Donnerstag, 29. April 2010

Scientist (Postdoc) with NMR and HPLC experience

Department of Pharmaceutical Biotechnology at Universität des Saarlandes, Saarbrücken:

Scientist (Postdoc) with NMR and HPLC experience

Description of the position: Using the NMR infrastructure available at Saarland University (Bruker 700 MHz NMR equipped with Cryoprobe and LC-coupling), your new job includes establishing LC-NMR methods aimed at the structural elucidation of natural products. You are about to join a multidisciplinary team with colleagues trained in chemistry, pharmacy, biology or biotechnology, contributing your skills to numerous projects. It is the primary objective of your research to conduct the de novo structure elucidation of newly discovered, complex bacterial secondary metabolites which are frequently available in low yields only. Your expert knowledge enables you to actively pursue the development and optimisation of analytical methods for that purpose.

Requirements: Degree in chemistry or pharmacy with completed PhD, ideally with an analytical focus (NMR, HPLC, MS).

Additional specifications: Besides a profound knowledge of NMR spectroscopy, liquid chromatography and mass spectrometry, the successful applicant has prior experience with the separation of complex metabolite mixtures. Furthermore, he/she has experience with studies of biosynthetic pathways and basic knowledge about feeding experiments with producers of natural products. Ideally, successful research activity since PhD completion is well-documented by publications. Fluency in scientific English, both spoken and written is essential, German language skills are appreciated but not required.

Please visit the University website for further details and refer to position "W246" when sending your application to: Prof. Dr. Rolf Müller, Pharmazeutische Biotechnologie, Campus C2 3, Postfach 15 11 50, 66041 Saarbrücken.

Link to pdf File:

Donnerstag, 22. April 2010

Scientist – NMR Spectroscopist Genentech San Francisco

Scientist – NMR Spectroscopist

We have an opportunity for a highly talented and motivated NMR spectroscopist to join
the Protein NMR Group at Genentech. The primary responsibilities of this position will be to help develop, lead, and implement NMR-based strategies to support small molecule drug discovery programs, working closely with the Biochemical Pharmacology
and Discovery Chemistry Departments, and participating directly with small molecule project teams to aid the design of new small molecule compounds.
Job responsibilities include protein sample preparation, protein characterization, hands-on NMR data acquisition and analysis, focused on assessing ligand-binding and analyzing the solution structures of proteins or protein/ligand complexes involved in modulating cell-signaling events of therapeutic interest. The protein NMR facility includes dedicated 800, 600, and 500 MHz spectrometers, Linux workstations, and access to the Central California 900 MHz spectrometer. Our NMR group complements protein expression, purification and crystallography efforts within the Structural
Biology Department.

The successful candidate will have a Ph.D and postdoctoral training in chemistry,
biochemistry or a related biophysics field, with a minimum of five years of technical
experience in areas related to protein NMR, protein biochemistry, and/or NMR in a drug discovery environment. The successful candidate will show evidence of productive, independent contributions in science, as demonstrated by a strong publication record. Knowledge and hands-on expertise in protein expression, purification, NMR sample preparation, and protein NMR spectroscopy is required; experience using automation would be a plus. He/she must also be an excellent problem-solver, have a strong work ethic, and be capable of working independently within a collaborative team setting. Strong analytical, communication, and organizational skills also required.

Genentech is dedicated to fostering an environment that is inclusive and encourages
diversity of thought, style, skills and perspective.
To learn more about our current opportunities, please visit:
and reference Req. #1000031194.
Please use “gene” when a source is requested.
Genentech is an equal opportunity employer.

Group leader position in NMR at Institut Curie

Group leader position in NMR at Institut Curie
Institut Curie, a leading biomedical research institute devoted to the understanding of normal and cancerous cells, is looking for a junior/senior group leader to join the “Integrative imaging: from molecules to organisms” Department (Institut Curie – INSERM U759). The candidate is expected to perform an independent and high quality research program to develop and apply recent NMR spectroscopy approaches including the study of non-ordered protein domains and in-cell NMR. He (she) is expected to establish collaborations with groups working on proteins complexes which form part of centrosomes or which are related with the microtubular system.
Application deadline is July 14th 2010.
Applicants should include a brief description of research accomplishments and future research plans (less than 5 pages in total), CV and names and addresses of three references to:
Dr. Sergio Marco
Institut Curie
Bat 112, Centre Universitaire
91405 Orsay, France
email :
Information about the Research Center and the Hospital are available on our website :

Post-doctoral position in membrane protein structural biology Biozentrum Basel

A postdoctoral position is available in the group of Sebastian Hiller at the Biozentrum of the University Basel, starting August 1, 2010. We are studying the structure and function of integral membrane proteins and their complexes with NMR. Our projects address fundamental biological processes of high impact. A representative example for our research is the human voltage-dependent anion channel (VDAC) (1,2).

