Montag, 7. März 2011

Genentech Postdoctoral Fellow

Genentech Postdoctoral Fellow: Structural Biology/NMR Spectroscopy

We have an opportunity for a highly talented Postdoctoral Fellow to join the Protein NMR Group in the Structural Biology Department at Genentech. Our research encompasses the structural analysis of proteins of therapeutic interest, with an emphasis on determining their conformations and ligand-binding properties.

Genentech is now applying our expertise in protein expression, assay development, antibody engineering and drug design to pursue some of the most challenging therapeutic targets in the human proteome, including G protein-coupled receptors and ion channels. The successful candidate will focus their postdoctoral research on the NMR structural analysis of human membrane proteins involved in ion transport and the mechanisms of their functional regulation. The interaction of these proteins with potent and selective antibody fragments, peptides and/or small molecule inhibitors will also be examined. Significant progress on the high-level expression and purification of the proposed membrane structural targets has already been achieved. Moreover, you would be working with a highly collaborative group of scientists whose expertise includes protein NMR spectroscopy, soluble and membrane protein crystallography, ion channel electrophysiology and assay development.

The protein NMR facility includes dedicated 800, 600, and 500 MHz spectrometers, Linux workstations, a fully equipped protein expression and purification lab with expertise in membrane protein production, and access to the Central California 900 MHz spectrometer.
Requirements:

Recent PhD graduate in Biochemistry, Structural Biology or a related discipline, with a strong publication record providing evidence of productive, independent contributions in science. The applicant must have demonstrated expertise in protein expression and purification, and protein NMR spectroscopy . Prior experience working with membrane proteins will be a strong asset, but is not essential. The successful candidate must be motivated, capable of working independently, and enjoy working in a collaborative setting.

Interested candidates should apply at www.gene.com, but feel free to send their CV and cover letter directly to Dr. Melissa Starovasnik (star@gene.com) and Dr. Christopher Koth (kothc@gene.com). Please visit http://www.gene.com/gene/research/postdoctoral for additional information.

solid-state NMR engineer position

A one-year solid-state NMR engineer position available

A one-year engineer position is available in the Magnetic Resonance Laboratory (LRM), INAC/SCIB at CEA Grenoble for the technical maintenance of three BRUKER solid-state NMR spectrometers: two AVANCE 400, one of them coupled to a gyrotron, and one DSX 200. The NMR facility is localized at two different sites and will get very soon a complete system to perform solid-state high-resolution NMR coupled to Dynamic Nuclear Polarization (DNP).

Applications fields in high-resolution solid-state NMR at CEA-Grenoble are very broad, ranging from synthetic polymers to biological material, as well as new materials for nanotechnologies. Research at LRM includes methodological developments (pulse sequence design, DNP, NMR/DFT coupling, …) and original instrumentation in order to improve the low intrinsic sensitivity of NMR.

The successful candidate will be in charge of the maintenance and troubleshooting of the spectrometers, contact with suppliers, spectrometer time schedule, supervising external users, and users training. The candidate will be strongly involved in the setup of DNP/NMR experiments, including optimization of sample-preparation protocols for DNP.

The candidate profile includes a PhD thesis in high-resolution solid-state NMR. Previous professional experience in a NMR facility will be particularly considered. Communication and integration skills are highly appreciated.

Further information concerning this position can be obtained from the LRM scientists Sabine Hediger (sabine.hediger@cea.fr, tel +33 4 38 78 68 12) and Gaël De Paepe, DNP project leader (gael.depaepe@cea.fr, tel +33 4 38 78 58 30).

Motivated candidates should send their CV, two letters of reference, and one letter of motivation before 21st of March 2011 to:

Michel Bardet
INAC/SCIB/LRM
17 rue des Martyrs
38054 Grenoble
Cedex 9 - France
tel. 33 4 38 78 57 72 (office)
33 4 38 78 38 33 (secretary)

email : michel.bardet@cea.fr

Two Group Leader Positions – Bio NMR

Rector of Masaryk University opens positions

Two Group Leader Positions – Bio NMR, CEITEC - Central European Institute of Technology, Brno, Czech Republic

We are seeking outstanding applicants for two positions of group leaders who are willing to accept the challenge of starting independent world-class research groups in the field of bio-NMR for Structural Biology Research Program of CEITEC. Structural Biology Research Program will run core facilities for X-ray crystallography, high-end cryo electron microscopy and tomography, studies of biomolecular interactions, and high-field NMR spectroscopy.

