Donnerstag, 11. Februar 2010

Assistant / Associate Professor Bordeuax

Position to be opened in Bordeaux, France at the Assistant / Associate Professor level ("Maitre de Conferences"). NMR of nucleic acids.

University of Bordeaux 2 – INSERM "Chaire Université – Organismes"

French citizens are expected to be registered on "listes de qualification". Foreigners may possibly skip this step; in that case their resume will first be evaluated by the Scientific board of the University. Please enquire. Short-listed candidates will be interviewed in Spring 2010 and are expected to start in Fall 2010.

Laboratory: INSERM U869 Director: Dr. J.J. Toulmé, Université Victor Segalen Bordeaux II INSERM U869, (

The candidate will be located in the "European Institute of Chemistry and Biology (IECB)": and hosted in the team of Dr. J.L. Mergny (

Teaching Profile: Bioorganic Chemistry. Teaching will have to be in French at the Licence level for students in Life Sciences. A transition period may be negociated if necessary.

Research profile: J.J. Toulmé & J.L. Mergny are leaders in the fields of aptamer selection and unusual nucleic acids conformations, respectively. Solving the structure of a number of relevant sequences for these studies would be of great interest. An NMR platform is available in the institute, with 800 and 700 MHz apparatus. Expertise in NMR of biomolecules - and especially nucleic acids - is a prerequisite. Minimum PhD + at least 3-5 years post doctoral experience, strong publication record.

5 recent publications:

Lim, K.W. Alberti, P., Guédin, A., Lacroix, L., Riou, J.F., Royle, N., Mergny, J.L. & Phan, A.T. (2009) Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G•C•G•C tetrad. Nucleic Acids Res. 37, 6239-6248.

Monchaud, D., Yang, P., Lacroix, L.,Teulade-Fichou, M.P. & Mergny, J.L. (2008) A Metal-Mediated Conformational Switch That Controls G-Quadruplex Binding Affinity. Angew. Chem. Int Ed. 47, 4858-4861.

Van Melckebeke, H., Devany, M., Di Primo, C., Beaurain, F., Toulmé, J.J., Bryce, D.L. and Boisbouvier, J. (2008) Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex. Proc. Natl. Acad. Sci. USA, 105, 9210-9215.

De Cian, A., Cristofari, G., Reichenbach, P., Delemos, E., Monchaud, D., Teulade-Fichou, M.P., Shin-ya, K., Lacroix, L., Lingner, J. & Mergny, J.L. (2007) Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc. Natl. Acad. Sci. USA. 104, 17347-17352.

Lebars, I., Richard, T., Di Primo, C. and Toulmé, J.J. (2007) NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer. Nucleic Acids Res., 35, 6103-6114

Research Specialist in Chemical Sciences

Research Specialist in Chemical Sciences

University of Illinois at Urbana-Champaign

The Department of Chemistry at the University of Illinois at Urbana-Champaign is searching for a Research Specialist in Chemical Sciences. This position will support the investigation of structural studies of proteins by solid-state NMR spectroscopy. Duties include operation of high-field NMR spectrometers with magic-angle spinning and variable temperature capabilities, development of pulse sequences, data collection, and data analysis protocols, and collaborating with researchers to achieve ambitious scientific objectives in the structural biology of membrane proteins and fibrils.

This is a full-time, regular academic professional position. The position requires a minimum of a Ph.D. in Biophysics, Physical Chemistry, or Physics with a dissertation awarded from a research group specializing in advanced NMR spectroscopy techniques. Preference will be given to candidates with previous postdoctoral experience of at least two to three years, in addition to prior experience in probe design and maintenance, pulse sequence development, and computational analysis of NMR data. Salary is commensurate with experience. Start date is as soon as possible following the closing date.

To ensure full consideration you must provide a cover letter, curriculum vitae and email addresses for 3 references by the close date of February 15, 2010. Create your U of I application through and upload your cover letter and curriculum vitae. The Department of Chemistry will then send you an email (within 2 days) with instructions for entering contact information for three references. For questions, contact Research Specialist Search,, (217) 333-5071. Applicants may be interviewed before the closing date; however, no hiring decision will be made until after that date.

