Post-Doctoral Research Associate: Druggability of Multi-Subunit Protein Interfaces
Department of Chemistry
Vacancy Reference No: MA07682 Salary: £27,319-£35,646
Limit of tenure applies*
A postdoctoral position is available in the research group of Dr Alessio Ciulli to study the druggability of protein-protein interfaces within a family of multi-subunit E3 Ubiquitin Ligases involved in protein degradation. Our goal is to understand the molecular basis underlying small molecule recognition of native interfaces of multi-protein complexes and to exploit the information gained for the fragment-based design of novel chemical probes of biological function. The project will use a combination of structural, biophysical, computational and biochemical techniques to study protein-ligand and protein-protein interactions. For more information, please check our group website (http://www-ciulli.ch.cam.ac.uk/).
The successful candidate will have the opportunity to join the Cambridge Molecular Therapeutics Programme (see http://www.cmtp.cam.ac.uk/cmtp.html), an interdisciplinary initiative based in Cambridge to explore new strategies for drug discovery against cancer and infectious diseases. We are equipped with state-of-the-art facilities to conduct cutting-edge research in all aspects of modern chemical biology, structural biology and biophysics.
Applicants should have (or be about to receive) a PhD in chemistry, biochemistry, structural biology, or a related area. Proven experience in NMR spectroscopy, X-ray crystallography or related techniques in chemical/structural biology and structure-based drug design is essential. Some experience in synthetic organic chemistry or cell biology is desirable but not necessary. The ability to work in a creative, interdisciplinary and dynamic research environment at the interface of chemistry and biology is paramount, and good written and oral communication skills are essential.
The post is available from March 2011. Applications should include a CV, publications list, a cover letter summarising research experience and interests, contact details for three professional referees, and a completed form CHRIS/6 Parts I and III (downloadable from http://www.admin.cam.ac.uk/offices/hr/forms/chris6/), and should be sent to Dr Alessio Ciulli, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW (email: ac313@cam.ac.uk).
* The funds for this post are available until December 31st 2012 in the first instance.
Closing date: 28 February 2011.
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