You will be part of CEITEC - Central European Institute of Technology in Brno, Czech Republic (www.ceitec.eu), an academic research institution established jointly by Masaryk University, Brno University of Technology, Mendel University in Brno, University of Veterinary and Pharmaceutical
Sciences Brno, Institute of Physics of Materials, Veterinary Research Institute. The institute will host 600 scientists in state-of-the-art equipped laboratories. Genomics and Proteomics of Plant Systems, Molecular Medicine, Molecular Veterinary Medicine, and Brain and Mind Research represent other Life Science Research Programs of CEITEC. CEITEC will also host high throughput –omics core facilities. The material sciences programmes are part of CEITEC as well.

The High-field NMR Core Facility will be equipped with six high-resolution NMR systems ranging from 500 to 950 MHz. Central Supporting Laboratory for preparation of biomacromolecules for NMR, X-ray, and CRYO-EM and Laboratory of Protein Expression in Eukaryotic Cells will be available on site. Group resources include funds for post-doc positions, personnel and running costs.

The successful candidate must hold a PhD degree in a relevant field and should show:

- proven track record of high quality scientific productivity as judged by publications in high-impact peer-reviewed journals, providing evidence of excellence in bio NMR research and its applications
- success in obtaining extramural research funding
- experience in supervising other scientists

An interest in close collaboration with local experimental groups is essential. We will offer internationally competitive conditions and benefits in line with your experience. The positions are available from 2011 on for an initial period of five years. The beginning of the employment relationship and the onset of group operations is negotiable.

Your application should include:
- CV
- detailed description of your training and research career
- list of publications (separate listings of original research papers, reviews, book chapters)
- list of obtained research grants (name, topic, funding source, amount)
- summary of your teaching experience
- reprints of selected publications (10 at maximum)
- outline of your research plan in a form of a brief and concise executive summary (1-2 pages, A4 or Letter format)

Electronic applications must be received by 15 April, 2011, to ensure consideration. Please submit your application to the coordinator of the Structural Biology Research Program Prof. Vladimír Sklenář at:

sb.nmr(at)ceitec.muni.cz

Postdoctoral Fellowship

Postdoctoral Fellowship in NMR Methods to Study Molecules of Environmental and Biological Interest
(Project Ref. PTDC/QUI-QUI/100998/2008)

Job Description:
A 1-year postdoctoral position is available starting from May 2011, (extendable for additional 7 months) to study the “solid structure” of ionic liquids (ILs) with relevance to the pharmaceutical industry. For this purpose solid-state NMR will be used to study selected ionic solids (ISs). The research will be centered in the use of NMR techniques in tandem with molecular modelling to study the physical chemistry of molecular interactions in ILs and ISs.

This project will be performed at the NMR centers at the Universities of Aveiro (solids NMR) and Nova de Lisboa (liquids NMR).

Multinuclear liquid-state NMR experiments (including diffusion NMR experiments) will be employed to study ILs. This project will have a strong emphasis in the study of ISs, with low melting points, using advanced high-resolution multinuclear solid-state NMR methods. These studies will be complemented with first principles calculation of NMR parameters and molecular dynamics simulations. In a later stage the solvation of different molecules of pharmaceutical interest in biocompatible ILs will be addressed.

The successful candidate will have the opportunity to work in a challenging environment with access to state-of-the-art NMR equipment. The successful candidate will have the opportunity to work in a competitive and multidisciplinary environment and participate in a project of relevance to the pharmaceutical industry and with impact in environmental issues. Aveiro is a very pleasant city near the seacoast, located between Porto and Lisbon with everything within walking distance.

Equipment: The candidate will have access to all equipments within the Portuguese NMR network (http://ptnmr.dq.ua.pt) ranging from 400 MHz to 800 MHz solid-state and solution NMR spectrometers with a variety of probes and other accessories for solids and liquids and will have access also to a shared computer cluster (http:// http://wikis.ua.pt/flamingo/). Both institutes are well equipped with 6 BRUKER AVANCE III NMR (400 to 600 MHz) spectrometers equipped with more than 20 probes. Details may be found in the aforementioned link.

