Mittwoch, 11. Januar 2012

PhD studentship

A 4 year PhD studentship contract is available in my group starting september 2012 to work on the structural and functional aspects of the recognition of chromatin structure by the ING4 tumor suppressor.

We seek a motivated student with a strong interest in structural biology, and with a Master degree (to be completed before september 2012).

The PhD researcher will be involved in sample preparation and structural analysis by NMR and other techniques. The laboratory hosts two Bruker spectrometers (800 and 600 MHz) with a full complement of probes for biomolecular studies). Electron microscopy and crystallography platforms are also available at CIC bioGUNE. Functional assays will be carried out in collaboration with an external group.

CIC bioGUNE (http://www.cicbiogune.es) is a research institute in biosciences created and supported by the Basque Government in 2005 to foster bioresearch and biotech industry in the Basque Country. It is located near Bilbao, an area with a high standard of living, a mild climate and a vibrant cultural environment.

Information about the current activity and publications of the lab can be found in the following link

http://www.cicbiogune.es/secciones/investigacion/ficha_laboratorio.php?idioma=en&unidad=5&subgrupo=28


Interested applicants should send their CVs to fblanco@cicbiogune.es before the 31st of january 2012.


Best regards

---
Francisco J. Blanco
Ikerbasque Research Professor
Structural Biology Unit, CIC bioGUNE
Parque Tecnológico de Bizkaia, Edificio 800
48160 Derio, Spain
Phone: 34 946572521
Fax: 34 946572502
fblanco@cicbiogune.es
www.cicbiogune.es

Post-Doc in Montpellier

The NMR group at the Centre de Biochimie Structurale (CBS) in Montpellier (France) is looking for a highly motivated researcher to join the team as a post-doc to work for two years on a project funded by the Chaires d’Excellence program of the French Research Funding Agency (ANR). The project, leaded by Pau Bernadó, aims the structural and dynamic characterization of a family of intrinsically disordered proteins linked to neurodegenerative diseases, and to reveal the molecular basis of the aggregation process causing these pathologies. This objective will be achieved by the integration of NMR, SAXS and single-molecule FRET data into novel computational approaches.

The successful candidate should have a PhD in chemistry, biology or physics and experience in solution state biomolecular NMR spectroscopy. Previous experience with protein expression and purification will be considered favourably. Knowledge in other biophysical techniques and computational methods will be favourably evaluated.

The laboratory hosts high-field state-of-the-art NMR spectrometers for biomolecular applications: A 700 MHz and a 500 MHz both equipped with cryoprobes and a 600 MHz. In addition to NMR, the CBS has an outstanding infrastructure covering all techniques for structural biology and biophysics including X-ray crystallography, cryo-electron microscopy, advanced fluorescent and super-resolution microscopes, single-molecule manipulation, molecular and cell biology, and high-performance computation.

Montpellier is a major biology area with a focus on basic research, biomedicine, plant biology and environmental science. Its science drive, the beauty of the region and its high quality of life, and the short commute to other major regional research areas (Barcelona, Paris, Toulouse, Marseille) make it an ideal destination for scientists from all over the world.

Applications and informal queries about the project and the lab should be addressed to Pau Bernadó (pau.bernado@cbs.cnrs.fr). Interested candidates should send their CV and the names of persons willing to write a recommendation letter in a cover letter describing their research interests and motivation.

Pau Bernadó, PhD
Group Leader

Centre de Biochimie Structurale
29, rue Navacelles
34090 Montpellier
France

Tel. +33(0)467417912
e-mail: pau.bernado@cbs.cnrs.fr

Postdoc

Post-Doc Position at CEA-Saclay (Paris) in NMR / MRI instrumentation


A one-year post-doctoral position is available to join the group of Dr. Dimitris Sakellariou at the Laboratory of Structure and Dynamics by Magnetic Resonance at the French Alternative Energies and Atomic Energy Commission of Saclay in Paris. Our focus is primarily directed at developing a novel instrumentation for in vivo Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) of complex matter and small animals. The project is funded by the European Research Council for the next two years.

The duration is 12 months (with the possibility to renew it for another 12 months) and the net salary will be approximately 2100 - 2600 Euros/month (depending on the experience of the candidate).

