (PI Eric Guittet)
- Fragment-based drug design, including methological developments. (PI Eric Guittet)
- Solid-state NMR characterization of amyloid fibrils (PI Christina Sizun)

Our laboratory offers access to several high field liquid state NMR spectrometers, including a 950 MHz, a 800MHz and two 600MHz spectrometers equipped with cryoprobes, as well as a 700MHz for dual liquid and solid-state NMR use. Our institute (ICSN) is located on the CNRS campus of Gif-sur-Yvette, a charming village with countryside flavour, 40mn away from Paris by train. The campus, which is mainly dedicated to life sciences, is part of the large scientific community located South-West of Paris, next to the Soleil synchrotron and Paris XI-Orsay University.

Highly motivated applicants with a strong background in biochemistry, biophysics and/or NMR spectroscopy are invited to apply. Please contact eric.guittet_at_icsn.cnrs-gif.fr for more information and include a CV with a summary of research interests and accomplishments.

Selected publications from the lab:
- Buosi V, Placial JP, Leroy JL, Cherfils J, Guittet E, van Heijenoort C. "Insight into the role of dynamics in the conformational switch of the small GTP-binding protein Arf1." J Biol Chem. 2010;285:37987-94
- Stratmann D, Guittet E, van Heijenoort C. Robust structure-based resonance assignment for functional protein studies by NMR. J Biomol NMR. 2010;46:157-73.
- Lescop E, Briand L, Pernollet JC, Guittet E. Structural basis of the broad specificity of a general odorant-binding protein from honeybee. Biochemistry. 2009;48:2431-41.
- Lescop E, Brutscher B. Highly automated protein backbone resonance assignment within a few hours: the "BATCH" strategy and software package. J Biomol NMR. 2009;44:43-57.
- Catoire LJ, Zoonens M, van Heijenoort C, Giusti F, Popot JL, Guittet E. Inter- and intramolecular contacts in a membrane protein/surfactant complex observed by heteronuclear dipole-to-dipole cross-relaxation. J Magn Reson. 2009;197(1):91-5.
- Lescop E, Rasia R, Brutscher B. Hadamard amino-acid-type edited NMR experiment for fast protein resonance assignment.J Am Chem Soc. 2008;130:5014-5
- Carlier MF, Hertzog M, Didry D, Renault L, Cantrelle FX, van Heijenoort C, Knossow M, Guittet E. Structure, function, and evolution of the beta-thymosin/WH2 (WASP-Homology2) actin-binding module. Ann N Y Acad Sci. 2007;1112:67-75
- Hertzog M, van Heijenoort C, Didry D, Gaudier M, Coutant J, Gigant B, Didelot G, Préat T, Knossow M, Guittet E, Carlier MF. The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly. Cell. 2004;117:611-23.
- Catoire LJ, Damian M, Giusti F, Martin A, van Heijenoort C, Popot JL, Guittet E, Banères JL. Structure of a GPCR ligand in its receptor-bound state: leukotriene B4 adopts a highly constrained conformation when associated to human BLT2. J Am Chem Soc. 2010;132:9049-57
- Aliprandi P, Sizun C, Perez J, Mareuil F, Caputo S, Leroy JL, Odaert B, Laalami S, Uzan M, Bontems F. S1 ribosomal protein functions in translation initiation and ribonuclease RegB activation are mediated by similar RNA-protein interactions: an NMR and SAXS analysis. J Biol Chem. 2008;283:13289-301

Postdoc EPR

2011-01-12T11:48:00.000+01:00

Myself and Chris Kay have a realistic chance of getting funding for a 3 year postdoc. The prospective candidates must send their CVs to me (victor.chechik@york.ac.uk) before the end of this Sunday 16 January. The interviews will be held on 2nd February in London, and the outcome will be known shortly afterwards. The project will start in May.

The project is a collaboration between myself, Chris Kay and National Physical Laboratory. The project aims to unravel factors determining self-assembly of amyloid peptides relevant to Alzheimer's disease, and to explore the structural features of self-assembled peptide fibres. The project will involve peptide synthesis, spin labelling, cw EPR studies including dynamics, pulsed EPR including DEER, ENDOR, ESEEM. Extensive expertise is available in all areas and appropriate training will be provided.