Duration: 12 months extendable to 19 months, preferably from May 2011.

Candidate Profile:
- The candidate should hold a PhD in Chemistry, Physics, Physical Chemistry, Materials Sciences or related disciplines.
- Previous experience in solid-state NMR spectroscopy (instrumentation and theory) is required.
- Good informatics skills and experience with molecular modelling calculations is highly appreciated.
- Candidates with previous experience in NMR studies, considering this project research topic, are also of our interest.

Selection criteria:
1- Evaluation of the CV:
- Past experience in NMR spectroscopy, with preference for those candidates with experience in solids NMR is required.
- Analysis of relevant publications of interest for this project.
2- Interview if necessary, where proof of knowledge is tested.
3- Analysis of the reference contacts given by the candidates

Salary: 1495 EUR/month (Free of taxes)

Documents for the application:
Applicants should send: Cover letter, Detailed Curriculum Vitae and at least two reference contacts, preferably, by email to Dr. Luís Mafra (lmafra@ua.pt)

Alternatively, the documents should be sent to:

Dr. Luís Mafra
Departamento de Química
CICECO
Universidade de Aveiro,
3810-193 Aveiro
Portugal
Tel. (+351) 234 370620
(Reception of the documents by email is preferable)

Deadlines:
Applications will be accepted from March 1 to March 31, 2011.

The candidates will be informed by email about the result of the selection process.

Professorship Rennes

A permanent professor position is available at the University of Rennes 1 (Pharmaceutical and biological sciences faculty and LTSI) in september 2011.

Teaching
The Professor will be in charge of the education department of Mathematics and Physics pharmaceuticals. She/He will teach Mathematics, Statistics, Physics and Informatics in different levels of the curriculum of Pharmacy and Nutraceutical Engineering. She/He will be responsible for the development of innovative teaching at the interface between different disciplines.

Research
The research project focuses on methodological and technological developments in the domain of quantification in Magnetic Resonance Imaging and Spectroscopy (MRI, MRS), including an important translational component.
This professor position is attached to the Laboratory of Signal Processing and Image (LTSI, UMR INSERM 642), in the emerging team METRIQ currently made up of 1 full professor, 5 associate professor, 1 researcher, 4 PhD students and 1 technician. The Professor, by his/her experience, will be more particularly brought to reinforce and instigate research topics recently initiated by the team including methodological (physical, information processing) and technological aspects (electronic sensors, computer engineering) of MRI / MRS. One goal is to bring the innovations within the clinical team on the field. To do this, the local environment is particularly favorable: the team is the “support”, with a dedicated research engineer, of the small animal imaging component of the PRISM* platform, while having access to MRI of Rennes University Hospital (a 1.5 T and a 3 T clinical systems, and a 3 T with 50% time dedicated for research).She/He will be brought to work closely with, biologists, pharmacists and physicians.

* The PRISM platform gathers several imaging facilites on three sites :
- Beauregard (Cemagref) : 1 whole body MRI (0.2 T and 1.5 T)
- Villejean (UR1 IFR 140) : small animal MRI 4.7 T, 2 vertical 500MHz NMR spectrometers
- Saint-Gilles (INRA) : CT-scan, US, γ-scintigraphy and PET scan

Contacts :
Hervé Saint-Jalmes : herve.saint-jalmes@univ-rennes1.fr
Marie Le Floch : marie.le-floch@univ-rennes1.fr
Lotfi Senhadji : lotfi.senhadji@univ-rennes1.fr

Professor position at Paris 13 University

Professor position (sections 31/64) at Paris 13 University – Bobigny campus
NMR: Metabolomics or Structural Biology

The CSPBAT (Chemistry, Structure, and Properties of Biomaterials and Therapeutic Agents) laboratory, UMR CNRS 7244, was created in January of 2009 to regroup several research teams affiliated to the Paris 13 University that previously belonged to other laboratories in the Paris area (Ile de France). The SBMB team is a multi-disciplinary group that uses various spectroscopic methods to study biomolecules and biological samples (liquids, cells, and tissues).

