Montag, 30. August 2010

Postdoctoral Position at St. Jude Children’s Research Hospital

Postdoctoral Position at St. Jude Children’s Research Hospital

Title: Structural Biology: Tanja Mittag, PhD

Requisition Number: 6447

A postdoctoral position is available immediately for a highly motivated individual interested in studying the molecular basis of dynamic protein complexes in the ubiquitination pathway and cell cycle control in the laboratory of Tanja Mittag at St. Jude Children's Research Hospital in Memphis, TN USA. 70% of cancer-related proteins contain long disordered regions that convey important roles in cells, particularly in mediating interactions with other macromolecules in signal transduction. Disordered protein regions can execute their functions in the absence of a well-defined structure. It is becoming increasingly clear that even their complexes may remain largely disordered, allowing for unusual properties such as signal integration, graded and ultrasensitive responses. We will use NMR spectroscopy and other biophysical methods to elucidate molecular mechanisms of these protein interactions to understand their biological functions and the benefits of protein disorder.

The position is an ideal opportunity for either a candidate with experience in NMR spectroscopy to complement their training by learning other biochemical and biophysical techniques or for a biochemist/biophysicist interested in advanced protein NMR spectroscopy techniques. The fellow would benefit both from the excellent departmental facilities and from the collaborative St. Jude community. Candidates should have (or expect) a Ph.D. and/or M.D. and should have experience in protein expression, purification, and/or NMR spectroscopy.

Please apply online ( ) and send a CV with list of publications, a brief letter of research interests and goals and arrange for three reference letters to be forwarded to

Tanja Mittag, PhD
Assistant Member
Department of Structural Biology
St. Jude Children's Research Hospital
262 Danny Thomas Place, MS 311
Memphis, TN 38105