Dienstag, 20. Juli 2010

Postdoctoral Positions in NMR Studies of Large Biomolecular Machineries

Postdoctoral Positions in NMR Studies of Large Biomolecular Machineries

In the context of a project funded by European Research Council, several postdoctoral positions are available in the NMR laboratory of the Structural Biology Institute in Grenoble (France). Positions are available on the following topics:

- Development of Isotopic labeling and NMR spectroscopy methods for the study of high molecular weight protein assemblies.

- Real-time NMR investigation of folding and mechanisms of biological NanoMachines.

The laboratory hosts three NMR spectrometers equipped with cryogenic probes (600 MHz and 800 MHz) and with a solid state MAS equipment (600 MHz). It has access to the nearby 1 GHz NMR spectrometer of the European high field NMR centre in Lyon. Applicants will also have access to a fully equipped wetlab for isotopically labeled NMR sample preparation.

Grenoble is a pleasant city situated in the heart of the French alps, and has one of Europe’s most vibrant structural biology communities centred around the European Synchroton Radiation Facility (ESRF), the Laue Langevin Institute (ILL), the Structural Biology Institute (IBS) and the EMBL Grenoble Out-Station.

Competitive salary (based on previous research experience) is offered with health insurance, retirement plan, and language training allowance. Interested candidates should forward a Curriculum Vitae in English, and electronic and postal addresses of potential references via e-mail to : diff-jobs-nmr@listes.ibs.fr

Selected publications of the team :

• Gans P, Hamelin O, Sounier R, Ayala I, Durá MA, Amero CD, Noirclerc-Savoye M, Franzetti B, Plevin MJ, Boisbouvier J. Stereospecific isotopic labeling of methyl groups for NMR spectroscopic studies of high-molecular-weight proteins. Angew Chem Int Ed Engl. 49:1958-62 (2010).

• Plevin MJ, Bryce DL, Boisbouvier J. Direct detection of CH/pi interactions in proteins. Nature Chemistry. 2:466-71 (2010).

• Amero C, Schanda P, Durá MA, Ayala I, Marion D, Franzetti B, Brutscher B, Boisbouvier J. Fast two-dimensional NMR spectroscopy of high molecular weight protein assemblies. J Am Chem Soc.131:3448-9 (2009).

• Ayala I, Sounier R, Usé N, Gans P, Boisbouvier J. An efficient protocol for the complete incorporation of methyl-protonated alanine in perdeuterated protein. J Biomol NMR. 43:111-9 (2009).

• Rasia RM, Noirclerc-Savoye M, Bologna NG, Gallet B, Plevin MJ, Blanchard L, Palatnik JF, Brutscher B, Vernet T, Boisbouvier J. Parallel screening and optimization of protein constructs for structural studies. Protein Sci.18:434-9 (2009).

• Van Melckebeke H, Devany M, Di Primo C, Beaurain F, Toulmé JJ, Bryce DL, Boisbouvier J. Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex. Proc Natl Acad Sci U S A. 105:9210-5 (2008).

• Sounier R, Blanchard L, Wu Z, Boisbouvier J. High-accuracy distance measurement between remote methyls in specifically protonated proteins. J Am Chem Soc. 129:472-3. (2007).

Dr Jerome Boisbouvier
NMR Laboratory
Institut de Biologie Structurale
41 rue Jules Horowitz
38027 GRENOBLE Cedex 1
FRANCE

http://www.ibs.fr/content/ibs_eng/presentation/lab/lrmn/

one-year renewable postdoctoral position

A one-year renewable postdoctoral position is available in the laboratory of
Magnetic Resonances (LRM) at CEA/INAC in Grenoble (France) under the
supervision of Dr. M. Bardet.

The candidate will be involved in a joint project with the Advance Battery
Laboratory (LBA) of CEA/LITEN in Grenoble which aims at improving the
understanding of Li-ion battery properties (calendar life, cycle life, shelf
life, etc.) through the use of appropriate solid-state NMR experiments.

The candidate will have the opportunity to strongly interact with
solid-state NMR researchers (Coll. Dr. S. Hediger, Dr. G. De Paëpe). He or
she will be involved in material sample preparation at LBA (Coll. Dr. S.
Patoux, Dr. J. F.Martin) as well as in NMR data interpretation through the
use of DFT calculations (Coll. Dr. J.M. Mouesca).