Research profile: This Professorship position is open to candidates with a research program centered on one of the themes developed by the SBMB team of the CSPBAT laboratory:

Metabolomics based on NMR spectroscopy: The approach has been developed in our laboratory over the past ten years through collaborations with the nearby hospital research groups. The major themes involve exploration of kidney function, liver function, and cancer. The metabolomic studies will be conducted in the SMBH medical Faculty and will fall within the scope of the scientific interests of the medical staffs of Jean Verdier and Avicennes Hospitals.

NMR Structural studies on model systems in vitro: Another group in the SBMB team develops research in the field of DNA-protein interactions, particularly involving DNA aptamers. The goal is to improve the affinity or specificity of the aptamers for their targets (proteins, antibiotics, RNA or DNA structural motifs) to develop therapeutic or diagnostic tools.

New research projects in collaboration with the other teams in the laboratory would be considered, in particular projects concerned with the development of bio-captors or polymer-based biomaterials with biological activity.

Teaching profile:
General teaching in the field of Chemistry and/or Biology (undergraduate level). NMR and its applications in the field of public health (Masters level).

The laboratory is located at UFR SMBH in Bobigny.

People to contact:
Veronique Migonney (Director of the CSPBAT Laboratory) : Veronique.migonney@univ-paris13.fr
Telephone number: +(33) 1 4940 33 52/33 46 (secretary)

Edith Hantz: (Head of the SBMB team)
edith.hantz@univ-paris13.fr
Telephone number: +(33) 1 4838 76 85

Professorship

We are looking to recruit a ‚young’ talent (age 35-40) for a professorship in chemistry / physical chemistry at the University of Strasbourg, one of the best French research institutions in sciences. The candidate should be an expert in solution NMR spectroscopy and in the physical chemistry of molecular systems in solution. She/He should develop independent research on complex molecular systems. Ideally static or dynamic mixtures should be investigated using NMR spectroscopy under consideration of the thermodynamics and kinetics of such systems.

Nous souhaitons recruter un "jeune" talent (35-40 ans) sur un poste de Professeur cette année. Le(a) candidat(e) dois posséder à la fois de solides connaissances en spectroscopie RMN en solution et en physico-chimies des molécules et systèmes moléculaires en solution. En particulier, il(elle) doit développer des recherches indépendantes sur des systèmes moléculaires complexes et des mélanges statiques ou dynamiques alliant la RMN liquide et les processus d'équilibres à la fois sous l'angle thermodynamiques et cinétiques.

Contact (if possible before end of February 2011):
Prof. M. W. Hosseini
UMR-CNRS 7140 (Tectonique Moléculaire)
Université de Strasbourg
Institut Le Bel
4, rue Blaise Pascal CS 90032
67081 STRASBOURG CEDEX France
Tel. (33) 0368851323
Fax (33) 0368851325
E-Mail: hosseini@unistra.fr

Dienstag, 8. Februar 2011

Postdoctoral Research Fellowships at the University of Warwick

The solid-state NMR group at the University of Warwick would like to advertise the following University of Warwick scheme to fund post-doctoral research fellowships.

Candidates with strong CVs and publication records meeting the eligibility requirements (have passed PhD viva and be within 3 years of PhD graduation) are requested to contact

Steven Brown (S.P.Brown@warwick.ac.uk)
or John Hanna (J.V.Hanna@warwick.ac.uk)

by 15th February.

http://www2.warwick.ac.uk/fac/cross_fac/ias/prf/

Institute of Advanced Study
University of Warwick
Postdoctoral Research Fellowships (5 posts)
(£27,428 pa)

Fixed Term Contract for 2 years, beginning October 2011

The Institute of Advanced Study (IAS) at the University of Warwick invites applications from outstanding researchers who are at the beginning of a promising academic career. Applications are welcome from across all Faculties and disciplines, and, in keeping with the ethos of Warwick’s IAS, interdisciplinary research applications are strongly encouraged.

You will be based in the IAS but will have a strong presence in a home academic department. Therefore, all applications MUST be supported by a Warwick academic nominator and your proposed research project should closely complement your nominated academic department’s current research interests. Nominators will be required to make a strong case for the applicant’s strategic contribution to the research within their department.

You will have been awarded your PhD, or equivalent, in any discipline and be within 3 years of your PhD graduation. Therefore you must have passed your viva and submitted the final copy of your thesis to be eligible. You should also not have more than 3 years postdoctoral research/teaching experience or hold, nor have held, a permanent academic post.

