Donnerstag, 26. März 2009

Professor at Rennes

Professor at Rennes : molecular modeling, NMR constraints


The candidate will join the NMR - Interactions Lipides
Protéines team belonging to the CNRS UMR 6026. The research team area
focuses on structural modifications of peptide or protein interacting
with model membranes such as micelles or liposomes of various lipidic
compositions. The team is responsible of the NMR part of a magnetic
resonance platform of the University of Rennes and is involved in
structural studies of proteins by NMR.

The candidate will contribute to develop the use of molecular
modeling using NMR constraints. Interest and competence in studies in
lipidic environment is welcome.

Contact :
Equipe RMN-ILP, UMR CNRS 6026
Université de Rennes 1, Campus de Villejean
CS 34317, 35043 Rennes cedex
Tel : (0)2 23 23 65 61
Email :

Dienstag, 24. März 2009

Un poste de MCF l'Université de Versailles

Un poste de MCF est ouvert à l'Université de Versailles dans le groupe Tectospin de l'Institut Lavoisier de Versailles.

Description du poste:
MCF, N0 0807 Section CNU 33

Profil : Détermination structurale, RMN et Matériaux Nanoporeux.
Le candidat assurera des enseignements de chimie générale et inorganique et de spectroscopies en licence et en master Sciences et Technologies de l'université de Versailles-Saint-Quentin-en-Yvelines dans le cadre des enseignements généraux et/ou professionnels. Il lui sera également demandé de participer aux enseignements de la première année de préparation au concours des études médicales.
La recherche se déroulera dans le groupe de RMN des solides de l'ILV, Tectopsin. Le développement des méthodes de cristallographie par RMN sera appliqué à la détermination structurale de matériaux nanoporeux, plus particulièrement des matériaux hybrides organiques-inorganiques (Metal-Organic Frameworks). Résolution structurale par diffraction, RMN et modélisation sera le thème principal de la recherche développée par le(a) candidat(e).
Recherche Francis Taulelle,, tel 01 39 25 44 77
Enseignement: Christine Greck, , tel 01 39 25 44 74
Dr. Francis Taulelle, Directeur de Recherche CNRS
Tectospin, Institut Lavoisier de Versailles, UMR 8180
Université de Versailles Saint Quentin en Yvelines
45 Avenue des Etats-Unis, 78035 Versailles Cedex
Tel: 01 39 25 44 77 Fax:01 39 25 44 76

Freitag, 20. März 2009

Postdoctoral position in Paris

*Postdoctoral position opened in Paris for exploring the physics of NMR
in highly polarized liquid samples (18 months).*

A collaborative work is performed by two teams, one at the Ecole Normale
Supérieure and the other one at CEA/Saclay, to study new physical
phenomena related to the non-linear evolution of magnetization observed
in NMR of hyperpolarized liquid samples. For instance, the team in Paris
has achieved NMR time-reversal in liquid polarized 3He in spite of
spin-turbulence [1] while the team in Saclay has studied multiple
chaotic maser emissions in dissolved polarized 129Xe [2]. The main
activity of the recruited researcher will be experimental NMR studies in
these systems, with the help of existing simulation tools to design
sequences and interpret results.

The experiments in Paris are performed at very low magnetic field (2mT)
using a Tecmag Apollo console and dedicated hardware at low temperature
(1K). In Saclay, experiments are performed at 11.7T and room temperature
using a Bruker Avance II spectrometer. The applicants should preferably
be experimental physicists or research engineers with a strong general
background and significant experience in NMR techniques. The position
will primarily be localized at the Laboratoire Kastler-Brossel [3]
(Physics Department of the ENS) in downtown Paris but part of the work
will be performed at CEA's Lab distant from about 40 minutes by ground
transportation from downtown Paris. The preferred starting date lies
between spring and autumn 2009.

Further information and contacts:
Dr. P.J. Nacher,
Laboratoire Kastler-Brossel
Physics Department, Ecole Normale Supérieure
24, Rue Lhomond, F-75231 Paris cedex 05

Dr. Hervé Desvaux,
Laboratoire Structure et Dynamique par Résonance Magnétique,
CEA/Saclay, F-91191 Gif/Yvette

[1] M. E. Hayden, E. Baudin, G. Tastevin, and P. J. Nacher, "NMR time
reversal as a probe of incipient turbulent spin dynamics" Phys. Rev.
Lett., 99 (2007) 137602
[2] D. J. Y. Marion, G. Huber, P. Berthault, and H. Desvaux,
"Observation of noise-triggered chaotic emissions in an NMR-maser"
ChemPhysChem, 10 (2008) 1395-1401.

