MRI Programmer

MRI Programmer

We seek a PhD graduate or equivalent to help develop a new MRI prototype based on a small-scale superconducting magnet, The position will suit someone with a background in MRI and NMR physics or engineering, who is interested in working in a more applied environment. The position is for two years, based in Wellington New Zealand, but the possibility exists for further employment in commercialisation work.

The MRI Programmer will be responsible for a range of software and MRI pulse sequence development, hardware construction, electronic and electromagnetic engineering, application design, technical documentation and support activities around the MRI system. The work will involve aspects of the whole range of NMR and MRI from engineering to data processing. The appointee will also assist in applications development for other prototype NMR systems developed by the team.

In addition to a good understanding of NMR, applicants should have good software programming skills, and a knowledge of Matlab, C++, and the Windows environment.

Applications, including a CV, a covering letter explaining the candidates interest in the job, and the names and email addresses of two referees, should be addressed to Professor Paul Callaghan, Victoria University of Wellington, New Zealand, and sent by email (paul.callaghan@vuw.ac.nz). Applications close on 31 January, 2011.

For more information, please visit

http://vacancies.vuw.ac.nz

Manager of Science and Technology (M/F), Portugal

Within the framework of the Portuguese National Nuclear Magnetic
Resonance Network (PTNMR), Centro de Química da Madeira (CQM),
Funchal, Madeira Island, Portugal, is seeking for a Manager of Science
and Technology (M/F), holding a PhD in Chemistry (or related fields)
with NMR experience, to be responsible for the technical maintenance of
a 400MHz NMR equipment, analytical services, teaching and research. The
offered position is ideal for PhDs with strong NMR experience and
interest in the field of Natural Products and/or Materials.
Salary: The monthly salary will be between 1495€ (for the first year)
and 1995€ (depending on performance) plus a personal accident
insurance. The contract offered, will have duration up to December 2012.

Additional support will be provided, including office and laboratory
space, plus access to the National Networks of Nuclear Magnetic
Resonance, Mass Spectrometry and Nanotechnology. The right candidate
will also be given the opportunity to participate in
national/international scientific conferences as well as in the
research projects under development at CQM.

Candidate Profile: PhD in Chemistry, Physics, Biochemistry, Materials
Sciences or related areas with strong experience in liquid NMR.
Application Deadline: 31 of January 2011, 17h Lisbon time. Applications
should be submitted by e-mail (cqm@uma.pt), with the following
information: a. Motivation letter; b. A brief statement of the
applicant current and future research interest (Max. 2 A4 pag.);
c. Detailed Curriculum Vitae;
d. Academic certificates in Portuguese or translated to English
(certificated translation); e. Working program to be developed in the
scope of the Natural Products and/or Materials Groups of CQM (Max. 2 A4
pag.); f. Name and e-mail contacts of two referees. For further
details, candidates should consult CQM web pages at
http://bit.ly/dg6Nic or contact Prof. João Rodrigues by e-mail:
cqm@uma.pt.

Marie-Curie funded studentships / postdoc positions at Weizmann

In connection to the recent signing of the FP7 Marie Curie Initial Training Network (ITN) METAFLUX - Metabolic Flux Analysis and Cancer, I am looking to hire suitable Ph.D. students or post-doctoral researchers in support of work to be carried out at Weizmann within the 2011-2015 calendar years. These hirings are mainly aimed at citizens of the European Union and/or Associate Member states, who qualify for a full employment contract along with mobility, travel and career development allowances. These are salaries fundable according to the (very generous) Marie Curie rules, which can be found in ftp://ftp.cordis.europa.eu/pub/fp7/docs/wp/people/m_wp_201002_en.pdf.

