A two-year postdoctoral position is available in the NMR group headed by Prof. G. Bodenhausen in "Laboratoire des Biomolécules" in Paris (France), under the supervision of Prof. O. Lequin.
The selected candidate will be involved in a project which aims at analyzing structure-function relationships of homeoproteins. Homeoproteins form a large class of transcription factors characterized by a conserved DNA binding domain called homeodomain. These proteins possess the striking property to be internalized within cells by direct membrane translocation processes which are not yet well understood. Homeoproteins are thus involved in original modes of cell signalling. The work of the selected candidate will mainly focus on studying the structure and interactions of homeodomains in aqueous environments, in membrane environments and in cellular environments. This project is funded by the French Agence Nationale pour la Recherche (ANR grant "PARAHP") and will be carried out in collaboration with biochemists and cell biologists (groups of A. Joliot, A. Prochiantz, L. Venance, CNRS-INSERM-Collège de France).
The candidate should have a strong expertise in NMR spectroscopy and be motivated in developing multidisciplinary research fields including liquid state NMR, solid state NMR of protein/lipid complexes, in cell NMR, and biochemistry (protein expression, membrane models, cell culture).
Laboratoire des Biomolécules, UMR 7203
Université Pierre et Marie Curie – ENS – CNRS