/The DIPOL project (Non-linear NMR in polarised liquids) is funded by
the Agence Nationale de la Recherche./

Donnerstag, 19. März 2009

post-doc position Marseille HRMAS

A post-doctoral position is available immediately and upon fulfillment in Marseille.
The ideal candidate will have a Ph. D. in methodological NMR, and ease with the implementation of new multidimensional NMR techniques. The candidate will work in collaboration with HPLC and NMR experts on the characterization of solid/liquid interactions via HRMAS-DOSY NMR, with the aim of implementing a new analytical technique for the study of mixtures (see references below). Experience with selective excitation and advanced solvent suppression methodology would be preferred. Knowledge of PFG methods and fast acquisition/processing schemes are also a plus. The position is for 12 months, renewable once.

The research will be performed on a dedicated 400 MHz spectrometer of the last generation, with access to five more spectrometers from the local facility.

Located on the coast in southern France, midway between Italy and Spain, Marseille enjoys a very pleasant natural environment.

Contact: Stefano Caldarelli

- Simplified Analysis of Mixtures of Small Molecules by Chromatographic NMR Spectroscopy
G. Pages, C. Delaurent and S. Caldarelli, Angew. Chem. 2006, 45 , 5950-5953
- Pulsed Field Gradient Magic Angle Spinning NMR Self-diffusion Measurements in Liquids
Stéphane Viel, F. Ziarelli, G. Pagès, C. Carrara, and S. Caldarelli J. Magn. Reson. 2008, 190, 113-123
- Chomatographic NMR in NMR solvents C. Carrara, G. Excouffier, C. Delaurent,S. Viel, S. Caldarelli J. Magn. Reson. 2008, 194, 303-306

Project Leader position in Structural Biology

Project Leader position in Structural Biology

The European Institute of Chemistry and Biology, “Institut Européen de
Chimie et Biologie” (IECB) is a recently created research institute
sponsored by the University of Bordeaux, CNRS and INSERM. It is located
on the University of Bordeaux campus in the Southwest of France. The
Institute already hosts 15 research groups working at the interface of
chemistry and biology in a new building (6000 sq meters) with state of
the art equipment and facilities. Several on-site spectrometers include
a liquid/solid 700 MHz, and the arrival of an 800 Mhz spectrometer
predicted for later this year. The scientific policy of the Institute is
under the responsibility of an International Scientific Board which is
responsible for the selection of new group leaders.

IECB is recruiting a PROJECT LEADER within the field of STRUCTURAL

We seek biochemists working on structure/function relationship of
biological macromolecules or on molecules of biomedical interest in
particular in the field of neurobiology. The candidate will be asked to
apply for start-up funding from ATIP-Avenir Inserm-CNRS programme.
Deadline, April 16.

We are looking for motivated young scientists who will demonstrate a
strong potential for the development of an ambitious research programme.
The applicant is expected to run independent and creative projects. They
should be open to interdisciplinary collaborations with other groups of
the Institute. The successful candidate will benefit from a strong
financial support (including post-doctoral salary and/or PhD fellowship)
for the first two years. They will have access to state of the art
facilities in structural biology, chemistry, molecular and cellular
biology. The applicants should be fluent in English. Knowledge of French
would be useful but not mandatory.

Applicants are invited to submit a detailed biography together with a
research project and a list of potential referees to: Dr Jean-Jacques
Toulmé, Scientific Director of IECB – 2 rue Robert Escarpit 33607 Pessac
Cedex France

e-mail :

Postdoctoral Research Associate Biomolecular NMR Hamilton College

Postdoctoral Research Associate in Biomolecular NMR at Hamilton College

Hamilton College is seeking applications for a postdoctoral research associate in chemistry starting as soon as possible. Responsibilities include research on membrane-active peptides using NMR and other biophysical techniques. Required qualifications include a Ph.D. in chemistry, biochemistry, biophysics, or related field and experience with protein purification and biomolecular solution and/or solid-state NMR spectroscopy. A commitment to supervising undergraduate research projects is preferred. Experience with protein expression is desirable. Opportunities exist for mentored teaching.

