Freitag, 27. Februar 2009

Postdoctoral Position

Postdoctoral Position -- Computational Modeling and NMR Structural Studies of pH Sensor Proteins Involved in Cell Mobility

A postdoctoral position is available in the groups of Matt Jacobson and Mark Kelly in the Department of Pharmaceutical Chemistry at UCSF (Mission Bay Campus) to investigate how small changes in pH affect the conformations and dynamics of proteins regulating the actin cytoskeleton and cell mobility (Srivastava et al., 2008 PNAS 105:14436-41; Frantz et al., J Cell Biol. 183:865-79). In collaboration with Diane Barbers’ group these studies will bridge cell signaling, cell biology, and computational and experimental biophysics to determine at the molecular level the regulation and function of pH sensors in cell polarity, actin-dependent membrane protrusion, and cell adhesion. Investigations will involve applying physics-based predictive protein modeling and NMR investigations of conformational and dynamic changes in regulatory proteins. The position is ideal for applicants who have a strong background in biophysics, chemistry or related field and experience of either computational structural biophysics or NMR, and wish to broaden their expertise. The UCSF Mission Bay campus offers an excellent scientific environment for computational and structural biology (computing clusters, 500, 600 and 800 MHz spectrometers with cryogenic probes, and access to a 900 MHz instrument).

Applications should be addressed to or for further information please contact:

Matt Jacobson Ph.D.
UCSF MC 2240
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. 415-514-9811


Mark Kelly Ph.D.
UCSF, MC 2280
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. (415)-476-8143

Freitag, 20. Februar 2009

Postdoc - NMR of polymers and inorganic nanotubes

Immediate opening for a post-doc trained in NMR. The project involves study of (1) structure, dynamics and morphology of additive-filled materials for barrier applications; and (2) structural evolution of inorganic nanotubes. Work in close collaboration with other groups in the College of Engineering here on the Georgia Tech campus in Atlanta, Georgia. $45k/year for at least one year.

If interested, pls send cover letter, CV, and 3 letters of reference to E-mail also with questions and requests for further information.

Haskell W. Beckham, Ph.D.
School of Polymer, Textile and Fiber Engineering
Georgia Institute of Technology
Atlanta, GA, USA 30332-0295
office: 404-894-4198
fax: 404-894-9766

Mittwoch, 18. Februar 2009

Research Associate in Solid-State NMR and Materials Science

Research Associate in Solid-State NMR and Materials Science

The Materials Structure and Function group of NRC's Steacie Institute
for Molecular Sciences (Ottawa, ON) is looking to fill a Research
Associate position in the area of solid-state NMR and materials.

The group has excellent modern solid-state NMR facilities and access to
the 900 MHz NMR spectrometer at the National Ultrahigh-Field NMR
Facility for Solids housed in the same building (

High level candidates, with extensive experience in modern solid-state
NMR, a strong interest in novel materials and experience in materials
synthesis, should apply through the Research Associate Program on the
NRC website under

and contact Dr. Chris Ratcliffe (
Candidates must be within five years of having obtained their PhD, or be
expecting to complete their PhD in the near future.


PhD Scholarship Biomolecular NMR Auckland, New Zealand

PhD Scholarship in Biomolecular NMR at the University of Auckland, New Zealand

A three-year PhD scholarship is available to investigate the role of protein dynamics in the assembly of a cytokine-signaling complex involved in cell growth, survival and defense against pathogens. This project is part of an international research effort aimed at designing cytokines as therapeutic agents.

Besides solution-state NMR spectroscopy, other techniques to be used include cell-free protein expression, protein purification and computer modeling.

Students will receive an annual stipend plus fees via a Royal Society NZ Marsden Scholarship.

Applicants should have an excellent academic record and completed a BSc (honors), Masters or equivalent degree in biochemistry/biophysics/chemistry. Proficiency in English (both spoken and written) and an understanding of protein structure and function are essential. Laboratory experience in protein preparation would be advantageous.