The candidate will also have the opportunity to complement the NMR data with
the use of other methods (IR, XPS, EIS…) available at INAC and to access the
large scale facilities (ESRF, ILL) in Grenoble.

We are seeking a candidate with strong background in solid state NMR applied
to Li-ion batteries. Prior knowledge in DFT calculations will be highly
appreciated but is not mandatory. Candidates must be fluent in English
(written/spoken). Applicants can have any nationality. The position can
start from September-october 2010. The monthly salary is 2200 € (before
tax). Interested candidates should send a CV and three recommendation
letters to: michel.bardet@cea.fr
_____________________________________________________________

Sabine Hediger
INAC/SCIB/LRM
CEA Grenoble
17 rue des Martyrs
38054 Grenoble Cedex 9
France

Tel.: +33 4 38 78 68 12
Fax : +33 4 38 78 50 90

Email : sabine.hediger@cea.fr

Chemisch-Technische/r-Assistent/in

Chemisch-Technische/r-Assistent/in, zum 1.10.2010, Teilzeit (19,92
Wochenstunden), befristet bis 31.12.2012
Vertretung

Universitaet zu Koeln, Department fuer Chemie, NMR-Abteilung

Ihre Aufgaben:
Sie betreuen die NMR-Geraete der Abteilung und fuehren selbstaendig Routine- und
Spezialmessungen durch. Sie verstehen sich als Dienstleister/in fuer die
Wissenschaftler/innen und Studierenden, die Sie in Bezug auf die
Experimente beraten. Außerdem uebernehmen Sie einfache Wartungsaufgaben.

Ihr Profil:
Sie haben eine Ausbildung zum/zur CTA oder gleichwertige Qualifikation und
Berufserfahrung auf dem Gebiet der Instrumentellen Analytik – im optimalen Fall
in der NMR-Spektroskopie. Englischkenntnisse und der Umgang mit moderner
Buerotechnik sind fuer Sie selbstverstaendlich. Sie sind teamfaehig,
flexibel, verantwortungsvoll und belastbar.

Bei Vorliegen der tarifrechtlichen Voraussetzungen erfolgt die Eingruppierung in
Entgeltgruppe 6 TV-L.

Bitte senden Sie Ihre schriftlichen Bewerbungsunterlagen an die
Geschaeftsfuehrung des Departments für Chemie, Frau Dr. Birgit Seyberlich,
Greinstraße 4–6, 50939 Koeln, (birgit.seyberlich@uni-koeln.de).

---------------------------------------------------------


Dr. Nils Schloerer Department fuer Chemie der Universitaet zu Koeln NMR-Abteilung Greinstr.4 D-50939 Koeln (Germany) (+49) (0)221 470 3081 (office) (+49) (0)221 470 5057 (fax) http://www.oc.uni-koeln.de/nmr/index.html

MR Scientist (m/f) position, GE Global Research Munich, Germany

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MR Scientist (m/f)
------------------
Please only apply online through the following link: www.ge.com/researcheurope Job # 1016545

Responsibilities
----------------
As an MR scientist, you will be developing new techniques and algorithms in magnetic resonance imaging, magnetic resonance spectroscopy, or functional magnetic resonance imaging. Broad goals of this position are the improvement of image quality, development of new technology that will enhance the MR system performance, clinical performance and efficacy.

You will be expected to work independently and also within a larger team to innovate and push the technical envelope in all aspects of magnetic resonance imaging. You will have access to a state-of-the-art 3.0T whole body MR scanner.
Your main responsibilities are:
- Apply knowledge and experience in MR physics to develop new technological solutions for MR imaging
- Work with clinical partners to refine emerging technology for clinical applications
- Maintain external visibility through conference presentations and peer-reviewed publications

Qualifications
----------------
- A Ph.D. in Medical Physics, Electrical Engineering, Chemistry or Biomedical Engineering or a Masters Degree in Medical Physics, Electrical Engineering, Chemistry or Biomedical Engineering. At least 3 years experience in the field
of magnetic resonance imaging (including time in graduate school) is desired.
- A demonstrated record of research and development in MR imaging as evidenced by conference proceedings and peer-reviewed publications
- Proficiency in programming of MR pulse sequences or image reconstruction algorithms, and demonstrated expertise in MR physics.
- A strong foundation in MR systems architecture is required
- Proficiency in programming in C, simulation tools (MATLAB, IDL, Mathematica, etc.).
- Excellent academic track record and proven scientific achievements
- Excellent communication skills
- Ability to work in a matrix environment
- Can-do attitude
- Open, creative & flexible
- Team-work & commitment
- Global mindset & customer focus
- Solution oriented & pragmatic
- Entrepreneurial mindset & acquisition expertise
- Fluency in English