The University of Illinois is an Affirmative Action, Equal Opportunity Employer.

Chad M. Rienstra
Associate Professor of Chemistry
University of Illinois at Urbana-Champaign
600 South Mathews Avenue, Box 50-6
Urbana, IL 61801

Phone: 217 244-4655, Fax: 217 244-3186
Office: A120 CLSL, Lab: A125 CLSL

Postdoc Paris Modelling

Institut Pasteur Paris
Department of Structural Biology and Chemistry
Structural Bioinformatics Unit

24 month post-doctoral position in Computational Structural Biology.
The postdoctoral position is available immediately.

The aim of the project is to use and develop molecular modeling techniques,
to understand the architectural principles of bacterial pili, and to get insight into
their assembly.

In the project, the candidate will be responsible for the molecular modeling of
bacterial pili, based on known structures of the individual constituents, and structural
data on the assembly (from electron microscopy, and from biochemical experiments);
for modifying and developing modeling software, and for conducting molecular
dynamics simulations.

Applicants should have a Ph.D. in Physics, Biochemistry, or Chemistry with strong
experience in structure refinement, molecular modeling, and/ or structure analysis.

For any queries about the lab and further details of the research project, please contact:

Michael Nilges

Prof. Michael Nilges
Structural Bioinformatics Unit, Head
Department of Structural Biology and Chemistry, Head
Pasteur Institute, CNRS URA 2185
25-28 rue du docteur Roux, F-75015 Paris, France.
Tel: +33 1 45 68 82 30; Fax: +33 1 45 68 87 19
secrétariat: +33 1 44 38 91 09


The NMR and Structure Analysis unit of the Department of Organic Chemistry of Gent University (Belgium) is involved in research activities in the (bio)chemical and material sciences using NMR spectroscopy as the main investigative tool.

For this purpose, it has available a range of fully equipped Bruker NMR spectrometers, including Avance 300 and 500 MHz spectrometers, and an AVANCE–II 700 MHz instrument, housed within the unit and part of the Interuniversitary NMR Facility, jointly operated between Ghent University, the Vrije Universiteit Brussel (VUB) and Antwerp University (UA).
By the end of 2010, a new 500 MHz system including a high gradient diffusion probe head will be delivered. Within this context, a three year, University funded postdoctoral position is available starting no later than June 1st 2010, to perform research in one of the following areas: characterisation of colloidal dispersions from quantum dot to pigment particles, the investigation of supramolecular structure and self-assembly, the study of intermolecular interactions and investigations of biomolecular dynamics. Techniques and methods used include high resolution diffusion NMR spectroscopy, high resolution MAS, heteronuclear relaxation methods and advanced structure analysis.

The duties of the successful applicant include:
Scientific research within the context of NMR research projects within the department. Scientific support and co-manager of the Interuniversity 700 MHz high field NMR facility and the new 500 MHz facility within the department. Mentoring of Master and PhD students. Contribute to the educational activities of the department – a minimum of 70% of the appointee’s time must be spent on scientific research.

We offer:
• The opportunity to fully participate in current research projects of the unit, in one of the areas mentioned above.
• The opportunity to play an active part in the creation and exploitation of the highest field NMR facility in the region.
• A competitive salary amounting to 1800-21100 €/month (commensurate with age and experience).

To be eligible, applicants should:
• Demonstrate knowledge and practical expertise in solution NMR spectroscopy, as demonstrated by publications in international journals and/or oral communications at national or international meetings.
• Demonstrate technical knowledge in the operation of Bruker NMR equipment (hardware and software) including implementation of new and existing pulse sequences.
• Demonstrate outspoken interest for student mentoring
• Have acquired a PhD degree by the time of appointment.