The short deadline is due to the Research Council changing their procedures earlier this morning. Please advise the prospective candidate to email me NOW.
Dr Victor Chechik
Department of Chemistry
University of York
Heslington, York YO10 5DD
U.K.
Tel: (+)-44-1904-324185
Fax: (+)-44-1904-322516
Email: victor.chechik@york.ac.uk

POSTDOCTORAL POSITION IN PROTEOMICS

2011-01-12T11:47:00.001+01:00

POSTDOCTORAL POSITION IN PROTEOMICS / CELLULAR BIOLOGY FOCUSED ON THE ROLE OF NUCLEAR LAMINS IN THE RESPONSE TO OXYDATIVE STRESS

A new postdoctoral position is becoming available at CEA, a research institute located in the south-west suburb of Paris. The postdoctoral project aims at determining essential molecular mechanisms linking genome spatial organization and genome integrity. It is focused on the elucidation of the role of nuclear lamins in the response to oxidative stress. It will be carried out at the interface between two teams of complementary expertises: (1) the team of Pascale Bertrand, which recently characterized lamin defaults in cells deficient in DNA damage signalling proteins on the basis of cell biology experiments and is running a proteomic core facility to detect partners from 2D gels of complexes; (2) the team of Sophie Zinn-Justin, which has determined the 3D structures of several nuclear envelope protein domains as in particular the lamin C-terminal domain and is now involved in the characterization at the atomic level of interactions between these domains and their biological partners. Experience in cell biology and/or biochemistry is essential. The candidate should also be interested by molecular aspects and biophysics. Competitive salary (2230 euros for the fellow, i.e. 2800 euros comprising the social taxes, per month or more, based on previous research experience) is offered with health insurance, retirement plan, and language training allowance. Starting date is flexible. Interested candidates should forward a Curriculum Vitae, and electronic and postal addresses of potential references via e-mail: pascale.bertrand@cea.fr et sophie.zinn@cea.fr

STAGE POST-DOCTORAL EN BIOLOGIE CELLULAIRE/PROTEOMIQUE SUR LE ROLE DES LAMINES NUCLEAIRES EN REPONSE AU STRESS OXYDATIF.
Une offre de séjour post-doctoral est proposée au CEA, un Institut de Recherche situé dans la banlieue sud de Paris. La cellule de mammifère met en place un réseau de mécanismes protégeant l’intégrité de son génome en présence de dommages de l’ADN: le contrôle du cycle cellulaire, la réparation, l’apoptose et la sénescence. Des nombreuses recherches ont montré également que l’organisation spatiale et temporelle du génome est critique pour les fonctions du génome mais aussi pour son intégrité. Le projet de recherche post-doctoral propose d’analyser les mécanismes moléculaires associant cette organisation spatiale et l’intégrité du génome. En particulier, le rôle des lamines nucléaires dans la réponse au stress oxydatif sera caractérisé. Ce projet se fera dans le cadre d’une collaboration entre deux équipes d’expertises complémentaires : 1) l’équipe de Pascale Bertrand, spécialisée dans la réparation de l’ADN, a caractérisé récemment une dérégulation des lamines dans des cellules déficientes pour la réponse aux dommages de l’ADN; 2) l’équipe de Sophie Zinn-Justin a déterminé la structure de domaines de différentes protéines de l’enveloppe nucléaire et est impliquée maintenant dans la caractérisation à un niveau atomique des interactions entre ces domaines et leurs partenaires biologiques. Une expérience en Biologie cellulaire et/ ou en Biochimie est essentielle au projet. Le candidat devra aussi être intéressé par les aspects moléculaires et biophysiques. Un salaire compétitif sera offert (2230 euros net pour le candidat, correspondant à 2800 euros brut par mois, ou plus en fonction de son expérience). Les candidats devront envoyer un Curriculum Vitae (comprenant l’adresse électronique de personnes amenées à les recommander) aux adresses e-mail suivantes pascale.bertrand@cea.fr et sophie.zinn@cea.fr.

