Postdoc Berkeley

A postdoctoral position is available for research in laser-detected NMR/MRI.
Applications range from microfluidics to in vivo human studies. Experience
with lasers and/or microchips desirable. Details about the work can be
discussed with current lab associates, in particular Dr David Michalak,
currently working on this project. Contact details can be found on the web
page: http://waugh.cchem.berkeley.edu
Please send CV, two or three letters of recommendation, and details about
possible starting dates to pines@berkeley.edu with copies to
amjacobson@lbl.gov
___________________________________________
Alexander Pines
Glenn T. Seaborg Professor of Chemistry
University of California, Berkeley, and
Senior Scientist, Lawrence Berkeley National Laboratory
D64 Hildebrand Hall, Berkeley, CA 94720, U.S.A.
Tel: +1 510-642-1220
Lab: +1 510-642-2094
E-mail: pines@berkeley.edu
Web: http://waugh.cchem.berkeley.edu/

Alyse M. Jacobson
Pinenuts Administrator
D64 Hildebrand Hall
Tel: +1 510-486-6097
Fax: +1 510-486-5744
E-mail: AMJacobson@lbl.gov

NMR Applications Specialist - University of California, Berkeley

University of California, Berkeley
NMR Applications Specialist

The College of Chemistry at University of California, Berkeley seeks an
Applications Specialist for its NMR facility. The facility currently houses
five NMR spectrometers (two 500, two 400, and one 300 MHz instruments) and
several workstations; a 600 MHz instrument will be installed later this year.

Primary responsibility is to provide comprehensive NMR spectroscopy support
and user training to approximately 350 users with varying needs and diverse
research efforts. Additional duties include assisting with upgrades, writing
proposals for new instrumentation, assisting technical staff with spectrometer
maintenance, and performing administrative duties. Research opportunities
will be available and are actively encouraged.

Required qualifications: Ph.D. and 1+ yrs. experience in NMR; strong
background in liquids (and, ideally, solids) NMR using Bruker and/or Varian
instruments; solid understanding of NMR hardware and software technology,
design, and application of complex pulse experiments; experience in structural
and conformational analysis. Basic UNIX, C, Perl, Tcl/Tk and CGI background a
plus. Excellent written and verbal communication skills are essential.

To apply: please send cover letter, resume, and contact information for three
references to: NMR Search Committee, c/o Rebecca Egger, Dean?s Office, 420
Latimer Hall, College of Chemistry, University of California, Berkeley
94720-1460. Salary and appointment commensurate with experience. Closing
date for receipt of applications is April 11, 2008. The University of
California, Berkeley is an Equal Opportunity/Affirmative Action Employer.

Rebecca Egger
Assistant to the Dean
College of Chemistry
University of California
420c Latimer Hall
Berkeley, CA 94720-1460
Phone: (510) 643-0472
Email: egger@berkeley.edu

NMR Scientist/Senior Scientist Job Opening

NMR Scientist/Senior Scientist Job Opening

Protein Engineering, Small Molecule Drug Discovery

Genentech, Inc.

We have an opportunity for a highly talented and motivated NMR spectroscopist to join the Protein NMR Group at Genentech. The primary responsibilities of this position will be to help develop, lead, and implement NMR-based strategies to support small molecule drug discovery programs, working closely with the Biochemical Pharmacology and Discovery Chemistry Departments, and participating directly with small molecule project teams to aid the design of new small molecule compounds. Job responsibilities include hands-on NMR data acquisition, processing, and analysis, focused on assessing ligand-binding and analyzing the solution structures of proteins or protein/ligand complexes involved in modulating cell-signaling events of therapeutic interest. The protein NMR facility includes dedicated 800, 600, and 500 MHz spectrometers, Linux workstations, and access to the Central California 900 MHz spectrometer. Our NMR group complements protein engineering, protein crystallography and modeling efforts within the Protein Engineering Department.

Requirements:
A successful candidate should have a Ph.D degree in a relevant discipline with at least 3-5 years of postdoctoral training. Industry experience in fragment-based small molecule drug discovery strongly preferred (significantly more work experience is required for consideration at the senior scientist level). The successful candidate will show evidence of productive, independent contributions in science, as demonstrated by a strong publication/patent record. Extensive knowledge and hands-on expertise in all aspects of protein and small molecule NMR spectroscopy is required. Excellent verbal and written communication skills, as well as the ability to work in large, multidisciplinary project teams are essential. Senior candidates with experience participating in or leading multi-disciplinary structure-based drug design efforts are encouraged to apply.