Desired
----------------
- Basic German

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GE Global Research
-------------------------------------------
GE Global Research is one of the world's largest and most diversified
industrial research laboratories. The key technologies of our new
European Research Center in Munich range from renewable energies,
environmental and sensors technologies and composite manufacturing
to advanced clinical applications.
To get to know more about us, log on to www.ge.com/researcheurope.
Go for a future full of possibilities
-------------------------------------------

-------------------------------------------
Dr. Marion I. Menzel
Imaging Technologies Europe
GE Global Research

T +49 89 55 283 730
F +49 89 55 283 185
E marion.menzel@research.ge.com
www.ge.com/research

Freisinger Landstr. 50
85784 Garching bei München
Germany

GE Global Research, Zweigniederlassung der General Electric Deutschland Holding GmbH. Sitz von/Registered Office of General Electric Deutschland Holding GmbH: Neu-Isenburg.
Registergericht/Commercial Register: Amtsgericht/Lower District Court Offenbach; HRB 10773. Geschäftsführer/Managing Director: Werner van Wickeren, Udo Klaeren.
GE imagination at work

two positions (1 RF engineer and 1 Pulse Sequence Developer)

This is to inform you about two positions (1 RF engineer and 1 Pulse
Sequence Developer) just opened in Pisa to work with a GE 7T system,
which will be installed later this year.

http://www.inpe.unipi.it/imago7/job_position_img7T_eg.pdf
http://www.inpe.unipi.it/imago7/job_position_img7T_it.pdf

http://www.inpe.unipi.it/imago7/job_position_rfcoil_eg.pdf
http://www.inpe.unipi.it/imago7/job_position_rfcoil_it.pdf

If you are interested or know a good candidate who would be interested,
please have a look at the details or forward this information. These
scientists will work in close collaboration with the GE MR Applied
Science Lab at one of GE's key academic sites in Europe.

Assistant Professor position(s) in Physical Chemistry

Assistant Professor position(s) in Physical Chemistry

An opportunity exists for post(s) in physical chemistry at the University of Warwick. Physical Chemistry will be interpreted broadly across all relevant areas of activity, with magnetic resonance (both NMR and EPR) being possible areas of appointment.

For Further details please see https://secure.admin.warwick.ac.uk/webjobs/jobs/academic/job12168.html

Warwick has a state of the art Magnetic Resonance Laboratory opened in summer 2008. Applicants who can make links with the Centre and make use of these outstanding facilities are encouraged to reply. For more details about the Centre please see

http://www2.warwick.ac.uk/fac/sci/physics/research/condensedmatt/nmr/

The Head of Physical Chemistry is Prof. Tim Jones T.S.Jones@warwick.ac.uk who is happy to answer informal approaches.

Mark E. Smith
Department of Physics
University of Warwick
Tel: +44 - (0)24 76 522380
Fax: +44 - (0)24 76 150897
http://physweb.spec.warwick.ac.uk/nmr/nmr.html

For appointments
Ayesha Rahman (A.Rahman@warwick.ac.uk)
Tel: 44 - (0) 24 765 23965

postdoctoral position in NMR/diffusion

A postdoctoral position in NMR/diffusion in nanoporous materials is available immediately at the University of Florida (UF) in Gainesville. The research will involve combined application of hyperpolarized NMR and pulsed field gradient (PFG) NMR to study diffusion and related phenomena in materials with one-dimensional nanochannels. This project is a collaboration between Prof. Clifford R Bowers (www.chem.ufl.edu/~bowers/) and Prof. Sergey Vasenkov (www.che.ufl.edu/faculty/vasenkov/). The successful candidate will benefit from access to the resources of the National High Magnetic Field Lab (magnet.fsu.edu), including the AMRIS facility in Gainesville, FL. In particular, the 750 MHz PFG NMR spectrometer located in AMRIS is available to perform diffusion studies with ultra-high gradients at the highest magnetic field in the USA for this type of application.

Position: Funding for this postdoctoral position is provided by the National Science Foundation. The initial appointment will be in the UF Chemistry Department for a period of one year with a possibility for renewal for an additional year or two years.
Qualifications: The successful candidate should hold a Ph.D. (or equivalent) in chemistry, physics, chemical engineering or a related field. Significant prior experience with hyperpolarized NMR, diffusion NMR, or solid-state NMR is a requirement. An ability to learn new NMR techniques, high motivation, a strong publication record and fluency in English are expected.

