postdoctoral position Saclay

A postdoctoral position is available in the Structure and Dynamics by Magnetic Resonance Laboratory from Science Matter Division, and the Nuclear Magnetic Resonance Laboratory (LRMN), NeuroSpin, CEA, Saclay, France (http://www-dsv.cea.fr) under the supervision of Patrick Berthault and Luisa Ciobanu. The appointment will be made for a period of 12 months, starting immediately.

The position will be to work on an ANR funded project to perform in vivo laser-polarized 129Xe molecular imaging experiments. In this project, after optical pumping, laser-polarized xenon is encapsulated in cage-molecules functionalized with biological ligands and transported to the receptors of interest where it is imaged. The project involves collaboration with chemists (synthesis of cage-molecules of high affinity for xenon), biochemists (choice of the biological systems and of the ligands) and spectroscopists (handling of the hyperpolarized gas in fast imaging experiments).

The candidate will participate in the installation and optimization of the optical pumping setup designed to deliver high quantities of hyperpolarized xenon. He/she will be in charge of the spectroscopy and imaging experiments on small animals, in close collaboration with all partners. The MR experiments will be implemented on a 7T animal imager.

Applicants must have a doctorate degree in engineering (biomedical or chemical preferred), physics, chemistry, or other relevant discipline. Previous experience in NMR/MRI is desirable.

Interested individuals should e-mail their CV and the contact information of at least two recommenders to Luisa Ciobanu (luisa.ciobanu@cea.fr ) or Patrick Berthault (patrick.berthault@cea.fr ).

Luisa Ciobanu

Post-Doctoral Fellow Leiden

Post-Doctoral Fellow – NMR Spectroscopy Ref.: E.09.GJ.05
Leiden University Medical Center (The Netherlands)

Job Description
An opening is available for a post-doctoral fellow in the Biomedical NMR Spectroscopy group within the Biomolecular Mass Spectrometry Unit at Leiden University Medical Center (The Netherlands). As successful candidate you will be responsible for research in the field of NMR-based metabonomics with strong emphasis on lipidomics. You will contribute to several projects in collaboration with internal and external partners in the fields of endocrinology, cardio vascular disease, metabolic syndrome, diabetes and ageing. In addition you will take an active role in advancing and developing new methodologies for lipid profiling in biological fluids.

Organization
At the Leiden University Medical Center (LUMC), we are continually seeking to improve the quality of healthcare. The LUMC aims for excellence in patient care, research, teaching, training and continuing education. The Biomedical NMR Spectroscopy group at LUMC conducts research in the field of molecular biomarker discovery, NMR and MS-based metabonomics as well as method development for biomedical NMR spectroscopy with strong emphasis on automation, hyphenation and analysis of complex mixtures. Main focus of the group is on investigation of metabolic pathways and biological functions in health and disease for application in clinical research and diagnostics, as well as in disease prevention, health and nutritional science. The lab is equipped with a Bruker state-of-the-art 600 MHz NMR Metabolic Profiler including a microTOF-Q mass spectrometer.

Job requirements
We are looking for a highly motivated individual with a PhD degree in biochemistry / chemistry or equivalent. You have a sound knowledge of NMR spectroscopy; experience in multivariate data analysis and / or Matlab programming is a plus. We are seeking a team player with good communication skills and a vital interest in NMR method development. Good knowledge of English is required.

How to apply
If you are interested in the position listed above, please apply before 23rd of March 2009 by sending your application, including your CV and a brief statement of interest, to
LUMC
Attn. G.P. de Jong, P&O-advisor
Bureau Bedrijfsvoering division 5 (T7-P)
PO Box 9600
2300 RC Leiden
The Netherlands.

Please clearly quote the vacancy number E.09.GJ.05 both on the envelope and on the letter. You may also apply by e-mail, div5secretariaat@lumc.nl. For further information on the position or online application please visit our website at http://www.lumc.nl (select English website (upper right corner) and ‘working for us -> vacancies -> research’ from the main menu).

Research Associate London

Research Associate
Biophysics of Antimicrobial Peptides
Pharmaceutical Science Division, King's College London

A Research Associate post in Biophysics of Antimicrobial Peptides is available in the Pharmaceutical Science Division. The purpose of the job is to undertake research, led by Dr A. J. Mason of the Molecular Biophysics Group, into peptides with potential anti-bacterial and anti-malarial capabilities.

The post holder will employ a combination of biophysical methods including Circular Dichroism and solid-state NMR to study the membrane interactions of synthetic and naturally derived peptides. He or she will also be responsible for the E. coli based expression, purification and reconstitution of human beta defensin peptides.

