Dienstag, 19. Mai 2009

Postdoc fellowship: Applications of NMR in solid materials

Postdoc fellowship: Applications of NMR in solid materials

The Institute for Transuranium Elements in Karlsruhe (ITU) invites applications for a post-doctoral fellowship in the field of actinide chemistry and physics. The appointment is for 2 years, with the potential for a one year extension.
ITU is one of the seven Institutes of the Joint Research Centre, the service of the European Commission providing scientific and technical support for the conception, development, implementation, and monitoring of the European Union policies. ITU is a reference centre for basic actinide research, with a broad range of analytical capabilities for the study of nuclear materials. Major duties and responsibilities of the successful candidate will include the development of NMR spectroscopy techniques for the study of actinide compounds in the solid state, whereby structure and magnetic property determination through magic angle spinning and cryogenic methods will be deployed. The area of investigation will cover basic science applications as well as applied domains (e.g. fuels and waste forms).

The successful candidate must have a Ph.D. in Chemistry or Physics, a strong knowledge of NMR techniques, with applications in the solid state.

Candidates are invited to visit the ITU webpage http://itu.jrc.ec.europa.eu for further information and application.

Deadline for applications: 15.06.2009

For additional information please contact: Joseph Somers, +49 (0)7247 951 359.

European Commission
Joint Research Centre
Institute for Transuranium Elements
Hermann-von-Helmholtz-Platz 1
D - 76344 Eggenstein-Leopoldshafen

Research Fellow - KTP Associate in SSNMR United Kingdom

Research Fellow - KTP Associate in Solid State NMR
United Kingdom

£27,183 - £35,469 pa

You will work between the NMR group of the Physics Department at the University of Warwick and the Johnson Matthey Technology Centre, Sonning Common funded under the KTP Scheme. You will be supervised at Warwick by Prof. Mark E. Smith and John V. Hanna, and at Sonning Common by Dr T.I. Hyde and Dr P. Ash. The aim of the project is to establish a solid state NMR facility at Sonning Common that provides in-house characterisation for Johnson Matthey and complements the facilities and relationship with Warwick's Magnetic Resonance Centre. This is an excellent opportunity to play a pivotal role in developing a new facility and to develop a wide ranging research programme that has direct impact on industry.

Johnson Matthey is a speciality chemicals company focused on its core skills in catalysis, precious metals, fine chemicals and process technology, developing and selling products that enhance the quality of life for millions of people around the world. Warwick's Solid State NMR group (http://go.warwick.ac.uk/nmr/) is extremely well-equipped with 7 solid state NMR spectrometers, a very wide range of probes, a large diverse portfolio of grants and an excellent track record of collaboration with other research groups within Physics, the wider University of Warwick and beyond. The group moved into new purpose-built accommodation in April 2008. For informal enquiries please contact Mark Smith (M.E.Smith.1@warwick.ac.uk) or John V. Hanna (J.V.Hanna@warwick.ac.uk)

KTP is one of Europe's leading graduate recruitment programmes. High calibre graduates are employed to work on specific projects of strategic importance to companies, whilst being supported by a dedicated University. All graduates spend around 10% of their time in training and development and are offered the opportunity to gain a Diploma in Management. While you will be recruited by the University and work to our terms and condition of employment, your role will be based at the company. For more information, visit: www.ktponline.org.uk/greatcareeroptions

Please see the following web page for further details of the position and how to apply:

Minicom users can call +44 (0)24 7615 0554 if they require any further help.

Please quote job vacancy reference number 59975-059 in any correspondence.

The closing date/time for applications is midnight (British time) at the end of Friday 12 June 2009.

For further details on how to apply for a post at Warwick, the employee benefits that we offer, information on Warwick people, what it is like working at Warwick, and more, please see our jobs introduction page.

The university values diversity.

E-Mail: Recruit@warwick.ac.uk
Positions available at Warwick: go.warwick.ac.uk/jobs
Solid State NMR group web site: go.warwick.ac.uk/nmr

Mittwoch, 13. Mai 2009

NMR technician with a PhD degree

Dear colleagues,
We have available a position for an NMR technician with a PhD degree at the NMR laboratory of the Center of Neurosciences of the University of Coimbra.
The site below can be consulted for details:

I would like to ask you to give as much advertisement as possible to this announcement, eg. through the GERM and the AUREMN lists.

