Donnerstag, 29. Januar 2009

PhD Biomolecular NMR Grenoble (France)

PhD Position in Biomolecular NMR at the Institute of Structural Biology in Grenoble (France)
The biomolecular NMR laboratory of IBS (Grenoble -France) is interested in identifying motivated candidate for a PhD Fellowship. Applications from foreign students of all nationalities will be accepted.
The position foresees investigation of biomedically relevant proteins involved in maturation of human oncogenic microRNAs. The studies will include biomolecular NMR investigations (structural and dynamic) and elucidation of protein/RNA interactions by NMR spectroscopy. Analysis of protein/RNA interactions will serve to design drugs able to inhibit biogenesis of oncogenes.
The laboratory hosts three NMR spectrometers equipped with cryogenic probes (600 MHz and 800 MHz) and with a solid state MAS equipment (600 MHz). It has access to the nearby 900 MHz and the first 1 GHz NMR spectrometer (2009) of the European high field NMR centre in Lyon. Applicants will also have access to a fully equipped wetlab for isotopically labeled NMR sample preparation. More information can be found on the laboratory web site :
Grenoble is a pleasant city situated in the heart of the French alps, and has one of Europe’s most vibrant structural biology communities centred around the European Synchroton Radiation Facility (ESRF), the Laue Langevin Institute (ILL), the Structural Biology Institute (IBS) and the EMBL Grenoble Out-Station.
Applicants must have completed a master degree (or equivalent) in biochemistry, biophysics, chemistry or other relevant discipline before july 2009. The salary of the grant holder for the three years of the thesis contract is nationally and internationally competitive (as an indicator, the first-year annual gross salary will be 23,800 euros). Applications from foreign students of all nationalities will be accepted. Informal enquiries and applications (including CV and letter of motivation) should be directed before February 20th to :

Laboratoire de RMN
Institut de Biologie Structurale Jean-Pierre Ebel
41 rue Jules Horowitz
38027 GRENOBLE Cedex 1 - FRANCE
Phone : (+33) 4 38 78 95 60
Fax : (+33) 4 38 78 54 94
Email :

Postdoc University of Arizona, Tucson

A postdoctoral position is available at the University of Arizona, Tucson in
the field of protein and membrane biophysics. The main focus of the project
will be on the structural transitions and on membrane interactions of proteins
that are associated with neurodegeneration, e.g. Parkinson's or Alzheimer's
diseases. Practical expertise in protein expression and purification will be
essential. Experience with analytical techniques such as fluorescence,
circular dichroism, NMR spectroscopy, and atomic force microscopy would be very
welcome. Starting date as early as possible. Please send a CV by email to Dr.
Klaus Beyer at

Donnerstag, 22. Januar 2009

post-doctoral position at the CEA

A post-doctoral position is available at the CEA (Commissariat l'Energie
Atomique) to work in the group "Laboratoire de Structure et Dynamique
par Resonance Magnetique". This position is intended to an experienced
NMR spectroscopist
and will start March-June 2009.

The general goal of this project is to apply and develop high field high
resolution NMR techniques for the structural characterization of
silicate and borosilicate glasses. Composition of the studied glass are
chosen as simplified model of the french nuclear waste glass (from 3 to
6 oxides) in order to address important fondamental issues such
alkali/earth alkali mixed effect (Ca/Na), zirconium and calcium
environnement in borosilicate glass. We aim to improve our understanding
and fundamental knowledge of the glass structure, and its alteration by
irradiation or lixiviation (water dissolution).
During this project, experiments will be carried out on labeled samples
(29Si, 17O ,43Ca and doubly 29Si/43Ca are avalaible , 29Si/17O are in
preparation), offering many opportunities for exciting applications ( XY
HETCOR, J-HMQC, REDOR, ... ) and methodological developments.
The candidate will be involved in our collaborative work on GIPAW /
Molecular Dynamics simulations
in order to bring more insight into the collected data.

This is a one-year post-doctoral position available as soon as possible.
Possibility to extend to two years.

Our lab is equipped with three NMR spectrometers, 500 NB (with micro
imaging, gas and hyperpolarized xenon NMR facilities), 300 WB and 500 WB
Bruker Avance II spectrometers.

Postdoctoral salary will be around 2000/2500 Euro per month.