The Universiteit Gent is an equal opportunity employer.
For further information contact Prof. José Martins as soon as possible and before February 26th via e-mail:

Prof. dr. José C. Martins
Eenheid NMR en Structuuranalyse
Vakgroep Organische Chemie
Universiteit Gent
Krijgslaan 281 S4
B-9000 Gent
Tel.: +32(0)9-264-44-69
Fax: +32(0)9-264-49-72

NMR job in Toronto, Canada


Site: TDMT and Max Bell Research Center, University Health Network
Department: Research
Reports to: Dr. Cheryl Arrowsmith, Senior Scientist
Status: Permanent Full-time for Scientific Associate

The Arrowsmith research laboratory and the Structural Proteomics in Toronto (SPiT) group, located at the University Health Network and affiliated with the University of Toronto, is one of the leading centres for genome-scale protein science in cancer structural biology. With support in place from the provincial and federal governments, U.S. National Institutes of Health and the private sector, we are currently expanding our research team in the area of Nuclear Magnetic Resonance.

We are seeking a SCIENTIFIC ASSOCIATE or POSTDOCTORAL FELLOW whose primary responsibility will be providing support to our NMR group.

We use state- of- the-art NMR instrumentation: Bruker 800, 600 and 500 MHZ, all equipped with cryoprobes. We also have regular user time on Varian 600 and 500 MHz spectrometers. Specialized and qualified expertise is required for maintaining and running the instruments as well as training other members of the group. The service component of the position is estimated at 50% of the time. The successful candidate should have a solid background in biomolecular NMR and is expected to pursue independent research projects as a member of the structural proteomics team. Additional responsibilities may include the management of fee-for-service projects and academic collaborations.

The ideal candidate will be a team player, able to learn and adapt quickly and have excellent interpersonal and communication skills. He/she will be detail-oriented, self-organized, motivated, and energetic. Computer skills (Linux and NMR related software) are required.

We offer competitive salaries, commensurate with experience.

·PhD in Biophysics or related disciplines
·0-to 10 years of experience post PhD
·Ability to work independently, yet be a team player
·Excellent verbal and written communication skills

Please submit your resume to Michelle Deeton, Manager:
fax to (416) 340-4004




Postdoctoral Position in NMR New York

Postdoctoral Position in NMR Methods Development
City University of New York

A postdoctoral position is available immediately at the City College of the
City University of New York.

The project involves development of NMR methodology to determine the structure
and dynamics of large proteins. The candidate will have significant access to
the NMR facilities in-house (600 MHz with a cryoprobe) and to those at the New
York Structural Biology Center (NYSBC, 500-900 MHz all with cryoprobes). The
NYSBC is situated on the City College campus a few yards from the laboratory
and is the largest such center in the United States.

(1) PhD or equivalent.
(2) Background in NMR theory and simulations.
(3) Background in NMR methods development for solid-state or solution NMR.
(4) Ability to implement novel pulse sequences for Bruker and/or Varian

Commensurate with experience and negotiable. A comprehensive benefits package
will also be provided.

Please apply by email ( and include CV, the names of 3
referees and 1-2 representative reprints.

Ranajeet Ghose Ph.D.
Associate Professor
Department of Chemistry, The City College of New York
The Graduate Center of the City University of New York
160 Convent Avenue
New York, NY 10031
Phone : (212) 650 6049
Fax : (212) 650 6107
Email :

Mittwoch, 3. Februar 2010

Post-Doctoral Position Opening

Post-Doctoral Position Opening

A post-doctoral research associate is required to work with Dr. Mateus Webba da Silva on control of folding of G-quadruplex nucleic acids (see e.g. Angew. Chem. Int. Ed. 48 (2009) 9167-9170)

Applicants should have a PhD in chemistry, biochemistry, physics or a related area. Two years experience in applying NMR spectroscopic methods is essential. Experience with one or more of software programming, biomolecular structure calculations, and kinetics studies would be desirable.

This is a BBSRC funded post available for three years from April 2010. For any inquiries applicants should contact Dr. Mateus Webba da Silva (, and include a CV and contact details for two referees.

PhD grant: nanomaterials and solid state NMR

Nanomaterials and solid state NMR ("Brushes of Self-Assembled Nanotubes for Temperature or Stress Responsive Biocatalysis: From Structure and Dynamics to Applications"). The grant is fully integrated in the newly funded european project: IDSFunMat (International Doctoral School for Functional Materials).

Interested students have to connect to:
Deadline: february, 20, 2010.

Christian Bonhomme, Professor

-> On the website: see proposal n°12.