Application: Interested candidates should send a cover letter with the description of research interests and future plans, curriculum vitae, list of publications, and the full contact details of three references by e-mail to:

Prof. Clifford R Bowers
University of Florida
Department of Chemistry
Email: russ@ufl.edu

three-years post-doctoral position

A three-years post-doctoral position is opened in the group of biomolecular NMR of the IGBMC institute in Illkirch (near Strasbourg), France.

The research project is related to the field of the chromatin remodelling processes. In particular, we are interested to decipher the molecular mechanisms underlying the interaction between specific transcription factors, such as the deubiquitination module of the SAGA complex, and the nucleosome. The work will be conducted within a highly multidisciplinary environment involving several teams of the institute (X-ray crystallography, functional genomics). The study will necessitate the production of several large molecular complexes, specifically labelled at methyl group positions to enable their observation by NMR and follow their interaction with purified nucleosomes. A particular attention will be paid to the dynamical aspects of these interactions, using relaxation measurements. More information on the system can be read in Bonnet et al., EMBO reports (in press).

We are seeking for a highly motivated candidate, displaying good skills in protein expression and purification methods and isotopic labelling schemes. The candidate should be interested in elaborating innovative and appropriate labelling strategies to study interactions between large molecular complexes. A good knowledge of biomolecular NMR methods is therefore requested.

Interested candidates should contact:
Pr Bruno KIEFFER
kieffer@igbmc.fr____________________________________________________________________
Bruno KIEFFER

Freitag, 2. Juli 2010

Faculty Positions, Univ. British Columbia

The Michael Smith Laboratories (MSL) and the Centre for High-throughput Biology (CHiBi) at the University of British Columbia are jointly
launching a major recruiting initiative and invite applications for six new faculty positions. These full-time tenure-track positions will be
filled primarily at the Assistant Professor level but exceptional candidates at a higher rank may be considered. The six new faculty will be
located in exceptional research space at the centre of campus within a highly interdisciplinary and collaborative environment that
includes biological and physical scientists and engineers, as well as proteomics and bioinformatics experts.

METABOLIC ENGINEERING and SYNTHETIC
BIOLOGY (competition # 7789)
All facets of metabolic engineering and
synthetic biology, from technology
development and computational
approaches to innovative applications, will
be considered. Applicants with an interest
in bioenergy and biorefining are
particularly encouraged to apply.

CHEMICAL, MOLECULAR AND SYSTEMS
BIOLOGY, and BIOENGINEERING
(competition # 7790)
Approaches using molecular genetics,
chemical, computational or molecular
biology or bioengineering to probe animals,
plants and unicellular organisms, and
models of disease therein, will be
considered.

COMPUTATIONAL TOOLS AND
TECHNOLOGY DEVELOPMENT
(competition # 7795)
The development of innovative
technologies, devices, computational
approaches or chemical and biophysical
techniques is welcomed, with particular
emphasis on genome-wide and high-
throughput approaches.

Successful applicants for these positions must have a Ph.D., will have demonstrated outstanding research strength and creativity, have
several years of productive experience, will be expected to contribute to high quality undergraduate/graduate teaching and to effectively
supervise graduate students, and be prepared to integrate their expertise with innovative researchers at the University. Academic
appointments could be within or between departments in the Faculties of Applied Science, Forestry, Medicine and/or Science, evidence
of teaching effectiveness would be an asset.

The Michael Smith Laboratories and the Centre for High-throughput Biology comprise a diverse group of 22 research and teaching faculty
and over 150 graduate students, post-doctoral fellows and research associates. Research strengths include medical and animal
molecular genetics/biology, plant and forest molecular genetics/biology, bioprocess engineering, chemical biology, proteomics, micro-
fluidics bioinformatics and statistical genomics. Importantly the group is also providing leadership for the Bio-energy and Refining
Innovation (BERI) network as part of a university-wide initiative in sustainability. Applicants are strongly encouraged to visit
http://www.michaelsmith.ubc.ca/ and http://www.chibi.ubc.ca/ to learn more about the unique technological and research
opportunities available to new faculty members. Substantial start-up funds and exceptional mentoring will be provided.