Depending on their status and interests, candidates would enter the Weizmann's Institute PhD or postdoctoral programs, under my supervision (Chemical Physics Department, Faculty of Chemistry) –and in certain cases coadvised by Prof Hadassa Degani (Biological Regulation Department, Faculty of Life Sciences). The candidate’s research would deal with a number of multidisciplinary problems within the field of magnetic resonance; particularly in connection to the use of hyperpolarized nuclei towards in vitro, in cell and biological NMR and MRI characterizations. Our aim is to bring together complementary aspects of dynamic nuclear polarization, and advanced in cell / in vivo MRI/NMR spectroscopies, towards the development of new methodologies to better understand and characterize cancer metabolism. If interested in pursuing a PhD at the Weizmann, the candidate should also have a strong curriculum, a good motivation, and a willingness to be exposed to a variety of topics in magnetic resonance. Background in at least one of the above-mentioned research areas (at a Ph.D. level) is required for a post-doctoral appointment. The training program will include in either case state-of-the-art activities such as network-wide courses, attendance/participation in a variety of workshops, and training experiences in other partner laboratories within the network. Further information on both our graduate or postdoctoral programs, can be found at http://www.fgs.org.il/en/.

The Weizmann Institute is located in a small, affordable and friendly town at the feet of the Judean hills, and is one of Israel's premier scientific institutions. It is a research center whose official language is English and which offers numerous facilities to international visitors, including furnished apartments for students and postdocs. From its inception the Institute has shown an unequivocal commitment to all areas of magnetic resonance and over the years it has made extensive investments in NMR faculty, staff and in infrastructure. As a result the Institute possesses an 800 MHz NMR with a cryoprobe, a 600 MHz widebore triple-resonance solids/liquids/imaging machine, a 3 T whole-body MRI scanner, a 95 GHz pulse EPR spectrometer, 4.7 and 9.4 T animal MRI scanners, an OI Hypersense DNP, para-hydrogen NMR facilities, and numerous (dozens) of other NMR instruments placed in various magnetic resonance buildings as well as several groups involved in all areas of magnetic resonance. The incorporation of significant new MR hardware is also in progress. Those interested in being considered for these positions should send their Vitae and at least two References to lucio.frydman@weizmann.ac.il.

Postdoc Positions

Postdoctoral Opportunities: Structural Biology in Ubiquitination and Signaling

The Macromolecular NMR Section in the Structural Biophysics Laboratory has openings for postdoctoral fellows to work in the structural biology of protein complexes related to ubquitination, Arf proteins, and signaling via the STAT proteins. Our laboratory is involved in the application and development of state-of-the-art NMR spectroscopy, SAXS, and biophysics techniques to determine protein structures, investigate critical protein:protein interactions relevant to biological systems, analyze dynamic processes, and integrate these studies with molecular and cellular biology. We collaborate interactively with several biological, structural, and chemical groups in the Center for Cancer Research. Excellent NMR facilities (500-850 MHz), protein expression capabilities, and computational facilities are available.

Interested applicants should have a background in structural biology and experience in NMR spectroscopy. For examples of our work, please see Das, R., et al., Mol. Cell 34(6):674-685 (2009) and Das, R., et al., J. Mol. Biol. 376(3):705-720 (2008).

R. Andrew Byrd, Chief [byrdra@mail.nih.gov]
Structural Biophysics Laboratory
Center for Cancer Research
National Cancer Institute

PhD positions Lund

PhD Positions in Lund

Two PhD positions are available in my group at the Division of Biophysical Chemistry in Lund. Both positions are linked to projects where magnetic relaxation dispersion (MRD) will be applied (and developed) to complex biological systems:

[1] Detection of pathological protein aggregation by field-cycled magnetic resonance imaging

[2] Molecular basis of heat and desiccation tolerance of bacterial cells and spores

For information about these two projects and the associated PhD positions, including application procedure, please go to

http://www.cmps.lu.se/bpc/research/halle/phd_and_postdoc_openings/

Application deadline is January 31, 2011.

Engineer/Physicist Post-Doc position in New Zealand

We seek a PhD graduate or equivalent to help develop a new Magnetic Resonance Imaging prototype based on a small-scale superconducting magnet. The position will suit someone with a background in MRI and NMR physics or engineering, who is interested in working in a more applied environment. The position is for two years, based in Wellington New Zealand, but the possibility exists for further employment with a partner company.

The MRI Engineer/Physicist will be responsible for a range of software and MRI pulse sequence development, hardware construction, electronic and electromagnetic engineering, application design, technical documentation and support activities around the MRI system. The work will involve aspects of the whole range of NMR and MRI from engineering to data processing. The appointee will also assist in applications development for other prototype NMR systems developed by the team.

