Dienstag, 20. Oktober 2009

VACANCY for one NMR physicist or chemist

VACANCY for one NMR physicist or chemist at Invento Srl.

- POSITION: This is a fulltime, one-year initial position with the possibility
to be extended.
- THE SALARY offered is adequate and dependent on the experience and skills of
the candidate.
- LOCATION: Invento S.r.l. at Molecular Imaging Center of the University of
Turin – Italy

Invento is a new growing NMR research company focusing on the development of
novel analytical procedures for the characterization of complex matrix in the
field of Biomedicine Food and Material science.

Invento is partner in a large research project to develop new hyperpolarisation
methods and compounds to be applied in MRI. We are currently looking to recruit
one NMR physicist or chemist with strong NMR backgrounds and expertise to join
and work in our research group.

Strong problem solving mindset, awareness and willingness to work in a small
multidisciplinary team as well as the capability to work independently with
the minimum supervision is required for this position.

Research activities at INVENTO( www.invento-lab.com )are carried out in modern
laboratories based the new Molecular Imaging Centre of University of
Torino,( http://www.cim.unito.it/research.html ) with facilities for the
following Instruments & Equipments: High resolution NMR and solid state NMR
spectrometers, Fast Field Cycling NMR relaxometer, IR with Imaging, ICP-MS,
SEM (Scanning Electron Microscope), TEM (Transmission Electron Microscope),
UV-VIS Spectrometer, Mass Spectrometer, Analytical and preparative HPLC.

Main R&D activities will be carried out in strict collaboration with research
team of Prof. Aime ( silvio.aime@unito.it )

- Degree or equivalent in Chemistry or Physics
- a PhD in NMR Spectroscopy is welcome.
- Experience in the design of NMR sequences and new protocols and
methodologies for structure determination and analysis.
- Organizational and time management skills.
- Capability to work under pressure, independently with minimal supervision to
meet deadlines.
- Fluent in English.

If you are interested in applying for this role and feel you can be a candidate
please email your CV in PDF format to( info@invento-lab.com ).
When possible the candidate should arrange to have one letter of recommendation
to be sent along with curriculum vitae, and a list of publications.

Montag, 12. Oktober 2009

1 Year post-doctoral position in Grenoble

CERMAV is a research institute devoted to the study of oligo- and polysaccharides, from their biological role to structural analysis. The "glycomaterials" group is specialised in the investigation of crystalline polysaccharides with a great number of tools like Electron Microscopy, X-Ray diffraction or solid state NMR. We offer a post-doc position opened for 1 year funded by an ANR program that groups several research groups in Grenoble and Toulouse.

The objective of the project is to understand the role of chitooligosaccharides (COs) present in the cell wall of pathogenic fungi Aphanomyces euteiches. that causes severe damage in legume crops. These COs are essential for cell wall integrity and are exposed at the cell surface. The nature of the amorphous and crystalline cell wall polysaccharides, their
structural and functional links accounting for cell wall physical properties and integrity, and
the nature of the exposed chitosaccharides, remain to be determined.

In that context, the role of our group is to set-up a purification procedure by preparative chromatography and to achieve structural studies, mainly by liquid and solid state NMR, but most probably combined with Electron Microscopy studies. In order to have the most precise information, 2D-NMR will be performed on the crude cell wall after an isotopic labelling that will be done by the biologists group in Toulouse.

The candidate should be a biophysicist, a chemist or a biochemist that have a PhD, in which he (she) has extensively used modern NMR techniques. Knowledge in biochemistry will be appreciated but is not mandatory. Solid state NMR could be learned during the post-doc.

Send a CV and a short cover letter to Laurent Heux, heux@cermav.cnrs.fr, please type the reference number in the title.

Freitag, 9. Oktober 2009

postdoctoral position in Orleans

Postdoctoral position in CEMHTI, CNRS Orleans, France. “PFG NMR in molten inorganic salts at high temperature”.