The department of chemistry, which is hosted in a new state-of-the-art facility, is equipped with a Bruker 500 MHz spectrometer. Further information about Hamilton and the department can be found at This is a full-time, one -year position with possibility to extend to two years. Annual full-time salary range is $36,000-39,000. Please send curriculum vitae and two related publications, and arrange for two letters of recommendation to be sent to: Myriam Cotten, Associate Professor, Hamilton College, 198 College Hill Rd, Clinton, NY 13323. Hamilton College ( is a residential liberal arts college located in the Mohawk Valley of upstate New York; for applicants with dual-career considerations, Hamilton participates in the regional Higher Education Recruitment Consortium, which posts additional area employment opportunities at Hamilton College is an affirmative action, equal opportunity employer and is committed to diversity in all areas of the campus community. Hamilton provides domestic partner benefits. Candidates from underrepresented groups in higher education are especially encouraged to apply.

Myriam Cotten
Associate Professor of Chemistry
Department of Chemistry
Hamilton College
198 College Hill Road
Clinton NY 13323
Phone: (315) 859-4243
Fax: (315) 859-4807

Mittwoch, 4. März 2009

Maître de Conference

Maître de Conference / Chaire CNRS in Marseille (Poste MCF 0348 Méthodologie RMN et chimiométrie)
This opening concerns a new kind of tenured position designed for outstanding young scientists. The successful candidate will profit of a reduced (-2/3) teaching load and of an increased (+30%) salary for a period of 5 years, renewable once.
The ideal candidate will have excellent records in methodological NMR (development and implementation of multidimensional experiments), to be applied in conjunction with chemometrics for the analysis of complex mixtures, one notable example being metabolomics.

Contact : Stefano Caldarelli

postdoctoral position Saclay

A postdoctoral position is available in the Structure and Dynamics by Magnetic Resonance Laboratory from Science Matter Division, and the Nuclear Magnetic Resonance Laboratory (LRMN), NeuroSpin, CEA, Saclay, France ( under the supervision of Patrick Berthault and Luisa Ciobanu. The appointment will be made for a period of 12 months, starting immediately.

The position will be to work on an ANR funded project to perform in vivo laser-polarized 129Xe molecular imaging experiments. In this project, after optical pumping, laser-polarized xenon is encapsulated in cage-molecules functionalized with biological ligands and transported to the receptors of interest where it is imaged. The project involves collaboration with chemists (synthesis of cage-molecules of high affinity for xenon), biochemists (choice of the biological systems and of the ligands) and spectroscopists (handling of the hyperpolarized gas in fast imaging experiments).

The candidate will participate in the installation and optimization of the optical pumping setup designed to deliver high quantities of hyperpolarized xenon. He/she will be in charge of the spectroscopy and imaging experiments on small animals, in close collaboration with all partners. The MR experiments will be implemented on a 7T animal imager.

Applicants must have a doctorate degree in engineering (biomedical or chemical preferred), physics, chemistry, or other relevant discipline. Previous experience in NMR/MRI is desirable.

Interested individuals should e-mail their CV and the contact information of at least two recommenders to Luisa Ciobanu ( ) or Patrick Berthault ( ).

Luisa Ciobanu

Post-Doctoral Fellow Leiden

Post-Doctoral Fellow – NMR Spectroscopy Ref.: E.09.GJ.05
Leiden University Medical Center (The Netherlands)

Job Description
An opening is available for a post-doctoral fellow in the Biomedical NMR Spectroscopy group within the Biomolecular Mass Spectrometry Unit at Leiden University Medical Center (The Netherlands). As successful candidate you will be responsible for research in the field of NMR-based metabonomics with strong emphasis on lipidomics. You will contribute to several projects in collaboration with internal and external partners in the fields of endocrinology, cardio vascular disease, metabolic syndrome, diabetes and ageing. In addition you will take an active role in advancing and developing new methodologies for lipid profiling in biological fluids.

At the Leiden University Medical Center (LUMC), we are continually seeking to improve the quality of healthcare. The LUMC aims for excellence in patient care, research, teaching, training and continuing education. The Biomedical NMR Spectroscopy group at LUMC conducts research in the field of molecular biomarker discovery, NMR and MS-based metabonomics as well as method development for biomedical NMR spectroscopy with strong emphasis on automation, hyphenation and analysis of complex mixtures. Main focus of the group is on investigation of metabolic pathways and biological functions in health and disease for application in clinical research and diagnostics, as well as in disease prevention, health and nutritional science. The lab is equipped with a Bruker state-of-the-art 600 MHz NMR Metabolic Profiler including a microTOF-Q mass spectrometer.

Job requirements
We are looking for a highly motivated individual with a PhD degree in biochemistry / chemistry or equivalent. You have a sound knowledge of NMR spectroscopy; experience in multivariate data analysis and / or Matlab programming is a plus. We are seeking a team player with good communication skills and a vital interest in NMR method development. Good knowledge of English is required.