The postdoctoral research project concerns the de novo structure determination of a membrane protein complex involved in substrate transport across membranes. We will establish the sample preparation using native-like membrane mimics and determine the structure to atomic resolution using solution and solid-state NMR. Subsequently, the functioning of the protein complex and its interactions with ligands are characterized. An integral part of our projects is the use and development of state-of-the-art biochemical and NMR techniques (3).

Interested candidates need a Ph.D. in Biochemistry, Biophysics, Structural or Molecular Biology or related fields. Expertise in at least one of the following areas is mandatory: NMR, protein biochemistry, membrane proteins, molecular biology. The successful candidate is highly motivated, creative and capable of contributing productively in a team environment. Communication skills in oral and written English are essential.

The position and the research projects are long-term funded by the Swiss National Science Foundation (SNSF). We offer an exciting and enthusiastic work environment with scientific collaborations in the institute and worldwide. The Biozentrum Basel is one of the leading biomedical research institutions in Switzerland and has recently been placed among the Top 10 international “Best Places to Work for Postdocs” by The Scientist magazine. Facilities for structural biology include 600 MHz and 800 MHz Bruker spectrometers equipped with cryogenic and magic angle spinning probes. Salary and benefits are attractive, following the guidelines of the Swiss National Science Foundation. The start date is August 1, 2010 or on mutual agreement.

Applications and informal queries about the lab and research projects should be directed by email to Sebastian Hiller. Applications should include a cover letter summarizing current and future research interests, a CV, list of publications and contact information for at least two references.

Prof. Sebastian Hiller
Biozentrum, University of Basel
Klingelbergstrasse 50/70
4056 Basel, Switzerland

Phone: +41 44 633 43 45
Fax: +41 44 632 16 21


1. Hiller S, Garces RG, Malia TJ, Orekhov VY, Colombini M and Wagner G. Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 321, 1206–1210 (2008).
2. Raschle T, Hiller S, Yu TY, Rice AJ, Walz T and Wagner G. Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J. Am. Chem. Soc. 131, 17777–17779 (2009).
3. Hiller S, Ibraghimov I, Wagner G and Orekhov VY. Coupled decomposition of four-dimensional NOESY spectra. J. Am. Chem. Soc. 131, 12970–12978 (2009).

Donnerstag, 15. April 2010

Post-doctoral position

The laboratory of Prof. Dominique Frueh in the department of Biophysics at Johns Hopkins School of Medicine offers Post-doctoral positions to investigate dynamic modular enzymatic systems related to antibiotics biosynthesis. While we use a multidisciplinary approach, Nuclear Magnetic Resonance (NMR) is our primary technique. We seek candidates with a high expertise in protein production and purification and with an interest in learning advanced biomolecular NMR techniques. The post-doctorant will benefit from our strong expertise in NMR (both applied and theoretical) and from a comfortable setup at Johns Hopkins University (800 MHz, four 600 MHz, two 500 MHz and current expansion in progress). In addition, the laboratory has access to new state-of-the-art wetlab equipment and benefits from the collegial and dynamic framework of the Johns Hopkins Medical Institute. No prior knowledge of NMR is required but a strong motivation to learn the technique is necessary and complete independence in the wetlab is expected.

Outstanding benefits are offered and international candidates are welcomed (see note below)

See also

Interested candidates should submit a CV and a cover letter as well as two letters of references (or contact information) to:

Applications from all countries will be considered but applicants that can arrange for an interview (in one form or another) will be preferred.

Research Assistant / Associate

Research Assistant / Associate in NMR Spectroscopy
The University of Manchester - School of Chemistry
Closing date: 27/04/2010

Reference: EPS/10204

Applications are invited for an EPSRC Research Associate to work with Dr
Mathias Nilsson and Professor Gareth Morris on the development of
techniques in diffusion-ordered NMR spectroscopy (DOSY). The project
will combine high quality NMR measurements using world-class facilities
in the School of Chemistry, theoretical analysis, pulse sequence
development, and multivariate analysis, and offers an excellent
opportunity for a suitable candidate to build a wide NMR skill set.The
successful candidate will implement, analyse, evaluate and apply a range
of new NMR experiments in the field of matrix-assisted DOSY, working
closely with Dr. Nilsson, Prof. Morris and other members of the research
group. Equipment available includes Bruker and Varian spectrometers at
300, 400, 500 MHz field strengths.The appointee will have, or be about
to obtain, a doctoral degree in a relevant subject (e.g. Chemistry,
Physics, Engineering, Computer Science). They should possess good
written and oral communication skills, the ability to function
efficiently as part of a team, and experience in and understanding of
some or all of:

* NMR methods, especially DOSY and others involving pulsed field
* Software for NMR data processing
* NMR spectrometer hardware
* Surface chemistry/chemical interactions
* Unix and C programming
* Mathematica and Matlab programming

The position is available from 1 May 2010 for up to 36 months.


£28,983 - £35,646 p.a.

