The biomolecular NMR research group of Dr. Eric Guittet (http://www.icsn.cnrs-gif.fr/guittet) at the Institut de Chimie des Substances Naturelles in Gif-sur-Yvette (France) is looking for Master and PhD students and postdocs from all nationalities.
Our laboratory uses modern NMR techniques to decipher the molecular mechanisms underlying biological functions for a variety of systems involving proteins such as enzymes, unfolded proteins and macromolecular complexes. We are also interested in structure-based drug design and in developing new methodology for protein NMR resonance assignment.
Three projects are currently under investigation in the lab:
- Structural and dynamics studies of small G-proteins Arfs: investigation of the GDP/GTP-bound switch mechanism and analyses of interactions with regulators and effectors. PI: Carine van Heijenoort.
- Structural and dynamics investigation of the C-terminal intrinsically disordered regulatory domain of the tyrosine kinase receptor ErbB2 (270aa): influence of proline rich regions and of tyrosine phosphorylation in disorder and local structuration and impact on its interactions with signalling partners. PI: Carine van Heijenoort.
- Investigation of the catalytic role of interdomain motion in the 75 kDa Cytochrome P450 Reductase in electron transfer from NADPH to Cytochrome P450. PI: Ewen Lescop.
Our lab hosts several high field liquid state NMR spectrometers including the recently installed 800MHz and 950 MHz and the solid state 700MHz. Our institute (ICSN) is located inside the CNRS campus mainly dedicated to biology. The campus is in the centre of Gif-sur-Yvette, a charming village with a countryside flavour, 45mn by train from the centre of Paris and belongs to the large scientific community located in the South-West of Paris, including Soleil synchrotron and Paris XI-Orsay University.
Highly motivated applicants that have a strong background in biochemistry and/or biophysics are invited to apply. Please contact firstname.lastname@example.org for more information and include a CV with a summary of research interests and accomplishments.
Ewen LESCOP, PhD
Laboratoire de Chimie et Biologie Structurales
Institut de Chimie des Substances Naturelles - CNRS
1, avenue de la Terrasse