Prospective candidates should have demonstrated experience in Magnetic Resonance magnet and coil (shims, gradients and rf) engineering, in clinical or pre-clinical MRS studies, solid-state NMR, instrumentation or connected areas experimental physics and engineering.

Applicants should send 3 references in a cover letter as well as a full CV including the list of their publications and conference presentations to dsakellariou@cea.fr.

NMR tenure track position at Brown University

Structural Biology Faculty Position - Assistant Professor

The Department of Molecular Pharmacology, Physiology & Biotechnology at Brown
University announces the opening of a faculty position at the rank of Assistant
Professor, effective July 1, 2012. Qualifications include a Ph.D. and/or M.D.
degree with relevant postdoctoral research training and a record of excellence
in research. The successful applicant will be an experimentalist in the area
of NMR spectroscopy who will be expected to pursue an independent,
externally-funded research program. The applicant should demonstrate a
commitment to graduate and undergraduate education, and will have the
opportunity to participate in predoctoral training programs within the Division
of Biology and Medicine and the campus at large. Research space will be
provided in a new, state-of-the-art facility with access to modern core
facilities, NMR spectrometers, X-ray equipment, crystallization robotics, and
biophysical analysis instrumentation, such as ITC, DSC, CD and mass
spectrometry (LTQ Orbitrap) among others. Recent upgrades to the Brown
University structural biology infrastructure include the planned addition of an
850 MHz NMR spectrometer and new X-ray crystallography and small angle X-ray
scattering (SAXS) equipment.

Candidates should submit a curriculum vitae with complete bibliography, a 3-5
page description of research plans, and a one-page teaching statement.
Applicants should arrange for at least three reference letters to be sent under
separate cover. Review of materials will commence on January 15, 2012, and will
continue until the position is filled. Materials should be submitted
electronically in PDF format to Structural_Biology@brown.edu or by mail to:
Betsy Jacobson, Department of Molecular Pharmacology, Physiology &
Biotechnology, Brown University, Box G-E3, Providence, RI 02912.

Brown University is an Equal Opportunity/Affirmative Action employer and
welcomes applications from women and minorities.

Postdoc

In connection with a collaboration agreement with Janssen Pharmaceutica,
Beerse, Belgium, the University of Liege has a postdoctoral vacancy available.

We are looking for a highly motivated individual with a sound understanding of
ssNMR theory and extensive experience in implementing, setting up, running,
processing and evaluating ssNMR experiments, preferably in the context of
pharmaceutical applications. The successful candidate will be responsible for
setting-up a ssNMR research environment suitable for pharmaceutical
applications of ssNMR - as a tool for trouble shooting as well as a tool for
the development and characterization of solid form formulations (tablets,
powders, suspensions, including nano-particle based forms). Ability to work
independently and very good communicative skills are a must. He/she will be
involved in collaborative projects with Janssen Pharmaceutica.
The NMR group in Liege is equipped with two Bruker 400 MHz ssNMR spectrometers.
Potential applicants are encouraged to contact Christian Damblon for more
information about this position (or life in the historic city of Liege).
Applications must be received before end of February 2012.

Prof. Christian Damblon
Institut de Chimie
allée de la Chimie, 3 (Bât. B6)
Sart Tilman - 4000 Liège
Tel. +32 4 366 3788
c.damblon@ulg.ac.be

Postdoc

A two-year post-doc position is available in the field of Solid State NMR

At: Nano-SiSTeMI Interdisciplinary Centre, University of Piemonte Orientale

Where: Alessandria, Italy; Milan, Italy

Task: The aim of the project, in collaboration with Bruker (Italy) is to develop,

implement and use innovative solid state NMR (SS-NMR) techniques for the study of

a broad range of solids including catalysts, materials for photovoltaic devices,

optoelectronic and sensing, polymer composites, hybrid materials, cements, etc... The

responsibility also includes in providing (a) assistance and training in SS-NMR, (b)

designing and development of pulse programs, (c) experimental and interpretational

service to support collaborative and multidisciplinary research on national and

international levels and (d) day-to-day maintenance and upgrading of the facility.

The position plays two distinct roles. One is part of the NMR centered program of the

Prof. Marchese group. The other is as part of the characterization facilities available

to collaborating research groups, both within the department and external, that service an extremely wide-ranging program of materials-centered research.