UBC with over 12,000 faculty and staff plus 8,000 graduate students, has deep research strength across the Applied Sciences, the Life
Sciences, the Physical Sciences and Computation, and has formal associations with research hospitals, the British Columbia Cancer
Agency, Genome British Columbia, the Genome Sciences Centre, the Centre for Drug Research and Development and the Institute for
Systems Biology in Seattle. Researchers thus enjoy numerous opportunities for stimulating and productive collaborations. Opportunities
exist to attract substantial research funding from government (e.g. Canadian Institutes for Health Research, Natural Sciences and
Engineering Research Council of Canada, Canadian Foundation for Innovation), foundations (e.g. Michael Smith Foundation, Genome
Canada) and industry.

Applications are being accepted on-line at http://www.hr.ubc.ca/careers/faculty_postings.html and should include a letter of
application indicating the appropriate competition number, a detailed curriculum vitae, a list of publications, a statement of research and
teaching interests, and the name, address, e-mail address and phone number of at least three referees. All positions are subject to final
budgetary approval. The closing date for all applications is September 14, 2010.




~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Lawrence McIntosh

mcintosh@chem.ubc.ca
http://otter.biochem.ubc.ca/
office (001) 604 822-3341
lab -3029
NMR -9447
cell 604 562-9447
Departments of Biochemistry and Chemistry
Room 4.551 Life Sciences Centre
2350 Health Sciences Mall
University of British Columbia
Vancouver BC Canada V6T 1Z3
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

PhD studentship in solid-state DNP/NMR - Lille, France

A three-years PhD position in solid-state DNP/NMR is available in the group of Prof. J.-P. Amoureux, University of Lille, Lille, France. It will start preferably in October 2010.

The project: The Ph.D. project aims to develop a new technique for the characterization of materials : the Dynamic Nuclear Polarization (DNP) for solid-state samples at high magnetic field. Recently the group of R. G. Griffin at MIT demonstrated that this technique is feasible at high magnetic field (9.4 T) and increases the sensitivity of nuclear magnetic resonance (NMR) by a factor of 100. Such a gain in sensitivity provided by DNP paves the way for new applications of solid-state NMR. The objectives of this Ph.D. are to study and show the potential of DNP for the characterization of important materials, such as heterogeneous catalysts used for the biofuel production. The Ph.D. will consist in preparing the catalyst samples containing paramagnetic agents, characterizing them by electronic paramagnetic resonance (EPR) and NMR spectroscopies and performing DNP experiments for such materials. The project is a collaboration between the university of Lille and Bruker company.

Facilities: Facilities for solid-state NMR spectroscopy has five superconducting magnets, ranging from 900 MHz (proton Larmor frequency) to 100 MHz. Over 20 probes enable solid-state NMR to be performed with different rotor diameters, from 1.3 mm to 7 mm. The 1.3 mm rotor can rotate at up to 70 kHz. Lille is a pleasant city situated in the heart of Europe (30 min from Brussels, 1 h from Paris, 1h from London by train). The university of Lille combines research groups with strong expertise in NMR and EPR spectroscopy as well as catalysis and material science. In particular, it is the coordinator of European project for designing next-generation bio-refinery.

The person: We seek application from national and international students who have graduated in physics or chemistry, preferably with a background in NMR. The successful applicant will be given the opportunity to work in an exciting environment with national and international collaborations.

Remuneration: The studentship includes a stipend of 20 118 € per year with health insurance and language training allowance.

Contact: Applications and informal queries about the lab and research projects should be directed by email to Jean-Paul Amoureux or Olivier Lafon. Applications should include a cover letter, a CV and contact information for two references.
Department of chemical engineering
University of Lille
F-59652, Villeneuve d'Ascq, Cedex, France
Tel : 33 3 20 43 41 43 Fax : 33 3 20 43 68 14
email : jean-paul.amoureux@univ-lille1.fr

Dr. Olivier Lafon
Department of chemical engineering
University of Lille
F-59652, Villeneuve d'Ascq, Cedex, France
Tel : 33 3 20 43 41 43 Fax : 33 3 20 43 68 14
email : olivier.lafon@ensc-lille.fr
webpage adress : http://uccs.univ-lille1.fr/spip.php?article199.fr

--
Dr Olivier Lafon
Unité de Catalyse et de Chimie du Solide (UCCS) - UMR CNRS 8181
Ecole Nationale Supérieure de Chimie de Lille (ENSCL)
Cité scientifique, Bât. C7, B.P. 90108
F-59652, Villeneuve d'Ascq, Cedex, France