In addition to a good understanding of NMR, applicants should have good software programming skills and a knowledge of Matlab, C++, and the Windows programming environment.

Applications, including a cv, a covering letter explaining the candidate’s interest in the job, and the names and email addresses of two referees, should be addressed to Professor Paul Callaghan, Victoria University of Wellington, New Zealand, and sent by email (paul.callaghan@vuw.ac.nz). Applications close on 31 January, 2011.

Paul T. Callaghan
Alan MacDiarmid Professor of Physical Sciences
School of Chemical and Physical Sciences
Victoria University of Wellington
Wellington
New Zealand

Fax 64-4-4635237
Tel 64-4-4635945
e-mail paul.callaghan@vuw.ac.nz

Postdoctoral Position at Cowburn Lab

Postdoctoral Position at Cowburn Lab, Albert Einstein College of Medicine

An open postdoctoral position in structural biology is available for research on protein structure, dynamics, and function focusing on kinases and inteins.

Interested candidates should have a strong background in one or more of the following areas: multidimensional NMR, crystallography, protein expressions methods, and computer simulations of molecular structure and have completed their Ph.D.

Einstein provides a modern cross-disciplinary environment for research and education. NMR facilities include nine solution NMR spectrometers from 500 to 900 MHz equipped with cryogenic probes on site or at the New York Structural Biology Center. Extensive shared resources are available for protein production, crystallography, and high-performance computing.

The position is now available. Interested candidates should send their biographical sketch identifying three referees by email ( dc@cowburnlab.org ).

David Cowburn
Professor, Depts. of Biochemistry and of Physiology & Biophysics
Albert Einstein College of Medicine of Yeshiva University

PhD position Wellington / New Zealand

The MacDiarmid Institute for Advanced Materials and Nanotechnology at
the Victoria University of Wellington (Wellington / New Zealand) is
offering two PhD position, available from February 2011.

The research will be in the field of soft matter (complex fluids
investigated by means of Rheo‐NMR under high shear rates, application
of multidimensional NMR methods) with the focus on spatio‐temporal
fluctuations in banded‐flow, wall slip effects and start up flow of
micellar, polymeric and colloidal particles based on fast 3D NMR
velocimetry. The research to be undertaken concerns addressing
fundamental questions related to soft matter as well as the
development of the necessary NMR methodology (including hardware).

The successful applicant will be given the opportunity to work with
Dr. Petrik Galvosas and Professor Paul Callaghan in a well recognised
NMR group (http://www.macdiarmid.ac.nz/nmr/) with strong national and
international collaborations.

The PhD position is fully funded (including fees) and will enable the
successful applicants to stay in a well established academic
(http://www.victoria.ac.nz/scps/index.aspx) as well as urban
environment (http://www.wellingtonnz.com/). The scholarship provides a
non‐taxed living allowance of NZ$25,000 per annum, which is a very
comfortable living salary in Wellington, plus the PhD tuition fee for
three years. The commencement date can be as early as 1 February 2010.

Please refer to the Soft Matter and RheoNMR link at
http://www.victoria.ac.nz/scps/study/scholarships.aspx for further
details.

------------------------------------------------------------------------
Dr. Petrik Galvosas
School of Chemical and Physical Sciences
Victoria University of Wellington
PO Box 600
Wellington 6140, New Zealand
Tel: +64-4-463 6062 (office)
+64-4-463 5911 (lab)
Fax: +64-4-463 5237
mailto:Petrik.Galvosas@vuw.ac.nz

Group Leader Positions – Bio NMR Brno

Two Group Leader Positions – Bio NMR, Central European Institute of Technology, Brno, Czech Republic

We are looking for two group leaders in the field of Bio-NMR in Structural Biology Research Program to accept the challenge of starting a world-class research group

We are recruiting two internationally established scientists to set up independent world-class research groups in the field of Bio-NMR spectroscopy in a highly inter-disciplinary setting. You will be part of the Central European Institute of Technology in Brno, Czech Republic (www.ceitec.eu). The institute will host 600 scientists and state-of-the-art equipped laboratories. The campus receives funding as a European Centre of Excellence, with a variety of international partner institutes.