Further particulars:

Informal enquiries

Dr. Mathias Nilsson.
Tel: + 44 (0) 161 306 4465


Professor Gareth Morris
Tel: + 44 (0) 161 275 4665



The CEISAM laboratory (UMR 6230, CNRS-University of Nantes), located in Nantes, France, is recruiting a highly motivated student for a 3-years PhD position. Subject: "Methodological developments in ultrafast 2D NMR for metabolic studies". Financial support from the French Ministry of Research or from the French National Research Agency (ANR) is expected.

2D NMR is a powerful analytical tool, widely used in chemistry, biochemistry or for biomedical applications. However, its use for quantitative studies is limited by long acquisition durations that characterize this methodology. A so-called “ultrafast” methodology was recently proposed1 to record a full 2D spectrum in a single scan and in a fraction of a second. Our group is one of the world’s leading teams for developing this novel and promising methodology. We have recently shown that it could be used for quantitative purposes with an excellent precision2 . However, further development is necessary to make it suitable for studying complex metabolic mixtures.

The recruited candidate will develop ultrafast 2D NMR methods to improve their performances for studying complex samples. The methodology will be evaluated for a variety of applications such as chemical or microbiological kinetic studies, and metabolic applications. The student will be encouraged to present his/her results in national and international conferences.

Prospective PhD candidates must hold a Master degree in Physical Chemistry, Chemical Physics or Analytical Chemistry and have solid knowledge in NMR. A previous experience in experimental NMR and/or programming will be a plus. The candidates should be highly motivated and show an aptitude to work independently.


Patrick Giraudeau (
Serge Akoka (
CEISAM, Bât. 9, Faculté des Sciences et des Techniques – BP 92208
2 rue de la Houssinière 44322 Nantes Cedex 3

Tel : /

Références :

1. L. Frydman, T. Scherf, A. Lupulescu, Prod. Natl. Acad. Sci. USA 99 (2002) 15858-15862.
2. P. Giraudeau, G.S. Remaud, S. Akoka, Anal. Chem. 81 (2009) 479-484.

Assistant Professor Position

Assistant Professor, Tenure Track
The University of British Columbia
Department of Biochemistry and Molecular Biology

The Department of Biochemistry and Molecular Biology at the
University of British Columbia is seeking an outstanding new
investigator for a full time tenure track faculty position, at the rank of
Assistant Professor. Candidates must have a Ph.D. degree, a minimum
of 2 years postdoctoral research experience, and a record of
accomplishment that demonstrates their potential as an independent
researcher and teacher. Candidates with research and teaching interests
in any area of contemporary Biochemistry or Molecular Biology are
encouraged to apply. All members of the Department maintain active,
well-funded research programs that encompass many areas of modern
biochemistry, molecular and structural biology. Successful candidates
should complement and extend the Department's expertise in research
and education. Applicants should send their curriculum vitae, a record
of teaching effectiveness, 3-4 relevant reprints and a brief (2-3 page)
outline of their proposed research program to:

Irene Ho, Secretary to the Department Head
Department of Biochemistry and Molecular Biology
Faculty of Medicine
The University of British Columbia
2350 Health Sciences Mall
Vancouver, BC V6T 1Z3 Canada

Applicants should also arrange for 3 letters of reference to be sent to the
above address. The deadline for applications is May 31, 2010. The
anticipated start date is July 1, 2010 and is negotiable. Salary will be
commensurate with qualifications and experience.

UBC hires on the basis of merit and is committed to employment equity.
All qualified persons are encouraged to apply. UBC is strongly
committed to diversity within its community and especially welcomes
applications from visible minority group members, women, Aboriginal
persons, persons with disabilities, persons of any sexual orientation or
gender identity, and others who may contribute to the further
diversification of ideas. However, Canadian and permanent residents of
Canada will be given priority.

Postdoctoral scientist position dynamic NMR/structural biology

A postdoctoral position in NMR/protein crystallography is available immediately
in the laboratory of Dr. Michelle Krogsgaard at the Department of Pathology and
NYU Cancer Institute, NYU Medical School in New York to study the biophysical
basis of T-cell receptor recognition of self-antigens (Krogsgaard et al., Mol
Cell, 2003; Krogsgaard et al., Nature, 2005; Krogsgaard and Davis, NI, 2005).

Interested candidates should have a recent Ph.D. in biochemistry, biophysics,
bioengineering or related fields. Experience in molecular biology, protein
purification, and dynamic NMR structure analysis is ABSOLUTELY MANDATORY. Some
experience in X-ray crystallography would be a significant plus. The successful
candidate is expected to be highly motivated, creative and capable of
contributing productively in a team environment. Excellent publication record
and communication skills in oral and written English are essential.

The laboratory is located in the Smilow Research Center: , a new 13-story building with excellent
research facilities on the NYU Medical School Campus located in mid-town

Salary and benefits will be commensurate with experience. Interested applicants
should forward a cover letter summarizing current and future research interests
related to the laboratory’s research interest (max 1 page), curriculum vitae,
list of publications, and the names, telephone numbers and e-mail addresses of
three references by e-mail to:

Michelle Krogsgaard, Ph.D
NYU Cancer Institute and Department of Pathology
NYU School of Medicine, New York
phone: 212 263 9266