Salary: 24-26 k€/year depending on the candidate experience


Contacts:
Prof. Leonardo Marchese, +39 0131 360262 (mob. + 39 3482879225) leonardo.marchese@mfn.unipmn.it
Dr. Angelo Ripamonti, +39 02 70 63 63 70, angelo.ripamonti@bruker.it

solid state NMR Platform Manager

***A Position as solid state NMR Platform Manager is being offered at

CIC Energigune, Parque Tecnologico de Alava, 01510, Spain

CIC Energigune is a new energy research centre based in the Basque Country of Spain. Its mission is to play a leading role on the international stage in the field of energy storage technologies and contribute to the industrial competitiveness of Basque Country. CIC has a world-class research facility, cutting-edge equipments, an experienced management team, and a scientific committee composed of prominent scientists, entrepreneurs, and industrial experts. (www.cicenergigune.com).
The Basque Country is renowned for the beauty of its natural surroundings. It offers high standards of living and quality of life, in terms of health, housing, leisure, sports, etc, making it an attractive area to live in.

CIC Energigune is now inviting applications for the position of Nuclear Magnetic Resonance (NMR) Platform Manager to custom-build the area´s NMR platform in the field of energy storage technologies.

***What we offer

We are offering a permanent position that will give you a unique opportunity to apply your capabilities and develop new projects related to this technical platform.

In addition to the appeal of the entire project, the CIC Energigune offers a competitive basic salary augmented by benefits that compare favourably with the best European private and public institutions.


***What we need

We are looking for a motivated and experienced professional capable of taking this unique opportunity with the following requirements:

* An MS degree preferably in Physics or Chemistry. PhD is not compulsory but will be valuable.

* Ideally several years of experience doing research with solid state NMR and also if possible some liquid NMR. More specifically, the candidate should have :

- An experience in multidimensional quadrupole and spin 1/2 solid state NMR is required

- An ability to match/tailor suitable NMR experiments to the scientific inquiries in materials research for energy applications

- The understanding of the pulse sequences and have the ability to modify and/or write them, and

- The skills to use simulation programs of solid state NMR parameters such as SIMPSON or SPINEVOLUTION are also valued

* An open-mind and creativity, willing to work in new experiments such as in-situ NMR of batteries or other energy harvesting, conversion or storage devices

* Inter-personal and communication skills to work effectively within a multi-disciplinary team or to provide supports for other facility users

Applicants should be fluent in English. Knowledge of Spanish and/or Basque will be considered useful but not compulsory.


All applicants are invited to submit a detailed curriculum vitae and two reference letters. Applications should be loaded at http://www.cicenergigune.com/en/trabajar/enviar-curriculo/.

Applications will be reviewed upon receipt and the search will continue until the position is filled.

CIC energiGUNE is committed to affirmative action, equal opportunity and the diversity of its workforce.

Postdoc

A postdoc position on protein-ligand interactions and fragment-based drug design by NMR is available at the Helmholtz Zentrum München


http://www.helmholtz-muenchen.de/fileadmin/0-templates/www-helmholtz-muenchen-de/php/jobs.php?id=1243&L=1

Job Details

The candidate will be responsible for characterizing protein-ligand interactions and implementing fragment-based approaches by NMR spectroscopy for the identification and optimization of small molecule inhibitors targeting disease-linked pathways. The scientist will be working in the group of Michael Sattler at the Institute of Structural Biology (http://www.helmholtz-muenchen.de/stb) in close collaboration with structural biologists using NMR-spectroscopy and X-ray crystallography for studying protein-ligand interactions. Interactions are expected with the Protein Expression and Purification Facility and the Assay Development and Screening Facility. The scientist should establish NMR-monitored fragment-based screening and support on-going projects in the identification and optimization of small molecule hits and leads using structural biology (NMR and X-ray crystallography). Tasks include:

- Implementing a fragment library and NMR-monitored screening
- Application of NMR based methods for protein-ligand interactions (ligand and target based)
- Hit validation and structural analysis of protein-ligand complexes by NMR and/or X-ray crystallography
- Implementation and development of new methods and techniques
- Interaction and project-driven collaborations with biologists and chemists, e.g. for establishing structure-activity relationships

The candidate is expected to interact and collaborate with researchers at HMGU.

