Samstag, 26. Juni 2010

Postdoctoral research position in Gothenburg, Sweden

*Postdoctoral Research Position within Solution NMR Spectroscopy is available at the Department of Chemistry, University of Gothenburg, Sweden*

We are seeking an experienced and highly motivated postdoctoral associate with a solid background in solution NMR spectroscopy to join our group. The position is funded by the European Research Council and is offered for two years, including a three months probationary employment, with possibility for extension.

*Research project:*
The successful candidate will work on several subprojects of a multidisciplinary investigation focusing on understanding the role and behaviour of very weak chemical interactions in solution and in biological contexts. Our collaborative project employs a wide range of synthetic, computational and spectroscopic as well as molecular biological techniques and attempts to reach an improved understanding of a protein-ligand interaction-mediated human disease.
The primary responsibility of the successful applicant will be the investigation of protein-ligand interactions. In addition, the postdoctoral associate will be involved/co-supervise the small molecular NMR studies related to further subprojects run in our group. Direct involvement in protein expression and in electrophysiological studies is also possible.

*Required qualifications:*
The successful candidate should hold a Ph.D. in chemistry/biochemistry/biophysics or a related field and have complete her/his thesis defense by September, 2010. Experience with protein NMR spectroscopy is a requirement. The applicant must have already solved solution structures of proteins, having published at least one first-author manuscript describing the atomic structure of a protein or a protein-ligand complex. Familiarity with paramagnetic NMR, RDC-based structure elucidation and small molecular NMR techniques is seen as a strong merit. Good publication record, fluency in English, high motivation and excellent social competence as well as ability to learn new techniques are expected. Experience in molecular biology, computation or synthetic organic chemistry will be beneficial.

*Expected Starting date: *September-December 2010.

*For additional information please contact:*
Mate Erdelyi (+46-31-7869033; mate@chem.gu.se; http://halogenbond.weebly.com)

*Application:*
The application should be sent as a pdf file, marked with the announcement code “HALO-03” and should enclose a (1) cover letter, in which the applicant describes his/her research interests as well as his/her career vision, a (2) Curriculum Vitae, a (3) list of publications, a (4) copy of official Ph.D. transcript, and (5) the full contact addresses of two references.
Application deadline: July 25, 2010.

--
Mate Erdelyi
Assistant Professor
Department of Chemistry, University of Gothenburg
Kemigården 4, Office 8071,SE-412 96 Göteborg, Sweden
Tel + 46 31 786 9033, FAX: +46 31 772 3840
E-mail: mate@chem.gu.se

postdoctoral position in London

Postdoctoral Research Position is available in Annalisa Pastore's group at
the Molecular Division of the National Institute for Medical Research,
Mill Hill, London

We are seeking an experienced and highly motivated postdoctoral fellow
with a solid background in Structural Biology. The position is funded by a
EU grant (EFACTS) and is offered for three years, with possibility for an
extension up to 11 additional months.

Research project: The successful candidate will work on a project
focusing on understanding the primary function of frataxin, the protein
responsible for Friedreich's ataxia. The project requires collaborative
effords and the use of a wide range of structural, computational and
spectroscopic as well as molecular biological techniques and attempts to
reach an improved understanding of the role of frataxin in iron-sulfur
cluster biogenesis and in disease. The primary responsibility of the
successful applicant will be the investigation of the interactions between
frataxin and components of the iron-sulfur cluster machinery.

Required qualifications: The successful candidate should hold a Ph.D. in
chemistry/biochemistry/biophysics or a related field and have complete
her/his thesis defense by July, 2010. Experience with protein NMR
spectroscopy and/or crystallography is a requirement. The applicant must
have already solved structures of proteins and published at least one
first-author manuscript describing the atomic structure of a protein or a
protein-ligand complex. Knowledge of enzymology is considered a merit.
Good publication record, fluency in English, high motivation and excellent
social competence as well as ability to learn new techniques are expected.
Experience in molecular biology and computation chemistry will be
beneficial.

Expected Starting date: September-October 2010.

For additional information please contact: Annalisa Pastore
(+44-20-88162630; apastor@nimr.mrc.ac.uk)

Application: The application should be submitted to the NIMR website. It
should include: (1) cover letter, in which the applicant describes his/her
research interests as well as his/her career vision, a (2) Curriculum
Vitae, a (3) list of publications, a (4) copy of official Ph.D.
transcript, and (5) the full contact addresses of two references.
Application deadline: July 5, 2010.

