A postdoc position on protein-ligand interactions and fragment-based drug design by NMR is available at the Helmholtz Zentrum München
http://www.helmholtz-muenchen.de/fileadmin/0-templates/www-helmholtz-muenchen-de/php/jobs.php?id=1243&L=1
Job Details
The candidate will be responsible for characterizing protein-ligand interactions and implementing fragment-based approaches by NMR spectroscopy for the identification and optimization of small molecule inhibitors targeting disease-linked pathways. The scientist will be working in the group of Michael Sattler at the Institute of Structural Biology (http://www.helmholtz-muenchen.de/stb) in close collaboration with structural biologists using NMR-spectroscopy and X-ray crystallography for studying protein-ligand interactions. Interactions are expected with the Protein Expression and Purification Facility and the Assay Development and Screening Facility. The scientist should establish NMR-monitored fragment-based screening and support on-going projects in the identification and optimization of small molecule hits and leads using structural biology (NMR and X-ray crystallography). Tasks include:
- Implementing a fragment library and NMR-monitored screening
- Application of NMR based methods for protein-ligand interactions (ligand and target based)
- Hit validation and structural analysis of protein-ligand complexes by NMR and/or X-ray crystallography
- Implementation and development of new methods and techniques
- Interaction and project-driven collaborations with biologists and chemists, e.g. for establishing structure-activity relationships
The candidate is expected to interact and collaborate with researchers at HMGU.
Qualifications
- Doctoral degree in Chemistry, Biochemistry, Life Sciences, Physics, or related
- Demonstrated strong experience with structural biology and/or structure-based techniques for studying protein-ligand complexes
- Experience with training and supervision of students is desired
- We expect high motivation, creativity and a strong commitment to team work.
- Strong communication and organizational skills are expected
- Previous experience with chemical compound libraries is desirable
Our Offer
- Research scientist in the Institute of Structural Biology at the Helmholtz Zentrum München
- Supporting innovative research on important biological pathways linked to human disease.
- Working in a vibrating and scientifically stimulating environment with excellent facilities for NMR (http://www.bnmrz.org), structural biology, protein biochemistry, cell biology, imaging, animal models, and more.
- Opportunities and support in management skills
For further information please contact Michael Sattler (sattler@helmholtz-muenchen.de)
The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.
Applications should be addressed to Waltraud Wolfson (waltraud.wolfson@helmholtz-muenchen.de)
Helmholtz Zentrum München
German Research Center for Environmental Health (GmbH)
Ingolstädter Landstr. 1
85764 Neuherberg
Germany