Interested applicants are encouraged to make informal enquiries to Dr Andrew Dingley. The closing date for applications is the 30th of March, 2009. To apply, please send/email your curriculum vitae, a copy of your academic transcript and the names of two referees with a covering letter to:

Dr Andrew Dingley
Department of Chemistry/School of Biological Sciences
The University of Auckland
Private Bag 92019
Auckland Mail Centre
Auckland 1142
New Zealand

Phone: ++64 9 373 7599 ×86801

Mittwoch, 11. Februar 2009

Staff NMR spectroscopist at University of Illinois

Dear Colleagues,

The University of Illinois at Urbana-Champaign currently has an opening for a PhD-level spectroscopist in the School of Chemical Sciences' NMR Facility. Primary responsibilities are support of solid-state NMR, instrument maintenance and repair, and interacting with researchers on issues of experiment selection and data analysis.

The full ad is posted at

For full consideration all application material should be submitted by March 16, 2009, but we will continue to accept applications until a hire is made.

We would appreciate your bringing this to the attention of qualified graduate students, postdoctoral associates and experienced spectroscopists who are seeking permanent employment.

Thank you,


Chad M. Rienstra
Associate Professor of Chemistry
University of Illinois at Urbana-Champaign
600 South Mathews Avenue, Box 50-6
Urbana, IL 61801

Phone: 217 244-4655, Fax: 217 244-3186
Office: A120 CLSL, Lab: A125 CLSL

Dienstag, 10. Februar 2009

Postdoctoral Research Assistant

Applications are invited for a three-year funded postdoctoral research position within the Biological NMR group in the Department of Chemistry.

Although this position is to be formally located within Dr Matt Crump’s group at the University of Bristol, you will also be fully integrated with research scientists within UCB, the global biopharmaceutical company ( UCB’s funding of this position is part of the company’s outward-looking structural biology strategy, and will offer the opportunity to work at UCB’s Research & Development facilities in Slough, Berkshire, as the project demands.

The last couple of years has seen the emergence of a host of computational techniques that use NMR chemical shifts to derive the structure of proteins without the need for NOE data. The current project will involve the application of this technology to enable the rapid structural elucidation of protein targets and the development of methods to facilitate unambiguous docking of low molecular weight ligands (fragments) into the protein target using minimal NMR data (ie chemical shift perturbations alone). We are therefore seeking a candidate with a strong computational and theoretical NMR background, preferably with experience in NMR driven structure determination of macromolecules.

If successful, you may be appointed either on a fixed term or a permanent contract depending on the extent of your previous relevant research experience. Further information can be found at

Grade : Level a in Pathway 2
Salary : £29,704-£33,432

Contact: ( School of Chemistry )
Dr M P Crump
Tel: 0117 331 7163
Alternative Contact: ( School of Chemistry )
Dr R Taylor


Closing Date : 27 February 2009

Interview Date : not set

Timescale of Appointment(s) -
Contract : Fixed Term Contract
Three years

Further details and an application form can be found at
Alternatively you can telephone (0117) 954 6947, minicom (0117) 928 8894 or
E-Mail (stating postal address ONLY), quoting reference number 14563.

The closing date for applications is 9.00am, 27 February 2009

An Equal Opportunities Employer.


Thank you,

Julie Bull
Senior Recruitment Assistant

University of Bristol
Personnel Services
Senate House,
Tyndall Avenue,
Bristol, BS8 1HH
Tel: 0117 928 8512 Fax: 0117 925 9473

Freitag, 6. Februar 2009

Postdoc position NMR Non-Crystalline Materials

Postdoc position to develop NMR Methods for Non-Crystalline Materials

A postdoctoral position is available at Ohio State University in Columbus, Ohio to work on developing new NMR methods with a focus on structure determination in non-crystalline materials. Experience in advanced magnetic resonance theory and experiment is required. Starting date is flexible. Please submit application and CV, and have two or three letters of recommendation sent to: grandinetti.1 at

two-year postdoctoral research position, Jülich

A two-year postdoctoral research position with a possibility of extension and a few PhD positions are available at the Institute of Neuroscience and Medicine - Medical Imaging Physics, Forschungszentrum Jülich.

These positions will be coupled to an exciting new project related to a construction of 9.4T whole-body MR-PET scanner. This scanner, which is unique worldwide, will be capable of the simultaneous acquisition of MRI and PET data sets in humans at 9.4T. Additionally, the Institute houses state-of-the-art 1.5T, 3T, 4T whole-body MR scanners and a 3T MR-PET scanner. These facilities are complemented by a home-built 9.4T animal scanner also based on the Siemens software and hardware platform.