Applicants are invited to send a curriculum vitae and a brief statement
of research along with letters of reference to:
Thibault Charpentier
LSDRM - Service de Chimie Moléculaire
CEA Saclay - 91191 Gif-sur-Yvette, FRANCE.
Tél: (33) 1 69 08 23 56 / 82 75 - Fax: (33) 1 69 08 66 40

For further details, you are welcome to contact Thibault Charpentier,

-- Dr. Thibault Charpentier Commissariat à l'Energie Atomique IRAMIS - Service de Chimie Moléculaire Laboratoire de Structure et Dynamique par Résonance Magnétique (LSDRM) F-91191 Gif-sur-Yvette, France. Tel 33 1 69 08 23 56 / 82 75 Fax 33 1 69 08 98 06 / 66 40

Montag, 19. Januar 2009

Two Magnetic Resonance Scientist positions at PNNL

The Environmental Molecular Sciences Laboratory (EMSL), a DOE User
Facility administered by Pacific Northwest National Laboratory (PNNL),
has immediate positions available for two exceptional candidates in the
area of magnetic resonance spectroscopy (either NMR or EPR). One
position represents a senior hire while the other position is a mid- to
entry-level position. Both candidates must establish a preeminent
research operation that engages the user community and takes advantage
of the novel infrastructure present within the EMSL. More information
about the EMSL can be found at the following web address:

The senior hire must have an established national/international record
of accomplishment with a strong funding base. Further, this individual
must have a record of accomplishment in the development of novel
experimental methods to accomplish his or her experimental objectives.
Additionally, this individual must become a team leader in addressing
research objectives that cannot be typically accomplished in an academic
environment. The successful candidate should provide names of three
individuals who could serve as letters of reference. Additionally, the
applicant should provide a description of your current research efforts
(including funding sources, percent effort, etc).

The mid- to entry-level person must have at least 2 years of
postdoctoral research experience and a strong evidence of productivity.
Successful candidates will be expected to develop an exceptional
externally supported research program and also be expected to contribute
to the existing collaborative research environment. The applicant must
have three letters of reference and a statement of research plans. These
plans should reflect the research programs the applicant wants to
initiate. These plans should also include utilization of some of the
unique resources available within the EMSL.

Applicants should apply for these positions via the web by visiting

and enter the search finder for positions 116586 (the senior position)
or 116587 (the mid- to entry-level position). Letters of reference can
be directed towards the same site. Those letters should be addressed:

Mr. Gary Worrell
Senior Technical Recruiter
Pacific Northwest National Laboratory

The closing date for this search is April 10th 2009. Questions can be
addressed to Paul Ellis ( or Gary Worrell

Pacific Northwest National Laboratory (PNNL) is an Affirmative Action /
Equal Opportunity Employer and supports diversity in the workplace. All
employment decisions are made without regard to race, color, religion,
sex, national origin, age, disability, veteran status, marital or family
status, sexual orientation, gender identity, or genetic information.



A new postdoctoral position is becoming available at Berkeley in
high-field multiple-pulse multidimensional NMR, to be coupled with an
exciting new project in mobile NMR using laser magnetometry. Experience
in advanced liquid-state and/or solid-state NMR theory and experimental
mutidimensional pulse sequences, and technical expertise with commercial
high-resolution high-field NMR instrumentation are essential. Starting
date is flexible. Please submit application and CV, and have two or
three letters of recommendation sent to:

professor position in Texas

We are writing to request your assistance in identifying qualified applicants at the Assistant, Associate, or Full Professor levels for a tenure track faculty position in the area of Macromolecular NMR Spectroscopy in the Department of Biochemistry at the University of Texas Health Science Center in San Antonio. This is part of our efforts to expand the structural biology program we have built over the past decade, including groups in NMR Spectroscopy (A. Hinck), X-ray crystallography (P. J. Hart, R. Sousa, C. Kim), and membrane biophysics (N. Robinson and B. Nicholson).

Applicants are expected to have strong backgrounds in both theoretical and experimental aspects of modern NMR spectroscopy as applied to biological macromolecules. The successful applicant will be appointed as a full-time tenure-track faculty member and will have preferential access to state-of-the-art equipment available within, and operated by, the Department, including four-channel Bruker AV 500, 600, and 700 MHz NMR spectrometers, together with high sensitivity cryogenically cooled probes for the 600 and 700 MHz spectrometers (see The NMR Facility, along with a state-of-the-art X-ray crystallography facility (including a Rigaku MIcroMax 007HF generator fitted with Varimax optics and R-AXIS HTC detectors, as well as robotic crystallization and imaging stations), analytical ultracentrifugation (including developmental machines for fluorescent and multi-wavelength detection), dynamic light scattering, surface plasmon resonance, and mass spectrometry are all operated as University Core Facilities ( within the Department (see Additional shared facilities for microcalorimetry (DSC and ITC), stopped flow and high pressure spectroscopy and circular dichroism are also available within, and operated by, the Department.

