Donnerstag, 14. August 2008

Post-Doctoral Position Spinnovation

Reference Hyph-05: Post-Doc, Biomolecular NMR in application to metabolomics (2-3 years).

Spinnovation Analytical BV is a private Contract Research Organization located in Nijmegen, The Netherlands. The company is specialized in offering analytical service and contract research to Industry carrying out intense Research & Development effort in the field of Pharmaceuticals, Chemicals/Polymers or Food Products. Its expertise and capacity are focused on NMR-based spectroscopic techniques and applications. Since its establishment in 2004, Spinnovation has established itself as a leading company on the worldwide market of NMR-based analytical services.

Spinnovation has currently an opened post-doctoral position in the field of biomolecular NMR applied to metabolomics.

Description. The project is based on a joint research initiative from several industrial (Pharmaceutical companies, analytical system supplier and service supplier) and academic parties. The project deals with the development and use of NMR-based analytical methods, in combination with LC/MS and LC/SPE, in the study of biological fluids for metabonomic applications. Spectrometric, spectroscopic, and chromatographic data will be used to establish unambiguous identification / characterization of endogenous metabolites develop profiling methods, support enrichment of existing database. For e.g., specific measurement of NMR parameters such as relaxation times will be carried out and issues related to protein/metabolite interactions will be addressed.
Spinnovation analytical platform combines state-of-the-art LC-SPE-NMR-MS methods, dedicated analytical systems and applications developed to address issues in the field of metabolomic (automation, throughput, sensitivity, dedicated database...). Spinnovation has a staff of highly skilled and experienced employees (researchers and engineers. NMR capacity is further supported by the access to an NMR facility with spectrometers operating at 500MHz, 600MHz and 800MHz and fitted with cryo-cooled probes.

Candidate profile. The candidate (m/f) will have a Ph.D. in biophysical chemistry with a speciality in bio-molecular NMR. He/she will have a significant background and expertise in NMR theory and operation (pulse programming, data acquisition, processing and troubleshooting), expertise that he/she would for instance have applied to solution NMR protein structure investigation. Additional expertise in chemometrics, metabolomics/nomics, other analytical methods such as MS, LC-MS will be valued.
The candidate should be interested in applied science and technological aspects, efficient in teamwork, have broad scientific interest, recognized organizational skills, with validated project management experience, be opened with good communication ability (oral / writing), fluent in English.

Further information and application. The position will be opened at Spinnovation, Nijmegen (The Netherlands). Salary will be discussed according to experience. Application shall be sent in English, including CV, accompanying letter and names of two reference persons that can be contacted, by email to the address: , mentioning the position reference ref. Hyph-05 in the subject.