MRI Programmer

2010-12-28T12:48:00.001+01:00

MRI Programmer

We seek a PhD graduate or equivalent to help develop a new MRI prototype based on a small-scale superconducting magnet, The position will suit someone with a background in MRI and NMR physics or engineering, who is interested in working in a more applied environment. The position is for two years, based in Wellington New Zealand, but the possibility exists for further employment in commercialisation work.

The MRI Programmer will be responsible for a range of software and MRI pulse sequence development, hardware construction, electronic and electromagnetic engineering, application design, technical documentation and support activities around the MRI system. The work will involve aspects of the whole range of NMR and MRI from engineering to data processing. The appointee will also assist in applications development for other prototype NMR systems developed by the team.

In addition to a good understanding of NMR, applicants should have good software programming skills, and a knowledge of Matlab, C++, and the Windows environment.

Applications, including a CV, a covering letter explaining the candidates interest in the job, and the names and email addresses of two referees, should be addressed to Professor Paul Callaghan, Victoria University of Wellington, New Zealand, and sent by email (paul.callaghan@vuw.ac.nz). Applications close on 31 January, 2011.

For more information, please visit

http://vacancies.vuw.ac.nz

Manager of Science and Technology (M/F), Portugal

2010-12-28T12:47:00.001+01:00

Within the framework of the Portuguese National Nuclear Magnetic
Resonance Network (PTNMR), Centro de Química da Madeira (CQM),
Funchal, Madeira Island, Portugal, is seeking for a Manager of Science
and Technology (M/F), holding a PhD in Chemistry (or related fields)
with NMR experience, to be responsible for the technical maintenance of
a 400MHz NMR equipment, analytical services, teaching and research. The
offered position is ideal for PhDs with strong NMR experience and
interest in the field of Natural Products and/or Materials.
Salary: The monthly salary will be between 1495€ (for the first year)
and 1995€ (depending on performance) plus a personal accident
insurance. The contract offered, will have duration up to December 2012.

Additional support will be provided, including office and laboratory
space, plus access to the National Networks of Nuclear Magnetic
Resonance, Mass Spectrometry and Nanotechnology. The right candidate
will also be given the opportunity to participate in
national/international scientific conferences as well as in the
research projects under development at CQM.

Candidate Profile: PhD in Chemistry, Physics, Biochemistry, Materials
Sciences or related areas with strong experience in liquid NMR.
Application Deadline: 31 of January 2011, 17h Lisbon time. Applications
should be submitted by e-mail (cqm@uma.pt), with the following
information: a. Motivation letter; b. A brief statement of the
applicant current and future research interest (Max. 2 A4 pag.);
c. Detailed Curriculum Vitae;
d. Academic certificates in Portuguese or translated to English
(certificated translation); e. Working program to be developed in the
scope of the Natural Products and/or Materials Groups of CQM (Max. 2 A4
pag.); f. Name and e-mail contacts of two referees. For further
details, candidates should consult CQM web pages at
http://bit.ly/dg6Nic or contact Prof. João Rodrigues by e-mail:
cqm@uma.pt.

Marie-Curie funded studentships / postdoc positions at Weizmann

2010-12-28T12:44:00.002+01:00

In connection to the recent signing of the FP7 Marie Curie Initial Training Network (ITN) METAFLUX - Metabolic Flux Analysis and Cancer, I am looking to hire suitable Ph.D. students or post-doctoral researchers in support of work to be carried out at Weizmann within the 2011-2015 calendar years. These hirings are mainly aimed at citizens of the European Union and/or Associate Member states, who qualify for a full employment contract along with mobility, travel and career development allowances. These are salaries fundable according to the (very generous) Marie Curie rules, which can be found in ftp://ftp.cordis.europa.eu/pub/fp7/docs/wp/people/m_wp_201002_en.pdf.

