Dienstag, 21. August 2012

PostDoc Basel

Postdoctoral position in membrane protein structural biology with NMR A postdoctoral position is available in the group of Prof. Sebastian Hiller at the Biozentrum of the University Basel. We are studying structure, function and folding of integral membrane proteins and their complexes using solution and solid-state NMR, as well as complementary biophysical methods. Our projects generally address fundamental biological systems of high impact. The postdoctoral research project concerns the structure determination of a membrane protein complex using solution NMR as the main technique. Subsequently, the functioning of the protein complex and its interactions with substrates are characterized. An integral part of our projects is the use and development of state-of-the-art preparative, biochemical and NMR techniques. Interested candidates need a Ph.D. in Biochemistry, Biophysics, Structural or Molecular Biology or related fields. Expertise in at least one of the following areas is mandatory: NMR, protein biochemistry, membrane proteins, molecular biology. The successful candidate is highly motivated, creative and capable of independent research in a team environment. Communication skills in oral and written English are essential. The position and the research projects are long-term funded by the European Research Commission and the Swiss National Science Foundation. We offer an exciting and enthusiastic work environment with scientific collaborations in the institute and worldwide. The Biozentrum Basel is one of the leading biomedical research institutions in Switzerland and has recently been placed among the Top 10 international “Best Places to Work for Postdocs” by The Scientist magazine. Facilities for structural biology include 600, 700 and 800 MHz Bruker spectrometers equipped with cryogenic and magic angle spinning probes. Salary and benefits are attractive, following the guidelines of the Swiss National Science Foundation. The start date is available as of immediately or on mutual agreement. Applications and informal queries about the lab and research projects should be directed by email to Sebastian Hiller. Applications must include a letter of motivation summarizing current and future research interests, a CV, list of publications and contact information for at least two references. Prof. Sebastian Hiller SNSF Professor Biozentrum, University of Basel Klingelbergstrasse 50/70 4056 Basel, Switzerland http://www.biozentrum.unibas.ch/hiller/ Email: sebastian.hiller@unibas.ch

PhD/PostDoc Zürich

A PhD and a Postdoc position are available in the group of Oliver Zerbe in Zurich. You will be working on a collaborative and highly interdisciplinary effort to create repeat proteins that serve as binders to extended peptides. Participating groups on the campus are from the field of protein design, crystallography and computational (modelling) sciences. The project has entered its second phase and many highly interesting data have been already derived and much has been achieved already. Both the graduate student as well as the Postdoc will be working in biochemistry (protein expression and purification, in particular protein ligation techniques) and NMR spectroscopy/structure determination. Knowledge in protein structure determination by NMR and good biochemical skills are required for the Postdoc position. Candidates on this very interdisciplinary project will have access to state-of-the-art NMR facilities and biochemistry labs at the University of Zurich. Anyone with a strong interest in protein design and NMR is encouraged to apply. Positions are paid according to salaries from the Swiss National Science Foundation. Please provide a CV, a short description of your interests and the names and addresses of 2-3 references. Please feel free to contact me any time if you are interested. I will also be at the ICMRBS conference in Lyon and please talk to me there if you happen to be there and want to hear more about the project or our lab. Oliver Zerbe ______ University of Zurich Prof. Dr. Oliver Zerbe Institute of Organic Chemistry Winterturerstrasse 190 CH-8057 Zurich oliver.zerbe@oci.uzh.ch http://www.oci.uzh.ch/group.pages/zerbe/

Dienstag, 7. August 2012

Postdoc NMRFAM

The National Magnetic Resonance Facility at Madison (NMRFAM) has immediate openings for two postdoctoral research associates. Please visit the NMRFAM website www.nmrfam.wisc.edu for information about our instrumentation and research programs. (1) Structure determination by hybrid methods (NMR, SAXS, computation) The ideal candidate will be a recent PhD with experience in solution structure determination making use of data from NMR spectroscopy and small angle X-ray scattering (SAXS). This position will work with NMRFAM staff members developing technology and applying it to collaborative projects. (2) Metabolomics by NMR and MS The ideal candidate will have had extensive experience in LC-MS and NMR spectroscopy with applications to metabolomics. This position will develop technology and work on projects initiated by biomedical collaborators. Salary will be commensurate with the candidate's qualifications and experience at least at the NIH rate (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-12-033.html). Applicants should send a cover letter (including the names and e-mail addresses of three mentors willing to provide letters of recommendation) and curriculum vitae to: Prof. John Markley NMRFAM Biochemistry Department University of Wisconsin-Madison 433 Babcock Drive Madison WI 53706 USA jmarkley@wisc.edu

Postdoc FSU

A postdoctoral position is available at Florida State University and the National High Magnetic Field Laboratory in the group of Rafael Brüschweiler to study the functional dynamics of Arginine Kinase and its interactions with various ligands. This NIH-funded research, which will primarily use solution NMR spectroscopy and computation, is a collaboration with the group of Michael Chapman at OHSU. FSU's Department of Chemistry and Biochemistry and the NHMFL provide a cross-disciplinary research environment with access to a 800 and a 700 solution NMR spectrometer equipped with cryogenic probes as well as to FSU's high-performance computing facility (http://www.hpc.fsu.edu/). Interested candidates with a background in biomolecular NMR spectroscopy and/or biomolecular computation should email their CV along with the names and contact information of 3 individuals who can be asked for a reference. Rafael Brüschweiler Department of Chemistry & Biochemistry and National High Magnetic Field Laboratory Florida State University Tallahassee, FL 32306 E-Mail: bruschweiler@magnet.fsu.ed Web: http://spin.magnet.fsu.edu Web server: http://spinportal.magnet.fsu.edu


Postdoctoral positions are available in the research group of Professor Josh Wand in the Department of Biochemistry & Biophysics and the Johnson Research Foundation of the University of Pennsylvania Perelman School of Medicine. Located in Philadelphia, the University of Pennsylvania is a cosmopolitan center of advanced research across the spectrum of the life and physical sciences. Areas of current interest in the Wand laboratory are creative uses of high pressure NMR to explore protein structural cooperativity; NMR spectroscopy of encapsulated proteins dissolved in low viscosity fluids to examine protein hydration and hydration dependent dynamics; uses of reverse micelle encapsulation in structural biology especially membrane-anchored proteins; development and use of advanced NMR relaxation methods to illuminate the character of protein motion and to provide a dynamic proxy for conformational entropy in a variety of functional contexts such as ligand binding, catalysis and evolution; development of NMR data collection strategies and associated software particularly in the realm of sparse sampling; validation of molecular dynamics simulations. Extensive NMR instrumentation is available. See wandlab.org for additional information. Candidates should hold the Ph.D. degree or equivalent and have extensive experience in protein biophysics and/or NMR spectroscopy. Applicants should forward a c.v. and have two letters of reference sent directly to Professor Wand (wand@mail.med.upenn.edu). A. Joshua Wand, Ph.D. Benjamin Rush Professor of Biochemistry & Biophysics Department of Biochemistry & Biophysics University of Pennsylvania Perelman School of Medicine 905 Stellar Chance Laboratories 422 Curie Blvd Philadelphia, PA 19104-6059 telephone 215-573-7288 facsimile 215-573-7290 e-mail wand@mail.med.upenn.edu

Experimental Officer in Nuclear Magnetic Resonance

Experimental Officer in Nuclear Magnetic Resonance University of York - Department of Chemistry Ref: 2497 You will be responsible for the day-to-day operation primarily of the 700 MHz and 600 MHz instruments which are used for a wide variety of experiments supporting inorganic and organic chemistry, the development of hyperpolarisation methods and studies of proteins and carbohydrates. You will also provide training for users of the instruments where necessary and support the general research aims of the centre. You will require both excellent knowledge and practical experience of NMR spectroscopy of small molecules; knowledge and experience of experiments for studying proteins and other biomolecules would be an advantage. Salary will be within the range £29,249 - £30,122 per annum and the post is available immediately for a period of 3 years in the first instance. Closing date: 9 September 2012 For further information and to apply on-line, please visit our website: https://jobs.york.ac.uk The University of York is committed to promoting equality and diversity

Mittwoch, 25. Juli 2012

Postdoc at DKFZ

The Cancer Drug Development group is seeking a postdoctoral NMR specialist to run and maintain two Bruker NMR instruments (400 and 600 MHz). A number of research groups within the DKFZ require these instruments with needs ranging from the complete spectral assignment of natural products and stereochemically complex small molecules to in situ reaction monitoring and kinetic measurements. You will be responsible for designing, performing, and analyzing the experiments necessary for these studies. We would like to expand our capabilities to be able to study the interactions of small molecules with protein targets of interest in the context of drug discovery research.

Your profile:
You are a motivated and creative individual with a PhD or related experience in NMR spectroscopy, including hardware maintenance and upkeep with Bruker instrumentation and software. You are well versed with a variety of multi-dimensional experiments and can use the data thereby obtained to solve the structures of complex unknowns. Experience in studying small-molecule/protein binding is a big plus. Ability to communicate clearly and supervise technical assistants. Your application should include a CV with publication list, two letters of reference, a summary of your recent work, and copies of your University certificates.

Duration: The position is limited until August 31, 2014.
Compensation/Financing: E13, Grant funding
Contact: Dr. Aubry Miller, phone 06221 42-3307, aubry.miller@dkfz.de

Freitag, 27. Januar 2012

Ph D thesis in MRI velocimetry

Dear colleagues

the laboratoire Navier (Universite Paris Est, France) is offering a Ph D position
in the field of MRI velocimetry for rheo-NMR, available from September 2012.
We would be happy to consider the application of any of your motivated students.
Details and contacts:


With best regards

Stephane Rodts

Tenured researcher position

Dear colleagues

we would like to bring to your attention a tenured researcher position that is
available at Universite Paris Est, France, in the field of NMR and MRI for material
sciences. We are looking for someone who can contribute to our activities in the field
of MR applications to civil engineering and environmental sciences, with a wide flexibility
as to the nature of the main interests of the individual concerned. Details and contacts:


With best regards

S. Rodts

Postoctoral position in Structural Biology


Postdoctoral Research Associate in Structural Biology

We are seeking to appoint a highly motivated Postdoctoral Research
Associate in the laboratory of Dr. Ioannis Vakonakis for studies of
proteins involved in centriole assembly. The successful candidate will
join a multidisciplinary collaboration between Oxford and the groups of
Prof. Pierre Gönczy (EPFL) and Dr. Michel Steinmetz (Paul Scherrer
Institute) in Switzerland. Recently, our joint efforts elucidated the
origins of centriolar 9-fold symmetry (Kitagawa, Vakonakis et
al.,Cell144, 364-375, 2011), a critical step in the centrosomal
duplication process that ensures genome stability in animals. We now
seek to build upon this breakthrough by studying the structure/function
relationship of centriolar components such as SAS-6, SAS-5, SAS-4,
ZYG-1, SPD-2 and others. The successful candidate will contribute to the
analysis of these targets using structural (crystallography, solution
NMR and/or small angle scattering) and biophysical methods.

Applicants should possess/be expected to obtain a PhD in natural
sciences and should have experience in aspects of the structural biology
pipeline, for example protein production and purification, NMR
spectroscopy or X-ray crystallography. Past experience with
complementary biophysical techniques (ITC, AUC, CD etc) and biomolecular
interactions is desirable. Previous familiarity with centriolar or
relevant biological systems would be an advantage but is not essential.

This full-time post is funded by the Biotechnology and Biological
Sciences Research Council (BBSRC)for up to three years in the first
instance and is based in the New Biochemistry building, South Parks
Road, Oxford. More information about our group can be found by clicking
on the link below:


This position is graded on the University’s grade 7 scale, for which the
salary range is £29,099 - £35,788 per annum. The actual starting salary
offered will be based on qualifications and relevant skills acquired and
will also be determined by the funding available.

For further general information, phone (01865) 613204, quoting reference
number BR/493.

Applications for this vacancy are to be made online.

To apply for this role and for further details, including the job
description and selection criteria,

please click on the link below:


The closing date for applications is Monday, 20thFebruary 2012. It is
envisioned that interviews for shortlisted candidates will take place
within approximately 10-14 days.

The University of Oxford is committed to equality and values diversity

Position at NMRTEC

NMRTEC is opening a position for a doctoral thesis in the field of analytical chemistry dedicated to complex system and combinatorial chemistry.

As a part of the ITN READ European network, it is intended to conduct an extensive study on the development of analytical methods for the analysis of complex mixtures. This will include the study of large chemical libraries, auto-assembling systems, complex protein ligand interactions, and the study of polymers and disordered biological systems. Methods developed will include mostly NMR (1D, 2D, and multinuclear), diffusion measurement by NMR (DOSY) but also other techniques such as SAXS and mass spectrometry.
This is a joined PhD project between NMRTEC and the biomolecular NMR academic laboratory (IGBMC, Dr. Marc André Delsuc).

A successful candidate should have strong interest specifically in NMR but also in analytical and spectroscopic techniques. A good knowledge in biological and pharmaceutical sciences is an advantage.
According to EU rules for ITN projects the applicant:
- has less than 4 years of experience since gaining a university degree and has not been awarded a doctoral degree;
- shall not be a national of the State in which the hosting partner's research team is located (France);
- must have resided in the France for no more than 12 months during the past 3 years.

The application should consist of the following parts:
• a brief letter explaining/motivating your interest in the position;
• a detailed Curriculum Vitæ, including a list of publications (if appropriate);
• a complete list of courses taken and grades obtained (including transcripts of academic records);
• contact details of two referees;
• any other relevant information.

links : http://www.systemschemistry.com/read/index.htm

Contact : Marc-André Delsuc : madelsuc@unistra.fr

Research Fellowship NMR

Research Fellow in Nuclear Magnetic Resonance Technology
University of Nottingham, UK
School of Physics & Astronomy

Applications are invited for the above post based in the Sir Peter
Mansfield Magnetic Resonance Centre which is part of the School of
Physics and Astronomy. The successful candidate will lead an ambitious
hardware development project that focuses on the the design and
implementation of a novel spectrometer for dynamic nuclear polarisation (DNP) enhanced NMR spectroscopy. The project involves extensive industrial collaboration and is funded by the Novel Technology Initiative in Cross-disciplinary Sciences of the EPSRC. The project covers the whole field of DNP research, including the testing of novel radicals, theoretical spin dynamics calculations and the design and construction of novel hardware.

Candidates should have a PhD in physics, physical chemistry or a related
discipline and preferably have experience in one or several of the
following fields: Microwave technology, Cryotechnology, Magnetic
Resonance hardware technology, Laser Optics. Additional expertise in NMR
theory or practical experience with dynamic nuclear polarisation would
be beneficial but not essential. Candidates should have good
communication skills and enjoy working with a variety of different
people across discipline boundaries.

This post will be offered on a fixed-term contract for a period of three
years. Salary will be £27,319 - £31,671 per annum, depending on skills and experience.

Informal enquiries should be addressed to Dr Walter Köckenberger, email:

For more details and/or to apply on-line please access:
http://www.nottingham.ac.uk/Jobs/CurrentVacancies/ref/SCI992X2. If you
are unable to apply on-line please contact the Human Resources
Department, tel: (44 (0)115 846 6172. Please quote ref. SCI/992X2.

PhD student position at Wageningen

Diffusional Nanoprobes for Multi-length Scale material Characterisation (DINAMISCH)

In the DINAMISCH project we aim at overcoming the current bottlenecks in non-invasive multi-length scale characterisation during structure formation and degradation in semi-solid matter by diffusional probing using advanced magnetic resonance methods. DINAMISCH is an academic-industrial collaboration between Wageningen University and two industrial partners, SyMO-Chem and Unilever. DINAMISCH is part of the research programme of COAST, the Dutch public-private partnership on Analytical Science and Technology.

We are now searching for a Ph.D. Student (4 years) who will develop and apply novel magnetic resonance methods for probing materials at different length scales (nano/meso/micro). The focus will be on PFG and MRI methodologies for assessment of structure formation/degradation under dynamic conditions. This will also require the joint deployment of novel rheo- and DNP approaches. The student will work closely with a postdoc working on design and manufacturing of diffusional nanoprobes and with industrial researchers at Unilever and SyMO-Chem. The PhD student will be based at the Laboratory of Biophysics, Wageningen University.

For more information contact Dr. Henk Van As (Henk.VanAs@wur.nl) or Prof. Dr. John van Duynhoven (John.vanDuynhoven@wur.nl).

NMR position Glasgow

Characterisation of an endotoxin-sensing molecular switch

This project, in collaboration with Marine Biotech Limited, will examine the molecular recognition events that underlie the recognition of bacteria by Factor C, the initiator of the Horseshoe Crab’s innate defence system, using structural biology and biophysical techniques. The successful applicant will be a highly qualified and motivated graduate with a life sciences or chemistry degree and relevant experience. They will be trained in molecular biology, recombinant protein expression and purification, structural biology and biophysical techniques - in particular biomolecular NMR spectroscopy.


Dr. Brian O. Smith --------------------------- Brian Smith at glasgow ac uk
Institute of Molecular, Cell and Systems Biology & School of Life Sciences,
College of Medical, Veterinary & Life Sciences,
Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
Tel: 0141 330 5167/6459/3089 Fax: 0141 330 4600
The University of Glasgow, charity number SC004401

Mittwoch, 18. Januar 2012

Post Doc low field NMR

Post-Doc Position at CEA-Saclay (Paris) in low-field NMR

A one-year post-doctoral position is available to join the group of Dr. Dimitris Sakellariou at the Laboratory of Structure and Dynamics by Magnetic Resonance at the French Alternative Energies and Atomic Energy Commission of Saclay in Paris. Our focus is primarily directed at developing low-field (0.5 to 2.5 Tesla) NMR spectroscopic applications. The project is funded by the CEA for one year.

The net salary will be approximately 2000 - 2500 Euros/month (depending on the experience of the candidate).

Prospective candidates should have demonstrated experience in Magnetic Resonance Spectroscopy, relaxometry, in solid-state NMR, instrumentation or connected areas experimental physics and engineering.

Applicants should send 3 references in a cover letter as well as a full CV including the list of their publications and conference presentations to dsakellariou@cea.fr. Deadline for the application: January 30, 2012.

PhD projects

4 year PhD studentships in Translational Medicine are available at the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at Guy’s & St Thomas’ NHS Foundation Trust (GSTFT) and King’s College London (KCL). Excerpts from the call are copied below while the full call can be found here:


The BRC’s new 4 Year PhD Studentship programme represents an innovative approach to supporting the most promising graduates to undertake in depth postgraduate training in translational research leading to the award of a PhD. To facilitate training in Translational Medicine, students will have dual supervision by one clinician/clinical scientist and one basic scientist. The programme is designed to allow students to broaden their knowledge of translational research by undertaking three laboratory rotations and core training modules during Year 1. Applicants will select their choice of potential PhD projects from the BRC Studentship project list posted on the BRC website. This training period will help prepare students in the relevant research methodologies and/or develop the necessary understanding of the project area relevant to the final PhD project, to be undertaken during Years 2-4.

PhD Students will become full time students of King’s College London, and members of the BRC Faculty of Translational Medicine. Students will have access to core facilities, write up areas, bioinformatics and training support via the BRC resource centre.

Under this PhD Studentship programme call, the BRC are seeking to appoint up to 10 PhD Students to undertake translational biomedical research in a scientific area covered by the Centre. Funding under this scheme provides:

1) a stipend of £20,191 per annum for 4 years, which should also be used to cover MRes and PhD registration/tuition fees at the UK student rate.

2) a £2,000 contribution towards laboratory rotation expenses in year 1.

3) a £5,000 per annum consumables budget for years 2-4.


Available projects include a number focussed on the translatable application of magnetic resonance including a cluster of Magnetic Resonance Imaging based projects while our own group offers a project in the area of NMR metabolomics.


Applicants should have or expect to obtain a first-class or upper second-class degree or equivalent and have a track record in academic excellence. Previous research experience is desirable. Additional eligibility criteria for entry into the KCL graduate programme is detailed on the online postgraduate prospectus which can be accessed via the following link http://www.kcl.ac.uk/gsp08

Applications to the BRC should be made by electronic submission to include the following:

1) A two page CV

2) A covering letter setting out clearly which THREE BRC projects the applicant is most interested in applying for (the list of available projects is available at www.biomedicalresearchcentre.org ). These should be ranked in priority order 1-3, with projects ranking 1 being the candidate’s 1st choice.

Applications should be emailed to brc@gstt.nhs.uk by the deadline below.

The deadline for receipt of applications under this scheme is 5pm on Monday 30 January 2012. A structured visit to the BRC at Guy’s Hospital and interviews for shortlisted candidates has been provisionally scheduled for 13-14 February 2012 in the BRC on the guy’s Hospital Campus of KCL. All applicants should make a note of these interview dates, since it is likely that candidates shortlisted for interview will be notified only the week before. Successful applicants are expected to take up their studentships in October 2012.

Donnerstag, 12. Januar 2012

NMR Spectroscopist

The Department of Chemistry and Biochemistry at the University of Delaware
seeks an NMR Spectroscopist for its departmental NMR Facility. The rapidly
growing NMR facility is located in a newly built 4,650 ft2 NMR Magnet Hall, and
consists of 6 spectrometers operating at frequencies from 400 to 850 MHz.
These instruments serve more than 30 research groups at the University of
Delaware and beyond, and are used for modern NMR experiments on a wide variety
of systems, including biomacromolecules, inorganic materials, polymers, and
small molecules, both in solution and the solid state. The successful
candidate will report to the NMR Facility Director, and will be responsible for
operating and maintaining the instrumentation, for implementing new NMR
experiments, for training and supervising student and postdoc users, and for
assisting in the preparation of proposals for new equipment. The candidate
will be expected to maintain a broad knowledge of state-of-the-art NMR
technology and equipment.

Candidates must have a Ph.D. in chemistry or a related area with four years'
experience in solid-state and solution NMR spectroscopy and its applications to
biological systems and small molecules. Candidates must have demonstrated
expertise in solid-state and solution NMR spectroscopy, including development
and implementation of new NMR experiments, and in particular multidimensional
experiments for structural analysis of biological systems. Candidates must
have knowledge of NMR hardware and software for data collection and processing
in modern solution and solid-state NMR spectrometers, as well as extensive
experience with computers. Candidates must have excellent communication and
organizational skills, the ability to positively interact with a diverse group
of NMR users, and a strong motivation to learn new NMR techniques. More
information is available at the departmental web site
(http://sites.udel.edu/nmr). Applications and three letters of recommendation
should be electronically submitted to Ms. Susan Cheadle (scheadle@udel.edu).
In addition, applicants should go to http://www.udel.edu/udjobs/ and attach a
letter of application and curriculum vitae (including telephone number and
e-mail address) as one document. Review of applications will begin on Jan. 30,
2012, and will continue until the position is filled. All application
materials shall be shared with departmental faculty.

Employment offers will be conditioned upon successful completion of a criminal
background check. A conviction will not necessarily exclude you from

The University of Delaware is an Equal Opportunity Employer which encourages
applications from Minority Group Members and Women. The University's Notice of
Non-Discrimination can be found at

Post-Doctoral Position

Post-Doctoral Position in NMR Spectroscopy of Lithium Ion Battery Materials

An opening for a Postdoctoral Fellow is available in the Department of Chemistry and Chemical Biology at McMaster University. The successful candidate will work in the research group of Dr. Goward and the focus of this industry-funded position will be research on development and application of in situ NMR measurements of electrochemical lithium ion cells, with an aim to understand processes in vehicle batteries. This position is intended for a physical chemist interested in moving into a new research area, or for an NMR spectroscopist, interested in using their NMR expertise in this applied field. (knowledge of electrochemistry and material chemistry is also an asset). This research project will involve close collaboration with material scientists, chemists, and mathematicians, as well as research scientists with our Industrial Partners.

The fellowship is open to candidates of any nationality and selection will be based upon the candidate's research potential. The start date of the position is May 1, 2012. The duration of the position will be initially one year with extension for the second year contingent on satisfactory performance. The annual salary will be $45,000 CAD. We will begin reviewing applications on March 1, 2012. Applications received after this date will be accepted until the position is filled, and to ensure full consideration, applicants are advised to submit all supporting materials by the deadline.

Applicants should provide at least three letters of recommendation. They may be sent directly to:

Dr. Gillian Goward
Department of Chemistry and Chemical Biology
McMaster University
Hamilton, Ontario, CANADA L8S 4M1
Phone: +1 (905) 525 9140 ext. 24176
Fax: +1 (905) 522-2509
Email: goward@mcmaster.ca
URL: www.chemistry.mcmaster.ca/goward

McMaster is committed to Employment Equity and encourages applications from all qualified candidates, including aboriginal peoples, persons with disabilities, members of visible minorities and women.

Mittwoch, 11. Januar 2012

Postdoctoral position in solid state NMR

In the Research Group Macromolecular Interactions at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany. We are looking for an open-minded, enthusiastic candidate motivated to employ solid-state NMR spectroscopy to study the molecular mechanisms of host-pathogen interactions involved in innate immunity. The project focuses on the recognition of bacterial amyloid-like fibrils by specific host proteins and aims to identify molecular patterns of these fibrils recognized by the innate immune system. The successful candidate will join an interactive, dedicated team using NMR spectroscopy in combination with a wide range of state-of-the-art biophysical and proteinbiochemical techniques to study the structure and function of amyloids and other ordered aggregates in bacterial and viral infections. The project will be carried out in close collaboration with Dr. Barth van Rossum at the FMP in Berlin, and there will be the opportunity to tightly interact with both groups.

The HZI is a member of the Helmholtz Association of German Research Centres and dedicated to undertake biomedical research in the field of infection biology to expand our knowledge of the fundamental mechanisms behind medically relevant infectious diseases. It is part of a lively scientific community connected to the Technical University of Braunschweig, the University of Hannover and the Hannover Medical School. The Institute offers excellent working conditions for structural biologists, with state of the art technical equipment including facilities for the expression of proteins in mammalian, insect cell and bacterial systems, and excellent support for the development of personal soft-skills.


Strong experience in biomolecular NMR spectroscopy, ability to work as part of an international team and excellent communication skills in English (written and spoken) are a prerequisite. Experience in protein expression and purification will be considered an advantage. Candidates should hold a PhD in biophysics, biochemistry, chemistry, biology or related fields.

Starting date: as soon as possible

Duration: Initial contract for 2 years, with option for extension

Salary: TVöD E13 + Bonus to E14

Please send your application including CV, publication list, statement of research interests and the contact data of at least two referees referring to code 68/2011 to:

Helmholtz Centre for Infection Research, Dept. of Human Resources, Inhoffenstraße 7,
38124 Braunschweig, or by E-Mail: JobsHZI@helmholtz-hzi.de

For further information, please contact Prof. Christiane Ritter
Telephone: +49-531-6181-7065, e-mail: christiane.ritter@helmholtz-hzi.de.

Postdoctoral positions Spain

PhD student and two Postdoctoral positions in Structural determination of protein complexes at the IRB Barcelona (SPAIN)

The protein NMR group of Dr. Maria J. Macias has openings for two positions, a PhD and a Postdoct, to conduct solution NMR and/or X-Ray studies of proteins and complexes. Applicants should have a degree in Chemistry, Biochemistry or related. For the Postdoctoral position experience in structural biology is required.
The offered positions correspond to the project named "Structural and functional studies on Smad transcription factors" (PI: Maria J. Macias)

A second Postdoctoral position is available for the project Synthesis of modified peptides and structural characterization of their interactions with pharmacologically relevant proteins. Synthesis of inhibitors (PIs: Maria J. Macias and Antoni Riera). For this position, experience in peptide chemistry and/or chemical ligation is of advantage, and no experience in molecular biology is required.
Applicants should send to maria.macias@irbbarcelona.org or to antoni.riera@irbbarcelona.org their C. vitae, including a list of their publications, a cover letter explaining the candidate’s interest in the position and the names and contact details (including e-mails) of three individuals we may contact for reference letters.

Furthermore, applicants should be ready to apply for fellowships. Applications for the “la Caixa”/IRB Barcelona International PhD Programme Fellowships are now being accepted. The IRB Barcelona International Postdoctoral Programme co-funded by the FP7 Marie Curie-COFUND Programme is expected to be launched on 13 January 2012.

Pau Martín Malpartida
Protein NMR Lab.
Barcelona Science Park
Josep Samitier 1-5 08028 Barcelona, Spain
Tel : +34 93 4037190
eMail: pau.martin@irbbarcelona.org


An opening exists at the University of Georgia for a postdoctoral associate to work on structural characterization of proteins using advanced NMR techniques. Primary responsibilities reside with our role in the Northeast Structural Genomics Consortium (NESG). These responsibilities involve structure improvement and validation of structures using RDC and RCSA data, as well as the production of a number of biologically relevant protein structures. Our lab also has strong programs in the glycobiology and vesicle trafficking areas, and we anticipate opportunities to be involved with these activities as well. We have excellent NMR instrumentation with a 600 MHz machine dedicated to the NESG project and higher field instruments with cryogenic probes at 800 and 900 MHz.

It is especially important that candidates have experience with advanced NMR methodology (either solution or solids) and are interested in the development of novel approaches to solving challenging problems in the structural biology area. Please send a letter describing your interests, along with a CV and the names of three individuals that may be contacted for reference letters, to James H. Prestegard (jpresteg@ccrc.uga.edu) by January 25, 2012. The University of Georgia is an AA/EEO employer.

James H. Prestegard
Complex Carbohydrate Research Center
University of Georgia
315 Riverbend Rd
Athens, GA 30602-4712

2 years Post-doctoral position

2 years Post-doctoral position:

NMR study of paramagnetic AxMO2 (A = Li, Na) layered oxides to help understanding the structure-properties relationship

87, Avenue du Docteur Schweitzer , 33608 PESSAC cedex (France)

Starts in between May and October 2012.

For more information, please contact :
Tel : 00 33 (0)5 40 00 35 69

Maître de conférences - Université Bordeaux1
33 +5 40 00 35 69

PhD and PostDoc positions SSNMR

PhD and PostDoc positions in solid-state NMR

Development and applications of high-resolution solid-state NMR methods to study molecular systems of pharmaceutical, energy and environmental interest

Job summary:

Two research grants (1 PhD and 1 PostDoc) are available for highly motivated candidates with an outstanding academic record in the Science or Engineering disciplines, at the Group for Synthesis, Structure and Technological Application of Materials – SYSTAM – at the University of Oviedo (Spain) and the Center for Research in Ceramics and Composite Materials – CICECO – at the University of Aveiro (Portugal) within the framework of project MAT2010-15094. This project aims at employing state-of-the art solid-state NMR (SSNMR) methodology and computational methods to understand the underlying intermolecular interactions, which play a crucial role in the molecular arrangement of pharmaceutical systems and elucidate the chemical structure of inorganic-organic hybrid materials of environmental and catalytic interest. The successful candidates will have access to fully equipped SSNMR spectrometers ranging from 400 to 800 MHz located at both universities and at the installations of the Portuguese NMR network. The candidates will also have access to several diffraction equipments including sophisticated high-resolution single-crystal/powder X-ray and electron diffraction equipments.

See below the job description and application details for each position (Note: the PostDoc position description is just after the PhD position details written below)

L. Mafra

Luís Mafra, PhD
CICECO research laboratory
Chemistry Department
University of Aveiro
3810-193 Aveiro
e-mail: lmafra@ua.pt
Office: +351 234 247135 (ext. 24754)
Fax: +351 234 370 084

####### PhD position ##############################################

Job description:

Duration: The PhD grant will have an initial duration of 12 months, with a predicted starting date of 01 March 2012, and a possible extension up to a period of 60 months. The further extension will be possible depending upon the success on application to different Spanish (as FPI, FPU, Severo Ochoa or PPI-Uniovi) or European programs.

Application deadline: 31 January, 2012

Activity Outline: The objectives of the project will be to perform experimental and computational studies of tridimensional structure of compounds with pharmaceutical interest based on solid-state NMR spectroscopy combined with X-ray diffraction methods and computer simulations. The systems to be studied may include two research lines:
i) Pharmaceutical systems: polymorphism and the study of intermolecular forces implied in the transformation between pharmaceutical hydrates and anhydrates; study of polymeric scaffolds hosting drugs to investigate the structure and intermolecular drug-drug and drug-host interactions involved in the mechanism of swelling, drug impregnation, and drug release.
ii) Systems of environmental, energy and catalytic interest: Study of hybrid materials to capture CO2 and to convert catalytically the CO2 to various commodity chemicals. The hybrid materials to be studied include ionic liquids and Metal Organic Frameworks (MOFs).

Academic Requirements: Prospective applicants should possess a degree in Science or Engineering disciplines (Physics, Chemistry, Physical Chemistry, Computational Chemistry or related fields). Previous experience in computational methods or NMR spectroscopy is an advantage but not mandatory. The candidate should have a final course classification equal or above 16/20. The candidates should, preferably, have less than two years after graduation.

Evaluation Criteria and Process: The evaluation criteria are: i) Final classification of Undergraduate (value: 8/20) and Masters (value: 5/20) degrees; ii) Previous experience in related areas (value: 2/20); iii) Scientific publication record (value 2/20); Interview (value 3/20). All eligible candidates will first be classified in terms of absolute merit. Those approved will then be ordered consecutively in terms of relative merit. The candidate rated highest in the relative merit list will be invited to occupy the position. The selected person will be informed by email.

Documents Required: i) Application letter mentioning the contacts of two or three reference contacts; ii) Curriculum Vitae, dated and signed; iii) Photocopy (or scanned copy) of identity card or passport; iv) Academic degree certificate(s). Applications should be sent by email to Dr. Luís Mafra (lmafra@ua.pt) and Prof. Santiago García-Granda (sgg@uniovi.es) within the time frame of the call.

#######PostDoc position ##############################################

Job description:

Duration: The PostDoc grant will have an initial duration of 10 months, with a predicted starting date of 01 March 2012, and a possible extension period of 12 additional months till the end of 2013. Further contracts are possible depending upon the success on application to different Spanish programs (as Juan de la Cierva, Ramón y Cajal, Clarín) or European programs.

Application deadline: 31 January, 2012

Activity Outline: The objectives of the project will be to perform experimental and computational studies of tridimensional structure of compounds with pharmaceutical interest based on solid-state NMR spectroscopy combined with X-ray diffraction methods and computer simulations. The systems to be studied may include two research lines:
i) Pharmaceutical systems: polymorphism and the study of intermolecular forces implied in the transformation between pharmaceutical hydrates and anhydrates; study of polymeric scaffolds hosting drugs to investigate the structure and intermolecular drug-drug and drug-host interactions involved in the mechanism of swelling, drug impregnation, and drug release.
ii) Systems of environmental, energy and catalytic interest: Study of hybrid materials to capture CO2 and to convert catalytically the CO2 to various commodity chemicals. The hybrid materials to be studied include ionic liquids and Metal Organic Frameworks (MOFs).

Academic Requirements: Prospective applicants should possess a PhD in Science or Engineering disciplines (Physics, Chemistry, Physical Chemistry, Computational Chemistry or related fields). Previous experience in computational methods and/or solid-state NMR spectroscopy is an advantage. The candidate should have a top research profile with international experience. The candidates should be preferably under 35 and less than four years after the obtaining their PhD.

Evaluation Criteria and Process: The evaluation criteria are: i) Final classification of Undergraduate (value: 2/20) and Masters (value: 3/20) degrees; ii) Previous international experience in related areas (value: 5/20); iii) Scientific publication record (value 7/20); Interview in English (value 3/20). All eligible candidates will first be classified in terms of absolute merit. Those approved will then be ordered consecutively in terms of relative merit. The candidate rated highest in the relative merit list will be invited to occupy the position. The selected person will be informed by email.

Documents Required: i) Application letter mentioning the contacts of two or three international reference contacts; ii) Curriculum Vitae, dated and signed; iii) Photocopy (or scanned copy) of identity card or passport; iv) Academic degree certificate(s). Applications should be sent by email to Dr. Luís Mafra (lmafra@ua.pt) and Prof. Santiago García-Granda (sgg@uniovi.es) within the time frame of the call.

Senior Tenure-Track

Senior Tenure-Track or Tenure-Eligible Investigator Position in Structural Biology & Biophysics

The Structural Biophysics Laboratory (SBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) is seeking an outstanding tenure-track or tenure-eligible principal investigator to carry out original, independent, and innovative research in an area of Structural Biology or Biophysics integrated with molecular biology. This intramural position is similar to that of an associate (or higher) professor in academia.

Areas of emphasis include structural biology of biomacromolecular systems and/or characterization of dynamic assembly/function of macromolecular complexes that impact the biological processes relevant to cancer and/or AIDS. The incumbent will establish/continue a highly competitive and collaborative program, with an emphasis or utilization of NMR spectroscopy, including solid-state NMR. Applicants must have a Ph.D. or equivalent degree and have demonstrated expertise and a record of achievement.

To apply, please submit a cover letter, curriculum vitae, description of research plans (~ 5 pages), and have 3 letters of recommendation set to: Ms. Deanna Doughtery, Administrative Officer, NCI-Frederick, PO Box B, Bldg. 578, Frederick, Maryland, 21702-1201, Tel. 301-846-5199, FAX 301-846-6053, E-mail: SBLsearch@mail.nih.gov. PDF files are encouraged.

Please share this announcement with your colleagues.
Best wishes,
Andy Byrd

R. Andrew Byrd 301-846-1407
Chief, Structural Biophysics Laboratory FAX 301-846-6231
Macromolecular NMR byrdra@mail.nih.gov

Center for Cancer Research
National Cancer Institute-Frederick
P.O. Box B, Bldg. 538
Frederick, MD 21702-1201

PhD studentship

A 4 year PhD studentship contract is available in my group starting september 2012 to work on the structural and functional aspects of the recognition of chromatin structure by the ING4 tumor suppressor.

We seek a motivated student with a strong interest in structural biology, and with a Master degree (to be completed before september 2012).

The PhD researcher will be involved in sample preparation and structural analysis by NMR and other techniques. The laboratory hosts two Bruker spectrometers (800 and 600 MHz) with a full complement of probes for biomolecular studies). Electron microscopy and crystallography platforms are also available at CIC bioGUNE. Functional assays will be carried out in collaboration with an external group.

CIC bioGUNE (http://www.cicbiogune.es) is a research institute in biosciences created and supported by the Basque Government in 2005 to foster bioresearch and biotech industry in the Basque Country. It is located near Bilbao, an area with a high standard of living, a mild climate and a vibrant cultural environment.

Information about the current activity and publications of the lab can be found in the following link


Interested applicants should send their CVs to fblanco@cicbiogune.es before the 31st of january 2012.

Best regards

Francisco J. Blanco
Ikerbasque Research Professor
Structural Biology Unit, CIC bioGUNE
Parque Tecnológico de Bizkaia, Edificio 800
48160 Derio, Spain
Phone: 34 946572521
Fax: 34 946572502

Post-Doc in Montpellier

The NMR group at the Centre de Biochimie Structurale (CBS) in Montpellier (France) is looking for a highly motivated researcher to join the team as a post-doc to work for two years on a project funded by the Chaires d’Excellence program of the French Research Funding Agency (ANR). The project, leaded by Pau Bernadó, aims the structural and dynamic characterization of a family of intrinsically disordered proteins linked to neurodegenerative diseases, and to reveal the molecular basis of the aggregation process causing these pathologies. This objective will be achieved by the integration of NMR, SAXS and single-molecule FRET data into novel computational approaches.

The successful candidate should have a PhD in chemistry, biology or physics and experience in solution state biomolecular NMR spectroscopy. Previous experience with protein expression and purification will be considered favourably. Knowledge in other biophysical techniques and computational methods will be favourably evaluated.

The laboratory hosts high-field state-of-the-art NMR spectrometers for biomolecular applications: A 700 MHz and a 500 MHz both equipped with cryoprobes and a 600 MHz. In addition to NMR, the CBS has an outstanding infrastructure covering all techniques for structural biology and biophysics including X-ray crystallography, cryo-electron microscopy, advanced fluorescent and super-resolution microscopes, single-molecule manipulation, molecular and cell biology, and high-performance computation.

Montpellier is a major biology area with a focus on basic research, biomedicine, plant biology and environmental science. Its science drive, the beauty of the region and its high quality of life, and the short commute to other major regional research areas (Barcelona, Paris, Toulouse, Marseille) make it an ideal destination for scientists from all over the world.

Applications and informal queries about the project and the lab should be addressed to Pau Bernadó (pau.bernado@cbs.cnrs.fr). Interested candidates should send their CV and the names of persons willing to write a recommendation letter in a cover letter describing their research interests and motivation.

Pau Bernadó, PhD
Group Leader

Centre de Biochimie Structurale
29, rue Navacelles
34090 Montpellier

Tel. +33(0)467417912
e-mail: pau.bernado@cbs.cnrs.fr


Post-Doc Position at CEA-Saclay (Paris) in NMR / MRI instrumentation

A one-year post-doctoral position is available to join the group of Dr. Dimitris Sakellariou at the Laboratory of Structure and Dynamics by Magnetic Resonance at the French Alternative Energies and Atomic Energy Commission of Saclay in Paris. Our focus is primarily directed at developing a novel instrumentation for in vivo Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) of complex matter and small animals. The project is funded by the European Research Council for the next two years.

The duration is 12 months (with the possibility to renew it for another 12 months) and the net salary will be approximately 2100 - 2600 Euros/month (depending on the experience of the candidate).

Prospective candidates should have demonstrated experience in Magnetic Resonance magnet and coil (shims, gradients and rf) engineering, in clinical or pre-clinical MRS studies, solid-state NMR, instrumentation or connected areas experimental physics and engineering.

Applicants should send 3 references in a cover letter as well as a full CV including the list of their publications and conference presentations to dsakellariou@cea.fr.

NMR tenure track position at Brown University

Structural Biology Faculty Position - Assistant Professor

The Department of Molecular Pharmacology, Physiology & Biotechnology at Brown
University announces the opening of a faculty position at the rank of Assistant
Professor, effective July 1, 2012. Qualifications include a Ph.D. and/or M.D.
degree with relevant postdoctoral research training and a record of excellence
in research. The successful applicant will be an experimentalist in the area
of NMR spectroscopy who will be expected to pursue an independent,
externally-funded research program. The applicant should demonstrate a
commitment to graduate and undergraduate education, and will have the
opportunity to participate in predoctoral training programs within the Division
of Biology and Medicine and the campus at large. Research space will be
provided in a new, state-of-the-art facility with access to modern core
facilities, NMR spectrometers, X-ray equipment, crystallization robotics, and
biophysical analysis instrumentation, such as ITC, DSC, CD and mass
spectrometry (LTQ Orbitrap) among others. Recent upgrades to the Brown
University structural biology infrastructure include the planned addition of an
850 MHz NMR spectrometer and new X-ray crystallography and small angle X-ray
scattering (SAXS) equipment.

Candidates should submit a curriculum vitae with complete bibliography, a 3-5
page description of research plans, and a one-page teaching statement.
Applicants should arrange for at least three reference letters to be sent under
separate cover. Review of materials will commence on January 15, 2012, and will
continue until the position is filled. Materials should be submitted
electronically in PDF format to Structural_Biology@brown.edu or by mail to:
Betsy Jacobson, Department of Molecular Pharmacology, Physiology &
Biotechnology, Brown University, Box G-E3, Providence, RI 02912.

Brown University is an Equal Opportunity/Affirmative Action employer and
welcomes applications from women and minorities.


In connection with a collaboration agreement with Janssen Pharmaceutica,
Beerse, Belgium, the University of Liege has a postdoctoral vacancy available.

We are looking for a highly motivated individual with a sound understanding of
ssNMR theory and extensive experience in implementing, setting up, running,
processing and evaluating ssNMR experiments, preferably in the context of
pharmaceutical applications. The successful candidate will be responsible for
setting-up a ssNMR research environment suitable for pharmaceutical
applications of ssNMR - as a tool for trouble shooting as well as a tool for
the development and characterization of solid form formulations (tablets,
powders, suspensions, including nano-particle based forms). Ability to work
independently and very good communicative skills are a must. He/she will be
involved in collaborative projects with Janssen Pharmaceutica.
The NMR group in Liege is equipped with two Bruker 400 MHz ssNMR spectrometers.
Potential applicants are encouraged to contact Christian Damblon for more
information about this position (or life in the historic city of Liege).
Applications must be received before end of February 2012.

Prof. Christian Damblon
Institut de Chimie
allée de la Chimie, 3 (Bât. B6)
Sart Tilman - 4000 Liège
Tel. +32 4 366 3788


A two-year post-doc position is available in the field of Solid State NMR

At: Nano-SiSTeMI Interdisciplinary Centre, University of Piemonte Orientale

Where: Alessandria, Italy; Milan, Italy

Task: The aim of the project, in collaboration with Bruker (Italy) is to develop,

implement and use innovative solid state NMR (SS-NMR) techniques for the study of

a broad range of solids including catalysts, materials for photovoltaic devices,

optoelectronic and sensing, polymer composites, hybrid materials, cements, etc... The

responsibility also includes in providing (a) assistance and training in SS-NMR, (b)

designing and development of pulse programs, (c) experimental and interpretational

service to support collaborative and multidisciplinary research on national and

international levels and (d) day-to-day maintenance and upgrading of the facility.

The position plays two distinct roles. One is part of the NMR centered program of the

Prof. Marchese group. The other is as part of the characterization facilities available

to collaborating research groups, both within the department and external, that service an extremely wide-ranging program of materials-centered research.

Salary: 24-26 k€/year depending on the candidate experience

Prof. Leonardo Marchese, +39 0131 360262 (mob. + 39 3482879225) leonardo.marchese@mfn.unipmn.it
Dr. Angelo Ripamonti, +39 02 70 63 63 70, angelo.ripamonti@bruker.it

solid state NMR Platform Manager

***A Position as solid state NMR Platform Manager is being offered at

CIC Energigune, Parque Tecnologico de Alava, 01510, Spain

CIC Energigune is a new energy research centre based in the Basque Country of Spain. Its mission is to play a leading role on the international stage in the field of energy storage technologies and contribute to the industrial competitiveness of Basque Country. CIC has a world-class research facility, cutting-edge equipments, an experienced management team, and a scientific committee composed of prominent scientists, entrepreneurs, and industrial experts. (www.cicenergigune.com).
The Basque Country is renowned for the beauty of its natural surroundings. It offers high standards of living and quality of life, in terms of health, housing, leisure, sports, etc, making it an attractive area to live in.

CIC Energigune is now inviting applications for the position of Nuclear Magnetic Resonance (NMR) Platform Manager to custom-build the area´s NMR platform in the field of energy storage technologies.

***What we offer

We are offering a permanent position that will give you a unique opportunity to apply your capabilities and develop new projects related to this technical platform.

In addition to the appeal of the entire project, the CIC Energigune offers a competitive basic salary augmented by benefits that compare favourably with the best European private and public institutions.

***What we need

We are looking for a motivated and experienced professional capable of taking this unique opportunity with the following requirements:

* An MS degree preferably in Physics or Chemistry. PhD is not compulsory but will be valuable.

* Ideally several years of experience doing research with solid state NMR and also if possible some liquid NMR. More specifically, the candidate should have :

- An experience in multidimensional quadrupole and spin 1/2 solid state NMR is required

- An ability to match/tailor suitable NMR experiments to the scientific inquiries in materials research for energy applications

- The understanding of the pulse sequences and have the ability to modify and/or write them, and

- The skills to use simulation programs of solid state NMR parameters such as SIMPSON or SPINEVOLUTION are also valued

* An open-mind and creativity, willing to work in new experiments such as in-situ NMR of batteries or other energy harvesting, conversion or storage devices

* Inter-personal and communication skills to work effectively within a multi-disciplinary team or to provide supports for other facility users

Applicants should be fluent in English. Knowledge of Spanish and/or Basque will be considered useful but not compulsory.

All applicants are invited to submit a detailed curriculum vitae and two reference letters. Applications should be loaded at http://www.cicenergigune.com/en/trabajar/enviar-curriculo/.

Applications will be reviewed upon receipt and the search will continue until the position is filled.

CIC energiGUNE is committed to affirmative action, equal opportunity and the diversity of its workforce.


A postdoc position on protein-ligand interactions and fragment-based drug design by NMR is available at the Helmholtz Zentrum München


Job Details

The candidate will be responsible for characterizing protein-ligand interactions and implementing fragment-based approaches by NMR spectroscopy for the identification and optimization of small molecule inhibitors targeting disease-linked pathways. The scientist will be working in the group of Michael Sattler at the Institute of Structural Biology (http://www.helmholtz-muenchen.de/stb) in close collaboration with structural biologists using NMR-spectroscopy and X-ray crystallography for studying protein-ligand interactions. Interactions are expected with the Protein Expression and Purification Facility and the Assay Development and Screening Facility. The scientist should establish NMR-monitored fragment-based screening and support on-going projects in the identification and optimization of small molecule hits and leads using structural biology (NMR and X-ray crystallography). Tasks include:

- Implementing a fragment library and NMR-monitored screening
- Application of NMR based methods for protein-ligand interactions (ligand and target based)
- Hit validation and structural analysis of protein-ligand complexes by NMR and/or X-ray crystallography
- Implementation and development of new methods and techniques
- Interaction and project-driven collaborations with biologists and chemists, e.g. for establishing structure-activity relationships

The candidate is expected to interact and collaborate with researchers at HMGU.


- Doctoral degree in Chemistry, Biochemistry, Life Sciences, Physics, or related
- Demonstrated strong experience with structural biology and/or structure-based techniques for studying protein-ligand complexes
- Experience with training and supervision of students is desired
- We expect high motivation, creativity and a strong commitment to team work.
- Strong communication and organizational skills are expected
- Previous experience with chemical compound libraries is desirable

Our Offer

- Research scientist in the Institute of Structural Biology at the Helmholtz Zentrum München
- Supporting innovative research on important biological pathways linked to human disease.
- Working in a vibrating and scientifically stimulating environment with excellent facilities for NMR (http://www.bnmrz.org), structural biology, protein biochemistry, cell biology, imaging, animal models, and more.
- Opportunities and support in management skills

For further information please contact Michael Sattler (sattler@helmholtz-muenchen.de)

The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.

Applications should be addressed to Waltraud Wolfson (waltraud.wolfson@helmholtz-muenchen.de)

Helmholtz Zentrum München
German Research Center for Environmental Health (GmbH)
Ingolstädter Landstr. 1
85764 Neuherberg

junior research associate

We are seeking for potential candidates to apply for a position as a
CNRS junior research associate in conjunction with our group.

The focus of the research will be on developing advanced NMR methods
for the analysis of mixtures of small molecules, with particular
attention to perspective applications to natural products. Our ongoing
activity aims at resolving the complex NMR spectra of multicomponent
mixtures by relying on pseudochromatographic experiments (Angew. Chem.
2006, 45 , 5950-5953), multiple-quantum analysis (Anal. Chem. 2010,
82, 3266-3269 ) and adapted signal processing.

The candidate will be located at the Institut de Chimie des Substances
Naturelles (Gif-sur-Yvette), in the Paris area, which hosts several
high-field spectrometers, including a 950 MHz.

The ideal candidate should have a disposition towards teamwork, an
inquisitive mind and a solid background on the development and application
of modern NMR methodology, with a Ph. D. degree and at least one year
of post-doctoral work in the area.

As the CNRS national competition is highly selective, a strong
publication record is necessary.

For additional information, please contact Stefano Caldarelli