Thank you in advance for your help.
Best regards
Carlos Geraldes

Carlos F. Geraldes
Department of Biochemistry
Faculty of Science and Technology
University of Coimbra
P.O. Box 3126
3001-401 Coimbra, Portugal
Email: geraldes@bioq.uc.pt
Fax: +351 239853607
Phone: +351 239853608

PhD thesis in the NMR team of Bodenhausen/Tekely/Abergel/Duma

Ecole Normale Supérieure, Paris, France
Department of chemistry
PhD thesis in the NMR team of Bodenhausen/Tekely/Abergel/Duma

Internal motions of proteins probed by solid-state NMR under magic-angle
spinning (MAS)

In the past decades, solution-state Nuclear Magnetic Resonance (NMR)
spectroscopy in liquids has evolved to become a powerful method for
the study of internal mobility in proteins and other biomolecules,
primarily through the measurement of spin relaxation rates and
residual dipolar couplings. These allow one to probe internal motions
occurring on different time scales, from picoseconds to milliseconds.
Moreover, structural biology has demonstrated the fundamental role of
the 3D structure of proteins to understand their biological function
at a molecular level. In addition to this well documented aspect,
recent studies have shown the importance of internal dynamics for
molecular interactions. This adds a third dimension to the classical
structure/function relationships, resulting in the more complex
structure/dynamics/function relationship.

Recent progress in solid-state NMR has opened the way to
investigations of proteins in microcrystalline form. It has become
possible to determine protein structures in the solid state. In
addition, recent observations suggest that internal dynamics of
microcrystalline proteins can also be accessed. In particular,
nitrogen-15 spin relaxation rates have been measured in small
proteins. This demonstrates the existence of motional processes on
time scales that are significantly longer than those accessible by NMR
relaxation measurements in solution.

The aim of this thesis is to explore the different ways for carrying
out successfully the study of internal dynamics in micro-crystalline
proteins by solid-state NMR. The proposed topic is a natural extension
of the research developed in our laboratory, namely the study of
internal dynamics of proteins in solution by NMR, and represents a
fundamental step towards the transition to a new spectroscopy allowing
the study dynamics of those systems, which cannot crystallize or be
studied in solution, i.e. solid-state NMR. First, the candidate will
endeavour to prepare the biologically relevant samples necessary for
probing dynamics by solid-state NMR either as micro-crystals or as a
micro-crystalline precipitate. Based on promising methods that are
currently under development in our laboratory, the candidate must
participate to the implementation of new approaches to the study of
proteins in the solid state. Another objective is the application of
these new methodologies to the study of the internal dynamics of the
human protein Centrin 2 (HsCen2) in micro-crystalline form. This
proposal also aims at characterizing the internal dynamics in the
complex formed by the C-terminal domain of this protein with a target
peptide (P17-XPC). Such studies involve protein expression,
purification and crystallisation, prior to the implementation of the
solid-state NMR methodologies for probing internal dynamics. Finally,
relying on numerical methods implemented recently in the host
laboratory, the candidate will further develop and adapt the model of
Network of Coupled Rotators to predict and interpret NMR relaxation
parameters observed in solids.

This PhD project will be conducted in close collaboration with
partners at CEA and Curie Institute. Strong knowledge in
biochemistry and crystallography will be highly valued but not
mandatory. Passion and interest for the combined
experimental/numerical approaches are essential. The thesis
will be supported by a grant that has been awarded by the
French Agence Nationale de la Recherche (ANR)

Postdoctoral Position Membrane Proteins, Oxford, USA

Postdoctoral Position: Magnetic Resonance Spectroscopy of
Membrane Proteins, Miami University, Oxford, USA

A postdoctoral position is available in the area of membrane protein/structural biology in the research lab of Dr. Gary A. Lorigan. Candidates who are interested in studying the structural and dynamic properties of membrane proteins are encouraged to apply. Experience in one of the following areas is desirable: molecular biology and biochemistry, protein purification, NMR spectroscopy, and EPR spectroscopy. A 500 MHz solid-state NMR spectrometer, a X-band/Q-band pulsed EPR spectrometer for DEER experiments, and a X-band/Q-band CW-EPR spectrometer are available for this project. Please send a CV and two letters of recommendation to: Professor Gary A. Lorigan, Department of Chemistry and Biochemistry, 701 E. High St., Miami University, Oxford, OH, 45056, garylorigan@muohio.edu. A Ph.D. in Chemistry/Biochemistry or related fields is required. Contact phone is 513-529-3338. Screening of applications begins May 14, 2009 and will continue until the position is filled. Miami University is an equal opportunity/affirmative action employer with smoke-free campuses. Campus Crime and Safety Report – http://www.muohio.edu/righttoknow. Hard copy upon request.

Gary A. Lorigan
Department of Chemistry and Biochemistry
Miami University
701 E. Hight St.
Oxford, Ohio 45056

Office: 137 Hughes Laboratories
Phone: (513) 529-3338
Fax: (513) 529-5715
e-mail: garylorigan@muohio.edu
web: www.users.muohio.edu/lorigag/index.html
EPR facility: epr.muohio.edu

PHD position in Pulsed Field Gradient NMR

PHD position in Pulsed Field Gradient NMR

A PhD position is available in PFG-NMR in the Cemagref’s NMR research group. The position will focus on the investigation of tracer diffusion in protein gel assemblies. This work will be carried out in collaboration with International Food Company

Cemagref’s NMR research group is one of the European leaders in NMR and MRI applied to food processing. The main force of the research team lies on its multidisciplinary approach, integrating expertise in NMR and MRI relaxometry, in food engineering but also in signal and images analysis.