Depending on their status and interests, candidates would enter the Weizmann's Institute PhD or postdoctoral programs, under my supervision (Chemical Physics Department, Faculty of Chemistry) –and in certain cases coadvised by Prof Hadassa Degani (Biological Regulation Department, Faculty of Life Sciences). The candidate’s research would deal with a number of multidisciplinary problems within the field of magnetic resonance; particularly in connection to the use of hyperpolarized nuclei towards in vitro, in cell and biological NMR and MRI characterizations. Our aim is to bring together complementary aspects of dynamic nuclear polarization, and advanced in cell / in vivo MRI/NMR spectroscopies, towards the development of new methodologies to better understand and characterize cancer metabolism. If interested in pursuing a PhD at the Weizmann, the candidate should also have a strong curriculum, a good motivation, and a willingness to be exposed to a variety of topics in magnetic resonance. Background in at least one of the above-mentioned research areas (at a Ph.D. level) is required for a post-doctoral appointment. The training program will include in either case state-of-the-art activities such as network-wide courses, attendance/participation in a variety of workshops, and training experiences in other partner laboratories within the network. Further information on both our graduate or postdoctoral programs, can be found at http://www.fgs.org.il/en/.

The Weizmann Institute is located in a small, affordable and friendly town at the feet of the Judean hills, and is one of Israel's premier scientific institutions. It is a research center whose official language is English and which offers numerous facilities to international visitors, including furnished apartments for students and postdocs. From its inception the Institute has shown an unequivocal commitment to all areas of magnetic resonance and over the years it has made extensive investments in NMR faculty, staff and in infrastructure. As a result the Institute possesses an 800 MHz NMR with a cryoprobe, a 600 MHz widebore triple-resonance solids/liquids/imaging machine, a 3 T whole-body MRI scanner, a 95 GHz pulse EPR spectrometer, 4.7 and 9.4 T animal MRI scanners, an OI Hypersense DNP, para-hydrogen NMR facilities, and numerous (dozens) of other NMR instruments placed in various magnetic resonance buildings as well as several groups involved in all areas of magnetic resonance. The incorporation of significant new MR hardware is also in progress. Those interested in being considered for these positions should send their Vitae and at least two References to lucio.frydman@weizmann.ac.il.

Postdoc Positions

2010-12-28T12:42:00.000+01:00

Postdoctoral Opportunities: Structural Biology in Ubiquitination and Signaling

The Macromolecular NMR Section in the Structural Biophysics Laboratory has openings for postdoctoral fellows to work in the structural biology of protein complexes related to ubquitination, Arf proteins, and signaling via the STAT proteins. Our laboratory is involved in the application and development of state-of-the-art NMR spectroscopy, SAXS, and biophysics techniques to determine protein structures, investigate critical protein:protein interactions relevant to biological systems, analyze dynamic processes, and integrate these studies with molecular and cellular biology. We collaborate interactively with several biological, structural, and chemical groups in the Center for Cancer Research. Excellent NMR facilities (500-850 MHz), protein expression capabilities, and computational facilities are available.

Interested applicants should have a background in structural biology and experience in NMR spectroscopy. For examples of our work, please see Das, R., et al., Mol. Cell 34(6):674-685 (2009) and Das, R., et al., J. Mol. Biol. 376(3):705-720 (2008).

R. Andrew Byrd, Chief [byrdra@mail.nih.gov]
Structural Biophysics Laboratory
Center for Cancer Research
National Cancer Institute

PhD positions Lund

2010-12-28T12:41:00.001+01:00

PhD Positions in Lund

Two PhD positions are available in my group at the Division of Biophysical Chemistry in Lund. Both positions are linked to projects where magnetic relaxation dispersion (MRD) will be applied (and developed) to complex biological systems:

[1] Detection of pathological protein aggregation by field-cycled magnetic resonance imaging

[2] Molecular basis of heat and desiccation tolerance of bacterial cells and spores

For information about these two projects and the associated PhD positions, including application procedure, please go to

http://www.cmps.lu.se/bpc/research/halle/phd_and_postdoc_openings/

Application deadline is January 31, 2011.

Engineer/Physicist Post-Doc position in New Zealand

2010-12-17T10:53:00.000+01:00

We seek a PhD graduate or equivalent to help develop a new Magnetic Resonance Imaging prototype based on a small-scale superconducting magnet. The position will suit someone with a background in MRI and NMR physics or engineering, who is interested in working in a more applied environment. The position is for two years, based in Wellington New Zealand, but the possibility exists for further employment with a partner company.