Currently, the following research areas are being actively pursued in the group:
· Diffusion Tensor Imaging.
· Development of new MRI sequences designed for brain imaging and neuroscientific applications targeting structural and functional MRI, e.g. ultra-fast MRI techniques, DTI, and contrast-enhanced, high-resolution imaging.
· Development of new in vivo methods for quantitative MRI including image processing of quantitative data.
· Development of new imaging methods for the in vivo quantification of other MR-active nuclei such as 23Na and 17O in the brain.
· Development of RF coils and coil arrays for high field MRI as well as multimodal MR-PET imaging.

The successful candidates will focus primarily on the development of MRI techniques and analysis tools for monitoring diffusion, functional activity and connectivity in the brain. They will investigate the potentials of the advanced methods in applications to neurodegenerative processes in brain tissues and study the biophysical mechanisms underlying the visualization contrast. They will contribute to the collaborative interdisciplinary projects involving physicists, neuroscientists, mathematicians, software designers, and others.

Ideally, the applicants for the postdoctoral position should have a PhD and a maximum of 5 years postdoctoral experience in NMR / MRI methods and applications. In depth experience in an environment using MRI / functional magnetic resonance imaging in human studies is desirable. Experience of object-oriented software design (C++), multivariate image analysis, digital signal processing, and algorithms of computer simulations would be extremely advantageous. Cooperative teamwork as well as a structured approach to problem solving are essential requirements.

The successful PhD candidates will be jointly supervised by Farida Grinberg and Jon Shah. They should be familiar with the basics of NMR / MRI techniques and have good computer skills. By the time of entrance, they should have finished a graduate education in either physics, biophysics or in other relevant disciplines.

Please send your application, CV and letters of recommendation to:

Dr. F. Grinberg (
Dr. Farida Grinberg
Medical Imaging Physics
Institute of Neuroscience and Medicine
Research Centre Juelich
52425 Juelich

Post-doc position Grenoble

Post-doc position: Sensitivity optimized NMR instrumentation for resistive high field magnets

Location: Grenoble, France

The NMR team at the Grenoble High Magnetic Field Laboratory (GHMFL) is looking for an experimental post-doctoral researcher for the development of NMR instrumentation for ultra high magnetic fields.

The GHMFL is Europe’s largest high magnetic field infrastructure. Amongst others, it operates a worldwide unique NMR user facility conducting ultra high field NMR research in 20 MW resistive magnets up to 34 T and at temperatures as low as 40 mK. Since January 2009 GHMFL has been engaged in the EuroMagNET II project of the European Commission ( that involves all European infrastructures for high magnetic fields located at Grenoble (GHMFL), Nijmegen (HFML), Dresden (HLD) and Toulouse (LNCMP).

The post-doctoral position is open within a Joint Research Activity (JRA) of EuroMagNET II aiming at Enhanced Sensitivity and Single Scan NMR (ES3-NMR). The JRA is conducted by NMR research groups at the four high field laboratories and associated partners. The Grenoble NMR team will develop tailored NMR instrumentation for enhanced resolution, field stability and optimized sensitivity in the field range up to 34 T and will place it at the disposal of the user groups. This activity will provide new options for the solid state physics community, and will also meet the particular demands of new user groups coming from the area of materials-related research and solid state chemistry.

Details of the position

* Development, commissioning and utilisation of sophisticated NMR instrumentation for magnetic fields up to 34 T including NMR probeheads, as well as high frequency and low temperature electronics in collaboration with the NMR team, service facilities at GHMFL and partners of the JRA.
* Development of equipment to overcome the intrinsic field instability and inhomogeneity of resistive high field magnets, as for example NMR spin-locks and shimming, in collaboration with the NMR team, GHMFL engineers and partners of the JRA.
* Experimental NMR research and support (local contact) for international visitors performing the ultra high field NMR at the GHMFL.


* PhD in physics, chemistry, materials science, physical engineering or related field.
* Enthusiasm and interest in development of sophisticated scientific instrumentation.
* Good communications skills and capacity for teamwork.
* Experience in experimental NMR would be advantageous.

Applications should include a CV, references and a statement of interests.
The position is available for at least one year with possibility of extension.


Steffen Krämer
Grenoble High Magnetic Field Laboratory - CNRS
25 rue des Martyrs
38042 Grenoble Cedex 9
Tel. +33 (0)4 76 88 74 44
Fax +33 (0)4 76 88 10 01

Further information on activities of the NMR group can be found on the Web site: