Montag, 27. September 2010


Position Title: Scholar/Scientist (CHM), Solid State Nuclear Magnetic Resonance (NMR) Spectroscopist
Appointment: 2 years renewable upon mutual agreement
Department: Chemistry and Biochemistry, Florida State University
Salary Range: $50,000 to negotiable

Qualifications: Ph.D. in chemistry with specialized training and experience in solid state NMR spectroscopy.

Knowledge of the terminology, principles and techniques of state of the art Nuclear Magnetic Resonance (NMR) spectroscopy, including solid state NMR.

Skill in the use, maintenance, and operation of modern solution and solid state NMR spectrometers.

Familiarity with NMR data processing software.

Knowledge of and experience with standard solid state pulse sequences.

Ability to implement new solid state pulse sequences.

Ability to identify NMR experiments to solve problems in solid state chemistry.

Ability to establish and maintain effective working relationships with faculty in Chemistry & Biochemistry and other departments.

Ability to communicate effectively both verbally and in writing.


Determine in consultation with faculty and students most effective NMR experiments and define experimental parameters for obtaining high resolution NMR data on a variety of solid materials; communicate results and consult with users regarding further experimentation as necessary. (25%)

Configure solid state NMR spectrometer(s), including rf-pulse sequences for optimum performance; perform routine maintenance on NMR spectrometers including regularly-scheduled cryogen maintenance. (25%)

Train and mentor graduate students and post doctoral associates in the use and applications of modern solid state NMR; supervise and monitor bi-weekly scheduling of time on instrument(s); prepare and deliver periodic lectures on emerging solid state NMR topics. (25%)

Collaborate with Faculty on ssNMR experiments. (25%)
If qualified and Interested please contact: Prof. Tyler McQuade (

Timothy A. Cross
NMR Spectroscopy and Imaging Program Director
National High Magnetic Field Laboratory
1800 E. Paul Dirac Dr., Tallahassee, FL 32310-3706
Tel: 850-644-0917; Fax:: 850-644-1366; email:

research technician

Dear colleagues,
A permanent position for a research technician (scientific associate, non-PhD level) is available immediately at Novartis in Basel. The description is attached below. Please note that this position is different and in addition to the PhD-level position which was advertised 2 weeks ago. The current position involves a broad range of biophysical methods, including NMR, SPR and crystallization, in addition to protein purification and characterization. While expertise in any of these techniques will be an advantage, training on the job will be provided for the other techniques. This should be a great opportunity for anyone with a masters or bachelors degree (or equivalent) and a strong desire to learn a broad range of biophysical methods.
If you are interested, or know anyone who is interested, please send me an email or apply online via - careers - Job ID 72251BR.
Best regards
Job ID 72251BR
Position Title Scientific Associate II
Division NIBR
Business Unit Research Europe
Country Switzerland
Work Location Basel
Company/Legal Entity Switzerland Novartis Pharma AG, Basel
Functional Area Research
Job Type Full Time
Employment Type Permanent
Job Description A permanent position is open in the Structural Biology Platform of the Center for Proteomic Chemistry, NIBR (NIBR/CPC/SBP).We are looking for a motivated person to work on the purification and characterisation of protein-ligand complexes in a structural biology laboratory. This will involve the application of multiple biophysical methods such as NMR, crystallography and SPR, among others. Experience with any of these techniques is considered a significant advantage, although training can be provided on the job.
Minimum requirements Bachelors or Masters degree or equivalent. Strong background in chemistry or biochemistry. Experience in protein handling, purification and characterisation. Background in protein chemistry with protein crystallography, NMR or biophysics experience would be an advantage. Ability to work in a team and interact with colleagues in a multicultural environment. Ability to work on different projects in parallel. Desire to learn new methods and apply them to answer scientific questions.
The candidate should be prepared to implement novel approaches. Open communication, an independent and precise way of working, and excellent team work skills are important. Good knowledge of spoken and written English is required, and communication skills in German and/or French are desirable.

Biomolecular NMR Spectroscopy

Positions in Biomolecular NMR Spectroscopy at Maastricht


The Maastricht University Medical Center and the Faculty of Health, Medicine and Life Sciences (FHML) seek to fill several positions for the newly established center for NMR Structural Biology within the CARIM School for Cardiovascular Diseases and the Maastricht-Centre for Atherosclerosis Research (M-CAR). Applications are sought for a senior NMR spectroscopist, a postdoctoral associate and a technician. The senior NMR spectroscopist will essentially operate the NMR Facility under faculty directorship, and will also be encouraged to develop an independent line of research consistent with the goals of CARIM and M-CAR.

In general, successful applicants will be highly motivated individuals interested in studying the molecular basis of cardiovascular disease, as well as on the design and discovery of novel pharmaceutical agents e.g. targeting chemokine and galectin oligomers to ameliorate cardiovascular disorders.

Although NMR spectroscopy will be major focus of the Center for Structural Biology at CARIM, other biophysical methods may be employed to elucidate specific molecular mechanisms of action to better understand biological function.

The senior NMR and postdoctoral position require a PhD degree in physical sciences and experience in advanced biomolecular NMR spectroscopy of proteins and protein structure elucidation. The candidate for the technical position should have experience in NMR spectroscopy, preferably with a degree in experimental physics, biophysics, or engineering. The successful applicant for the technical position should have experience in protein expression, mutagenesis, and purification.

Salary will be commensurate with experience and the guidelines set by the Maastricht University Medical Centre.

Additional information
CARIM School for Cardiovascular Diseases
Prof. C. Weber, Prof. K. Mayo, Prof. T. Hackeng

Those interested are requested to send a cover letter describing research interests, along with a CV and list of publications, and arrange for three letters of reference to be forwarded by November 24, 2010.


The NMR and Structure Analysis unit of the Department of Organic Chemistry of Gent University (Belgium) is involved in research activities in the (bio)chemical and material sciences using NMR spectroscopy as the main investigative tool.

For this purpose, it has available a range of fully equipped Bruker NMR spectrometers, including Avance 300 and 500 MHz spectrometers, and an AVANCE–II 700 MHz instrument, housed within the unit and part of the Interuniversitary NMR Facility, jointly operated between Ghent University, the Vrije Universiteit Brussel (VUB) and Antwerp University (UA).
By spring 2011, a new 500 MHz system including a high gradient diffusion probe head will be delivered.

The duties of the successful applicant include:
Scientific research within the context of NMR research projects within the department. Scientific support and co-manager of the Interuniversity 700 MHz high field NMR facility and the new 500 MHz facility within the department. Mentoring of Master and PhD students. Contribute to the educational activities of the department (at Master level) – a minimum of at least 70% of the appointee’s time must however be spent on scientific research. The main research topic for the current position will be the further development and application of liquid state NMR techniques for the investigation of colloidal nanoparticle dispersions, including quantumdots and pigments/latexes. An idea of the type of research and our recent results can be seen at .

We offer:
* The opportunity to fully participate in current research projects of the unit.
* The opportunity to play an active part in the creation and exploitation of the highest and most diversely equipped NMR facility in the region.
* A competitive salary amounting to 1800-2100 €/month (commensurate with age and experience).

To be eligible, applicants should:

* Demonstrate knowledge and practical expertise in solution NMR spectroscopy, as demonstrated by publications in international journals and/or oral communications at national or international meetings.
* Demonstrate technical knowledge in the operation of Bruker NMR equipment (hardware and software) including implementation of new and existing pulse sequences.
* Demonstrate interest for student mentoring
* Have acquired a PhD degree by the time of appointment (foreseen 1/1/2011).

The Universiteit Gent is an equal opportunity employer.
For further information contact Prof. José Martins via e-mail: as soon as possible . Deadline for official application is October 14th --

Mittwoch, 15. September 2010

permanent protein NMR position

A permanent protein NMR position is available at Novartis in Basel, Switzerland. The description is attached below. If you are interested, please apply online via - careers - Job ID 70618BR.
Kind regards
Position Title
Investigator II – Structural Biology
Job Description
Investigator II in the Structural Biology Platform (SBP) within the Center for Proteomic Chemistry (CPC) of NIBR Basel. As a member of a multidisciplinary research team you will apply NMR based techniques to study protein targets and antigen-antibody as well as protein-ligand interactions in order to facilitate the drug discovery process. Your work will include the purification of isotope labeled proteins. You will also be involved in evaluating potential new structural biology projects, coordinating the efforts of small teams towards providing structural and biophysical data to impact drug discovery projects, and representing the Structural Biology Platform in multidisciplinary/multinational project teams.
Minimum requirements

We are looking for a highly talented and motivated scientist with a PhD in biochemistry or related disciplines plus 1-3 years of postdoctoral experience in an academic or industrial setting. The ideal candidate will have extensive experience in a broad range of NMR techniques and in the area of protein purification. He/she will have a sound knowledge of biochemistry, analytics and a strong interest in the biology of human diseases. Experience in the use of additional biophysical methods to characterise protein-protein or protein-ligand interactions or crystallography would be advantageous. The candidate should be strongly committed and display a high level of creativity and passion for project work. He/she will be a member of a multi-disciplinary, multi-national team of drug discovery professionals. Excellent oral and written communication skills are required.

postdoctoral position in biomolecular NMR

A postdoctoral position in biomolecular NMR is available immediately at The
City College of New York (CCNY) located in New York City.

The selected candidate will work on a project that aims to deduce the
structural and dynamics of nick recognition and repair by DNA ligases (J. Mol.
Biol. 2010, 395, 291-308), and will join a group that includes graduate
students, postdoctoral associates and senior scientists.

The group has significant access to the NMR facilities in-house (600 MHz with a
cryoprobe) and to those at the New York Structural Biology Center (NYSBC,
500-900 all with cryoprobes). In addition, access to crystallization and
screening facilities (NYSBC) and the X4A, X4C beamlines (NSLS, Brookhaven
National Lab.) will also be available. The NYSBC is situated on the CCNY campus
a few yards from the laboratory and is the largest such center in the United

Potential applicants are expected to have extensive experience in biomolecular
NMR spectroscopy and in the expression, purification and biochemical
characterization of proteins. Applicants are requested to send their CVs and
three letters of recommendation by email to Ronnie Ghose (
A highly competitive salary and benefits package is available.

Additional information may be obtained from the group website

Postdoc Paris

A two-year postdoctoral position is available in the NMR group headed by Prof. G. Bodenhausen in "Laboratoire des Biomolécules" in Paris (France), under the supervision of Prof. O. Lequin.

The selected candidate will be involved in a project which aims at analyzing structure-function relationships of homeoproteins. Homeoproteins form a large class of transcription factors characterized by a conserved DNA binding domain called homeodomain. These proteins possess the striking property to be internalized within cells by direct membrane translocation processes which are not yet well understood. Homeoproteins are thus involved in original modes of cell signalling. The work of the selected candidate will mainly focus on studying the structure and interactions of homeodomains in aqueous environments, in membrane environments and in cellular environments. This project is funded by the French Agence Nationale pour la Recherche (ANR grant "PARAHP") and will be carried out in collaboration with biochemists and cell biologists (groups of A. Joliot, A. Prochiantz, L. Venance, CNRS-INSERM-Collège de France).

The candidate should have a strong expertise in NMR spectroscopy and be motivated in developing multidisciplinary research fields including liquid state NMR, solid state NMR of protein/lipid complexes, in cell NMR, and biochemistry (protein expression, membrane models, cell culture).

Laboratoire des Biomolécules, UMR 7203
Université Pierre et Marie Curie – ENS – CNRS

Engineer Position

Engineer Position in the NMR Biomolecular Group in Strasbourg

A three-years engineer position is available in the NMR Biomolecular Group of the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Illkirch (near Strasbourg), France.

The research project is focused on the study of RNA/protein interactions. In particular, we propose to develop a combined Nuclear Magnetic Resonance (NMR) and spin labeling approach for the structural and dynamics studies of RNA/protein complexes. The engineer to be recruited will be in charge of proteins expression and purification, RNAs synthesis and purification, and spin labeling. Knowledge of NMR would be appreciated.

The successful candidate will have access to a fully equipped laboratory for the preparation of proteins and RNAs samples. The laboratory also holds three NMR spectrometers equipped with cryogenic probes (600 MHz and 700 MHz) and with a TXI probe (500 MHz).

Candidates must hold a Master or have a two-years significant experience in Molecular Biology. Applications should include CV, statement of interest and references.

Starting date: 2010-12-01

Contact informations:
Pr Bruno KIEFFER, and Dr Isabelle Lebars,
IGBMC Biomolecular NMR group
1 rue Laurent Fries
BP 10142
67404 Illkirch CEDEX
Tel.: +33 (0) 3 68 85 44 07 / +33 (0) 3 68 85 47 22

Mittwoch, 1. September 2010

PhD studentship, Massey University, New Zealand

PhD studentship, Massey University, New Zealand

A PhD studentship is available to apply state-of-the-art NMR techniques, along with other biophysical approaches and computational analyses, to protein and RNA structure and dynamics. This project is a collaboration with the University of Sydney, where complementary Small Angle X-ray Scattering (SAXS) studies will be performed, and with the New York Structural Biology Center, which houses spectrometers up to 900 MHz. The Massey University Centre for Structural Biology houses a 700 MHz Bruker Avance NMR spectrometer with cryoprobe in addition to 500, 400 and 200 MHz spectrometers. Support is via a grant from the Royal Society of New Zealand.

The PhD fellowship carries a tax exempt stipend of NZD 23,000 per anna. There is no teaching requirement, and all student tuition and fees are covered by the grant. Students with exceptional undergraduate marks may be eligible for a University Scholarship which provides an increased stipend level.

The nominal closing date is 30 September 2010, however applications will be reviewed as they are received, and will be accepted until the position is filled.

Interested parties should email a cover letter, c.v. and contact information for three referees to Associate Professor Steven Pascal.

See for email address and further information.
Steven M. Pascal
Associate Professor and
Director of BioNMR Research
Centre for Structural Biology
Institute of Fundamental Sciences
Massey University
Palmerston North, New Zealand
voice: 646-356-9099 ext 3558
fax: 646-350-5682