The applicant needs to have a PhD or equivalent in Biochemisty, Biophysics or a related subject and be familiar with bacterial expression systems and the application of NMR to biological samples. The ability to undertake both spectroscopic measurements and microbiology experiments is essential. The ideal applicant will be someone who, as soon as is reasonably possible, can work independently with initiative based upon experience.

The post is funded for a period of three years. The post is based at the Franklin-Wilkins Building, Waterloo Campus, King's College London. The salary will be on Grade 6 post-doctoral scale, £32,917 to 35,755 per annum inclusive of £2,323 London Allowance per annum.

Further details and application packs are available on the College's website at www.kcl.ac.uk/jobs or by emailing james.mason@kcl.ac.uk . Please quote reference number W6/JGA/026/09-KB on all correspondence.

Closing date: 13th March 2009

Postdoctoral Fellowship Auckland

C at the University of Auckland, New Zealand

Applications are invited for a postdoctoral research fellow to work on an exciting project funded by a NZ Royal Society Marsden grant. The project will focus on the use of solution-state NMR spectroscopy to investigate how protein dynamics facilitates the assembly of a cytokine signaling complex involved in the immune response and inflammation.

Candidates should hold a PhD in biomolecular solution-state NMR spectroscopy. Demonstrated strengths in protein expression and purification and skills in computer data analysis and modeling are desirable. Experience in characterising protein dynamics by NMR spectroscopy would be an advantage.

This is a fixed term full-time position for two years with a start date in mid-2009.

Interested applicants are encouraged to make informal enquiries to Dr Andrew Dingley. The closing date for applications is the 26th of March, 2009. Applicants should email/send their applications including CV with the names and the contact details of three referees to:

Dr Andrew Dingley
Department of Chemistry/School of Biological Sciences
The University of Auckland
Private Bag 92019
Auckland Mail Centre
Auckland 1142
New Zealand

Email: a.dingley@auckland.ac.nz
Phone: ++64 9 373 7599 ×86801
Website: http://www.sbs.auckland.ac.nz/

For a full job description go to http://www.auckland.ac.nz/uoa/home/about/opportunities

The University has an equal opportunities policy and welcomes applications from all qualified persons.

Postdoc Bordeaux

Postdoctoral position in NMR spectroscopy

A one-year postdoctoral position is available starting in late
spring/summer 2009 at the European Institute of Chemistry and Biology /
Institut Européen de Chimie et Biologie (IECB)
(http://www.iecb.u-bordeaux.fr/). The institute was founded in 1998 and
hosts diverse and international groups covering a wide range of
scientific interests. The ideal candidate will have a PhD degree, as
well as experience in NMR spectroscopy and standard molecular biology
skills related to protein expression and biochemical assays. The
laboratory investigates structural aspects of proteins and nucleic
acids, with a focus on components of the mRNA processing machinery and
the post-translational modification of histones (for laboratory homepage
see http://www.nmrbordeaux.org/). Local equipment includes a 700MHz
spectrometer, with the addition of an 800MHz spectrometer predicted for
this year.

Interested candidates should send a curriculum vitae and the contact
information for three referees to c.mackereth@iecb.u-bordeaux.fr, or by
mail to Dr. Cameron Mackereth, IECB, 2 rue Robert Escarpit, 33607 Pessac
Cedex, France.


-- Dr. Cameron Mackereth NMR Spectroscopy of Protein/Nucleic Acid Complexes Institut Européen de Chimie & Biologie (IECB) 2 rue Robert Escarpit 33607 Pessac Cedex France +33 5 40 00 34 32 http://www.nmrbordeaux.org http://www.iecb.u-bordeaux.fr/index.php?id=96

Postdoctoral Position

Postdoctoral Position -- Computational Modeling and NMR Structural Studies of pH Sensor Proteins Involved in Cell Mobility

A postdoctoral position is available in the groups of Matt Jacobson and Mark Kelly in the Department of Pharmaceutical Chemistry at UCSF (Mission Bay Campus) to investigate how small changes in pH affect the conformations and dynamics of proteins regulating the actin cytoskeleton and cell mobility (Srivastava et al., 2008 PNAS 105:14436-41; Frantz et al., J Cell Biol. 183:865-79). In collaboration with Diane Barbers’ group these studies will bridge cell signaling, cell biology, and computational and experimental biophysics to determine at the molecular level the regulation and function of pH sensors in cell polarity, actin-dependent membrane protrusion, and cell adhesion. Investigations will involve applying physics-based predictive protein modeling and NMR investigations of conformational and dynamic changes in regulatory proteins. The position is ideal for applicants who have a strong background in biophysics, chemistry or related field and experience of either computational structural biophysics or NMR, and wish to broaden their expertise. The UCSF Mission Bay campus offers an excellent scientific environment for computational and structural biology (computing clusters, 500, 600 and 800 MHz spectrometers with cryogenic probes, and access to a 900 MHz instrument).