Please apply on-line at www.gene.com/gene/careers, and be sure to note REQ#: 08-1000021966

NMR-Stelle an der Leibniz Universität Hannover

Zum Sommer/Herbst 2008 möchte das Institut fuer Organische Chemie der Leibniz Universität Hannover eine unbefristete Stelle eines Wissenschaftlichen Mitarbeiters BAT II a zur Leitung und Betreuung der seiner NMR-Einrichtungen neu besetzen (zur Zeit kommissarisch: Dr. E. Hofer). Das NMR-Labor verfügt über ein 200-, zwei 400- und ein 500-MHz-NMR-Spektrometer (mit Cryoprobenkopf), alle von der Firma Bruker. Sie werden hauptsächlich bei der Strukturaufklärung kleiner und mittelgroßer Moleküle aus der Wirk- und Naturstoffchemie in Lösung eingesetzt; siehe Link "Arbeitskreise" auf der Instituts-Homepage "http://www.oci.uni-hannover.de/".

Gesucht wird ein/e promovierte/r Wissenschaftler/in, der/die mit allen aktuellen NMR-Messtechniken, aber auch mit der technischen Betreuung und Wartung der NMR-Geräte gut vertraut ist. Für die Mitarbeit im routinemaessigen Messbetrieb stehen zwei erfahrene Technikerinnen zur Verfuegung, die unter seiner/ihrer Anleitung arbeiten.

Zu den Aufgaben des/r Stelleninhabers/in gehören ausserdem die Teilnahme an NMR-relevanten Lehrveranstaltungen, Betrieb und Wartung des hausinternen NMR- und Mailservers sowie Beratung und Koordination der kommerziellen Software im Hause.

Der/die Stelleninhaber/in soll zudem die wissenschaftlichen Mitarbeiter des Hauses bei der Auswahl geeigneter NMR-Messtechniken und der Auswertung ihrer Spektren wissenschaftlich beraten und wird dazu in deren Forschungsprojekte eingebunden. Eigene Forschungsarbeiten sind im Rahmen der zur Verfügung stehenden Arbeits- und Spektrometerzeit willkommen.

Bewerber melden sich bitte bis spätestens 31.03.2008 unter Einsendung der üblichen Unterlagen schriftlich bei:

Prof. Dr. Helmut Duddeck
Leibniz Universität Hannover
Institut für Organische Chemie
Schneiderberg 1B
30167 Hannover
Tel.: +49 (0)511 762 4615
Fax: +49 (0)511 762 4615
Email: duddeck@mbox.oci-uni-hannover.de

Postdoctoral Fellow - in vivo MRI - New York

The Bone Cell Biology and Imaging Laboratory at the Hospital for Special Surgery together with the In Vivo Nuclear Magnetic Resonance Laboratory at Memorial Sloan-Kettering Cancer Center is seeking a postdoctoral fellow interested in leading the development of in vivo magnetic resonance imaging of bone cell activity. Candidates should have a strong background in magnetic resonance research as well as an interest in biology and translational research.

The Hospital for Special Surgery (www.hss.edu) and Memorial Sloan-Kettering Cancer Center (www.mskcc.org) are among the leading research institutions in the world and are located within the same campus in Manhattan, New York. Please direct inquiries to Dr. Philipp Mayer-Kuckuk at mayerkuckukp@hss.edu.

A 6 month position in Reims, France

A six month position is available in my group in Reims, France,
for a *non-French* visiting Professor or an Assistant Professor or
any holder of an equivalent *permanent* academic position.
It is open starting from now and will remain open until the end of 2008.
The position is funded by the CNRS, the French
National Concil for Scientific Research.
The research project deals with the application
of selective pulses for the NMR spectral assignment
of complex molecules in solution, mainly oligosaccharides.
Please send me a detailed CV is you want to apply.

Contact: jm.nuzillard@univ-reims.fr
NMR Web site: www.univ-reims.fr/LSD/JmnSoft
Publications: www.univ-reims.fr/Labos/FRE2715/publications-JMN.pdf
CV: www.univ-reims.fr/Labos/FRE2715/CV-JMN-en.pdf

Postdoc in solid-state NMR of pharmaceuticals at Durham (UK)

As a result of the imminent departure of the current position holder for a permanent position, the Durham Solid-State NMR group expects a postdoctoral vacancy of about 12 months (depending on appointment level) to be available from April.

The project ("Elucidating structure and dynamics in pharmaceutical solvates") essentially is show-casing the power of modern solid-state NMR to obtained detailed information about local structure and dynamics in complex materials of technological importance, and connects with innovative work in the group using molecular dynamics to relate molecular-level detail to bulk properties. A set of interesting systems (both from the NMR and applications viewpoint) has already been identified in the initial phase of the project. Since the systems are now familiar, the project is quite suitable for newly-qualified spectroscopists wishing to gain further experience in solid-state NMR, contacts with the pharmaceutical industry, and with specialist DFT-based code for calculating NMR parameters in solids (CASTEP).
But the project also offers opportunities for more experienced researchers to devise novel techniques for the characterisation of locally dynamic materials.

More information on the Solid-State NMR group in Durham can be found on our web pages (link below). Potential applicants are encouraged to contact me as soon as possible for more information about this position (or life in the historic cathedral city of Durham) so that we can make a rapid appointment when the position formally becomes available.