Please note that although the Fellowships will be located in the IAS, you must be nominated by an academic in a Warwick department. The nomination form can be downloaded www.go.warwick.ac.uk/ias/prf .

Closing date: 8 March 2011

Steven Brown
Department of Physics
University of Warwick
Coventry CV4 7AL

Tel: 00 44 24 76574359
Fax: 00 44 24 76150897

email: S.P.Brown@warwick.ac.uk
webpage address: http://go.warwick.ac.uk/nmr/members/academic/steven/
Warwick group webpage: http://go.warwick.ac.uk/nmr/
The UK 850 MHz solid-state NMR facility: http://go.warwick.ac.uk/850mhz/

Magnetic Resonance at Warwick: Watch the video: http://go.warwick.ac.uk/nmr/millburn

getting to Millburn House: http://go.warwick.ac.uk/nmr/getting_here

Full Time Position

The Rock and Fluid Science Department of Shell Innovation, Research & Technology seeks a PhD graduate in Physics or equivalent sciences for a full-time position to further advance Magnetic Resonance Relaxometry and Magnetic Resonance Imaging technologies at its research facility in Houston, TX USA. The position will suit an experimental researcher with a background in MRI and NMR physics or engineering, who is interested in working in a more applied environment.

Further information related to this position, as well as a link to submit applications, can be found at:

http://impact-gs.jobstreet.com/templates/shell_my/jobdesc_global.aspx?eid=NKnk6pi3lDhEDJ%2b5ntow7TQhp7M%3d&uid=469%7c23089%7c%7c&did=0&its=0&src=8&ref=&cc=&agn=

The deadline for submitting applications is 28 February 2011.

Matthias Appel
Project Leader, Rock and Fluid Science Department
Shell Innovation, Research and Technology
Houston, TX, USA

Postdoc Oxford

UNIVERSITY OF OXFORD
Department of Chemistry
Physical and Theoretical Chemistry Laboratory
Postdoctoral Research Assistant - NMR of photoactive proteins
Grade 07S : Salary £28,983 - £35,646 p.a.
Post Ref. DN11001/PJH

Applications are invited for a postdoctoral research assistant to work with Professor Peter Hore on a research project funded by DARPA (http://www.darpa.mil/). The post is available initially for up to 18 months, with a possible total duration of up to three years.

This position is part of a large project entitled Quantum Effects in Magnetoreception funded by the Defense Advanced Research Projects Agency as part of the programme Quantum Effects in Biological Environments (QuBE). The broad aims of the project are: (a) to design and perform a set of experiments that will determine definitively whether manifestly quantum effects are exploited in the avian magnetic compass sensor; (b) to develop the existing quantum mechanical model of magnetic effects on radical pair reactions; (c) to design and construct a proof-of-principle magnetic sensor around the reactions of radical pairs in model compounds. A central part of the project will involve optical and magnetic resonance experiments on the photo-active proteins photolyase and cryptochrome to establish their suitability as chemical sensors of weak magnetic fields.

The applicant should ideally have experience of protein NMR spectroscopy. The successful candidate will have the opportunity to work with colleagues from a range of disciplines on projects at the chemical/physical/life sciences interface.

The Hore group is located in the Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford, OX1 3QZ (www.chem.ox.ac.uk). To find out more about the group’s research, please visit http://research.chem.ox.ac.uk/peter-hore.aspx.

Applicants should either already have a PhD in a relevant subject area, or have submitted their thesis prior to taking up the post.

For further particulars of the post, including how to apply, please visit our website http://www.chem.ox.ac.uk/jobs.asp. These should be downloaded before an application is made. Informal enquiries should be addressed to peter.hore@chem.ox.ac.uk who would be pleased to supply further information about the project. Please quote reference DN11001/PJH in all correspondence.

The closing date for applications is 28 February 2011.
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P J Hore
Department of Chemistry, University of Oxford
Physical and Theoretical Chemistry Laboratory
South Parks Road, Oxford OX1 3QZ, UK

Tel: +44 (0)1865 275415 Fax: +44 (0)1865 275410

Email: peter.hore@chem.ox.ac.uk
Website: http://hore.chem.ox.ac.uk/
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