How to apply
If you are interested in the position listed above, please apply before 23rd of March 2009 by sending your application, including your CV and a brief statement of interest, to
Attn. G.P. de Jong, P&O-advisor
Bureau Bedrijfsvoering division 5 (T7-P)
PO Box 9600
2300 RC Leiden
The Netherlands.

Please clearly quote the vacancy number E.09.GJ.05 both on the envelope and on the letter. You may also apply by e-mail, For further information on the position or online application please visit our website at (select English website (upper right corner) and ‘working for us -> vacancies -> research’ from the main menu).

Research Associate London

Research Associate
Biophysics of Antimicrobial Peptides
Pharmaceutical Science Division, King's College London

A Research Associate post in Biophysics of Antimicrobial Peptides is available in the Pharmaceutical Science Division. The purpose of the job is to undertake research, led by Dr A. J. Mason of the Molecular Biophysics Group, into peptides with potential anti-bacterial and anti-malarial capabilities.

The post holder will employ a combination of biophysical methods including Circular Dichroism and solid-state NMR to study the membrane interactions of synthetic and naturally derived peptides. He or she will also be responsible for the E. coli based expression, purification and reconstitution of human beta defensin peptides.

The applicant needs to have a PhD or equivalent in Biochemisty, Biophysics or a related subject and be familiar with bacterial expression systems and the application of NMR to biological samples. The ability to undertake both spectroscopic measurements and microbiology experiments is essential. The ideal applicant will be someone who, as soon as is reasonably possible, can work independently with initiative based upon experience.

The post is funded for a period of three years. The post is based at the Franklin-Wilkins Building, Waterloo Campus, King's College London. The salary will be on Grade 6 post-doctoral scale, £32,917 to 35,755 per annum inclusive of £2,323 London Allowance per annum.

Further details and application packs are available on the College's website at or by emailing . Please quote reference number W6/JGA/026/09-KB on all correspondence.

Closing date: 13th March 2009

Postdoctoral Fellowship Auckland

C at the University of Auckland, New Zealand

Applications are invited for a postdoctoral research fellow to work on an exciting project funded by a NZ Royal Society Marsden grant. The project will focus on the use of solution-state NMR spectroscopy to investigate how protein dynamics facilitates the assembly of a cytokine signaling complex involved in the immune response and inflammation.

Candidates should hold a PhD in biomolecular solution-state NMR spectroscopy. Demonstrated strengths in protein expression and purification and skills in computer data analysis and modeling are desirable. Experience in characterising protein dynamics by NMR spectroscopy would be an advantage.

This is a fixed term full-time position for two years with a start date in mid-2009.

Interested applicants are encouraged to make informal enquiries to Dr Andrew Dingley. The closing date for applications is the 26th of March, 2009. Applicants should email/send their applications including CV with the names and the contact details of three referees to:

Dr Andrew Dingley
Department of Chemistry/School of Biological Sciences
The University of Auckland
Private Bag 92019
Auckland Mail Centre
Auckland 1142
New Zealand

Phone: ++64 9 373 7599 ×86801

For a full job description go to

The University has an equal opportunities policy and welcomes applications from all qualified persons.

Postdoc Bordeaux

Postdoctoral position in NMR spectroscopy

A one-year postdoctoral position is available starting in late
spring/summer 2009 at the European Institute of Chemistry and Biology /
Institut Européen de Chimie et Biologie (IECB)
( The institute was founded in 1998 and
hosts diverse and international groups covering a wide range of
scientific interests. The ideal candidate will have a PhD degree, as
well as experience in NMR spectroscopy and standard molecular biology
skills related to protein expression and biochemical assays. The
laboratory investigates structural aspects of proteins and nucleic
acids, with a focus on components of the mRNA processing machinery and
the post-translational modification of histones (for laboratory homepage
see Local equipment includes a 700MHz
spectrometer, with the addition of an 800MHz spectrometer predicted for
this year.

Interested candidates should send a curriculum vitae and the contact
information for three referees to, or by
mail to Dr. Cameron Mackereth, IECB, 2 rue Robert Escarpit, 33607 Pessac
Cedex, France.

-- Dr. Cameron Mackereth NMR Spectroscopy of Protein/Nucleic Acid Complexes Institut Européen de Chimie & Biologie (IECB) 2 rue Robert Escarpit 33607 Pessac Cedex France +33 5 40 00 34 32