Structural Biology Research Program will run core facilities for X-ray crystallography, high-end cryo electron microscopy and tomography, studies of biomolecular interactions, and high-field NMR spectroscopy. CEITEC will host also high throughput -omics facilities. Genomics and Proteomics of Plant Systems, Molecular Medicine, Molecular Veterinary Medicine, and Brain and Mind Research represent other Life Science Research Programs of CEITEC. High-field NMR Core Facility will be equipped with six 500 – 950 MHz NMR systems. Group resources include funds for post-doc positions, personnel and running costs.

You must have a PhD in a technical or scientific field and should show:
- A track record of high quality scientific publications, providing evidence of excellence in bio NMR research and applications
- Success in obtaining personal or research funding
- Experience supervising other scientists

An interest in close collaboration with local experimental groups is required. We will offer internationally competitive conditions and benefits in line with your seniority. The positions become available in 2011 and have an initial tenure of five years. We look forward to receiving your preliminary enquiries and applications addressed to Prof. Vladimír Sklenář (sklenar@chemi.muni.cz), the coordinator of the Structural Biology Research Program. The positions will be officially advertized early 2011. The onset of group operations is negotiable between 2011 and 2013.

Post Doc Toulouse

Post doctoral position announcement:

Characterisation of cholesterol – GPCR interactions by solid state NMR

As part of an Initial Training Network on the “Structural Biology of Membrane Proteins” (Marie Curie EU program SBMPs, http://www.sbmp-itn.eu), an Experienced Researcher position is available starting from 2011 in the group headed by Pr Alain Milon, “NMR and protein – membrane interactions”, Institute of Pharmacology and Structural Biology, Toulouse, France (http://www.ipbs.fr/english/teams/milon/index.htm).

G-protein coupled receptors (GPCRs) are playing a major role in signal transduction in eukaryotic cells and as such, they are of utmost pharmacological importance, being the target of about half of the major drugs currently used (1). It has been shown for several years that the lipidic environment, and in particular the sterol composition of membrane may influence the functional activation of GPCRs (2-4), and a specific cholesterol binding site has been found in the X-ray structure of the human b2 adrenergic receptor (5). Although the precise location of these cholesterol molecules bound to a GPCR are now known, much remains to be understood about their functional role and the way they actually modulate ligand binding and receptor activation. In particular the dynamics of exchange between bulk membrane cholesterol and receptor bound cholesterol remains to be determined and connected to the relevant functional time scales. Recent progresses in expression – purification of GPCRs and the availability of atomic resolution X-ray structures open the way to biophysical analyses of these interactions.

The “NMR and protein – membrane interaction group” has developed extensive expertise in the heterologous expression of GPCRs in Pichia pastoris and in E. coli (1, 6-11) and a variety opiate receptor constructs are available. It possesses a thorough expertise in analyzing sterol dynamics in model membranes by solid state NMR, using both wide line static approaches (12-17) and CP-MAS based approaches (15, 18-20). Using advanced liquid state NMR approaches and stable isotope labeling it has solved recently the 3D structure of the outer membrane protein A from Klebsiella pneumoniae, a 210 aa membrane protein domain (21, 22).

Based on this expertise, we will study cholesterol – protein interactions in lipid bilayers, micelles, and lipid cubic phases. Several membrane proteins will be used: kpOmpA, which is very stable in many environments and available in high amount with suitable stable isotope labeling, will be used to establish and develop NMR based strategies; GPCRs of the opiate family and the human b2 adrenergic receptor will be the target for understanding the functional role of cholesterol at a molecular level.

This position is opened for 12 month on the Marie Curie grant with a possibility of extension. Applicants should :

- have a PhD experience of either liquid or solid state NMR,
- have less than 5 years of research experience since the beginning of their PhD,
- not hold the french nationality,
- and not have resided in France for more than 12 months during the past 3 years.

Contact for application: Pr Alain MILON

alain.milon@ipbs.fr