Freitag, 20. August 2010

Postdoc Toronto

A postdoctoral position is available for a Canadian Institutes of Health
Research funded project in the laboratory of Professor Voula Kanelis at the
University of Toronto Mississauga (UTM). The successful candidate will
investigate the nucleotide binding domains (NBDs) of the sulfonyl urea
receptors (SURs) using biophysical approaches, including NMR spectroscopy. SUR
proteins are ABC transporters that form the regulatory subunits of
ATP-sensitive potassium (KATP) channels. We are studying the effects of
disease-causing mutations in the SUR NBDs on their stability, structure, and
interactions with other regions in the SURs and in KATP channels. A Ph.D. in
biochemistry or a related discipline is required. Candidates should have
experience with protein expression and purification and protein NMR

Located 30 km west of downtown Toronto, The University of Toronto Mississauga
( is a campus of the University of Toronto
(, the largest research University in Canada. UTM provides all
of the advantages of research at the University of Toronto, while additionally
providing a smaller, friendly campus environment in a beautiful natural setting
by the Credit river.

Our newly renovated and well-equipped laboratory contains all the equipment
necessary for protein biochemistry and fluorescence spectroscopy. Other
equipment (CD spectrophotometer, isothermal titration calorimeter, differential
scanning calorimeter) is available in the Center for Applied Bioscience and
Biotechnology at the University of Toronto Mississauga. NMR experiments will be
performed primarily on a Varian 600 MHz spectrometer equipped with a cryoprobe
at UTM. We also have access to high-field spectrometers located at the
University of Toronto NMR facility.

Interested applicants should submit their CV, contact information for three
references, and a description of previous research experience to Voula Kanelis
Voula Kanelis
Assistant Professor
Department of Chemical and Physical Sciences
University of Toronto Mississauga
3359 Mississauga Road North
South Building, Room 4042
Mississauga, ON, L5L 1C6
PHONE: 905-569-4542
FAX: 905-828-5425