The MRI Engineer/Physicist will be responsible for a range of software and MRI pulse sequence development, hardware construction, electronic and electromagnetic engineering, application design, technical documentation and support activities around the MRI system. The work will involve aspects of the whole range of NMR and MRI from engineering to data processing. The appointee will also assist in applications development for other prototype NMR systems developed by the team.

In addition to a good understanding of NMR, applicants should have good software programming skills and a knowledge of Matlab, C++, and the Windows programming environment.

Applications, including a cv, a covering letter explaining the candidate’s interest in the job, and the names and email addresses of two referees, should be addressed to Professor Paul Callaghan, Victoria University of Wellington, New Zealand, and sent by email (paul.callaghan@vuw.ac.nz). Applications close on 31 January, 2011.

Paul T. Callaghan
Alan MacDiarmid Professor of Physical Sciences
School of Chemical and Physical Sciences
Victoria University of Wellington
Wellington
New Zealand

Fax 64-4-4635237
Tel 64-4-4635945
e-mail paul.callaghan@vuw.ac.nz

Postdoctoral Position at Cowburn Lab

2010-12-16T14:10:00.001+01:00

Postdoctoral Position at Cowburn Lab, Albert Einstein College of Medicine

An open postdoctoral position in structural biology is available for research on protein structure, dynamics, and function focusing on kinases and inteins.

Interested candidates should have a strong background in one or more of the following areas: multidimensional NMR, crystallography, protein expressions methods, and computer simulations of molecular structure and have completed their Ph.D.

Einstein provides a modern cross-disciplinary environment for research and education. NMR facilities include nine solution NMR spectrometers from 500 to 900 MHz equipped with cryogenic probes on site or at the New York Structural Biology Center. Extensive shared resources are available for protein production, crystallography, and high-performance computing.

The position is now available. Interested candidates should send their biographical sketch identifying three referees by email ( dc@cowburnlab.org ).

David Cowburn
Professor, Depts. of Biochemistry and of Physiology & Biophysics
Albert Einstein College of Medicine of Yeshiva University

PhD position Wellington / New Zealand

2010-12-16T14:08:00.000+01:00

The MacDiarmid Institute for Advanced Materials and Nanotechnology at
the Victoria University of Wellington (Wellington / New Zealand) is
offering two PhD position, available from February 2011.

The research will be in the field of soft matter (complex fluids
investigated by means of Rheo‐NMR under high shear rates, application
of multidimensional NMR methods) with the focus on spatio‐temporal
fluctuations in banded‐flow, wall slip effects and start up flow of
micellar, polymeric and colloidal particles based on fast 3D NMR
velocimetry. The research to be undertaken concerns addressing
fundamental questions related to soft matter as well as the
development of the necessary NMR methodology (including hardware).

The successful applicant will be given the opportunity to work with
Dr. Petrik Galvosas and Professor Paul Callaghan in a well recognised
NMR group (http://www.macdiarmid.ac.nz/nmr/) with strong national and
international collaborations.

The PhD position is fully funded (including fees) and will enable the
successful applicants to stay in a well established academic
(http://www.victoria.ac.nz/scps/index.aspx) as well as urban
environment (http://www.wellingtonnz.com/). The scholarship provides a
non‐taxed living allowance of NZ$25,000 per annum, which is a very
comfortable living salary in Wellington, plus the PhD tuition fee for
three years. The commencement date can be as early as 1 February 2010.

Please refer to the Soft Matter and RheoNMR link at
http://www.victoria.ac.nz/scps/study/scholarships.aspx for further
details.

------------------------------------------------------------------------
Dr. Petrik Galvosas
School of Chemical and Physical Sciences
Victoria University of Wellington
PO Box 600
Wellington 6140, New Zealand
Tel: +64-4-463 6062 (office)
+64-4-463 5911 (lab)
Fax: +64-4-463 5237
mailto:Petrik.Galvosas@vuw.ac.nz