Paul Hodgkinson

E: paul.hodgkinson@durham.ac.uk
T: +44 191 334 2019
W: http://www.dur.ac.uk/paul.hodgkinson

Post Doc Strasbourg (France)

A two years post-doctoral position is available in the group of biomolecular NMR of IGBMC in Strasbourg (France) to work on the interactions between the HPV oncoprotein E6 and molecular partners involved in oncogenesis. The main investigation tools will be solution NMR in combination with complementary biophysical technics such as X-ray crystallography or biacore. More details may be found in Mol Cell. 2006 21:665-78. The project offers many opportunities to develop innovative approaches to study protein-protein interactions such as novel isotope labelling schemes.

This position is intended to young researchers having an experience in protein NMR spectroscopy (expression and purification, triple resonance, structure determination). Additional experience in molecular cloning will be also valuable but not necessary. The position is available immediately.

Our lab is equipped with one 600 Bruker Avance NMR spectrometer with cryoprobe, cloning platform and protein expression facilities.

Applicants are invited to send a curriculum vitae and a brief statement of research along with letters of reference to:

____________________________________________________________________

Bruno KIEFFER


IGBMC Biomolecular NMR group, CNRS UMR 7104


ECOLE SUPERIEURE DE BIOTECHNOLOGIE DE STRASBOURG

Boulevard Sebastien Brant BP10413

F-67412 ILLKIRCH Cedex FRANCE


Fax : (33) 03.90.24.47.18

Voice : (33) 03.90.24.47.22

web : http://www-igbmc.u-strasbg.fr/recherche/Dep_BGS/Eq_BruKief/

Post-doc in computational biomolecular NMR

Description of the Faculty / Research group
----------------------------------------------------------
The new Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Mathematics and Chemistry. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research.

The NMR Research Group (http://www.nmr.chem.uu.nl), headed by Prof. R. Boelens, is part of the Chemistry Department (http://www.chem.uu.nl) and belongs to the Bijvoet Center for Biomolecular Research (http://www.bijvoet-center.nl). The research within the NMR group is focused on the structure determination of proteins and protein complexes by high-resolution NMR spectroscopy and bio-computational modelling. The group has strong research lines on protein-DNA and protein-protein complexes in transcription and DNA repair and modelling of bio-molecular complexes. The NMR Research group also belongs to the European NMR Research Infrastructures (www.eu-nmr.eu), providing experimental NMR access to European groups.

We are searching for a researcher (post-doc) in computational biomolecular NMR.

Job description
---------------------
You will be part of a European team working toward the deployment and unification of the NMR computational infrastructure in system biology, a project funded under the 7th framework programme of the European Union (Contract no. 213010 – eNMR).
NMR plays an important role in life sciences (bio-NMR), and structural biology in particular, at both European and international levels. The main objective of this project is to optimize and extend the use of the NMR Research Infrastructures of EU-NMR through the implementation of an e-Infrastructure in order to provide the European bio-NMR user community with a platform integrating and streamlining the computational approaches necessary for bio-NMR data analysis (e-NMR). The e-NMR infrastructure will be based on the Grid infrastructure.
For this, you will work on the development of a uniformed and integrated e-NMR platform that will form the core of the e-NMR infrastructure. The work will be carried in close collaboration with our European partners.

Qualifications
-------------------
You should have a Ph.D. degree in chemistry, physics, bioinformatics, computational biology or a related field. You should possess a strong research background in the computational aspects of biomolecular NMR and structure calculations, experience with Linux and programming skills, and are expected to show initiative and be able to work independently.

Terms of employment
------------------------------
We offer initially a position for two years with a possible extension by one year. Salary is dependent on qualifications and experience and ranges from €2740.- to €3597.- gross per month (salary scale 10). The salary is supplemented with a holiday bonus of 8% per year and a year-end bonus of 3% per year. We also offer a pension scheme. Employment conditions are according to the Collective Labour Agreement of Dutch Universities.

Further details
--------------------
For further information contact Dr. Alexandre M.J.J. Bonvin (Phone: +31-30-2533859 Fax: +31-30-2537623 Email: a.m.j.j.bonvin@uu.nl).

How to apply
------------------
Your application, referring to vacancynumber 65720, including a CV with contact information of two referees, should be sent to Science.PenO@uu.nl or: Faculty of Science, Personnel department, PO Box 80010, 3508 TA Utrecht.

Post Doc Israel

Two post doc positions are available in the lab of Dr. Aharon Blank
at the Technion in the field of method developments in NMR and ESR.
Significant EU and local funding is expected to capable candidates.

Applicants should have high tendency to experimental/methodological
development work.

For further details, contact: Aharon Blank ab359@tx.technion.ac.il

Aharon Blank
Schulich Faculty of Chemistry
Technion - Israel Institute of Technology.
Haifa 32000
Israel
ab359@tx.technion.ac.il
Phone: +972-4-829-3679
Fax: +972-4-829-5948