The research work develops by the Cemagref’s NMR/MRI group is focus on the understanding of the interaction between food processing and food structure and molecular mobility. MRI is a non intrusive technique that permits to obtain 2D and 3D images of a product and specific MRI methods have been developed within the research team to assess phase transition and porosity changes in cereal products such as bread. Based on the unique MRI facilities, coupled with dedicated devices (oven, freezers etc), the continuous changes during processing can be monitor in real time. Original results have been obtained on bread cooking, during freezing and proofing of fermented cereal products, during cheese ripening, and curd draining.

Furthermore, the team is leader in the study of molecular diffusion in food product. Several projects have been focus on water diffusion in order to quantify the effect of food composition and food structure on water mobility. A wide range of products have been studied from simple protein gel systems up to real and complex products such as cheese and microscopic compartmented system such a vegetable tissue. These research works have been extended to a more general approach focus on the effect of gel structure and porosity on molecular tracer diffusion.

The research group is equipped of two whole body MRI scanners at 0.2 T and 1.5 T, of two low field NMR spectrometers equipped with pulsed field gradient probe (4T/m). In addition access to a 500 MHz spectrometer equipped with a pulsed filed gradient probe (12T/m) is available in the Research Plate-form PRISM.

Income: about 1500 euros per month (this is the remaining income after removal of every taxes)

If you are interested please send a copy of your CV to


CS 64427
17 avenue de Cucillé
35044 Rennes Cedex
email : francois.mariette@cemagref.fr
site web : www.rennes.cemagref.fr

Site web PRISM http://prism.univ-rennes1.fr/index.html

postdoctoral position Marseille

A 2-year postdoctoral position is available in the Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS 6612, dir. Pr PJ. Cozzone) in Marseille, France.
The main goal of the project is to improve the non invasive characterization of the spinal cord (SC) traumatic pathologies through the assessment of structural, vascular and metabolic MR informations.
The candidate will develop and/or validate MR techniques for mouse SC investigations at very high field (11.75T) and participate to the transfer to human SC study (1.5T and 3T). He/she will be integrated in a multidisciplinary experienced team of MRI method scientists, engineers and biologists.
The candidate should possess a Ph.D. in an appropriate discipline, such as physics, biomedical engineering, or biology. Competence in MR physics, MR engineering, physiology or biology is advantageous. Experience with post-processing environments like IDL or Matlab will be necessary. Skills in pulse sequence programming would be greatly appreciated.

The position is supported by a grant from the ANR (Agence Nationale de la Recherche) and is funded from July 1st 2009 for a period of two years.
A full description of the job is available from our website: http://crmbm.univmed.fr/spip.php?rubrique6

Applications, including a CV and the names and contact details for two referees should be addressed to:
virginie.callot@univmed.fr and guillaume.duhamel@univmed.fr

Virginie CALLOT (PhD, Chargée de Recherche CNRS)
Centre de Résonance Magnétique Biologique et Médicale (CRMBM)
UMR 6612 CNRS - Faculté de Médecine
27, bd Jean Moulin
13385 Marseille Cedex 5, France

Phone: +33 491 388465 (direct) / +33 491 324469 (secr.)
Fax : + 33 491 256539

Website: http://crmbm.univmed.fr

Pulsed EPR Postdoctoral Position in Dundee

Pulsed EPR Postdoctoral Position in Dundee, Scotland
Materials Physics pulsed EPR and ENDOR position

Informal enquires contact Dr David J Keeble d.j.keeble@dundee.ac.uk

The position is to exploit state-of-the-art pulsed electron magnetic resonance methods to indentify technologically relevant point defects and impurities in materials, and to obtain insight on local atomic structure. The position is for up to 24 months. Possibilities for an extension may exist.

A PhD in physics, or chemistry, with experience of electron magnetic resonance methods (EMR), for example electron paramagnetic resonance, electron nuclear double resonance, etc, is required. Experience in pulsed EMR, and of single crystal studies, would be desirable.

The position is funded by an EPSRC Basic Technology Translation Award and will have access to EMR facilities at Dundee and St Andrews. These include a Bruker E580 9 and 35 GHz pulsed EPR/ENDOR spectrometer, a 1kW pulsed 95 GHz EPR/ENDOR spectrometer, and CW spectrometers operating at 9, 95 and 180 GHz. Materials of interest include functional oxide materials for electronic applications, for example ferroelectric and piezoelectric materials. The project may also extend to inorganic or organic semiconductor materials.

The University of Dundee is a registered Scottish charity, No: SC015096