In addition to the extensive access to shared facilities both within and beyond the department, the successful candidate will be provided a generous start-up package, and newly renovated lab and office space adjacent to the NMR Facility. Candidates will be expected to develop, or bring with them (in the case of hires at the more senior level) a vigorous, externally funded, research program at the cutting edge of structural biology, and contribute to teaching in the graduate, medical and/or dental curricula. New faculty will also be encouraged to be actively involved in future recruiting and the continued growth of the Department, which has added seven new primary faculty in the last four years. The Department of Biochemistry has a strong commitment to mentorship of both junior and more senior faculty, with multiple opportunities for help in the preparation, critique, and submission of grants.

As a place to live, San Antonio offers a rich multicultural environment, a temperate climate, and a very reasonable cost of living, leading it to be the fourth fastest growing metropolitan areas in the country. There are also excellent educational and recreational opportunities, with San Antonio serving, along with Austin, as the gateway to the Texas Hill Country with its rolling hills, limestone caverns, hiking trails and wineries.

Applicants should submit, along with their cover letter, a curriculum vitae, a 2-3 page summary of past and proposed research, and names and contact information of at least three references to the address below. The applicant should also ask each referee to submit either electronic or hard copy reference letters to the same address.

Ms. Esther L. James
Department of Biochemistry, MC 7760
Allied Health Building Room 5.206
University of Texas Health Science Ctr. at San Antonio
7703 Floyd Curl Dr.
San Antonio, TX 78229-3900 U.S.A.
Tel: (210) 567-3772
Fax: (210) 567-6595

Any questions concerning the position should be addressed to
Professor A.
Hinck (

Thank you for your kind assistance.

Professor Andrew P. Hinck
Chair, NMR Search Committee

Professor Bruce J. Nicholson
Chair, Department of Biochemistry

Andrew P. Hinck, Professor
Department of Biochemistry, MC 7760
University of Texas Health Science Center at San Antonio
San Antonio, TX 78229-3900
office phone: 210-567-8780
lab phone: 210-567-8700
mobile phone: 210-725-4438
office fax: 210-567-8778

Postdoctoral Position Michigan

Postdoctoral Position:
Solution and/or Solid-state NMR Spectroscopy of Membrane Proteins
University of Michigan

The lab of Ayyalusamy Ramamoorthy at the University of Michigan (Ann Arbor, USA) has an immediate opening for a postdoctoral fellow to work on one or all of the following projects:
(1) Structure and Dynamics of Membrane Proteins using solution and solid-state NMR.
(2) Biophysical studies on the structure and membrane toxicity of amyloid peptides.
(3) Develop solid-state NMR Techniques and apply to study chemical and biological materials.
Excellent NMR (400 and 600 Varian solid-state NMR, 600 Bruker, 800 Varian, and 900 Bruker) and other biophysical/ biochemical facilities are available at Michigan. Please visit the Ramamoorthy lab website to see recent publications from our research group.
Excellent candidates should send a CV to:

Prof. Ayyalusamy Ramamoorthy,
Biophysics and Chemistry,
University of Michigan,
Ann Arbor, MI 48109-1055, USA
Phone: (734)647-6572

Lab web site:

Doctoral Fellowship in Hyperpolarized Magnetic Resonance Imaging Technologies

Hyperpolarized Magnetic Resonance is a revolutionary and promising technique
with a proven potential in biomedicine and biochemistry. Based on Dynamic
Nuclear Polarization (DNP), a low-temperature technique used to increase the
nuclear spin order for particle physics experiments in which the Paul Scherrer
Institute is one of the world’s leading institutions, hyperpolarization leads
to an improvement in signal-to-noise ratio on the order of 10’000 times. It
allows for the detection of tiny amounts of biological substances in vivo and
to follow the metabolic pathways of chosen molecules.

Two unique hyperpolarizers have been developed within the Swiss DNP Initiative
regrouping several departments of the EPFL and the Paul Scherrer Institute. The
Center for Biomedical Imaging (CIBM, provides access to two
high-field animal MRI systems, one working at 9.4T and the other at 14.1T. One
of the hyperpolarizers is currently coupled to the 9.4T scanner. For further
information on our Initiative, see

The aim of the proposed project is to improve and further develop the Dynamic
Nuclear Polarization technology for applications in biomedical imaging. The
project will involve experimental work with world-class magnetic resonance

We are seeking for a candidate with a background in Physics or Chemistry who is
interested in biological and biomedical applications. The candidate will have
the opportunity to interact with researchers involved in Particle Physics,
Chemistry, Biology and Biomedicine. The biomedical part of the project will be
performed at the CIBM while several fundamental DNP developments will take
place at the Paul Scherrer Institute.

If you are interested in this position, please send your resume and a cover
letter to