Freitag, 27. Februar 2009

Postdoctoral Position

Postdoctoral Position -- Computational Modeling and NMR Structural Studies of pH Sensor Proteins Involved in Cell Mobility

A postdoctoral position is available in the groups of Matt Jacobson and Mark Kelly in the Department of Pharmaceutical Chemistry at UCSF (Mission Bay Campus) to investigate how small changes in pH affect the conformations and dynamics of proteins regulating the actin cytoskeleton and cell mobility (Srivastava et al., 2008 PNAS 105:14436-41; Frantz et al., J Cell Biol. 183:865-79). In collaboration with Diane Barbers’ group these studies will bridge cell signaling, cell biology, and computational and experimental biophysics to determine at the molecular level the regulation and function of pH sensors in cell polarity, actin-dependent membrane protrusion, and cell adhesion. Investigations will involve applying physics-based predictive protein modeling and NMR investigations of conformational and dynamic changes in regulatory proteins. The position is ideal for applicants who have a strong background in biophysics, chemistry or related field and experience of either computational structural biophysics or NMR, and wish to broaden their expertise. The UCSF Mission Bay campus offers an excellent scientific environment for computational and structural biology (computing clusters, 500, 600 and 800 MHz spectrometers with cryogenic probes, and access to a 900 MHz instrument).

Applications should be addressed to or for further information please contact:

Matt Jacobson Ph.D.
UCSF MC 2240
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. 415-514-9811
matt.jacobson@ucsf.edu
http://www.jacobsonlab.org/

or

Mark Kelly Ph.D.
UCSF, MC 2280
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. (415)-476-8143
Mark.Kelly@ucsf.edu