Macromolecular NMR Spectroscopist

The Structural Biophysics Laboratory, National Cancer Institute is seeking the support of a Macromolecular NMR spectroscopist who will work with and support the PIs in the Structural Biophysics Laboratory (SBL) For info on the SBL visit: [ http://go.cancer.gov/sbljobs]. The position will be hired by the SAIC-Frederick and dedicated to the SBL.

The Scientist II will work with and support principal investigators in the Structural Biophysics Laboratory (SBL) in the determination of biological macromolecular structures using high-field NMR (500-850 MHz Varian and /or Bruker systems). The Scientist II will also work with an NMR engineer to trouble shoot and resolve instrumental issues. The duties in this position include, but are not limited to: Training and assisting users in operation of sophisticated multi-dimensional macromolecular NMR experiments; Maintenance and development of experimental protocols (either as implementation of published methods or development of new methods, with opportunity to collaborate with scientists within the SBL); General instrument oversight, including scheduling and supervision of cryogen and magnet maintenance; and Cooperation with an on-site NMR engineer for trouble shooting and problem resolution. This position is located in Frederick, Maryland.

REQUIRED SKILLS: Possession of Doctoral degree from an accredited college or university appropriate to biomedical research, or eight (8) years related experience in lieu of degree. Doctoral degree with postdoctoral experience in macromolecular nuclear magnetic resonance (NMR) is preferred. In addition to educational requirements, two (2) years of post doctoral education experience in NMR maintenance and application. Experience and expertise with current Varian and Bruker systems/software is essential. The ability to work in a highly interactive setting with a number of different investigators is critical.

DESIRED SKILLS: Background and expertise in the development and application of multi-dimensional biological NMR spectroscopy, both in the determination of protein and DNA structures. Proficiency in NMR engineering is also desirable. The ability to prepare and submit scientific manuscripts is highly desirable.

Interested applicants should visit the SAIC-Frederick website for more information.
https://cp-its-rmprd.saic.com/MAIN/careerportal/ and search for Job Posting No. 177172.

Attendees at the 2010 EUROMAR may contact R. Andrew Byrd for discussions of this position.

===============================================
R. Andrew Byrd 301-846-1407
Dir., Molecular Discovery Program
Chief, Structural Biophysics Laboratory FAX 301-846-6231
Macromolecular NMR byrdra@mail.nih.gov
http://ccr.cancer.gov/resources/sbl/

Center for Cancer Research
National Cancer Institute-Frederick
P.O. Box B, Bldg. 538
Frederick, MD 21702-1201
===============================================

Donnerstag, 17. Juni 2010

Dear colleagues

A one-year renewable postdoctoral position is currently available at the Saclay Institute of Matter and Radiation (IRAMIS), at CEA-Saclay, near Paris.

Please find herein the announcement.
Gaspard Huber


Towards a better understanding of gases encapsulation in cage-molecules
by NMR and computational chemistry approaches

Dissolved gases are of great importance in various fields of biology (e.g. oxygen, carbon dioxide), medicine (e.g. hyperpolarized 129Xe for MRI applications) and the environmental sciences (e.g. green house gas emission like methane or carbon dioxide). The laboratory is involved in a project that aims at a better understanding of hydrophobic interactions of dissolved gases in water through their encapsulation in synthetic cage-molecules. Only a few empirical rules governing the reversible gas receptor interactions are admitted and very little theoretical works have been reported in the literature. In this context, a one-year renewable postdoctoral position is available at CEA/IRAMIS in Saclay (France, near Paris) under the supervision of Gaspard HUBER, Patrick BERTHAULT and Jean-Pierre DOGNON.

The post-doctoral fellow will be involved in two joined aspects. First, he/she will have to devise and perform experiments designed to acquire reliable kinetic and thermodynamic data using liquid NMR spectroscopy, for various gases (e.g. small alkanes and noble gases) and cage-molecules (varying size, shape, electronegativity, steric hindrance within two cage-molecule families : cryptophanes and cucurbiturils). Second, he/she will be involved in a computational chemistry approach, mandatory for the interpretation of NMR results. Both aspects should result in the formulation of new laws on gases complexation. The candidate will also strongly interact with organic chemists, our partners in the project.