Qualifications

- Doctoral degree in Chemistry, Biochemistry, Life Sciences, Physics, or related
- Demonstrated strong experience with structural biology and/or structure-based techniques for studying protein-ligand complexes
- Experience with training and supervision of students is desired
- We expect high motivation, creativity and a strong commitment to team work.
- Strong communication and organizational skills are expected
- Previous experience with chemical compound libraries is desirable

Our Offer

- Research scientist in the Institute of Structural Biology at the Helmholtz Zentrum München
- Supporting innovative research on important biological pathways linked to human disease.
- Working in a vibrating and scientifically stimulating environment with excellent facilities for NMR (http://www.bnmrz.org), structural biology, protein biochemistry, cell biology, imaging, animal models, and more.
- Opportunities and support in management skills

For further information please contact Michael Sattler (sattler@helmholtz-muenchen.de)

The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.

Applications should be addressed to Waltraud Wolfson (waltraud.wolfson@helmholtz-muenchen.de)

Helmholtz Zentrum München
German Research Center for Environmental Health (GmbH)
Ingolstädter Landstr. 1
85764 Neuherberg
Germany

junior research associate

We are seeking for potential candidates to apply for a position as a
CNRS junior research associate in conjunction with our group.

The focus of the research will be on developing advanced NMR methods
for the analysis of mixtures of small molecules, with particular
attention to perspective applications to natural products. Our ongoing
activity aims at resolving the complex NMR spectra of multicomponent
mixtures by relying on pseudochromatographic experiments (Angew. Chem.
2006, 45 , 5950-5953), multiple-quantum analysis (Anal. Chem. 2010,
82, 3266-3269 ) and adapted signal processing.

The candidate will be located at the Institut de Chimie des Substances
Naturelles (Gif-sur-Yvette), in the Paris area, which hosts several
high-field spectrometers, including a 950 MHz.

The ideal candidate should have a disposition towards teamwork, an
inquisitive mind and a solid background on the development and application
of modern NMR methodology, with a Ph. D. degree and at least one year
of post-doctoral work in the area.

As the CNRS national competition is highly selective, a strong
publication record is necessary.

For additional information, please contact Stefano Caldarelli

Montag, 21. November 2011

PhD SSNMR

We are looking for a young, open-minded, enthusiastic, committed and diligent individual with a background in chemistry, physics or material-sciences (German Diploma/MSc equivalent).
The successful candidate will work on the multi nuclear solid state NMR characterization of immobilized catalysts, metal-clusters, metal-nanoparticles and their interactions with substrates. The immobilized catalysts are made in-house by covalently binding metal-containing catalysts to the surface of nano-structured silica materials with different morphologies (porous or nanoparticles) via organic linkers or obtained by a cooperating group at the CNRS-Toulouse.

The structure of the immobilized catalysts on the support material, its interactions with substrates and the influence of macroscopic parameters such as temperature on its properties are investigated. The catalytic activity of the catalysts is tested by model reactions, in particular hydrogenations.
Previous hands-on experience with solid state NMR or heterogeneous catalysis will be helpful, but is not necessary.

We offer a state-of-the-art research infrastructure including solid-state NMR (600, 500 400 and 300 MHz) spectrometers and a wet-chemistry lab including GC, HPLC, UV/Vis and other techniques. An additional 400MHz DNP-NMR solid state NMR spectrometer will be installed at the end of 2012.

The NMR lab is headed by an academic staff scientist, who provides user support. The group is part of the research group FOR-1583, the research network SFB 598, the LOEWE-research group SOFT-CONTROL and various national and international cooperation projects. The group is located at the Campus Lichtwiese of the Technical University Darmstadt.
Enquiries and applications shall be addressed to Gerd Buntkowsky (gerd.buntkowsky at chemie.tu-darmstadt.de).

Prof. Dr. Gerd Buntkowsky
Dekan
Physikalische Chemie der kondensierten Materie
Technische Universität Darmstadt
Eduard-Zintl-Institut für Anorganische und Physikalische Chemie
Petersenstr. 20, D-64287 Darmstadt
phone : +49 6151/16-2607 fax: +49 6151/16-4347

email : gerd.buntkowsky@chemie.tu-darmstadt.de
Research : http://www.researcherid.com/rid/B-3206-2010
WWW : http://www1.tu-darmstadt.de/fb/ch/akbuntkowsky