A postdoctoral position is immediately available in our laboratory. We are looking for a highly motivated Ph.D. researcher with a good expertise in NMR spectroscopy and strong experimental skills. He will have to participate to the development of PFG NMR measurements in a wide range of molten inorganic salts including fluorides, oxifluorides and oxides at high temperature. He will take benefit of the long experience of the CEMHTI laboratory in the development of NMR experiments at high temperature using laser heating.

The CEMHTI laboratory is mainly involved in experimental study of solid and liquid materials from room temperature to very high temperature (3000°C). Thanks to specific experimental developments we are able to investigate in situ by NMR the structure and the dynamics of inorganic melts such as molten fluorides, chlorides or oxides. The facilities available in our laboratory include NMR wide bore spectrometers at standard fields (300 and 400Mhz) and very high field (750Mhz), all adapted for high temperature experiments.

CV, letter of motivation as well as the contact details of at least 2 references should be directed to Dr C.Bessada : Catherine.bessada@cnrs-orleans.fr

Catherine BESSADA
1D avenue de la Recherche Scientifique
45071 Orléans cedex 2
Tel: +33 (0) 2 38 25 55 09
Fax: +33 (0) 2 38 63 81 03
Mob: +33 (0) 6 10 34 33 53
Email : catherine.bessada@cnrs-orleans.fr



Position: Permanent contract
Location: Manchester city centre, UK
Application Deadline: 20th November 2009
Salary: £20,000 - £35,000 GBP / annum + potential for share options, dependent on experience

Conformetrix is a rapidly growing biotechnology company with a focus on ligand-based drug discovery. We are currently looking to recruit solution-state NMR spectroscopists with strong chemistry backgrounds to join our successful R&D team.

The chief activity is the 4D-structure determination of small flexible molecules from NMR data using Conformetrix’s proprietary software tools. These structures provide the crucial structural data that enables truly rational ligand-based drug design to be realised, both for our in-house discovery programs and for our clients. Problem solving and an analytical mindset are very much required in this role, as is a willingness to work in a small multidisciplinary team.

The successful candidate(s) will be expected to have the ability to deliver high quality and precise results to tight deadlines with minimal supervision, and possess strong analytical and communication skills.

1. Determination of the 4D-structures of small flexible molecules from NMR data, which involves:
-NMR sample preparation
-Recording and processing of NMR spectra
-Analysis using Conformetrix’s proprietary software tools
2. Using the 4D-structures with the R&D team to identify and improve hit and lead drug molecules in our in-house discovery programs
3. Innovation of new protocols and methodologies for structure determination and analysis
4. Preparation of written reports and technical documentation packages on projects under guidance of supervisor

-Degree or equivalent in Chemistry (or Chemistry-based subject) is essential
-PhD in solution-state NMR is also essential, preferably with experience of small (<2000 Da) organic molecules.
-Good computer literacy is essential. In particular, familiarity with Unix and molecular visualisation software would be advantageous.
-Experience of chemical shift assignment and (protein) structure calculations is desirable.
-Practical experience of Bruker NMR equipment.

-Learn quickly and work independently with minimal supervision.
-Good organisational and time management skills.
-Flexible and able to change priorities at short notice.
-Able to work under pressure and meet deadlines.
-Excellent word-processing and presentation skills.
-Fluent in English and able to communicate results effectively.

-CSO to agree program of work
-CEO for training and professional development support
-Liaising with all members of the R&D team
-Liaise with R&D team and outside scientists to develop knowledge base and discuss ideas

Open To: Applicants must be eligible to work in the specified location
Posted Date: 08/10/2009
Reference: C4X-NMR02

If you are interested in applying for this role and feel that you have the appropriate experience, then please call Gordon Barker on 0161 606 7203 or email your CV in PDF format to: gordon.barker@conformetrix.com

Please check out our website for further information: www.conformetrix.com

Postdoctoral fellow RNA structural biology

A postdoctoral position is available immediately in the lab of Dr. Blanton S. Tolbert of the Department of Chemistry and Biochemistry at Miami University of Ohio. The position involves structural and biophysical studies of RNA and protein-RNA complexes involved in regulation of alternative splicing. Ideal candidates should have demonstrated experience in one or more of the following fields: multi-dimensional solution NMR spectroscopy, EPR spectroscopy, molecular biology, or protein/RNA biophysical chemistry. A PhD in Chemistry/Biochemistry or related field is required.