The candidate should have a solid background in chemistry and good skills in liquid NMR spectroscopy. An experience in computational chemistry would be greatly appreciated. Knowledge in statistics, useful for the determination of experimental errors, would be valuable, as well as an experience in gas handling.

Applicants can have any nationality. The position can start from October 2010. The monthly salary is ca. 2200 € (before tax). Interested candidates should send a CV and two recommendation letters to gaspard.huber@cea.fr.


SIS2M – UMR CEA-CNRS 3299, PC n°9
Commissariat à l'Energie Atomique – IRAMIS
91191 Gif sur Yvette Cedex, France.
Tél. : +33 (0)1 69 08 64 82 -Fax. +33 (0)1 69 08 98 06
gaspard.huber@cea.fr - http://iramis.cea.fr/sis2m/

Mittwoch, 16. Juni 2010

Post Doc Paris

A post-doctoral position is available at the Laboratoire de Chimie de la Matiere Condensee of the Universite Pierre et Marie Curie in Paris, France.

Research project : Caracterisation of interface and diffusion in "host-guest" systems by 129Xe-NMR and by pulsed field gradients NMR

Novel systems for guidance and vectorization of functional molecules have been under extensive development during the last decades and have lead in particular to imagine systems of encapsulation, such as MCM silicas. The main objective of this project is to obtain, by NMR, information on the dynamics of molecules, their distribution in the porous space, and in particular a better understanding of the nature of the physico-chemical interactions between the porous network and these molecules. Hyperpolarised Xenon NMR will constitute the major experimental technique, using in particular 2D exchange spectroscopy (EXSY) 129Xe NMR and polarization transfer experiments.
Another approach for a better understanding of the mobility of the organic phase would be the application of pulsed field gradients NMR to these systems in order to measure the diffusion coefficients of the encapsulated molecules. However the slow movements and largely anisotropic environment constitute a challenge that can be both overcome by the combination of large field gradients and magic angle spinning of the sample.

Profile : Ideally the candidate should have experience in either xenon or PFG NMR but solid state spectroscopists are encouraged to apply.
Duration : 1 year
Starting date : November 2010
Net income : 2000 €/month
Contacts : send a detailed CV and two recommandation letters to Flavien Guenneau (flavien.guenneau@upmc.fr) and Thierry Azais (thierry.azais@upmc.fr)

postdoctoral position Amherst

An NIH-funded postdoctoral position is available immediately to join a project investigating the mechanism of transmembrane signaling in bacterial chemotaxis receptors.

The successful applicant will apply solid-state NMR, combined with other biophysical, biochemical, and molecular biology approaches, to membrane-bound signaling arrays of bacterial chemotaxis proteins (eg Fowler, D. J.; Weis, R. M.; Thompson, L. K. Biochemistry 2010, 49, 1425. http://pubs.acs.org/doi/abs/10.1021/bi901565k).

Individuals with a PhD, relevant experience in NMR and other biophysical/biochemical studies, and strong interest in membrane proteins should email a CV and 3 letters of recommendation to Prof. Lynmarie K. Thompson, thompson@chem.umass.edu.


Lynmarie K Thompson, PhD
Associate Professor
Department of Chemistry, 701 LGRT
University of Massachusetts
710 North Pleasant St.
Amherst, MA 01003-9336

Voice: 413-545-0827
FAX: 413-545-4490
E-Mail: thompson@chem.umass.edu
http://people.chem.umass.edu/thompson/

Director, Chemistry Biology Interface Training Program
http://www.umass.edu/cbi/

Chemistry: http://www.chem.umass.edu/
Molecular and Cellular Biology: http://www.bio.umass.edu/mcb/

Instrumentation Facility Manager

Instrumentation Facility Manager

Miami University

Applications are invited for a full-time instrumentation facility manager in the Department of Chemistry and Biochemistry at Miami University, Oxford, OH. Job Description: manage, administer, instruct, train, and maintain an instrumentation facility for NMR researchers. The department has several NMR spectrometers operating up to 850 MHz and several MS instruments. Requirements: Ph.D. in Chemistry or a related field, with expertise in the area of NMR spectroscopy and/or mass spectrometry. The applicant will work under the supervision of the chair of the department. Preference will be given to those with previous instrumentation facility experience. Please send your CV and three letters of recommendation to: Professor Gary A. Lorigan, Dept. of Chemistry and Biochemistry, Miami University, Oxford, OH, 45056. Review of complete applications will begin July 15, 2010. The search will continue until the position is filled. Miami is an EOE/AA employer. Campus Crime and Safety Report is available at –www.muohio.edu/righttoknow. A hard copy is available upon request.

