Montag, 18. Februar 2008

NMR Scientist/Senior Scientist Job Opening

NMR Scientist/Senior Scientist Job Opening

Protein Engineering, Small Molecule Drug Discovery

Genentech, Inc.

We have an opportunity for a highly talented and motivated NMR spectroscopist to join the Protein NMR Group at Genentech. The primary responsibilities of this position will be to help develop, lead, and implement NMR-based strategies to support small molecule drug discovery programs, working closely with the Biochemical Pharmacology and Discovery Chemistry Departments, and participating directly with small molecule project teams to aid the design of new small molecule compounds. Job responsibilities include hands-on NMR data acquisition, processing, and analysis, focused on assessing ligand-binding and analyzing the solution structures of proteins or protein/ligand complexes involved in modulating cell-signaling events of therapeutic interest. The protein NMR facility includes dedicated 800, 600, and 500 MHz spectrometers, Linux workstations, and access to the Central California 900 MHz spectrometer. Our NMR group complements protein engineering, protein crystallography and modeling efforts within the Protein Engineering Department.

A successful candidate should have a Ph.D degree in a relevant discipline with at least 3-5 years of postdoctoral training. Industry experience in fragment-based small molecule drug discovery strongly preferred (significantly more work experience is required for consideration at the senior scientist level). The successful candidate will show evidence of productive, independent contributions in science, as demonstrated by a strong publication/patent record. Extensive knowledge and hands-on expertise in all aspects of protein and small molecule NMR spectroscopy is required. Excellent verbal and written communication skills, as well as the ability to work in large, multidisciplinary project teams are essential. Senior candidates with experience participating in or leading multi-disciplinary structure-based drug design efforts are encouraged to apply.

Please apply on-line at, and be sure to note REQ#: 08-1000021966