Paris Descartes University
UMR8601 CNRS
12 months post-doctoral position in Structural Biology NMR.
The postdoctoral position is available from February 2011 in the Paris Descartes University to characterize the interaction of new anti-cancer inhibitors with phosphorylated peptide-betaTrCP complex.
Applicants should have a Ph.D. in Biochemistry, Chemistry or related fields.
The candidate is expected to have a strong expertise in solution NMR with in-depth training in NMR receptor-ligand interaction, protein structures and dynamics, and drug-protein interactions. Familiarity with biochemistry, biophysics, and molecular biology is desirable.
Experience with molecular modelling (docking, virtual screening) and python language will be a big plus.
The candidate will join our NMR & Molecular modeling team of the laboratory of Chemical and Biochemical Pharmacology and Toxicology (UMR8601 CNRS), and be responsible for the development and structural analysis of anti-cancer by high-resolution solution NMR and molecular modeling. The main approach will be to characterize the interaction by transfer-NMR experiments (STD, WaterLOGSY, ...) and to participate in the development of AuPosSOM software (www.aupossom.com) to classify molecules according to their contact pattern with the target of interest and 2D/3D QSAR modeling.
Funding for the position is provided by the French National Agency of Research (ANR) for 1 year.
For any queries about the lab and research projects, please contact Nathalie Evrard-Todeschi by e-mail:
Nathalie.Evrard-Todeschi@parisdescartes.fr
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Dr Gildas BERTHO
Université Paris Descartes
UMR 8601 CNRS
Équipe de RMN et Modélisation Moléculaire
45 rue des Saints-Pères
75006 Paris, FRANCE
Tel : +33-(0)1-42-86-21-82
Fax : +33-(0)1-42-86-40-50
Email : gildas.bertho@parisdescartes.fr