The Department of Chemistry and Biochemistry at Miami University is equipped with solution NMR spectrometers operating at 850, 600, and 500 MHz frequencies, along with facilities for single crystal biomolecular x-ray diffraction, pulsed and constant wave EPR spectroscopy. In addition, the PI has an Isothermal Titration Calorimeter in the lab for routine biomolecular thermodynamic studies. This is a fulltime, one-year position with the possibility to extend to two years. All interested candidates should arrange to have two letters of recommendation, curriculum vitae, and a list of publications sent to: Dr. Blanton S. Tolbert, Department of Chemistry and Biochemistry, 701 E. High Street, Miami University, Oxford, OH 45056. Interested candidates may contact the PI at tolberbs@muohio.edu or by phone at 513-529-8072. Screening of the applications will began immediately and will continue until the position is filled. Miami is an equal opportunity/affirmative action employer. Applications from women and members from underrepresented groups are strongly encouraged to apply.

Mittwoch, 7. Oktober 2009

Postdoctoral Position in Protein NMR Spectroscopy

The Protein NMR research group of Dr. Lars T. Kuhn at the DFG Research Center for Molecular Physiology of the Brain (www.cmpb.de) and the Cluster of Excellence ‘Microscopy at the Nanometer Range’ of the University of Göttingen (Germany) is offering a "Postdoctoral Position in Protein NMR Spectroscopy" starting from 1 January 2010 for initially one year and nine months with an optional extension for another two to three years at the end of the first period.

The research of the prospective candidate will mainly focus on the characterization and the dynamic behaviour of the structures of native and non-native states of proteins that are involved in the generation of neurodegenerative diseases. Furthermore, our group undertakes the analysis of biologically active peptides and small model systems, with emphasis on determining their different conformations under changing experimentel conditions together with their folding behaviour. For these purposes, NMR spectroscopy and complementary techniques for the identification of structural elements (e.g. CD polarimetry) are being employed. The protein NMR facility includes dedicated state-of-the-art ‘high field’ NMR spectrometers at the Max Planck Institute for Biophysical Chemistry (Göttingen) (www.mpibpc.gwdg.de) in the laboratory of Prof. Dr. Christian Griesinger and fully equipped biochemistry ‘wet lab’ facilities for protein expression and purification.

A highly motivated researcher with a Ph.D. in biochemistry/structural biology or a related discipline, with evidence of productive, independent contributions in science, as demonstrated by a strong publication record, will be the preferred candidate for this position. The applicant should be familiar with the principles and practice of protein NMR spectroscopy and protein structure determination. Previous experience with protein expression and purification is not required but will be considered favourably if at hand. As the group’s working philosophy supports independent thinking, successful candidates will be encouraged to develop their own ideas and research objectives within the framework of the group’s field of research. Applications should include a meaningful CV together with the names/electronic mail addresses of three referees and should be sent to Dr. Lars T. Kuhn (e-mail: lars.kuhn@gwdg.de).

Freitag, 2. Oktober 2009

Postdoc in solid-state NMR, Ames Lab

Dear Colleague,

If anyone in your group is looking for a postdoctoral position, one is
immediately available in my laboratory. The purpose is to attract a
highly motivated Ph.D. researcher with expertise in solid-state NMR who
has the potential to become full time scientific staff at Ames Lab. Our
research involves development and applications of solid state NMR
methods to the studies of new types of mesoporous heterogeneous
catalysts and other materials. For description of research see the
following website:


I'd be glad to provide the interested candidates with information about
our most recent research and future plans. The start date is flexible,
but we would like to fill the position by the end of 2009.

Marek Pruski

Tel : 515-294-2017
Email : mpruski@iastate.edu