Postdoctoral Position in Solid State NMR at CEA Saclay (20 km S-W from
Paris)
Tritium solid-state NMR: Towards long-range distance measurements in
biological complexes
This position is funded by the National Agency for Research
(ANR) for a project entitled "Long range distance measurement by solid
state tritium NMR. Observing the structure and dynamics of biological
complex systems at work". The aim of this project is to develop a new
approach for measuring long-range inter-atomic distances in tritium
labeled systems. This is a collaborative project with chemists having an
expertise in tritium labeling and biochemists. 3H MAS NMR is offering
many exciting new perspectives for biological NMR methods as well as
many methodological developments are envisaged.
In a first step, long range distance measurements will be validated on
deuterated and protonated model compounds, with isolated 3H-3H spin
pairs whose distance will range from 6A to 15A. This step will require
an investigation of different recoupling techniques, as well as some
methodological work on specific recoupling schemes if necessary. In a
second step, the technique will be applied to important issues in
structural biochemistry.
First results have been presented at the 5th Alpine Conference on NMR
http://hal.archives-ouvertes.fr/hal-00173704/fr/.
This is a one-year post-doctoral position available starting at January
2008. Extension to two years is possible.
Our lab is equipped with three NMR spectrometers, 500 NB (with micro
imaging, gas and hyperpolarized xenon NMR facilities), 300 WB and 500 WB
Bruker Avance II spectrometers.
Postdoctoral salary will be around 2000/2500 Euro per month.
Applicants are invited to send a curriculum vitae and a brief statement
of research along with letters of reference to:
Thibault Charpentier
LSDRM - Service de Chimie Moléculaire
CEA Saclay
91191 Gif-sur-Yvette, FRANCE.
For further details, you are welcome to contact Thibault Charpentier,
tcharpentier@cea.fr or Patrick Berthault, pberthault@cea.fr.
Thibault Charpentier
Laboratoire de Structure et Dynamique par Résonance Magnétique Laboratoire Claude Fréjacques - CEA/CNRS URA 331 DSM/DRECAM/SCM - Bât 125 CEA Saclay 91191 Gif-sur-Yvette cedex, FRANCE
Tél: (33) 1 69 08 23 56 / 82 75 Fax: (33) 1 69 08 66 40
Email: tcharpentier@cea.fr