Applications should be addressed to or for further information please contact:

Matt Jacobson Ph.D.
UCSF MC 2240
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. 415-514-9811
matt.jacobson@ucsf.edu
http://www.jacobsonlab.org/

or

Mark Kelly Ph.D.
UCSF, MC 2280
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. (415)-476-8143
Mark.Kelly@ucsf.edu

Postdoc - NMR of polymers and inorganic nanotubes

Immediate opening for a post-doc trained in NMR. The project involves study of (1) structure, dynamics and morphology of additive-filled materials for barrier applications; and (2) structural evolution of inorganic nanotubes. Work in close collaboration with other groups in the College of Engineering here on the Georgia Tech campus in Atlanta, Georgia. $45k/year for at least one year.

If interested, pls send cover letter, CV, and 3 letters of reference to beckham@gatech.edu. E-mail also with questions and requests for further information.

Haskell W. Beckham, Ph.D.
School of Polymer, Textile and Fiber Engineering
Georgia Institute of Technology
Atlanta, GA, USA 30332-0295
office: 404-894-4198
fax: 404-894-9766
www.beckham.gatech.edu

Research Associate in Solid-State NMR and Materials Science

Research Associate in Solid-State NMR and Materials Science

The Materials Structure and Function group of NRC's Steacie Institute
for Molecular Sciences (Ottawa, ON) is looking to fill a Research
Associate position in the area of solid-state NMR and materials.

The group has excellent modern solid-state NMR facilities and access to
the 900 MHz NMR spectrometer at the National Ultrahigh-Field NMR
Facility for Solids housed in the same building (www.nmr900.ca).

High level candidates, with extensive experience in modern solid-state
NMR, a strong interest in novel materials and experience in materials
synthesis, should apply through the Research Associate Program on the
NRC website under

http://careers-carrieres.nrc-cnrc.gc.ca/programs/raprogram_e.html

and contact Dr. Chris Ratcliffe (chris.ratcliffe@nrc-cnrc.gc.ca).
Candidates must be within five years of having obtained their PhD, or be
expecting to complete their PhD in the near future.

NRC-SIMS http://steacie.nrc-cnrc.gc.ca/

PhD Scholarship Biomolecular NMR Auckland, New Zealand

PhD Scholarship in Biomolecular NMR at the University of Auckland, New Zealand

A three-year PhD scholarship is available to investigate the role of protein dynamics in the assembly of a cytokine-signaling complex involved in cell growth, survival and defense against pathogens. This project is part of an international research effort aimed at designing cytokines as therapeutic agents.

Besides solution-state NMR spectroscopy, other techniques to be used include cell-free protein expression, protein purification and computer modeling.

Students will receive an annual stipend plus fees via a Royal Society NZ Marsden Scholarship.

Applicants should have an excellent academic record and completed a BSc (honors), Masters or equivalent degree in biochemistry/biophysics/chemistry. Proficiency in English (both spoken and written) and an understanding of protein structure and function are essential. Laboratory experience in protein preparation would be advantageous.

Interested applicants are encouraged to make informal enquiries to Dr Andrew Dingley. The closing date for applications is the 30th of March, 2009. To apply, please send/email your curriculum vitae, a copy of your academic transcript and the names of two referees with a covering letter to:

Dr Andrew Dingley
Department of Chemistry/School of Biological Sciences
The University of Auckland
Private Bag 92019
Auckland Mail Centre
Auckland 1142
New Zealand

Email: a.dingley@auckland.ac.nz
Phone: ++64 9 373 7599 ×86801
Website: http://www.sbs.auckland.ac.nz/

Staff NMR spectroscopist at University of Illinois

Dear Colleagues,

The University of Illinois at Urbana-Champaign currently has an opening for a PhD-level spectroscopist in the School of Chemical Sciences' NMR Facility. Primary responsibilities are support of solid-state NMR, instrument maintenance and repair, and interacting with researchers on issues of experiment selection and data analysis.

The full ad is posted at http://www.scs.uiuc.edu/SCS/position/SOCSNMR09.pdf

For full consideration all application material should be submitted by March 16, 2009, but we will continue to accept applications until a hire is made.

We would appreciate your bringing this to the attention of qualified graduate students, postdoctoral associates and experienced spectroscopists who are seeking permanent employment.

Thank you,

Chad

Chad M. Rienstra
Associate Professor of Chemistry
University of Illinois at Urbana-Champaign
600 South Mathews Avenue, Box 50-6
Urbana, IL 61801

Phone: 217 244-4655, Fax: 217 244-3186
Office: A120 CLSL, Lab: A125 CLSL
rienstra@scs.uiuc.edu
http://www.scs.uiuc.edu/~rienstra