Gary A. Lorigan
Volwiler Distinguished Research Professor
Department of Chemistry and Biochemistry
Miami University
701 E. High St.
Oxford, Ohio 45056

Office: 137 Hughes Laboratories
Phone: (513) 529-3338
Fax: (513) 529-5715
e-mail: garylorigan@muohio.edu
web: www.users.muohio.edu/lorigag/index.html
EPR facility: epr.muohio.edu

PhD position in solid-state DNP/NMR

A three-years PhD position in solid-state DNP/NMR is available in the group of Prof. J.-P. Amoureux, University of Lille, Lille, France. It will start preferably in October 2010.

The project: The Ph.D. project aims to develop a new technique for the characterization of materials : the Dynamic Nuclear Polarization (DNP) for solid-state samples at high magnetic field. Recently the group of R. G. Griffin at MIT demonstrated that this technique is feasible at high magnetic field (9.4 T) and increases the sensitivity of nuclear magnetic resonance (NMR) by a factor of 100. Such a gain in sensitivity provided by DNP paves the way for new applications of solid-state NMR. The objectives of this Ph.D. are to study and show the potential of DNP for the characterization of important materials, such as heterogeneous catalysts used for the biofuel production. The Ph.D. will consist in preparing the catalyst samples containing paramagnetic agents, characterizing them by electronic paramagnetic resonance (EPR) and NMR spectroscopies and performing DNP experiments for such materials. The project is a collaboration between the university of Lille and Bruker company.

Facilities: Facilities for solid-state NMR spectroscopy has five superconducting magnets, ranging from 900 MHz (proton Larmor frequency) to 100 MHz. Over 20 probes enable solid-state NMR to be performed with different rotor diameters, from 1.3 mm to 7 mm. The 1.3 mm rotor can rotate at up to 70 kHz. Lille is a pleasant city situated in the heart of Europe (30 min from Brussels, 1 h from Paris, 1h from London by train). The university of Lille combines research groups with strong expertise in NMR and EPR spectroscopy as well as catalysis and material science. In particular, it is the coordinator of European project for designing next-generation bio-refinery.

The person: We seek application from national and international students who have graduated in physics or chemistry, preferably with a background in NMR. The successful applicant will be given the opportunity to work in an exciting environment with national and international collaborations.

Remuneration: The studentship includes a stipend of 20 118 € per year with health insurance and language training allowance.

Contact: Applications and informal queries about the lab and research projects should be directed by email to Jean-Paul Amoureux or Olivier Lafon. Applications should include a cover letter, a CV and contact information for two references.

Prof. Jean-Paul Amoureux

Department of chemical engineering
University of Lille
F-59652, Villeneuve d'Ascq, Cedex, France

Tel : 33 3 20 43 41 43 Fax : 33 3 20 43 68 14
email : jean-paul.amoureux@univ-lille1.fr
Dr. Olivier Lafon

email : olivier.lafon@ensc-lille.fr
webpage adress : http://uccs.univ-lille1.fr/spip.php?article199.fr

Analytical Instrumentation Facility Manager

University of North Florida, Department of Chemistry

Analytical Instrumentation Facility Manager (PhD analytical/physical chemistry)-- Search Re-opened

http://www.unf.edu/coas/chemistry/

Responsibilities include maintenance and upkeep of the departmental 500 MHz Varian NMR as well as other major instrumentation (both current and future acquisitions) in the Chemistry Department, training faculty and students, providing expertise to faculty and students in utilizing major instrumentation in research and their implementation in instruction, offering service to other departments at UNF and to the outside (academia and industry). Opportunities for collaborative research are available and strongly encouraged.

Anticipated start date: 9/1/2010 or earlier

Contact Chemistry Department Chairperson: kenneth.laali@UNF.edu

Kenneth K. Laali
Professor and Chair
Department of Chemistry
University of North Florida
Science and Engineering Building
1 UNF Drive, Jacksonville, FL 32224
USA
E-mail: Kenneth.Laali@UNF.edu
FAX: 904-620-3535
Tel: 904-620-1503